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Outcomes of androgen replacement therapy in adult male hypogonadism: recommendations from the Italian society of endocrinology.

Abstract：

OBJECTIVE:We developed clinical practice guidelines to assess the individual risk-benefit profile of androgen replacement therapy in adult male hypogonadism (HG), defined by the presence of specific signs and symptoms and serum testosterone (T) below 12 nmol/L. PARTICIPANTS:The task force consisted of eight clinicians experienced in treating HG, selected by the Italian Society of Endocrinology (SIE). The authors received no corporate funding or remuneration. CONSENSUS PROCESS:Consensus was guided by a systematic review of controlled trials conducted on men with a mean T < 12 nmol/L and by interactive discussions. The guidelines were reviewed and sequentially approved by the SIE Guidelines Commission and Executive Committee. CONCLUSIONS:We recommend T supplementation (TS) for adult men with severely reduced T levels (T < 8 nmol/L) to improve body composition and sexual function. We suggest that TS be offered to subjects with T < 12 nmol/L to improve glycaemic control, lipid profile, sexual function, bone mineral density, muscle mass and depressive symptoms, once major contraindications have been ruled out. We suggest that lifestyle changes and other available interventions (e.g. for erectile dysfunction) be suggested prior to TS. We suggest that TS should be combined with currently available treatments for individuals at high risk for complications, such as those with osteoporosis and/or metabolic disorders. We recommend against using TS to improve cardiac outcome and limited mobility. We recommend against using TS in men with prostate cancer, unstable cardiovascular conditions or elevated haematocrit. The task force places a high value on the timely treatment of younger and middle-aged subjects to prevent the long-term consequences of hypoandrogenism.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Isidori AM,Balercia G,Calogero AE,Corona G,Ferlin A,Francavilla S,Santi D,Maggi M

doi

10.1007/s40618-014-0155-9

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

103-12

issue

eissn

0391-4097

issn

1720-8386

pii

10.1007/s40618-014-0155-9

journal_volume

pub_type

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Outcomes of androgen replacement therapy in adult male hypogonadism: recommendations from the Italian society of endocrinology.