The use of ultrasensitive thyroglobulin assays reduces but does not abolish the need for TSH stimulation in patients with differentiated thyroid carcinoma.

abstract：:Neurological disorders, such as seizures, are not infrequently associated with anti-leukemic therapy. It has been hypothesized that a disrupted peptidergic transmission between neurons could be the cellular basis of the neurological dysfunction. Since endogenous opioids have been recently found to alter neuronal funct...

journal_title：Journal of endocrinological investigation

authors： Iannetti P,Fabbri A,Meloni G,Moleti ML,Ulisse S,Mandelli F,Isidori A,Imperato C

更新日期：1989-10-01 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH)-like material was found in human retina obtained at autopsy from eyes used for corneal grafts. The TRH-like material was extracted with methanol and was found to be indistinguishable from synthetic TRH in its immunoreactivity and bioreactivity and in its proteolytic degradation by f...

journal_title：Journal of endocrinological investigation

authors： Martino E,Nardi M,Vaudagna G,Simonetti S,Cilotti A,Pinchera A,Venturi G,Seo H,Baschieri L

更新日期：1980-07-01 00:00:00

abstract：AIM:The optimal GH regimen, in terms of cost-effectiveness, in children with normal GH immunoreactivity but reduced bioactivity is still debated. METHODS:In 12 GH-deficient (GHD) and 12 bioinactive GH children undergoing GH treatment we evaluated the increase in growth velocity, the difference between target height an...

journal_title：Journal of endocrinological investigation

authors： Pagani S,Meazza C,Laarej K,Cantoni F,Bozzola M

更新日期：2011-05-01 00:00:00

abstract：:Recent data seem to suggest that LHRH may be involved in the modulation of PRL secretion. We studied the PRL pattern in 9 males (age range 18-38 yr) with idiopathic hypogonadotropic hypogonadism (IHH) before and during long-term pulsatile LHRH therapy (120-160 ng/kg bw every 120 min sc) in order to evaluate variations...

journal_title：Journal of endocrinological investigation

authors： Giusti M,Traverso L,Cavagnaro P,Torre R,Durante R,Giordano G

更新日期：1989-09-01 00:00:00

abstract：:The outcome of radioiodine therapy of Graves' hyperthyroidism was retrospectively evaluated in 274 consecutive patients treated from 1975 to 1984. At 1-yr follow-up, permanent hypothyroidism occurred in 36.9% of patients and the cumulative incidence of hypothyroidism progressively increased up to 79.3% after 7-10 yr. ...

journal_title：Journal of endocrinological investigation

authors： Marcocci C,Gianchecchi D,Masini I,Golia F,Ceccarelli C,Bracci E,Fenzi GF,Pinchera A

更新日期：1990-06-01 00:00:00

abstract：UNLABELLED:Hypercalcemia occurring in patients with advanced breast cancer (BC) is generally due to osteolytic metastases or to the activity of circulating tumor-derived products. In these conditions, the production of endogenous PTH is reduced. The frequency of hypercalcemia due to primary hyperparathyroidism in breas...

journal_title：Journal of endocrinological investigation

authors： Fierabracci P,Pinchera A,Miccoli P,Conte PF,Vignali E,Zaccagnini M,Marcocci C,Giani C

更新日期：2001-05-01 00:00:00

abstract：:Prolactin, LH and FSH circadian secretion were studied in a group of 20 boys in various pubertal stages and in 13 normal male adults. Prolactin 24-hour integrated concentration was similar in all groups except in stage 2 boys, in which it was significantly higher with respect to stage 3-4 boys. This pattern was observ...

journal_title：Journal of endocrinological investigation

authors： Minuto F,Barreca A,Ferrini S,Del Monte P,Bernasconi D,Giordano G

更新日期：1984-06-01 00:00:00

abstract：:The long-acting somatostatin analogue SMS 201-995 has been used efficaciously in the therapy of metastatic carcinoid tumor, vasoactive intestinal peptide producing islet cell carcinoma, acromegaly, and TSH secreting pituitary tumors. We report the development of a gallstone in a patient treated for 23 months with a lo...

journal_title：Journal of endocrinological investigation

authors： Roti E,Minelli R,Gardini E,Salvi M,Bianconi L,Balducci L,Manfredi A,Braverman LE

更新日期：1990-01-01 00:00:00

abstract：:We describe a unique case of spontaneous resolution of hyperparathyroidism in a lady with combined parathyroid adenoma and prolactinoma, raising the possibility of underlying multiple endocrine neoplasia (MEN) 1 syndrome. We also discuss the mechanism and natural history of such spontaneous remission. ...

journal_title：Journal of endocrinological investigation

authors： Baskar V,Kamalakannan D,Singh BM,Odum J

更新日期：2004-05-01 00:00:00

abstract：:Few data are available on serum free thyroid hormone concentration in patients with T3-toxicosis. In this study total and free T4 and T3 and TBG were evaluated in 35 subjects with T3-toxicosis, including 12 with untreated Graves' disease, 5 Graves' patients on methimazole treatment, 13 with autonomous adenoma, 3 with ...

journal_title：Journal of endocrinological investigation

authors： Ferrari C,Romussi M,Rampini P,Benco R,Boghen M,Paracchi A,Frezzati S

更新日期：1983-02-01 00:00:00

abstract：PURPOSE:Interleukin (IL)-8 is a proinflammatory C-X-C chemokine involved in inflammation underling cardiac diseases, primary or in comorbid condition, such diabetic cardiomyopathy (DCM). The phosphodiesterase type 5 inhibitor sildenafil can ameliorate cardiac conditions by counteracting inflammation. The study aim is t...

journal_title：Journal of endocrinological investigation

authors： Giannattasio S,Corinaldesi C,Colletti M,Di Luigi L,Antinozzi C,Filardi T,Scolletta S,Basili S,Lenzi A,Morano S,Crescioli C

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:The diagnosis of polycystic ovary syndrome (PCOS) is based on a combination of various clinical phenotypes in each patient. However, insulin resistance (IR) and dysmetabolism are not included in the diagnostic criteria of PCOS. Therefore, the definition of PCOS is controversial. The objective of this study is t...

journal_title：Journal of endocrinological investigation

authors： Zhang L,Fang X,Li L,Liu R,Zhang C,Liu H,Tan M,Yang G

更新日期：2018-12-01 00:00:00

abstract：:In 1939 Alan Turing, a major scholar in the field of mechanical computation, described a system whose computational power was beyond that of a discrete, finite state machine (Turing Machine). The composition of this system was likely the first example of what is now called an hybrid computational system. Since then, d...

journal_title：Journal of endocrinological investigation

authors： Sandri G

更新日期：2004-01-01 00:00:00

abstract：:To investigate whether chronic endogenous hypercalcemia influences TSH and/or PRL release from pituitary thyrotrophs and lactotrophs in man, 10 patients with endogenous hypercalcemia, due either to cancer or to primary hyperparathyroidism, were injected with 25 micrograms TRH iv. The TSH and PRL responses were compare...

journal_title：Journal of endocrinological investigation

authors： Röjdmark S,Edström E,Nordlund M

更新日期：1984-12-01 00:00:00

abstract：:Forty-eight morbidly obese patients were placed on a very low calorie (800 kcal) formula diet (OPTIFAST) for a 10-week period with the goal of achieving 10% weight loss within this time. Weekly serum leptin measurements were performed to determine whether changes in this adipose protein would serve as a useful marker ...

journal_title：Journal of endocrinological investigation

authors： Xenachis C,Samojlik E,Raghuwanshi MP,Kirschner MA

更新日期：2001-12-01 00:00:00

abstract：PURPOSE:To review the proportion of diabetic patients reaching recommended therapeutic goals, as reported in intervention trials and observational studies, and to analyse the factors associated with success or failure in achieving these targets. METHODS:A systematic review and meta-analysis through a Medline and Embas...

journal_title：Journal of endocrinological investigation

authors： Mannucci E,Monami M,Dicembrini I,Piselli A,Porta M

更新日期：2014-05-01 00:00:00

abstract：:The mechanisms underlying the antifertility effects of hyperprolactinemia have yet to be established in an appropriate experimental model. Hyperprolactinemia is a known side effect of fluphenazine, a broad spectrum, long-acting phenothiazine known to be dopamine type-D2 receptor antagonist. In our earlier study in adu...

journal_title：Journal of endocrinological investigation

authors： Aleem M,Choudhari J,Padwal V,Balasinor N,Parte P,Gill-Sharma MK

更新日期：2005-01-01 00:00:00

abstract：:The underlying mechanism leading to carcinogenesis involves genomic instability, likely related to aneuploidy. While p53 as a "guardian of the genome" is an appealing candidate as an initiator of genomic instability, its mutations or deletions usually occur late in the course of tumor progression. P53 may, however, be...

journal_title：Journal of endocrinological investigation

authors： Farid NR

更新日期：2001-07-01 00:00:00

abstract：:Anorexia nervosa (AN) is an eating disorder characterized by self-induced starvation due to fear of adiposity. Ghrelin, gastric peptide with potent orexigenic, adipogenic, GH-releasing and metabolic properties, is elevated in AN. We have previously shown that intervention with exogenous ghrelin is not effective in ter...

journal_title：Journal of endocrinological investigation

authors： Miljic D,Djurovic M,Pekic S,Doknic M,Stojanovic M,Milic N,Casanueva FF,Ghatei M,Popovic V

更新日期：2007-10-01 00:00:00

abstract：:Somatostatin and its derivatives have been predominantly studied and succesfully used in endocrinological diseases. This article reviews the rationale of the use of somatostatin and its derivatives in ophthalmology based on current understanding of its action in the eye and summarizes previously published controlled s...

journal_title：Journal of endocrinological investigation

authors： Missotten T,Baarsma GS,Kuijpers RW,van den Born LI,van der Loos T,Croxen R,Hofland LJ,van Hagen PM

更新日期：2005-01-01 00:00:00

abstract：:The Nb2 rat lymphoma bioassay (BA) for prolactin (PRL) was performed in 26 subjects with hyperprolactinemia, 17 of whom had radiologic evidence of a pituitary adenoma. All subjects were treated with the long acting dopamine agonist CV 205-502. The radioimmunoassay (RIA) PRL significantly decreased with treatment but t...

journal_title：Journal of endocrinological investigation

authors： Peabody CA,Schultz PN,Warner MD,Worsley IG,Friesen HG,Samaan NA

更新日期：1992-07-01 00:00:00

abstract：:Gonadal sex hormones may account for the sexual dimorphism in the immune response and for the greater incidence of autoimmune disease in females. We have previously reported the presence of progesterone (P) deficiency in female patients with thyroid and ovarian autoimmune disease. In this context, the hormonal profile...

journal_title：Journal of endocrinological investigation

authors： Valentino R,Savastano S,Tommaselli AP,Riccio A,Mariniello P,Pronesti G,De Divitiis PM,Lombardi G

更新日期：1993-09-01 00:00:00

abstract：PURPOSE:To report the long-term effectiveness and safety of the recombinant human growth hormone Omnitrope®, a somatropin biosimilar to Genotropin®, in Italian patients with growth hormone deficiency (GHD) enrolled in the PATRO Adults study. METHODS:The PATRO Adults study is an ongoing observational, longitudinal, non...

journal_title：Journal of endocrinological investigation

authors： Ferone D,Profka E,Gasco V,Ambrosio MR,Colao A,Di Somma C,Puxeddu E,Arnaldi G,Pagano C,Zecchi E,Pietropoli A,Beck-Peccoz P

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:Hashimoto's thyroiditis (HT) is often associated with rheumatic disorders (arthritis, etc.), but many HT patients report non-specific rheumatic signs and symptoms in the absence of clinically evident rheumatic diseases. Aim of this study was to evaluate the prevalence of non-specific rheumatic manifestations (R...

journal_title：Journal of endocrinological investigation

authors： Giuffrida G,Bagnato G,Campennì A,Giovinazzo S,Keller KP,Alibrandi A,Roberts WN,Trimarchi F,Ruggeri RM

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Two yr after legislation of salt iodization of 40 parts per million (ppm) in 1994, goiter was still endemic and urinary iodine concentration (UIC) remained elevated in many provinces of Iran. Goiter prevalence and UIC were compared 2 and 7 yr after sustained consumption of uniformly iodized salt by Iranian ho...

journal_title：Journal of endocrinological investigation

authors： Azizi F,Mehran L,Sheikholeslam R,Ordookhani A,Naghavi M,Hedayati M,Padyab M,Mirmiran P

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the possible association of insulin-like growth factor-1 (IGF-1) with the pathogenesis of non-functioning adrenocortical adenomas (NFAs). METHODS:This study included 50 female patients (mean age 54 years) with NFAs, 55 patients (mean age 48 years; 20 male, 35 female) wi...

journal_title：Journal of endocrinological investigation

authors： Bahadir CT,Ecemis GC,Atmaca H

更新日期：2018-11-01 00:00:00

abstract：:The effect of right- and left-sided intra-amygdaloid injection of kainic acid on the hypothalamo-hypophyseal-testicular axis was studied in rats. Both right- and left-sided injection of the neurotoxin into the amygdala resulted in a significant decrease in basal testosterone secretion in vitro of both testes and in se...

journal_title：Journal of endocrinological investigation

authors： Banczerowski P,Csaba Z,Csernus V,Gerendai I

更新日期：2003-05-01 00:00:00

abstract：:We examined the distribution of nuclear T3 in mature rat brain with the aim of determining specific targets of thyroid hormones within this tissue. Saturation experiments, performed in 9 different structures of the brain and in 4 parts of the cortex, revealed the presence of a single class of binding sites with a mean...

journal_title：Journal of endocrinological investigation

authors： Ruel J,Faure R,Dussault JH

更新日期：1985-08-01 00:00:00

abstract：:We report here on the isolation and repertoire characterization of a Graves' thyroid T cell population which, unlike most Graves' thyroid T cell isolates reported before, was rich in CD4-CD8- T cells (16%, all TcR gamma delta+) and CD8+ T cells (75%) [TcR alpha beta+ (59%) and TcR gamma delta+ (16%)]. Only 7% of the i...

journal_title：Journal of endocrinological investigation

authors： Santamaria P,Lewis C,Barbosa JJ

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Studies from every continent have shown that only around 50% of the patients subjected to thyroid hormone replacement have TSH in the normal range. However, to date, there are no consistent data about Brazil. OBJECTIVES:To evaluate levothyroxine (LT4) replacement treatment in patients with primary hypothyro...

journal_title：Journal of endocrinological investigation

authors： Vaisman F,Coeli CM,Ward LS,Graf H,Carvalho G,Montenegro R Jr,Vaisman M

更新日期：2013-07-01 00:00:00