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Effect of a synthetic pineal tetrapeptide (Ala-Glu-Asp-GLy) on melatonin secretion by the pineal gland of young and old rats.

Abstract：

:The pineal gland contains many peptides known to be implicated in melatonin production. We examined the effects of a synthetic pineal tetrapeptide Ala-Glu-Asp-Gly on melatonin secretion by the pineal gland. The tetrapeptide effects on pineal gland melatonin secretion were studied in young (9 weeks) and old (27 months) male Wistar rats using a perifusion device. Pineal tetrapeptide at the concentrations used (10(-4) to 10(-6) M) had no significant effect upon melatonin secretion whatever the age of the animals, young or old. We also looked at the effect of the tetrapeptide on pineal melatonin stimulated by a beta-adrenergic agonist, isoproterenol. We found that isoproterenol-induced melatonin increase was not modified by the tetrapeptide. Our results suggest that the pineal tetrapeptide Ala-Glu-Asp-Gly, does not seem to play a role, at least in vitro, in the control of melatonin secretion by the rat pineal gland.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Djeridane Y,Khavinson VKh,Anisimov VN,Touitou Y

doi

10.1007/BF03345159

keywords:

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

211-5

issue

3

eissn

0391-4097

issn

1720-8386

pii

5690

journal_volume

26

pub_type

杂志文章

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