Abstract:
:The present study was designed to assess the transfer of thyroglobulin (Tg) and anti-Tg antibodies (TgAb) to saliva in subjects with positive TgAb in their sera. Group I consisted of normal euthyroid control subjects (n = 10). Group II were patients with various thyroid disorders and no TgAb in their sera (n = 6). Group III were patients with thyroid disorders and TgAb in their sera (n = 31). The mean serum Tg level (+/- SE) and mean TgAb level [mean % binding +/- SE (range)] were as follows: Group I, Tg: 22.0 ng/ml +/- 1.64 (n = 10); TgAb 1.91% +/- 0.34 (range 0.6% to 4%). Group II, Tg: 119.8 ng/ml +/- 28.0 (n = 6) TgAb 1.59% +/- 0.34 (0.64% to 2.7%). Group III Tg 167.9 ng/ml +/- 41.0 (n = 31) TgAb 23.2% +/- 3.87 (4.2% to 67.5%). The mean salivary Tg level (SaTg) and mean TgAb binding (% +/- SE range) in saliva were as follows: Group I SaTg 2.07 ng/ml +/- 0.39 (n = 10) SaTgAb 1.13% +/- 0.38 (0% to 3.1). Group II SaTg 3.41 ng/ml +/- 0.67 (n = 6), SaTgAb 0.55% +/- 0.29 (0-1.9%). Group III SaTg 5.22 ng/ml +/- 0.96 (n = 31), SaTgAb 3.1% +/- 1.58 (0 to 47.7%). Salivary TgAb were only present in 4 out of 31 cases of Group III. Mean serum Tg in group IV-A was 75.01 ng/ml +/- 52.1 (n = 11). Mean serum TgAb in group IV-A was 1.94% +/- 0.31 (n = 11).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Van Herle AJ,Rosenblit PD,Van Herle TL,Van Herle P,Greipel M,Kellett Kdoi
10.1007/BF03349955subject
Has Abstractpub_date
1989-03-01 00:00:00pages
177-82issue
3eissn
0391-4097issn
1720-8386journal_volume
12pub_type
杂志文章abstract:BACKGROUND:The data about cardiovascular (CV) changes in patients with asymptomatic primary hyperparathyroidism (PHPT) are scarce. AIM:The aim of this study is to compare cardiac structure and functions in patients with asymptomatic PHPT and controls by using tissue Doppler echocardiography. SUBJECTS AND METHODS:Thir...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/8961
更新日期:2013-11-01 00:00:00
abstract::Male to female sex reversal results from failure of testis development. Mutations in the SRY gene or in other genes involved in the sexual differentiation pathway are considered to cause XY gonadal dysgenesis. The majority of the mutations in the SRY described so far are located within the SRY coding region, mainly in...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347266
更新日期:2005-07-01 00:00:00
abstract::Erythrocytes glutathione (GSH) levels were measured in erythrocytes from 33 subjects, at baseline and after 2-hour glucose loading in order to investigate the effect of glucose ingestion on the erythrocyte GSH. According to the World Health Organisation criteria 18 subjects had normal glucose tolerance (NGT)(mean age ...
journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章
doi:10.1007/BF03348003
更新日期:1997-09-01 00:00:00
abstract::The aim of this prospective study was to investigate the effects of thyroid hormone levels on the sepsis criteria and mortality in septic newborns. This study was performed at the Firat University Hospital Neonatal Intensive Care Unit. A group of septic newborns and a control group of healthy non-infected newborns wer...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347098
更新日期:2011-04-01 00:00:00
abstract:INTRODUCTION:Phosphodiesterase 5 inhibitors (PDE5i) were developed while investigating novel treatments for coronary artery disease, but their andrological side effects shifted their indication toward the management of erectile dysfunction. Although PDE5i are now also indicated for pulmonary arterial hypertension and t...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/s40618-015-0339-y
更新日期:2016-02-01 00:00:00
abstract::Although adjustments to nutritional lifestyle and increased physical activity remain the milestones of weight loss therapy, it is evident from the exponential increase of the number of obese subjects in Western countries that these two approaches alone are no longer able to limit this progression. This alarming phenom...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:
更新日期:2006-01-01 00:00:00
abstract::Apparent mineralocorticoid excess (AME) is a syndrome attributable to congenital deficiency of the enzyme 11 beta-dehydrogenase (11 beta-OHSD) which converts active glucocorticoid cortisol to inactive cortisone. When 11 beta-OHSD activity is impaired, cortisol acts as a potent mineralocorticoid and causes hypertension...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/BF03349763
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:Increasing evidence showed that telomere length was shorter in age-related diseases, but the mechanism of this phenomenon is still unclear. AIM:To determine whether telomere shortening occurs in Type 1 diabetes (T1D) and Type 2 diabetes (T2D), and explore the effect of antioxidant status on the telomere len...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/9036
更新日期:2013-12-01 00:00:00
abstract::Nutritional and hormonal milieu in utero affect fetal growth. Both parties involved have an independent chance, for the occurrence of a developmental error at any stage of their constant developing system. Studies suggest that pregnancy outcome is associated with fetal demand for nutrients and the materno-placental ca...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/BF03345248
更新日期:2003-09-01 00:00:00
abstract::Isolated hypothyroxinemia (IH) is defined as a thyroxine level in the lower 5th (severe IH) or 10th percentile (mild IH) of the pregnancy-related reference range and a normal TSH. The etiology of IH remains unknown. This review aims to evaluate the biochemical criteria used to define IH in different published studies ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/s40618-014-0203-5
更新日期:2015-02-01 00:00:00
abstract::Impaired glucose tolerance is present in many acromegalic patients and treatment with somatostatin analogs has variable effects on glycemic control. The aim of this study was to compare the effects of 2 somatostatin analogs on glucose metabolism, lanreotide slow release (L-SR) and octreotide long acting release (O-LAR...
journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章
doi:10.1007/BF03345491
更新日期:2002-06-01 00:00:00
abstract::Differently from other metabolic conditions, most of calcium metabolism disorders are diagnosed through simple detection of both serum and urinary excretion (24-h urine collection), levels of calcium, total and ionized form, and phosphate, and of calciotropic hormone serum levels, such as calcitonin, PTH and vitamin D...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:
更新日期:2003-01-01 00:00:00
abstract::We summarized the clinical course of 10 patients with silent thyroiditis and evaluated the clinical usefulness of ultrasonography, in combination with clinical and laboratory findings, for the differentiation from Graves' disease. Serum T3 and T4 were increased in all cases, and the ratio of T3/T4 (ng/micrograms) was ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348732
更新日期:1992-04-01 00:00:00
abstract::The behavior of serum anti-thyroglobulin (Abs-Tg) and antimicrosomal antibodies (Abs-Mc) was examined during and after normal pregnancies. The antibodies titer decreases as pregnancy progresses; they cross the placenta and are present in the fetal serum. Infants' thyroid function is not affected by this transplacentar...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349385
更新日期:1980-10-01 00:00:00
abstract::To verify if the entity of the peak GH responses to the GHRH+arginine (ARG) test is able to show different degree forms of GH deficiency (GHD), we linked these responses with the number of other anterior pituitary deficits. These anterior pituitary deficits were also related with IGF-I levels. To this purpose, we stud...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03345381
更新日期:2005-03-01 00:00:00
abstract::To determine whether G proteins are involved in the regulation of mouse placental lactogen-I (mPL-I) and/or mPL-II secretion before midpregnancy, mouse placental tissue from day 7 of pregnancy was dispersed with collagenase, cells were fractionated on a percoll gradient, and the purified trophoblast cells were culture...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349006
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND AND AIM:Evidences suggest that androgen deficiency is associated with sudden cardiac death (SCD). Our purpose was to analyse some electrocardiographic (ECG) markers of repolarization phase in hypogonadal patients either at baseline or after testosterone replacement therapy (TRT). PATIENTS AND METHODS:Baseli...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-019-01026-5
更新日期:2019-09-01 00:00:00
abstract::The aim of this study was to determine the protein pattern of human thyroid fine needle aspiration fluid (FNA) using a proteomic approach. FNA proteins were separated using 2-dimensional gel electrophoresis (2DE), digested and then analyzed by peptide mass fingerprinting. For the first time, we provided an image of th...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349229
更新日期:2007-11-01 00:00:00
abstract::We report here on the isolation and repertoire characterization of a Graves' thyroid T cell population which, unlike most Graves' thyroid T cell isolates reported before, was rich in CD4-CD8- T cells (16%, all TcR gamma delta+) and CD8+ T cells (75%) [TcR alpha beta+ (59%) and TcR gamma delta+ (16%)]. Only 7% of the i...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348958
更新日期:1993-12-01 00:00:00
abstract::Metabolic diseases are associated with chronic low-grade inflammation, which has been indicated as a potential mediator of endothelial dysfunction and cardiovascular disease. Visceral adiposity is thought to be the starting condition of the inflammatory state through the release of inflammatory cytokines, including TN...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/s40618-018-0872-6
更新日期:2018-11-01 00:00:00
abstract::We describe a unique case of spontaneous resolution of hyperparathyroidism in a lady with combined parathyroid adenoma and prolactinoma, raising the possibility of underlying multiple endocrine neoplasia (MEN) 1 syndrome. We also discuss the mechanism and natural history of such spontaneous remission. ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03345292
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:Glucagon-like peptide-1 (GLP-1) and its potent analog, exendin-4, are well known to inhibit β- cell apoptosis and promote β-cell proliferation. Meanwhile, cytokines, such as interleukin-1β (IL-1β), stimulate inducible nitric oxide synthase (iNOS) expression and nitric oxide overproduction leading to β-cell d...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/8938
更新日期:2013-11-01 00:00:00
abstract::This study, carried out on 9 nonfunctioning pituitary adenomas, was undertaken in order to evaluate the ability of these tumors to synthesize and release gonadotropins and/or free alpha-subunit (alpha-SU) of glycoproteins. The morphological study included electron microscopy and immunofluorescence analysis while hormo...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347659
更新日期:1993-02-01 00:00:00
abstract::We describe a patient with Cushing's syndrome and metastatic small cell lung cancer. The plasma ACTH concentrations were markedly elevated (91.6 pmol/L), and the AM cortisol did not suppress by > 50% overnight after administration of 8 mg dexamethasone, both consistent with the ectopic ACTH syndrome. Immunohistochemic...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347737
更新日期:1994-06-01 00:00:00
abstract::Leptin may be a possible trigger for puberty. In normal males, it has been shown that leptin increases from the pre-pubertal to the early pubertal stage, and then declines in the late pubertal stage. We examined leptin levels in six male adolescents (mean age 16.3+/-0.6 yr; range 14.2-17.6 yr) with delayed puberty (co...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03345471
更新日期:1999-01-01 00:00:00
abstract::The physiological pulsatile secretion of GH in humans might be important for the metabolic effects of GH. In the treatment of GH-deficient (GHD) patients, the most common regimen is a single sc injection at bedtime. It has not been completely established if this is the optimal mode of GH administration during long-ter...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,随机对照试验
doi:10.1007/BF03349206
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND AND AIMS:C-reactive protein (CRP) is an inflammatory marker that predicts coronary heart disease (CHD) risk. Diabetes mellitus (DM) counts as a CHD risk equivalent. We aimed to compare serum high sensitivity CRP (hs-CRP) levels in Type 2 diabetic (T2DM) men without CHD, non-diabetic CHD patients and T2DM pat...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03345357
更新日期:2005-02-01 00:00:00
abstract::Unfortunately, the author name and his affiliation were published in the original publication. They have now been removed. ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,已发布勘误
doi:10.1007/s40618-019-01012-x
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Type 1 diabetes (T1DM) is an autoimmune disease in which both genetic and environmental factors play a role in the etiology. AIM:The aim of this study was to analyze the incidence of T1DM. METHODS:A retrospective technique was used to register all newly diagnosed cases of T1DM in Belgrade (Serbia) children...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,多中心研究
doi:10.3275/8619
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To determine the incidence and determinants of developing abnormalities on the 12-lead electrocardiogram (ECG) in persons with type 1 diabetes. METHODS:We evaluated the distribution of ECG abnormalities and risk factors for developing new abnormalities in 266 (mean age = 44 years ± 9.0; 50 % female) people wit...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-016-0564-z
更新日期:2017-03-01 00:00:00