Abstract：
:The status of the erythrocyte insulin receptor was investigated prior to and during storage at 4C in acid-citrate dextrose (ACD) solution. The receptors on cells that were obtained from both resting and exercised fasting subjects and stored for up to three days in ACD were unchanged as evaluated by both maximal specific hormone binding and the concentration of insulin required to one half maximally inhibit specific binding. These findings indicate, therefore, that the binding of insulin to its receptor on erythrocytes can be assayed in samples of stored blood and that this assay reflects the status of the receptor at the time of sampling.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Robbins PA,Kwan C,Searle GLdoi
10.1007/BF03347594subject
Has Abstractpub_date
1983-08-01 00:00:00pages
301-4issue
4eissn
0391-4097issn
1720-8386journal_volume
6pub_type
杂志文章abstract：PURPOSE:An increased aggressiveness of familial papillary thyroid carcinoma (FPTC) compared with sporadic form has been reported. On the contrary, the biological behavior of familial microPTC (FmPTC) is still debated. To assess if familial diseases should be considered as a negative prognostic factor in mPTC, the clini...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-019-01039-0
更新日期：2019-10-01 00:00:00
abstract：:Erythrocytes glutathione (GSH) levels were measured in erythrocytes from 33 subjects, at baseline and after 2-hour glucose loading in order to investigate the effect of glucose ingestion on the erythrocyte GSH. According to the World Health Organisation criteria 18 subjects had normal glucose tolerance (NGT)(mean age ...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章
doi：10.1007/BF03348003
更新日期：1997-09-01 00:00:00
abstract：BACKGROUND:During application of orthodontic force on the tooth, various molecular parameters associated with tissue remodeling are changed. IGF-I is a regulatory protein produced during periodontal regeneration. IGF binding proteins-3 (IGFBP-3), a specific IGF-I binding protein, is the major regulatory factor of IGF-I...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345340
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:We previously identified a four-generation family with medullary thyroid cancer (MTC) and a germline p.Y791F RET mutation whose cancer lacked a strong genotype-phenotype correlation. The entire gene coding region of the RET gene should be sequenced when genotype-phenotype discrepancies are observed in patien...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.3275/8997
更新日期：2013-12-01 00:00:00
abstract：:The somatostatin field has been a success story in terms of medicinal chemistry and drug discovery offering a variety of therapeutic opportunities. A rational medicinal chemistry approach capitalising on structure activity relationships has led to the discovery of SOM230, a novel, stable cyclohexapeptide somatostatin ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：INTRODUCTION:Phosphodiesterase 5 inhibitors (PDE5i) were developed while investigating novel treatments for coronary artery disease, but their andrological side effects shifted their indication toward the management of erectile dysfunction. Although PDE5i are now also indicated for pulmonary arterial hypertension and t...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/s40618-015-0339-y
更新日期：2016-02-01 00:00:00
abstract：PURPOSE:Initial surgery for medullary thyroid cancer (MTC) with no evidence of lymph node involvement in neck compartments consists of total thyroidectomy and prophylactic central neck dissection. This study evaluated the reliability of a radiotracer technique for the intraoperative detection of sentinel lymph nodes (S...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-014-0112-7
更新日期：2014-09-01 00:00:00
abstract：:Testosterone therapy has been reported to be useful in the treatment of hypogonadism and partial androgen deficiency of the aging male (PADAM) syndrome. Testosterone administration is needed in order to maintain secondary sexual characteristics, muscle mass, bone mineral density, cognitive function and sexual drive. N...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
abstract：:The usefulness of solubilized TSH-receptor for measuring TSH and TSH-displacing antibodies (TDA) in a radioligand receptor assay (RRA) was investigated. Crude thyroid membranes were solubilized with Triton X-100. A soluble protein fraction was isolated by DEAE-Sephadex A-50 ion-exchange chromatography. The binding of ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03350444
更新日期：1981-04-01 00:00:00
abstract：BACKGROUND:Levothyroxine (L-T4) treatment aims to minimize the risk of differentiated thyroid cancer (DTC) recurrence and should be tailored to patient risk stratification and potential morbidity from adverse effects. AIM:To evaluate the effectiveness of current recommendations on L-T4 treatment of DTC patients in cli...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.3275/8369
更新日期：2012-11-01 00:00:00
abstract：:The IGFs are ubiquitous and have pleoitropic effects. They are critical for normal growth and development, and for normal functioning of adult tissues. A liver-specific gene-deletion knockout of the IGF-I gene resulted in a mouse model with reduced circulating IGF-I levels, that led to insulin resistance due to the se...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
abstract：:The aim of the study was to assess iodine status in over 3800 young male subjects aged 18, living in 6 different provinces of Piemonte and in Aosta Valley, Italy. A cross-sectional study on 3837 young male subjects undergoing medical evaluation preliminary to military enrolment was performed. Spot urine samples were o...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349155
更新日期：2003-12-01 00:00:00
abstract：:The present study was performed in 30 patients who needed steroid therapy: courses of triamcinolone or DTM 8-15 given orally lasted 30 days. In 15 of these patients glucoactive corticosteroids were administered in combination with 5 micrograms/day of 25OH-vitamin D3 (25OHD3). 47Calcium oral test and 99mTc-MDP kinetics...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348448
更新日期：1984-10-01 00:00:00
abstract：:Hexarelin (Hex) is a synthetic hexapeptide with potent GH-releasing activity in both animals and men. Aim of this study was to evaluate the GH response to a maximal dose of Hex and GH-releasing hormone (GHRH) in a group of patients with Prader-Willi syndrome (PWS). Seven patients (4 boys and 3 girls, age 2.4-14.2 yr) ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347335
更新日期：1998-09-01 00:00:00
abstract：:Our aim was to investigate the effect of GnRH-agonist (GnRH-a) induced suppression of plasma sex steroids on serum GH, insulin like growth factor-I (IGF-I) and insulin levels after an oral glucose load (OGTT) in women with polycystic ovary syndrome (PCOS). Serum insulin, GH and IGF-I levels during a 75-g 4-h OGTT were...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346907
更新日期：1997-04-01 00:00:00
abstract：:The occurrence of metabolic bone disease in patients with renal dysfunction is due to the key role played by the kidney in regulating calcium-phosphate metabolism. The incidence of hip fractures in end-stage renal disease is 3- to 4-fold higher than the general population, while poor data about vertebral fractures sho...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/BF03346598
更新日期：2010-05-01 00:00:00
abstract：:Pituitary adenomas are common neoplasms requiring medical and/or surgical treatment when associated with hormonal hypersecretion. Treatment of non-functioning pituitary adenomas is necessary when symptoms of mass effect or hormonal deficits occur. However, therapeutic options, including surgical resection and/or radio...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347449
更新日期：2007-09-01 00:00:00
abstract：:A 36-year-old non-pregnant woman presented with a four-month history of progressive visual deterioration and amenorrhea. The latest gestation was 6 years earlier. Hormonal study revealed central diabetes insipidus, hypopituitarism, and slightly increased prolactin level. Ophthalmologic examination showed bilateral hem...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03343842
更新日期：2001-03-01 00:00:00
abstract：:A strong relationship was previously described between the nocturnal oscillations of plasma renin activity (PRA) and the sleep cycles, with levels of PRA that increase during non rapid eye movement sleep and decrease during rapid eye movement sleep. This study was designed to determine whether ritanserin, a 5-hydroxyt...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF03349016
更新日期：1996-09-01 00:00:00
abstract：:Papillary thyroid cancer (PTC) accounts for 80% of all thyroid malignancies, and genetic alterations associated to its etiology remain largely unknown. Chromosomal band 11q13 seems to be one of the most frequently amplified regions in human cancer, providing several candidate genes that need detailed characterization....
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345613
更新日期：2008-07-01 00:00:00
abstract：:Several cases of sporadic primary hyperparathyroidism in association with fibrous dysplasia of the bone have been reported in the English literature. Since fibrous dysplasia is a major feature and hyperparathyroidism is occasionally found in the McCune-Albright syndrome, we hypothesized that such cases may represent a...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348018
更新日期：1997-10-01 00:00:00
abstract：:The type of dietary fat affects the action of insulin by changes induced in the fatty acid composition of cell membranes. Little is known, however, about the effects of dietary fatty acids on insulin secretion or the possible relation between the fatty acid composition of the membrane phospholipids and insulin secreti...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03344034
更新日期：2002-05-01 00:00:00
abstract：:Ghrelin is a 28-amino-acid hormone produced mainly by the stomach which strongly promotes food intake. It is the only known peripheral orexigenic hormone that induces the release of GH. Ghrelin has been proposed as a link between the enteric system and central regulation of energy balance and growth. Although it has r...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03350806
更新日期：2007-10-01 00:00:00
abstract：:The aim of this paper is to briefly review some practical aspects of the relationship between thyroid function and several disorders of the hemostatic system in terms of bleeding and thrombosis. Thrombocytopenia, acquired hemophilia, hypercoagulability, cardioembolism and other biochemical coagulative and fibrinolytic...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/BF03345311
更新日期：2004-12-01 00:00:00
abstract：:Dopamine agonists have been associated with increased risk of cardiac valve regurgitation in patients with Parkinson's disease. Whether these drugs might be harmful for patients with hyperprolactinemia is still unsettled. Occasional case reports and 7 studies on the relationship between cabergoline and cardiac valve r...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,meta分析,评审
doi：10.1007/BF03345662
更新日期：2008-12-01 00:00:00
abstract：: ...
journal_title：Journal of endocrinological investigation
pub_type： 历史文章,杂志文章
doi：10.1007/s40618-018-0896-y
更新日期：2018-12-01 00:00:00
abstract：:Cardiovascular problems have long been recognized as responsible for an increased morbidity and mortality in patients with acromegaly. The aim of the present study was to evaluate echocardiographically the prevalence of cardiomyopathy in a cohort of acromegalic patients and to analyze the results in relation to demogr...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349779
更新日期：1995-09-01 00:00:00
abstract：:The enterohepatic circulation of thyroxine (T4) and triiodothyronine (T3) is higher in thyrotoxicosis. Bile-salt sequestrants bind iodothyronines and thereby increase their fecal excretion. We, therefore, evaluated the effect of colestipol-hydrochloride administration on clinical and biochemical indices of patients wi...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF03348036
更新日期：1998-12-01 00:00:00
abstract：:The occurrence of tumors originating from aberrant adrenocortical tissue in ectopic site is very rare. Up to now only two cases of ectopic aldosterone-producing adenoma have been described. We have observed another case of ectopic aldosteronoma, located in the retrocaval region, laterally to the body of the 12th thora...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349816
更新日期：1995-11-01 00:00:00
abstract：:We studied 8 insulin dependent stable young diabetics with a mean age of 20 yr. Each patient received 10 mg of diazepam orally after with drawing the baseline blood sample. Subsequent samples were obtained at 30 min intervals for 150 min. The oral administration of diazepam resulted in a significant increase in serum ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349471
更新日期：1982-05-01 00:00:00
