Abstract:
:Seventy-one white women within 6 months to 6 years postmenopause were randomly assigned to three treatment groups: (a) placebo, (b) calcium, (c) cyclic estrogen-progestin plus calcium. Calcium was given as calcium carbonate with meals to attain an intake of 1,700 mg daily in the latter two groups. All women received 400 IU of vitamin D daily. Samples were obtained at baseline and after 2 months therapy. The hormonal treatment group had a decline in serum calcium, osteocalcin and urinary hydroxyproline and an increase in levels of calcitonin, parathyroid hormone and calcitriol. The increase in the latter two measurements could have resulted from the drop in serum calcium, it is also possible that the increase in calcitonin levels was a result of calcium supplementation. Although all these changes were statistically significant for the estrogen treatment group when considered alone, analysis of variance including the 3 groups demonstrated significance for the estrogen group for the parameters of skeletal metabolism but not for the changes in the calciotrophic hormones. There was an increase in serum calcium (p = 0.05) in the calcium augmentation group. It would be of interest to determine the effects of higher intakes of calcium in both the calcium and the estrogen treatment groups and to further explore differences in effects on bone remodeling between the two treatment approaches as well as the possibility of a additive effects. Early effects of estrogen replacement reduce bone remodeling whereas calcium supplementation to 1,700 mg per day of Ca CO3 did not appear to affect the parameters of bone remodeling.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Aloia JF,Vaswani A,Yeh JK,McGowan DM,Ross Pdoi
10.1007/BF03347118subject
Has Abstractpub_date
1991-12-01 00:00:00pages
927-34issue
11eissn
0391-4097issn
1720-8386journal_volume
14pub_type
临床试验,杂志文章,随机对照试验abstract::Patients with simple exogenous obesity are characterized by increased B-endorphin (B-EP) plasma levels, despite normal ACTH and B-Lipotropin (B-LPH). To evaluate the origin of such an hyperendorphinemia, 42 obese patients were submitted to a short overnight dexamethasone suppression test (DST: 1 mg at 23:00 h). Blood ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350117
更新日期:1988-02-01 00:00:00
abstract::In order to precise the relationships between TSH, FT3, and FT4 nycthemeral variations and the relationships between thyroid hormone variations and sleep, 8 healthy young males were studied twice, once during a 24-h experiment with normal nocturnal sleep, and once during a night of sleep deprivation. The subjects rece...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347712
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:Leptin and ghrelin appear to play a role in weight regain after a successful weight loss. The pre-treatment plasma levels of leptin/ghrelin ratio (L/G) could have power to predict this clinically relevant issue in the obesity treatment. OBJECTIVE:To evaluate the ability of the L/G as a non-invasive tool for...
journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章
doi:10.1007/s40618-013-0004-2
更新日期:2014-02-01 00:00:00
abstract::In 1939 Alan Turing, a major scholar in the field of mechanical computation, described a system whose computational power was beyond that of a discrete, finite state machine (Turing Machine). The composition of this system was likely the first example of what is now called an hybrid computational system. Since then, d...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:
更新日期:2004-01-01 00:00:00
abstract::In acromegaly, clinical features are of the utmost importance, and biochemical confirmation is rarely difficult. However, some clinically manifest acromegalics have subtle abnormalities in GH secretion resulting in post-glucose GH nadir in the designated "normal" range with high IGF-I levels. Clinical decision may be ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
abstract::Numerous clinical and experimental reports suggest that a high von Willebrand factor (vWf) level reflects endothelial damage or endothelial dysfunction. The present study was designed to evaluate vWf in subclinical hyperthyroidic subjects compared with euthyroidic subjects. We selected 20 subclinical hyperthyroidic su...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03345539
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:Blood endothelial progenitor cells (EPC) and microparticles (EMP) have been proposed as markers of endothelial dysfunction. Aim of this study was to evaluate a new immunophenotype of EPC and EMP in patients with arterial erectile dysfunction (AED) compared to psychogenic erectile dysfunction (PED). MATERIALS...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346728
更新日期:2011-11-01 00:00:00
abstract::The aim of this prospective study was to investigate the effects of thyroid hormone levels on the sepsis criteria and mortality in septic newborns. This study was performed at the Firat University Hospital Neonatal Intensive Care Unit. A group of septic newborns and a control group of healthy non-infected newborns wer...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347098
更新日期:2011-04-01 00:00:00
abstract::1-123 metaiodobenzylguanidine (1-123 MIBG) scintigraphy is known for its high specificity in detecting pheochromocytoma and other tumors of neural crest origin. In this rare case report, we describe a definite adrenocortical adenoma that demonstrated false-positive uptake at I-123 MIBG scintigraphy and a remarkable ac...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348046
更新日期:1998-12-01 00:00:00
abstract:PURPOSE:Intravenous glucocorticoids (ivGCs) given as 12-weekly infusions are the first-line treatment for moderate-to-severe and active Graves' orbitopathy (GO), but they are not always effective. In this study, we evaluated whether response at 6 weeks correlated with outcomes at 12 (end of intervention) and 24 (follow...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-017-0608-z
更新日期:2017-05-01 00:00:00
abstract:CONTEXT:The latest guidelines of the 4th International Workshop on Asymptomatic Primary Hyperparathyroidism (aPHPT) reintroduced hypercalciuria (i.e. urinary calcium > 400 mg/day) as criterion for surgery. However, the value of hypercalciuria as a predictor of nephrolithiasis and the correct cut-off values still need t...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-019-01162-y
更新日期:2020-05-01 00:00:00
abstract:: ...
journal_title:Journal of endocrinological investigation
pub_type: 历史文章,杂志文章
doi:10.1007/s40618-018-0896-y
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Functional hypothalamic amenorrhea (FHA) refers to a functional menstrual disorder with various causes and presentations. Recovery of menstrual cyclicity is common in long-term follow-up but the affecting factors remain unknown. AIM:To explore factors affecting the menstrual resumption and to evaluate the p...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/8939
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:Acromegaly is a rare disorder existed in the result of overproduction of growth hormone (GH). The disorder is associated with increased cardiovascular risk factors and metabolic abnormalities. Urotensin II (UII), a secreted vasoactive peptide hormone, belonging somatostatin superfamily, plays an essential role ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-018-0905-1
更新日期:2019-02-01 00:00:00
abstract::Non-classical congenital adrenal hyperplasia (NCAH) is a morbid condition sustained by the reduced function of one of the enzymes involved in the adrenal steroid biosynthesis pathway, mainly the 21-hydroxylase. Different degrees of enzyme activity impairment determine different clinical pictures, with childhood or pos...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/7410
更新日期:2011-10-01 00:00:00
abstract::The aim of the study was to determine the main metabolic parameters of 11-beta-hydroxy-androstenedione (11 OHAD) in man. Seven normal subjects were investigated at 1-3 months interval by 2 types of isotope dilution techniques using a tritiated tracer: constant infusion and bolus iv injection. 3H-11 OHAD and 3H-11-beta...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349485
更新日期:1984-12-01 00:00:00
abstract::Graves' disease (GD) is the most prevalent cause of thyrotoxicosis in children. Because spontaneous and lasting resolution of this condition occurs in only a minority of patients, most pediatric patients with GD will need radioactive iodine treatment (131I) or thyroidectomy. Whereas the medication propylthiouracil (PT...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/s40618-016-0477-x
更新日期:2016-11-01 00:00:00
abstract::The coexistence of hyperparathyroidism complicating thyrotoxicosis is quite rare. We report the case of one patient who presented with thyrotoxicosis, (total thyroxine of 15.1 micrograms/dl (5-13), free thyroxine index of 18 (4-15) and triiodothyronine by RIA of 305 ng/dl (70-230) and asymptomatic hypercalcemia of 15 ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/BF03346819
更新日期:1991-04-01 00:00:00
abstract::In order to investigate the effect of gender, age and level of obesity on body composition and anaerobic power output, and to test the hypothesis that variation in body composition affects muscle power output in obesity, a cohort of 377 subjects (112 males and 265 females, aged 18-75 yr) with different levels of obesi...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346280
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:The relative contribution of fasting and post-prandial glucose to glycated hemoglobin (HbA1c) is controversial. In the present study, we assessed the relationship with HbA1c of fasting and post-prandial glucose measured in a more naturalistic setting, through home glucose self-monitoring or with a continuous ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03344161
更新日期:2006-07-01 00:00:00
abstract::An abnormal regulation of the hypothalamic-pituitary-adrenal (HPA) axis is associated with risk factors for cardiovascular disease and Type 2 diabetes mellitus. The objective of this study was to examine if morning saliva cortisols show similar associations. Twenty-eight men, all 53 yr of age, delivered during an ordi...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347017
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:Focal thyroid incidentaloma (TI) occurs in a 2% of 18F-FDG PET/CT and about one-third of TIs is cancer. Due to the lack of evidence on the optimal management of TI, current guidelines suggest performing fine-needle aspiration cytology (FNA). The study aim was to evaluate the reliability of ACR-TIRADS, EU-TIRA...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-020-01244-2
更新日期:2020-11-01 00:00:00
abstract::Serial weekly serum samples (for 3 weeks) were obtained from 42 patients with differentiated thyroid cancer (DTC, papillary no.=35, follicular no.=6, Hurthle cell no.=1) for serum thyroid hormone, TSH and TG before and after total thyroidectomy. Serum specimens were also obtained one month after radioiodine (131I) the...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03343973
更新日期:2002-02-01 00:00:00
abstract::General dynamic penile color doppler ultrasound (D-PCDU) screening in patients with erectile dysfunction (ED) has been questioned due to an inadequate cost-benefit ratio. The aim of the present study is to evaluate the validity of different risk scores in the identification of patients being screened for arteriogenic ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03345652
更新日期:2008-12-01 00:00:00
abstract:PURPOSE:To report the long-term effectiveness and safety of the recombinant human growth hormone Omnitrope®, a somatropin biosimilar to Genotropin®, in Italian patients with growth hormone deficiency (GHD) enrolled in the PATRO Adults study. METHODS:The PATRO Adults study is an ongoing observational, longitudinal, non...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,多中心研究
doi:10.1007/s40618-016-0604-8
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:To assess the relationship of waist circumference and weight/height ratio with height, and their association with components of the metabolic syndrome, in Type 2 diabetic patients. DESIGN:multicenter cross-sectional survey on a cohort enrolled in a prospective observational study. SUBJECTS:13,232 patients (...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,多中心研究
doi:10.1007/BF03347475
更新日期:2004-06-01 00:00:00
abstract::Six-day treatment of neonatal rats with T3 or T4 resulted in a considerable depression of T4 production in response to exogenous TSH in adulthood. This supports the hypothetical conclusion that hormonal imprinting, i.e. the presence of the hormone and its interaction with the cell during the period of receptor maturat...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348561
更新日期:1985-12-01 00:00:00
abstract::The case is described of a woman with a Verner-Morrison syndrome of extreme severity, caused by an occult VIPoma. Administration of SMS 201-995 (Sandoz) (SMS) at the dose of 150 and subsequently of 250 micrograms daily, decreased plasma levels of vasoactive intestinal polypeptide (VIP) from about 500 to 100 pg/ml (hig...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347894
更新日期:1991-09-01 00:00:00
abstract:PURPOSE:We did a meta-analysis with meta-regression to evaluate the relationship between hemoglobin A1c (A1C) reduction and the primary CV outcome of cardiovascular outcome trials (CVOTs). METHODS:We used a random effects meta-analysis of the 12 CVOTs to quantify the effect of A1C reduction on major cardiovascular eve...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,meta分析
doi:10.1007/s40618-019-01047-0
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Agents capable of increasing radioiodine concentration by stimulating the sodium/iodide symporter (NIS) expression have been extensively investigated for the treatment of certain well-differentiated breast cancers. AIM:In this study, we analyzed the regulation of the NIS and lactoperoxidase (LPO) gene expre...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346542
更新日期:2010-01-01 00:00:00