Raloxifene: bone and cardiovascular effects.

Abstract:

:Raloxifene (RLX), a selective estrogen receptor modulator (SERM), is currently indicated for the prevention and treatment of post-menopausal osteoporosis. At present, RLX is evaluated in other areas of study that include the reduction of the risk of breast cancer and cardiovascular (CV) disease in post-menopausal women. This SERM acts as an estrogen agonist in the skeleton, on serum lipid metabolism and on a number of coagulation factors, while it is an estrogen antagonist in the breast and uterus. Although our current data are incomplete, RLX has a favourable risk-benefit safety profile and is one of the most promising medical agents not only for the prevention of osteoporosis, but also for a large number of other disorders in post-menopausal women.

journal_name

J Endocrinol Invest

authors

Francucci CM,Romagni P,Boscaro M

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

85-9

issue

10 Suppl

eissn

0391-4097

issn

1720-8386

journal_volume

28

pub_type

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