Abstract:
:Recent data seem to suggest that LHRH may be involved in the modulation of PRL secretion. We studied the PRL pattern in 9 males (age range 18-38 yr) with idiopathic hypogonadotropic hypogonadism (IHH) before and during long-term pulsatile LHRH therapy (120-160 ng/kg bw every 120 min sc) in order to evaluate variations in the spontaneous PRL secretion or LHRH-induced presence of PRL pulse. LH, FSH and PRL secretion was evaluated every 15 min for 3 h on day 0, day 30 and days 90-150. Before and during LHRH therapy PRL 24-h integrated concentration (IC) and gonadotropin or PRL response to LHRH test (50 micrograms iv/bolus) were evaluated. On day 0 spontaneous PRL pulses were found in 2 IHH patients. On day 30 PRL pulses were found in 4 cases. On days 30-90 PRL pulses were sporadically concomitant with LHRH-induced LH pulses. Mean PRL levels and 24-h IC of PRL were found to be significantly (p less than 0.05) increased during pulsatile LHRH administration. A significant positive (p less than 0.01) correlation was observed between testosterone and PRL levels during LHRH therapy. When compared to a significant LH response to LHRH iv bolus, no modification of PRL secretion was found. The present study did not show any relationship between LHRH administration and PRL secretion. It might be hypothesized that LHRH does not play a determinant role in PRL secretion and does not seem to modulate PRL secretory pattern in IHH males.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Giusti M,Traverso L,Cavagnaro P,Torre R,Durante R,Giordano Gdoi
10.1007/BF03350751subject
Has Abstractpub_date
1989-09-01 00:00:00pages
523-9issue
8eissn
0391-4097issn
1720-8386journal_volume
12pub_type
杂志文章abstract::The 1865 volume of the "II Morgagni", one of the most important Italian medical journals of the 19th century, presented two important articles, milestones for further scientific studies in the field of sexual differentiation. One was the original description of the "ramified cells" of testicular tubules by E. Sertoli,...
journal_title:Journal of endocrinological investigation
pub_type: 历史文章,杂志文章
doi:10.1007/BF03345329
更新日期:2005-11-01 00:00:00
abstract::The changes occurring in the levels of circulating thyroid microsomal antibody (M-Ab) and antithyroglobulin antibody (Tg-Ab) during antithyroid drug therapy were studied in 32 patients receiving methimazole for Graves' disease. M-Ab was determined by competitive binding radioassay and Tg-Ab by a sandwich radiometric m...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350476
更新日期:1982-01-01 00:00:00
abstract:PURPOSE:Aims of this study were to evaluate the agreement between the short and long versions of the International Physical Activity Questionnaire (IPAQ: Italian versions), their reproducibility (agreement and reliability) and construct validity (relative to pedometry) in a clinical population. METHODS:Ninety patients...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-017-0746-3
更新日期:2018-03-01 00:00:00
abstract::Thyroid diseases may lead to endothelial dysfunction; however, the mechanism underlying the endothelial dysfunction in thyroid disease is not clear yet. Asymmetric dimethylarginine (ADMA), a novel inhibitor of endothelial nitric oxide synthase (eNOS), blocks nitric oxide (NO) synthesis from L-arginine. Symmetric dimet...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347423
更新日期:2007-03-01 00:00:00
abstract::The aim of the study was to determine the main metabolic parameters of 11-beta-hydroxy-androstenedione (11 OHAD) in man. Seven normal subjects were investigated at 1-3 months interval by 2 types of isotope dilution techniques using a tritiated tracer: constant infusion and bolus iv injection. 3H-11 OHAD and 3H-11-beta...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349485
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:One of the major topics in modern societies is the study of relationships between diet, stress and incidence of metabolic disorders. AIM:This study aimed to investigate possible impairment in glucose-stimulated insulin secretion induced by a high-fat (cow intra-abdominal fat) diet in response to acute stres...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/8959
更新日期:2013-11-01 00:00:00
abstract::The outcome of radioiodine therapy of Graves' hyperthyroidism was retrospectively evaluated in 274 consecutive patients treated from 1975 to 1984. At 1-yr follow-up, permanent hypothyroidism occurred in 36.9% of patients and the cumulative incidence of hypothyroidism progressively increased up to 79.3% after 7-10 yr. ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348615
更新日期:1990-06-01 00:00:00
abstract::It has recently been suggested that the classical routine of glucocorticoid administration before and after transsphenoidal surgery (TSS) in Cushing's disease (CD) patients may not be necessary, since it is likely that peritumoral normal corticotrophs are not completely suppressed during this period. We compared the d...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347237
更新日期:2005-06-01 00:00:00
abstract:PURPOSE:Remission of acromegaly has been reported after somatostatin analogs withdrawal, but not after withdrawal of combination therapy with cabergoline, and only in case reports of patients controlled by cabergoline alone. METHODS:To establish the remission rates (normal IGF-1 for age/sex: IGF-1 ≤ 1.00 xULN) after w...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,多中心研究
doi:10.1007/s40618-016-0595-5
更新日期:2017-05-01 00:00:00
abstract::Thyrocytes from normal and goitrous portions of the thyroid gland from a patient with an enormous (635 gm) goiter were cultured in media, and their relative abilities to uptake thymidine, synthesize DNA, and secrete Tg and T4 were assessed. Tg, T4 and the ratio Tg/T4 in media at 72 h were 120 micrograms/dl, 1.6 microg...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348184
更新日期:1987-10-01 00:00:00
abstract::Glucocorticoid receptors (GR) and 3-O-methyl-D glucose (3-O-MG) transport were determined in mononuclear leukocytes (MNL) from 11 abdominal obese subjects, 10 pituitary-dependent Cushing's syndrome (Cushing's disease) and 10 healthy controls. Using a whole-cell competitive binding assay and 3H-dexamethasone as tracer,...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350794
更新日期:1998-11-01 00:00:00
abstract:PURPOSE:Although a nation-wide salt iodization program on voluntary basis was implemented in 2005, many areas in our country are still characterized by mild iodine deficiency. Differently from the rest of Italy, an efficient program of iodine prophylaxis was implemented in 1981 in the Autonomous Province of Bolzano. Th...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-014-0206-2
更新日期:2015-02-01 00:00:00
abstract::LATS containing sera and a number of Graves' disease sera stimulated T4 release from mouse thyroids in vitro as determined by RIA, thus confirming the presence of a thyroid hormone releasing factor in sera of thyrotoxic patients. The pattern of stimulation was similar to that previously shown for TSH in terms of T4 re...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350973
更新日期:1978-10-01 00:00:00
abstract::Several clinical signs might be related to the decline of DHEA secretion in aged people: sarcopenia, osteopenia, atherosclerosis progression, impairment of cognitive and affective performances, deterioration of immunocompetence are the most significant evidences. In addition, in aged people this clinical condition mig...
journal_title:Journal of endocrinological investigation
pub_type:
doi:
更新日期:2002-01-01 00:00:00
abstract::Hypoparathyroidism cannot be cured by oral or intravenous calcium supplements. Using molecular biology techniques to induce the production of PTH is an ideal option to treat hypoparathyroidism. In this study, we established a recombinant plasmid encoding a mutant preproPTH with a skeletal muscle creatine kinase promot...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/7966
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:We designed a single-center retrospective study to assess the QT interval duration and to describe cardio vascular events among patients treated with mitotane for a adrenocortical carcinoma (ACC). DESIGN:We selected 14 patients (6 males and 8 females) that met the following criteria: ACC treated with mitotan...
journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章
doi:10.3275/8616
更新日期:2012-11-01 00:00:00
abstract::Few data are available on serum free thyroid hormone concentration in patients with T3-toxicosis. In this study total and free T4 and T3 and TBG were evaluated in 35 subjects with T3-toxicosis, including 12 with untreated Graves' disease, 5 Graves' patients on methimazole treatment, 13 with autonomous adenoma, 3 with ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350562
更新日期:1983-02-01 00:00:00
abstract:BACKGROUND:Studies from every continent have shown that only around 50% of the patients subjected to thyroid hormone replacement have TSH in the normal range. However, to date, there are no consistent data about Brazil. OBJECTIVES:To evaluate levothyroxine (LT4) replacement treatment in patients with primary hypothyro...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,多中心研究
doi:10.3275/8810
更新日期:2013-07-01 00:00:00
abstract:PURPOSE:Although men with spinal cord injury (SCI) exhibit a prostate volume significantly smaller compared to age-matched able-bodied men, the independent association of lower prostate volume with its putative determinants has never been analyzed in this population. This study was designed to identify variables indepe...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-020-01243-3
更新日期:2020-11-01 00:00:00
abstract::Severe vitamin D deficiency has been found to be prevalent in institutionalized elderly persons in several countries. The aim of the present work was to assess the vitamin D status of institutionalized elderly and compare it to that of community-living independent elderly in southern Greece during summer. Serum 25-hyd...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349258
更新日期:2008-09-01 00:00:00
abstract::We herein describe a family with thyroid hormone resistance. Thyroid hormones and basal TSH were elevated. Pituitary tumor or abnormality in thyroid hormone binding proteins were ruled out by appropriate tests. Mother and sister of the propositus presented similar abnormal hormonal features but no hyperthyroidism. Ini...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347890
更新日期:1991-09-01 00:00:00
abstract::The present study reports the biochemical and immunohistochemical findings in the cytosol of a Hürthle cell carcinoma as compared with that of normal thyroid tissue. Sephadex G-200 chromatography of the extract derived from a Hürthle cell carcinoma and from normal thyroid tissue revealed three identical pools. Pool I ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348449
更新日期:1984-10-01 00:00:00
abstract:BACKGROUND:Adipose tissue has emerged as an important endocrine regulator by secreting hormones referred to as adipokines. Recent studies showed that adipose tissue considerably responds to hypoxia. Although the impact of white adipose tissue on regulative processes is established, the importance of brown adipose tissu...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/7964
更新日期:2012-05-01 00:00:00
abstract::We experienced an unusual combination of painless thyroiditis and Sheehan's syndrome in a single patient. A 29-year-old postpartum woman was referred to us for suspected Sheehan's syndrome. Endocrine tests confirmed the diagnosis, but, unexpectedly, her thyroid hormone levels in the plasma were elevated. Based on the ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350313
更新日期:1997-06-01 00:00:00
abstract::The present study was performed in 30 patients who needed steroid therapy: courses of triamcinolone or DTM 8-15 given orally lasted 30 days. In 15 of these patients glucoactive corticosteroids were administered in combination with 5 micrograms/day of 25OH-vitamin D3 (25OHD3). 47Calcium oral test and 99mTc-MDP kinetics...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348448
更新日期:1984-10-01 00:00:00
abstract::We treated a 10 6/12 year old prepubertal male with hypophosphatemic rickets, who was growing poorly despite appropriate treatment with calcitriol and phosphate, with exogenous growth hormone (for an initial trial period of 4 months, followed by 14 months of continuous treatment at a dose of 4 IU three times weekly) e...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349633
更新日期:1990-11-01 00:00:00
abstract::Seasonal plasma testosterone and androstenedione levels were determined by radioimmunoassay in the Gentile di Puglia ram. Androstenedione remains steady throughout the years, while testosterone shows seasonal changes. Testosterone is at high levels in winter, spring and summer and drops to a low concentration in autum...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348490
更新日期:1985-06-01 00:00:00
abstract:BACKGROUND:Neonatal hypothyroidism has serious effects on growth, development, and metabolism. AIM:This study aims to investigate the effects of the neonatal hypothyroidism on carbohydrate metabolism, islet insulin secretion and morphology of the pancreatic islets in adult male offspring. MATERIALS/SUBJECTS AND METHO...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/8468
更新日期:2013-01-01 00:00:00
abstract::In testicular descent to the scrotum, a multistep process, many anatomical and hormonal factors play a role. Cryptorchidism occurs in about 1-2% of males and may cause secondary degeneration of the testes. Animal models have shown that abnormalities, in the calcitonin gene-related peptide (CgRP) activity, could be rel...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347519
更新日期:2004-09-01 00:00:00
abstract::We report a case of pulmonary multinodular mucormycosis in a Type 1 diabetic patient with diabetic ketoacidosis. He had a history of 20-pack-year tobacco use. The initial chest roentgenogram and thorax tomography (after the treatment of diabetic ketoacidosis) revealed multiple nodular lesions with cavitation in the up...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347433
更新日期:2007-03-01 00:00:00