当前位置： SCI文献检索 > JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION期刊下所有文献 > Use of eye muscle antibody measurements to monitor response to plasmapheresis in patients with thyroid-associated ophthalmopathy.

Use of eye muscle antibody measurements to monitor response to plasmapheresis in patients with thyroid-associated ophthalmopathy.

Abstract：

:We have measured eye muscle antibodies, in immunoblotting, in the serum from five patients with severe ophthalmopathy associated with Graves' hyperthyroidism who underwent plasmapheresis, correlating their levels with clinical features of the eye disorder and response to treatment. Blood taken before each plasma exchange was tested in SDS-polyacrylamide gel electrophoresis and Western blotting for antibodies reactive with pig eye muscle membrane (PEMM) antigens and in a 51Cr release assay for antibodies which are cytotoxic to human eye muscle cells in antibody-dependent cell-mediated cytotoxicity (ADCC). Antibodies reactive with a 64 kDa PEMM antigen were detected in three patients who had eye disease of less than six months duration, but not in the two with more chronic disease. Antibodies against a 95 kDa PEMM antigen were detected in one patient in whom anti-64 kDa antibodies were also demonstrated. All five patients showed significant improvement in their eye disease following plasmapheresis exchange and titres of the anti-64 kDa protein antibody decreased in the three patients with detectable levels before treatment. TSH receptor stimulating antibodies were detected in all five patients before treatment, falling during plasmapheresis in four and becoming undetectable in three by the end of treatment. There was no close correlation between levels of TSH receptor antibodies and titres of anti-64 kDa protein antibodies although both tended to fall during and following plasmapheresis. ADCC tests were negative in all five patients before plasmapheresis but, surprisingly, transiently positive in three following treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Atabay C,Schrooyen M,Zhang ZG,Salvi M,Glinoer D,Wall JR

doi

10.1007/BF03348906

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

669-74

issue

9

eissn

0391-4097

issn

1720-8386

journal_volume

16

pub_type

杂志文章

相关文献

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION文献大全
  • Galactosylhydroxylysine and pyridinium cross links in monitoring the bone response to hormone replacement therapy.

    abstract：:Aim of the study was to compare urinary galactosyl-hydroxylysine (GHyl), deoxypyridinoline (D-Pyr) and pyridinoline (Pyr) before and after 5 to 9 months of hormone replacement therapy (HRT) in postmenopausal women. The urinary markers were measured by HPLC in the second void of fasting samples and were expressed as ra...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349858

    authors： Marabini R,Sirtori P,Chionna R,Barzizza L,Rubinacci A

    更新日期：1996-03-01 00:00:00

  • Snoring, hypertension and Type 2 diabetes in obesity. Protection by physical activity.

    abstract：:Sleep-related breathing disorders are recognized as major health problems in obesity. They are involved in both hypertension and Type 2 diabetes, through mechanisms possibly related to increased sympathetic tone. We studied the association of habitual snoring with diabetes, hypertension, weight cycling and physical ac...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03346260

    authors： Marchesini G,Pontiroli A,Salvioli G,Novi RF,Vitacolonna E,Taboga C,Ciccarone AM,Grossi E,QUOVADIS Study Group.

    更新日期：2004-02-01 00:00:00

  • Effects of two different somatostatin analogs on glucose tolerance in acromegaly.

    abstract：:Impaired glucose tolerance is present in many acromegalic patients and treatment with somatostatin analogs has variable effects on glycemic control. The aim of this study was to compare the effects of 2 somatostatin analogs on glucose metabolism, lanreotide slow release (L-SR) and octreotide long acting release (O-LAR...

    journal_title：Journal of endocrinological investigation

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF03345491

    authors： Ronchi C,Epaminonda P,Cappiello V,Beck-Peccoz P,Arosio M

    更新日期：2002-06-01 00:00:00

  • Asymmetric dimethylarginine levels in thyroid diseases.

    abstract：:Thyroid diseases may lead to endothelial dysfunction; however, the mechanism underlying the endothelial dysfunction in thyroid disease is not clear yet. Asymmetric dimethylarginine (ADMA), a novel inhibitor of endothelial nitric oxide synthase (eNOS), blocks nitric oxide (NO) synthesis from L-arginine. Symmetric dimet...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03347423

    authors： Arikan E,Karadag CH,Guldiken S

    更新日期：2007-03-01 00:00:00

  • Isolated hyperthyrotropinemia in childhood obesity and its relation with metabolic parameters.

    abstract：PURPOSE:The aim of the presented study was to evaluate the prevalence of isolated hyperthyrotropinemia (IH) in obese children and the relation between anthropometric and metabolic parameters. METHODS:Hospital records of the children, who presented to the Pediatric Endocrinology outpatient clinic of our institution wit...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-014-0100-y

    authors： Unüvar T,Anık A,Catlı G,Esen I,Abacı A,Büyükgebiz A,Böber E

    更新日期：2014-09-01 00:00:00

  • Increased plasma levels of visfatin/pre-B cell colony-enhancing factor in obese and overweight patients with metabolic syndrome.

    abstract：BACKGROUND:Visfatin [pre-B cell colony- enhancing factor (PBEF)] is a cytokine highly expressed in visceral fat that exhibits insulin-mimetic properties. However, its role in insulin-resistant states, such as in metabolic syndrome (MetS), remains largely unknown. OBJECTIVE:To investigate the possible differences of pl...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03346300

    authors： Filippatos TD,Derdemezis CS,Kiortsis DN,Tselepis AD,Elisaf MS

    更新日期：2007-04-01 00:00:00

  • The role of somatostatin (octreotide) in the regulation of melatonin secretion in healthy volunteers and in patients with primary hypothyroidism.

    abstract：:Somatostatin has been found in the pineal gland of several animal species, which suggests that it may be involved in the regulation of melatonin secretion. Whether somatostatin has regulatory influence on melatonin secretion in man has never been unequivocally shown. We studied the nocturnal melatonin secretion in 8 h...

    journal_title：Journal of endocrinological investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF03343604

    authors： Wikner J,Wetterberg L,Röjdmark S

    更新日期：1999-07-01 00:00:00

  • Effect of propranolol on aldosterone response to heat exposure in sodium-restricted men.

    abstract：:To assess the role of the renin-angiotensin system in the control of aldosterone reease in response to heat exposure, 6 sodium restricted subjects were studied on three random experimental days: a control day and two heat exposure days (46C, 35 mbar, 90 min) with and without propranolol. Plasma aldosterone, renin acti...

    journal_title：Journal of endocrinological investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF03349377

    authors： Brandenberger G,Follenius M,Oyono S

    更新日期：1980-10-01 00:00:00

  • Epigenetics: spotlight on type 2 diabetes and obesity.

    abstract：:Type 2 diabetes (T2D) and obesity are the major public health problems. Substantial efforts have been made to define loci and variants contributing to the individual risk of these disorders. However, the overall risk explained by genetic variation is very modest. Epigenetics is one of the fastest growing research area...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.1007/s40618-016-0473-1

    authors： Desiderio A,Spinelli R,Ciccarelli M,Nigro C,Miele C,Beguinot F,Raciti GA

    更新日期：2016-10-01 00:00:00

  • Luteinizing hormone pulsatile secretion and pituitary response to gonadotropin releasing hormone and to thyrotropin releasing hormone in male epileptic subjects on chronic phenobarbital treatment.

    abstract：:Endocrine changes have been reported in treated epileptic subjects, who often exhibit sexual dysfunctions, but the endocrine effects of single antiepileptic drugs have not been completely elucidated. In this study we have investigated the influence of phenobarbital (PB) on adenopituitary function and on peripheral sex...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03347145

    authors： Murialdo G,Manni R,De Maria A,Bonura ML,Polleri A,Tartara A

    更新日期：1987-02-01 00:00:00

  • Efficacy and safety of growth hormone treatment in children with short stature: the Italian cohort of the GeNeSIS clinical study.

    abstract：PURPOSE:We examined auxological changes in growth hormone (GH)-treated children in Italy using data from the Italian cohort of the multinational observational Genetics and Neuroendocrinology of Short Stature International Study (GeNeSIS) of pediatric patients requiring GH treatment. METHODS:We studied 711 children (me...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s40618-015-0418-0

    authors： Cappa M,Iughetti L,Loche S,Maghnie M,Vottero A,GeNeSIS National Board on behalf of the GeNeSIS Italian Investigators.

    更新日期：2016-06-01 00:00:00

  • Vertebral fractures in dialysis: Endocrinological disruption of the bone-kidney axis.

    abstract：:The occurrence of metabolic bone disease in patients with renal dysfunction is due to the key role played by the kidney in regulating calcium-phosphate metabolism. The incidence of hip fractures in end-stage renal disease is 3- to 4-fold higher than the general population, while poor data about vertebral fractures sho...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.1007/BF03346598

    authors： Fusaro M,D'Angelo A,Scalzo G,Gallieni M,Giannini S,Guglielmi G

    更新日期：2010-05-01 00:00:00

  • Untreated adult GH deficiency is not associated with the development of metabolic risk factors: a long-term observational study.

    abstract：PURPOSE:Uncertainties exist about the predictors of the severity of the clinical picture of GH deficiency (GHD) syndrome. Aim of the study was to evaluate, in adult patients with GHD, the predictors of the development of hypercholesterolemia, hypertension, diabetes mellitus, and osteoporosis. METHODS:We retrospectivel...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-019-01100-y

    authors： Gasco V,Roncoroni L,Zavattaro M,Bona C,Berton A,Ghigo E,Maccario M,Grottoli S

    更新日期：2020-02-01 00:00:00

  • The inflammatory markers in polycystic ovary syndrome: association with obesity and IVF outcomes.

    abstract：OBJECTIVE:To investigate the inflammatory markers in polycystic ovary syndrome (PCOS) and associations of these markers with obesity and in vitro fertilization (IVF) outcomes. METHODS:A total of 292 women underwent IVF procedure either with PCOS (n = 146) or without PCOS (n = 146, age, and body mass index (BMI) matche...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-016-0446-4

    authors： Çakıroğlu Y,Vural F,Vural B

    更新日期：2016-08-01 00:00:00

  • Autoimmune regulator (AIRE) gene on chromosome 21: implications for autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) any more common manifestations of endocrine autoimmunity.

    abstract：:Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare, but well-defined monogenic disorder that is caused by mutations in the autoimmune regulator (AIRE) gene on chromosome 21q22.3. Patients most often suffer from loss of endocrine function in the parathyroid and adrenal glands but may also...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.1007/BF03345516

    authors： Meyer G,Badenhoop K

    更新日期：2002-10-01 00:00:00

  • Exercise-induced endocrine pathologies.

    abstract：:There has been a substantial increase in women practicing sports over the past 30 yr. While exercise provides many health benefits, there appears to be a unique set of risks associated with intense exercise for the female athlete. The female athlete triad encompasses these risks, including amenorrhea, osteoporosis and...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.1007/BF03345238

    authors： Warren MP,Goodman LR

    更新日期：2003-09-01 00:00:00

  • Small fibers peroneal mononeuropathy in a patient with Sjögren's syndrome.

    abstract：:Sjögren's syndrome (SS) is an autoimmune epithelitis characterized by lymphocytic infiltration of exocrine glands and epithelia in multiple sites. One third of the patients present with peripheral nervous system involvement. We describe the case of a woman aged 62 affected by a peroneal nerve mononeuropathy with painf...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：

    authors： Pavesi G,Cattaneo L,Chierici E,Marbini A,Sasso E,Mancia D

    更新日期：2004-01-01 00:00:00

  • Insulin action and secretion in healthy Hispanic-Mexican first-degree relatives of subjects with type 2 diabetes.

    abstract：:The aim of this study was to assess the early insulin secretion and insulin action of healthy non-diabetic Hispanic-Mexican subjects with and without family history of Type 2 diabetes (FHD). One hundred and twenty non-relative subjects were compared against 115 first-degree relatives of individuals with Type 2 diabete...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03343898

    authors： Guerrer-Romer F,Rodríguez-Morán M,González-Ortiz M,Martínez-Abundis E

    更新日期：2001-09-01 00:00:00

  • Long-term safety and efficacy of Omnitrope® in adults with growth hormone deficiency: Italian interim analysis of the PATRO Adults study.

    abstract：PURPOSE:To report the long-term effectiveness and safety of the recombinant human growth hormone Omnitrope®, a somatropin biosimilar to Genotropin®, in Italian patients with growth hormone deficiency (GHD) enrolled in the PATRO Adults study. METHODS:The PATRO Adults study is an ongoing observational, longitudinal, non...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s40618-016-0604-8

    authors： Ferone D,Profka E,Gasco V,Ambrosio MR,Colao A,Di Somma C,Puxeddu E,Arnaldi G,Pagano C,Zecchi E,Pietropoli A,Beck-Peccoz P

    更新日期：2017-06-01 00:00:00

  • Adipokine expression in brown and white adipocytes in response to hypoxia.

    abstract：BACKGROUND:Adipose tissue has emerged as an important endocrine regulator by secreting hormones referred to as adipokines. Recent studies showed that adipose tissue considerably responds to hypoxia. Although the impact of white adipose tissue on regulative processes is established, the importance of brown adipose tissu...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.3275/7964

    authors： Wree A,Mayer A,Westphal S,Beilfuss A,Canbay A,Schick RR,Gerken G,Vaupel P

    更新日期：2012-05-01 00:00:00

  • Alterations of gut microbiota composition in post-finasteride patients: a pilot study.

    abstract：PURPOSE:Post-finasteride syndrome (PFS) has been reported in a subset of patients treated with finasteride (an inhibitor of the enzyme 5alpha-reductase) for androgenetic alopecia. These patients showed, despite the suspension of the treatment, a variety of persistent symptoms, like sexual dysfunction and cognitive and ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-020-01424-0

    authors： Borgo F,Macandog AD,Diviccaro S,Falvo E,Giatti S,Cavaletti G,Melcangi RC

    更新日期：2020-09-19 00:00:00

  • Relation of adiponectin, visfatin and bone mineral density in patients with metabolic syndrome.

    abstract：BACKGROUND:Adipose tissue has been suggested to influence bone density and metabolism through the effect of some adipokines. However, whether adiponectin and visfatin may correlate with bone metabolism is still unclear. AIM:The aim of this study was to investigate the relationship of adiponectin and visfatin with bone...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03346703

    authors： Iacobellis G,Iorio M,Napoli N,Cotesta D,Zinnamosca L,Marinelli C,Petramala L,Minisola S,D'Erasmo E,Letizia C

    更新日期：2011-01-01 00:00:00

  • Use of granulosa-luteal cell culture to evaluate low and high clinical responses to menotropin stimulation.

    abstract：:The cause of a poor response to human menopausal gonadotropin (hMG) remains unexplained. To determine whether aromatase activity of cultured granulosa cells obtained from relatively low estradiol (E2) responders (serum E2 < 1000 pg/ml) to hMG therapy differed from that of good responders (E2 > or = 1000 pg/ml), we pro...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03344926

    authors： Hurst BS,Zacur HA,Schlaff WD,Berkovitz GD

    更新日期：1992-09-01 00:00:00

  • Growth hormone and lactate responses induced by maximal isometric voluntary contractions and whole-body vibrations in healthy subjects.

    abstract：BACKGROUND:In contrast with maximal voluntary resistance exercise, which is allegedly considered a potent GH stimulus in young subjects, evaluation of GH response to whole-body vibrations (WBV) has yielded conflicting results. METHODS:The acute effects of WBV alone (test A), maximal voluntary isometric contractions (M...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03347069

    authors： Sartorio A,Agosti F,De Col A,Marazzi N,Rastelli F,Chiavaroli S,Lafortuna CL,Cella SG,Rigamonti AE

    更新日期：2011-03-01 00:00:00

  • Growth hormone treatment in non-growth hormone-deficient short children.

    abstract：:The unlimited availability of GH obtained by recombinant DNA technology has allowed optimization of treatment in GH-deficient (GHD) children. At the same time it has prompted a number of studies in conditions not characterized by GHD such as Turner syndrome, intrauterine growth retardation, chronic renal failure and o...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.1007/BF03345367

    authors： Loche S,Casini MR,Ubertini GM,Cappa M

    更新日期：2005-02-01 00:00:00

  • Immunoreactive thyroglobulin in sera and saliva of patients with various thyroid disorders: role of autoantibodies.

    abstract：:The present study was designed to assess the transfer of thyroglobulin (Tg) and anti-Tg antibodies (TgAb) to saliva in subjects with positive TgAb in their sera. Group I consisted of normal euthyroid control subjects (n = 10). Group II were patients with various thyroid disorders and no TgAb in their sera (n = 6). Gro...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349955

    authors： Van Herle AJ,Rosenblit PD,Van Herle TL,Van Herle P,Greipel M,Kellett K

    更新日期：1989-03-01 00:00:00

  • Pituitary imaging abnormalities in patients with and without hypopituitarism after traumatic brain injury.

    abstract：:Recent evidence suggests that patients with traumatic brain injury (TBI) are at substantial risk of hypopituitarism. The pathomechanisms, however, are not completely understood yet. Little is known about the association of morphological changes in the sella region with pituitary function in TBI. In this study, we asse...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03346291

    authors： Schneider HJ,Sämann PG,Schneider M,Croce CG,Corneli G,Sievers C,Ghigo E,Stalla GK,Aimaretti G

    更新日期：2007-04-01 00:00:00

  • Variations of serum levels of adiponectin and resistin in chronic viral hepatitis.

    abstract：BACKGROUND AND AIMS:Several studies investigated the possible role of adipokines during chronic viral hepatitis, not producing defined results neither clearly establishing their behavior in course of anti-viral treatment. Our study evaluated blood concentrations of adiponectin and resistin in patients with chronic hepa...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.3275/8883

    authors： Durazzo M,Belci P,Niro G,Collo A,Grisoglio E,Ambrogio V,Spandre M,Fontana R,Gambino R,Cassader M,Bo S

    更新日期：2013-09-01 00:00:00

  • Supplementation with L-arginine favorably influences plasminogen activator inhibitor type 1 concentration in obese patients. A randomized, double blind trial.

    abstract：BACKGROUND:Elevated plasminogen activator inhibitor type 1 (PAI 1) plays an important role in the pathogenesis of excess blood coagulability in obese patients. L-arginine supplementation has shown to be associated with enhanced cardiovascular and metabolic health. The aim of the study was to assess the effect of L-argi...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,随机对照试验

    doi：10.3275/8467

    authors： Bogdanski P,Szulinska M,Suliburska J,Pupek-Musialik D,Jablecka A,Witmanowski H

    更新日期：2013-04-01 00:00:00

  • Graves' disease and thyroid associated ophthalmopathy triggered by 131I treatment of non-toxic goiter.

    abstract：:A 39-year-old Danish woman was treated with an oral dose of 400 MBq 131I for a non-toxic goiter with compression symptoms. Serum anti-TPO and TSH receptor antibodies were negative before radioiodine therapy. The patient developed hyperthyroidism four months after treatment and ophthalmopathy after another three months...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03343594

    authors： Nygaard B,Metcalfe RA,Phipps J,Weetman AP,Hegedüs L

    更新日期：1999-06-01 00:00:00