Abstract：
:A 33-year-old female presented in 1966 with striking pigmentation, typical of Addison's disease, and amenorrhea. Endocrine assessment then showed normal basal serum cortisol and urinary hydroxysteroid levels, but serum cortisol did not respond to stimulation with either exogenous ACTH or lysine vasopressin. Steroid replacement treatment was started. Treatment was discontinued by the patient on her own initiative and after some yr she was lost to follow-up. Reassessment in 1986 showed a pigmented patient who had continued in good health. She had a normal basal serum cortisol level with circadian variation. Plasma ACTH levels were high but showed diurnal rhythmicity and suppressed incompletely with 2 mg or 8 mg of dexamethasone/24 h. Plasma aldosterone levels were normal and showed appropriate postural changes, but plasma renin levels were high. This patient has an immunological profile of autoimmune disease with positive adrenal, thyroid microsomal and gastric parietal cell antibodies with a history of a premature menopause which may also be of autoimmune origin. She has been seen over a 20-yr period and despite her appearance still has no biochemical evidence of glucocorticoid or mineralocorticoid deficiency. It is suggested that the patient had compensated hypoadrenalism, with serum cortisol levels maintained in the normal range by high plasma ACTH levels and serum aldosterone levels maintained by high renin levels. The long term result of the high ACTH levels was increased skin pigmentation.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Whitehead EM,Atkinson AB,Hadden DR,Weaver J,Sheridan Bdoi
10.1007/BF03349957subject
Has Abstractpub_date
1989-03-01 00:00:00pages
187-91issue
3eissn
0391-4097issn
1720-8386journal_volume
12pub_type
杂志文章abstract：:Sjögren's syndrome (SS) is an autoimmune epithelitis characterized by lymphocytic infiltration of exocrine glands and epithelia in multiple sites. One third of the patients present with peripheral nervous system involvement. We describe the case of a woman aged 62 affected by a peroneal nerve mononeuropathy with painf...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Gonadal sex hormones may account for the sexual dimorphism in the immune response and for the greater incidence of autoimmune disease in females. We have previously reported the presence of progesterone (P) deficiency in female patients with thyroid and ovarian autoimmune disease. In this context, the hormonal profile...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347683
更新日期：1993-09-01 00:00:00
abstract：:Six-day treatment of neonatal rats with T3 or T4 resulted in a considerable depression of T4 production in response to exogenous TSH in adulthood. This supports the hypothetical conclusion that hormonal imprinting, i.e. the presence of the hormone and its interaction with the cell during the period of receptor maturat...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348561
更新日期：1985-12-01 00:00:00
abstract：:Human thyroid blood flow rate (TBF) was measured during operations by electromagnetic flowmetry in 75 euthyroid patients with normal thyroid tissue, nodular goiter, or solitary adenoma, and in 22 hyperthyroid patients with diffuse or nodular goiter. Blood flow rate was measured in one to four of the thyroid arteries. ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349454
更新日期：1981-07-01 00:00:00
abstract：:The TSH responses to the catecholamine depleting agent monoiodotyrosine (1 g po) and the dopamine receptor blocking drug metoclopramide (10 mg po) have been compared in euthyroid and hypothyroid subjects. Both drugs lead to a prompt and significant rise in TSH levels (peak values at 60-75 min) which is very much great...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348238
更新日期：1980-04-01 00:00:00
abstract：:The occurrence of tumors originating from aberrant adrenocortical tissue in ectopic site is very rare. Up to now only two cases of ectopic aldosterone-producing adenoma have been described. We have observed another case of ectopic aldosteronoma, located in the retrocaval region, laterally to the body of the 12th thora...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349816
更新日期：1995-11-01 00:00:00
abstract：:The present study investigated whether trophoblast, decidua and fetal membranes express nerve growth factor (NGF) mRNA and peptide. Tissue specimens were collected in the first and third trimester of pregnancy from women undergoing voluntary pregnancy interruption (no.= 6; from 8 to 12 gestational weeks) and from wome...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03344105
更新日期：2006-04-01 00:00:00
abstract：:The effect of exogenous prednisone on serum thyrotropin (TSH), thyroxine (T4), and triiodothyronine (T3) concentrations was investigated in four patients with non-functioning thyroid glands receiving T4 replacement therapy. Orally administered prednisone, in a dose of 20 mg each day for nine days, resulted in a signif...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03350367
更新日期：1978-04-01 00:00:00
abstract：:Final height was evaluated in 47 patients with classical 21-hydroxylase treated since diagnosis, and in 29 patients with nonclassical (NC) 21-hydroxylase deficiency who had never been treated before reaching final adult height. Classical patients achieved final heights consistently below the mean for the general popul...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:In mature female rats the administration of testosterone led to a striking reduction of hepatic alcohol dehydrogenase activity, whereas the hepatic microsomal ethanol oxidizing system as well as catalase were both increased in activity under these experimental conditions. Conversely, estradiol left the activities of a...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348330
更新日期：1982-07-01 00:00:00
abstract：OBJECTIVE:Focal thyroid incidentaloma (TI) occurs in a 2% of 18F-FDG PET/CT and about one-third of TIs is cancer. Due to the lack of evidence on the optimal management of TI, current guidelines suggest performing fine-needle aspiration cytology (FNA). The study aim was to evaluate the reliability of ACR-TIRADS, EU-TIRA...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-020-01244-2
更新日期：2020-11-01 00:00:00
abstract：PURPOSE:Few examples of the involvement of a single gene in idiopathic short stature have been described until now. Our aim was to identify the causative gene of proportionate short stature in a large family showing co-segregation of the phenotype with the reciprocal translocation t(10;15)(q22;q24). METHODS:FISH mappi...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-017-0819-3
更新日期：2018-08-01 00:00:00
abstract：:A dialyzable, thermostable inhibitor of normal thyroid peroxidase (TPO), with UV absorption maximum at 250-260 nm, was found in the digitonized, washed particulate fraction of two dyshormonogenetic goiters. No intrinsic TPO iodide-oxidation activity was detectable in either of these goiters, and their TPO iodination a...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349651
更新日期：1990-12-01 00:00:00
abstract：:The effect of the somatostatin analog (GHRIH-A) D-Trp8, D-Cys14 on plasma levels of growth hormone, pancreatic glucagon, insulin and glucose was studied in four acromegalic patients and in four maturity-onset mild diabetics. Acromegalics received a bolus iv injection of 25 microgram of GHRIH-A, followed by a continuou...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348250
更新日期：1980-04-01 00:00:00
abstract：:In mild glucose intolerance plasma concentration of C-peptide seems to give an estimate of pancreatic B cell secretion more reliable than plasma insulin itself. In the present study we measured the plasma levels of insulin and C-peptide after oral glucose load in 100 mildly glucose intolerant subjects, focusing our at...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346945
更新日期：1986-10-01 00:00:00
abstract：:The prevalence of primary aldosteronism has increased since many patients who were previously considered as being affected by low renin essential hypertension are actually satisfying the new diagnostic criteria using plasma aldosterone/ plasma renin activity (PRA) ratio. Many of these cases could be classified as subc...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346520
更新日期：2009-07-01 00:00:00
abstract：:It has been reported that adult obese subjects present a reduced growth hormone secretion. As no data are available in the pubertal period, which is characterized in lean subjects by an increased spontaneous growth hormone secretion, the growth hormone circadian concentration was studied in a group of 18 obese male su...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03350166
更新日期：1988-07-01 00:00:00
abstract：:Up to now, the diagnosis of silent corticotroph cell pituitary adenomas has been made only on histopathological basis. In this paper we describe 6 women affected with pituitary adenomas, without evident clinical features of hypercortisolism, in whom retrospective data suggested the possibility of clinically diagnosing...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348769
更新日期：1992-06-01 00:00:00
abstract：:Graves' disease (GD) is the most prevalent cause of thyrotoxicosis in children. Because spontaneous and lasting resolution of this condition occurs in only a minority of patients, most pediatric patients with GD will need radioactive iodine treatment (131I) or thyroidectomy. Whereas the medication propylthiouracil (PT...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/s40618-016-0477-x
更新日期：2016-11-01 00:00:00
abstract：AIM:The optimal GH regimen, in terms of cost-effectiveness, in children with normal GH immunoreactivity but reduced bioactivity is still debated. METHODS:In 12 GH-deficient (GHD) and 12 bioinactive GH children undergoing GH treatment we evaluated the increase in growth velocity, the difference between target height an...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347461
更新日期：2011-05-01 00:00:00
abstract：:Somatostatin has been found in the pineal gland of several animal species, which suggests that it may be involved in the regulation of melatonin secretion. Whether somatostatin has regulatory influence on melatonin secretion in man has never been unequivocally shown. We studied the nocturnal melatonin secretion in 8 h...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF03343604
更新日期：1999-07-01 00:00:00
abstract：AIM:In the last years there has been a progressive reduction of the average duration of sleep and an increase in the incidence of sleep disturbances. At the same time, an increase of the incidence of the metabolic syndrome has been described, partly attributable to the progressive worsening of dietary habits and the in...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40618-013-0016-y
更新日期：2014-02-01 00:00:00
abstract：:Two radioimmunological techniques for the measurement of anti-alpha-galactosyl (anti-Gal) antibodies were developed and we demonstrated that this antibody is present in the serum of most untreated patients with Graves' disease, thyroid-associated ophthalmopathy (TAO) and autoimmune thyroiditis. Thyrotropin-binding inh...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349806
更新日期：1995-11-01 00:00:00
abstract：PURPOSE:Aims of this study were to evaluate the agreement between the short and long versions of the International Physical Activity Questionnaire (IPAQ: Italian versions), their reproducibility (agreement and reliability) and construct validity (relative to pedometry) in a clinical population. METHODS:Ninety patients...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-017-0746-3
更新日期：2018-03-01 00:00:00
abstract：:The distribution of goiter prevalence in schoolchildren (no.=13,984, age 6-14 yr), the neonatal TSH results obtained from the congenital hypothyroidism screening program and the urinary iodine excretion values (no.=284) were employed for the assessment of iodine deficiency in Calabria, a Southern Italy region. Data we...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03343991
更新日期：2002-03-01 00:00:00
abstract：:GH may exert direct growth-promoting and metabolic actions on target tissues, but most of its effects are mediated by circulating (endocrine) or local (auto-/paracrine) IGF-I. The GH/IGF-I system has an important role in cardiac development and in maintaining the structure and function of the heart. A subgroup of chil...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345590
更新日期：2008-03-01 00:00:00
abstract：:We report an original application of quantitative reverse transcription-polymerase chain reaction (Q.RT-PCR) for the evaluation of atrial natriuretic factor (ANF), brain natriuretic peptide (BNP) and beta-actin mRNA in small atrial samples (10-15 mg). A fixed amount of total RNA was simultaneously reverse transcribed ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03343655
更新日期：1999-12-01 00:00:00
abstract：PURPOSE:This study was aimed at assessing the incidence and timing of thyroid nodules recurrence, defined as appearance of new benign or malignant nodules in contralateral lobe in patients with benign thyroid nodules or thyroid microcarcinoma treated with lobo-isthmectomy. Patient's characteristics and risk factors ass...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-018-0946-5
更新日期：2018-12-01 00:00:00
abstract：:Experimental data concerning the role of serotonin (5-HT) in the control of gonadotropins secretion remain controversial: different receptors subtypes should mediate the serotoninergic action. In the present work we analyzed in prepubertal and adult male rats the FSH and LH responses after administration of the follow...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347993
更新日期：1997-07-01 00:00:00
abstract：:We studied the possibility of an association between serum somatomedin-C (Sm-C) and thyroid hormone concentrations. For this purpose 34 hyperthyroid patients, 39 patients with primary hypothyroidism, 36 patients with severe nonthyroidal illnesses (NTI), and 63 euthyroid healthy control subjects were examined. The mean...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349528
更新日期：1990-02-01 00:00:00
