Corticotropin-releasing factor and adrenal function in major depression.

Abstract:

:We investigated ACTH and cortisol responses after ovine CRF injection (1 microgram/kg one bolus) in a group of 11 drug-free patients suffering from major depression. When compared to sex- and age-matched normal controls, our depressed patients showed: Higher ACTH basal values (p less than 0.002); higher cortisol basal values (p less than 0.009); blunted ACTH response to oCRF administration (p less than 0.23); higher cortisol response to oCRF (p less than 0.001). Our data show that in depressed patients the feed-back mechanism is functionally intact at the pituitary level on one hand, while on the other, a hyperresponsiveness of adrenal cortex (even to minimal stimuli) seems to be present. Moreover, a hypersecretion of endogenous CRF in these patients seems to be likely.

journal_name

J Endocrinol Invest

authors

Nerozzi D,Bersani G,Melia E,Magnani A,Antonozzi I,Frajese G

doi

10.1007/BF03350921

subject

Has Abstract

pub_date

1988-11-01 00:00:00

pages

697-701

issue

10

eissn

0391-4097

issn

1720-8386

journal_volume

11

pub_type

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