Somatostatin-related therapeutics in ophthalmology: a review.

abstract：:Ghrelin is a 28-amino-acid hormone produced mainly by the stomach which strongly promotes food intake. It is the only known peripheral orexigenic hormone that induces the release of GH. Ghrelin has been proposed as a link between the enteric system and central regulation of energy balance and growth. Although it has r...

journal_title：Journal of endocrinological investigation

authors： Seoane LM,Al-Massadi O,Barreiro F,Dieguez C,Casanueva FF

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:Thyroid hormone resistance (RTH β) is a rare genetic disorder characterized by an altered response of target tissue to the action of thyroid hormone. Few studies on RTH β have been carried out in southern European populations. We aimed to describe the clinical and genetic characteristics at the time of diagno...

journal_title：Journal of endocrinological investigation

authors： Vela A,Pérez-Nanclares G,Ríos I,Rica I,Portillo N,Castaño L,Spanish Group for the Study of RTH.

更新日期：2019-08-01 00:00:00

abstract：:Rats bearing mammosomatotropic tumors have raised insulin but lowered glucose concentrations. To determine if growth hormone (GH) secreted by these tumors causes insulin antagonism, pancreatic suppression tests utilizing infusions (per kg per min) of glucose (8 mg), insulin (200 ng) and somatostatin (1.4 micrograms) f...

journal_title：Journal of endocrinological investigation

authors： Davidson MB,Shen DC,Venkatesan N,Sladen G

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:The significance of vitamin D deficiency in the incidence of bone fractures in children has been under investigated. Here, we aimed to associate serum 25-hydroxyvitamin D levels and fractures in Saudi children. MATERIALS AND METHODS:This cross-sectional study was conducted in 1022 Saudi children without fra...

journal_title：Journal of endocrinological investigation

authors： Al-Daghri NM,Aljohani N,Rahman S,Sabico S,Al-Attas OS,Alokail MS,Al-Ajlan A,Chrousos GP

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the hypothesis that interleukin-1beta (IL-1beta) might be involved in the increase of the circulating levels of placental-derived CRH leading to the initiation of pre-term labor. SUBJECTS AND METHODS:Forty-eight primigravidae with a singleton viable pregnancy between ...

journal_title：Journal of endocrinological investigation

authors： Vitoratos N,Mastorakos G,Kountouris A,Papadias K,Creatsas G

更新日期：2007-01-01 00:00:00

abstract：:A 45-year-old man presented with gynecomastia, hypertension and a large left adrenal mass. Further evaluation revealed elevated serum concentrations of estrogen, estrone sulfate, androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate, deoxycorticosterone, and aldosterone and increased 24-hour urinary ...

journal_title：Journal of endocrinological investigation

authors： Zayed A,Stock JL,Liepman MK,Wollin M,Longcope C

更新日期：1994-04-01 00:00:00

abstract：PURPOSE:To investigate the effects of metabolic abnormalities, hyperandrogenemia and ovulation induction by clomiphene/acupuncture on liver function parameters among women with polycystic ovary syndrome (PCOS). METHODS:This is a secondary analysis of a randomized controlled trial. All 1000 subjects were diagnosed as P...

journal_title：Journal of endocrinological investigation

authors： Cai WY,Gao JS,Luo X,Ma HL,Ge H,Liu N,Xia Q,Wang Y,Han BW,Wu XK

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:To present the data on primary hyperparathyroidism (PHPT) in pregnancy from India obtained from a large database maintained over 15 years. METHODS:We retrieved data of all women with gestational PHPT from the Indian PHPT registry between July 2005 and January 2020, and compared their clinical, biochemical, and...

journal_title：Journal of endocrinological investigation

authors： Pal R,Bhadada SK,Gupta N,Behera A,Aggarwal N,Aggarwal A,Raviteja KV,Saikia UN,Kaur G,Arvindbhai SM,Walia R

更新日期：2020-10-09 00:00:00

abstract：AIM:Adult subjects with Prader-Willi syndrome (PWS) may show several conditions that are associated with an activation of innate immunity such as obesity, deficient GH secretion or hypogonadism. Our aim was to study whether obese adult PWS subjects show an additional low-grade systemic inflammation (LGSI) in relation t...

journal_title：Journal of endocrinological investigation

authors： Caixàs A,Giménez-Palop O,Broch M,Vilardell C,Megía A,Simón I,Giménez-Pérez G,Mauricio D,Vendrell J,Richart C,González-Clemente JM

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (MSC) mediate their protection by paracrine mechanism under ischemic conditions and anoxic pre-conditioning (AP) of MSC strongly enhances their survival and regenerative capacity. However, there is no report about the therapeutic potency of MSC transplantation on diabetic c...

journal_title：Journal of endocrinological investigation

authors： Li JH,Zhang N,Wang JA

更新日期：2008-02-01 00:00:00

abstract：PURPOSE:Spinal cord injury (SCI) affects sexual health of both male and female, but little attention has been given to sexuality of SCI women. Similar to penile erection, vaginal lubrication represents a neurovascular event and then both denervation and vascular damage might contribute to its impairment. Nevertheless, ...

journal_title：Journal of endocrinological investigation

authors： D'Andrea S,Castellini C,Paladino V,Totaro M,Felzani G,Francavilla S,Francavilla F,Barbonetti A

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:To report the long-term effectiveness and safety of the recombinant human growth hormone Omnitrope®, a somatropin biosimilar to Genotropin®, in Italian patients with growth hormone deficiency (GHD) enrolled in the PATRO Adults study. METHODS:The PATRO Adults study is an ongoing observational, longitudinal, non...

journal_title：Journal of endocrinological investigation

authors： Ferone D,Profka E,Gasco V,Ambrosio MR,Colao A,Di Somma C,Puxeddu E,Arnaldi G,Pagano C,Zecchi E,Pietropoli A,Beck-Peccoz P

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:During application of orthodontic force on the tooth, various molecular parameters associated with tissue remodeling are changed. IGF-I is a regulatory protein produced during periodontal regeneration. IGF binding proteins-3 (IGFBP-3), a specific IGF-I binding protein, is the major regulatory factor of IGF-I...

journal_title：Journal of endocrinological investigation

authors： Toia M,Galazzo R,Maioli C,Granata R,Scarlatti F

更新日期：2005-12-01 00:00:00

abstract：PURPOSE:An increased aggressiveness of familial papillary thyroid carcinoma (FPTC) compared with sporadic form has been reported. On the contrary, the biological behavior of familial microPTC (FmPTC) is still debated. To assess if familial diseases should be considered as a negative prognostic factor in mPTC, the clini...

journal_title：Journal of endocrinological investigation

authors： Capezzone M,Secchi C,Fralassi N,Cantara S,Brilli L,Ciuoli C,Pilli T,Maino F,Forleo R,Pacini F,Castagna MG

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Thyroid-stimulating hormone (TSH) plays an important role in the regulation of lipid metabolism. However, little is known about the role that exosomes play in the process of TSH-induced lipotoxicity in non-alcoholic fatty liver disease (NAFLD). As a preliminary step, the present study set out to investigate ...

journal_title：Journal of endocrinological investigation

authors： Ma S,Shao S,Yang C,Yao Z,Gao L,Chen W

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:Leptin is associated with cardiovascular risk factors (e.g. hypertension, insulin resistance, kidney disease and excess body weight). Experimental studies showed that leptin might affect serum uric acid, by modulation of the uric acid excretion. However, there are few observational data on the relationship betw...

journal_title：Journal of endocrinological investigation

authors： D'Elia L,Giaquinto A,Cappuccio FP,Iacone R,Russo O,Strazzullo P,Galletti F

更新日期：2020-05-01 00:00:00

abstract：PURPOSE:The pathogenesis of idiopathic hypogonadotropic hypogonadism (IHH) is genetically complex. The aims of this study were to investigate the genetic profile and clinical manifestation of IHH in a Chinese pedigree and to discover new IHH-associated genes. METHODS:The first step was to follow up the clinical phenot...

journal_title：Journal of endocrinological investigation

authors： Chen Y,Sun T,Niu Y,Wang D,Liu K,Wang T,Wang S,Xu H,Liu J

更新日期：2021-01-16 00:00:00

abstract：BACKGROUND:Autoimmune polyendocrinopathy-candidiasis-ectodermal-dystrophy (APECED) or autoimmune polyglandular syndrome type 1 (APS-1) is a rare autosomal recessive genetic disease due to mutations in the AIRE (AutoImmune REgulator) gene. The clinical diagnosis is classically based on the presence of at least two of th...

journal_title：Journal of endocrinological investigation

authors： Fierabracci A,Arena A,Toto F,Gallo N,Puel A,Migaud M,Kumar M,Chengappa KG,Gulati R,Negi VS,Betterle C

更新日期：2020-08-07 00:00:00

abstract：:A 36-year-old non-pregnant woman presented with a four-month history of progressive visual deterioration and amenorrhea. The latest gestation was 6 years earlier. Hormonal study revealed central diabetes insipidus, hypopituitarism, and slightly increased prolactin level. Ophthalmologic examination showed bilateral hem...

journal_title：Journal of endocrinological investigation

authors： Durán Martínez M,Santonja C,Pavón de Paz I,Monereo Megías S

更新日期：2001-03-01 00:00:00

abstract：:Typical modifications of cardiovascular activity and water and salt homeostasis throughout female reproductive life are well known. Differences in plasma levels of calcitonin gene-related peptide (CGRP) and atrial natriuretic peptide (ANP) have been observed in conditions characterized by different estrogenic levels, ...

journal_title：Journal of endocrinological investigation

authors： Bernardi F,Valentini A,Margutti A,Santuz M,Degli Uberti EC,Petraglia F,Genazzani AR

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Serum DHEAS has been found to be elevated in some women with polycystic ovary syndrome (PCOS). We wished to determine whether this prevalence is different in women with androgen excess who have different phenotypes and to correlate these findings with various cardiovascular and metabolic parameters. METHODS...

journal_title：Journal of endocrinological investigation

authors： Carmina E,Lobo RA

更新日期：2007-02-01 00:00:00

abstract：:GH may exert direct growth-promoting and metabolic actions on target tissues, but most of its effects are mediated by circulating (endocrine) or local (auto-/paracrine) IGF-I. The GH/IGF-I system has an important role in cardiac development and in maintaining the structure and function of the heart. A subgroup of chil...

journal_title：Journal of endocrinological investigation

authors： Nygren A,Sunnegårdh J,Albertsson-Wikland K,Berggren H,Isgaard J

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Neonatal hypothyroidism has serious effects on growth, development, and metabolism. AIM:This study aims to investigate the effects of the neonatal hypothyroidism on carbohydrate metabolism, islet insulin secretion and morphology of the pancreatic islets in adult male offspring. MATERIALS/SUBJECTS AND METHO...

journal_title：Journal of endocrinological investigation

authors： Farahani H,Ghasemi A,Roghani M,Zahediasl S

更新日期：2013-01-01 00:00:00

abstract：:Bone matrix is composed mainly of inorganic materials, while the bone organic compartment is a minor and complex structural entity, surrounding and supporting cells. Three major classes of biomolecules are involved in this organic part: structural proteins, specialized proteins, and proteoglycans. This review will bri...

journal_title：Journal of endocrinological investigation

authors： Camozzi V,Vescini F,Luisetto G,Moro L

更新日期：2010-01-01 00:00:00

abstract：:Ghrelin, a natural GH secretagogue, exerts remarkable endocrine and non-endocrine activities such as orexigenic effect and modulation of the endocrine and metabolic response to variations in energy balance. Ghrelin levels have been reported to be negatively associated to insulin secretion, enhanced in anorexia and red...

journal_title：Journal of endocrinological investigation

authors： Bellone S,Rapa A,Vivenza D,Castellino N,Petri A,Bellone J,Me E,Broglio F,Prodam F,Ghigo E,Bona G

更新日期：2002-05-01 00:00:00

abstract：:There has been a substantial increase in women practicing sports over the past 30 yr. While exercise provides many health benefits, there appears to be a unique set of risks associated with intense exercise for the female athlete. The female athlete triad encompasses these risks, including amenorrhea, osteoporosis and...

journal_title：Journal of endocrinological investigation

authors： Warren MP,Goodman LR

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:Metastases to the thyroid gland are uncommon and they represent 1-3% of all thyroid malignancy. The aim of this study is to analyze the diagnostic problems and the role of surgery in metastatic lesions to the thyroid. METHODS:We retrospectively analyzed all patients who had undergone thyroidectomy at our Cente...

journal_title：Journal of endocrinological investigation

authors： Battistella E,Pomba L,Mattara G,Franzato B,Toniato A

更新日期：2020-11-01 00:00:00

abstract：:Microvessel density (MVD) represents a measure of angiogenesis and may be used as an indicator of neoplastic aggressiveness. Vascular endothelial growth factor (VEGF) plays a pivotal role as angiogenic promoter by stimulating endothelial cell proliferation and migration and enhancing vascular permeability. The aim of ...

journal_title：Journal of endocrinological investigation

authors： Viacava P,Gasperi M,Acerbi G,Manetti L,Cecconi E,Bonadio AG,Naccarato AG,Acerbi F,Parenti G,Lupi I,Genovesi M,Martino E

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Although a nation-wide salt iodization program on voluntary basis was implemented in 2005, many areas in our country are still characterized by mild iodine deficiency. Differently from the rest of Italy, an efficient program of iodine prophylaxis was implemented in 1981 in the Autonomous Province of Bolzano. Th...

journal_title：Journal of endocrinological investigation

authors： Olivieri A,Radetti G,Medda E,Italian Study Group for Congenital Hypothyroidism.

更新日期：2015-02-01 00:00:00

abstract：:Osteoporosis is a multifactorial chronic disease that may become even more prevalent and more of a public health problem in the decades to come. Recent research has indicated that a number of macro- and micronutrients are involved in the development of bone health. In the past decade it became evident that vitamin K p...

journal_title：Journal of endocrinological investigation

authors： Francucci CM,Rilli S,Fiscaletti P,Boscaro M

更新日期：2007-01-01 00:00:00