GH-IGF-I axis in non-obese women with functional hyperandrogenism.

Abstract:

:The study was conducted to assess the GH-IGF-I axis in non-obese women with functional hyperandrogenism (FH). Eighteen FH women aged 18-35 yr with a body weight within 20% of ideal body weight and 10 weight-matched controls were included in the study. Basal serum GH, GH-binding protein (GHBP), IGF-I, IGF-binding protein-3 (IGFBP-3) levels were determined as well as GH levels during GHRH stimulation. In addition, basal serum androgens [free T (FT), delta4 and DHEAS], insulin and glucose levels were determined. The group of non-obese patients with FH differed from controls in GHBP (1.21+/-0.37 vs 0.93+/-0.25 nmol/l; p<0.05) and androgen levels (FT: 8.0+/-3.2 vs 1.9+/-1.2 pmol/l, p<0.001; delta4: 10.5+/-3.2 vs 5.9+/-2.1 nmol/l, p<0.001; DHEAS: 9.3+/-3.0 vs 5.1+/-1.8 micromol/l, p<0.001). GH (r=0.365; p<0.05) and IGF-I (r=0.508, p<0.01) serum levels were significantly correlated to serum DHEAS levels in a combined group of patients and controls. Our results support the suggestion that the GH-IGF-I axis plays an important role in the evolution of hormonal and metabolic derangement in non-obese FH women.

journal_name

J Endocrinol Invest

authors

Legan M,Kocijancic A,Prezelj J,Osredkar J,Fisker S

doi

10.1007/BF03345102

keywords:

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

691-5

issue

8

eissn

0391-4097

issn

1720-8386

pii

5882

journal_volume

25

pub_type

杂志文章
  • 5-HT2 receptors are partially involved in the relationship between renin release and delta relative power.

    abstract::A strong relationship was previously described between the nocturnal oscillations of plasma renin activity (PRA) and the sleep cycles, with levels of PRA that increase during non rapid eye movement sleep and decrease during rapid eye movement sleep. This study was designed to determine whether ritanserin, a 5-hydroxyt...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF03349016

    authors: Brandenberger G,Luthringer R,Muller G,Gronfier C,Schaltenbrand N,Macher JP,Muzet A,Follenius M

    更新日期:1996-09-01 00:00:00

  • Recombinant human thyroid-stimulating hormone (rhTSH): clinical development.

    abstract::Recombinant human thyroid-stimulating hormone (rhTSH) was developed to safely provide exogenous TSH stimulation in patients on thyroid hormone suppression therapy (THST), which is integral to long-term management of well-differentiated thyroid cancer. Such stimulation allows detection of thyroid remnant and neoplastic...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:

    authors: Incerti C

    更新日期:1999-01-01 00:00:00

  • Relationship between cerebrospinal fluid beta-endorphin and plasma pituitary-gonadal hormone levels in women.

    abstract::Brain beta-endorphin (beta-EP) plays an important role in regulating the hypothalamus-pituitary-gonadal axis activity. Cerebrospinal fluid (CSF) beta-EP levels seem to reflect the central rather than pituitary secretion. With the aim to correlate the changes of plasma estradiol (E2), progesterone, luteinizing hormone ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349526

    authors: Nappi C,Petraglia F,Gambardella A,De Masellis G,Di Carlo C,Genazzani AR,Montemagno U

    更新日期:1990-02-01 00:00:00

  • Effect of exposure to the altitude of 300 meters below sea-level on testosterone, luteinizing hormone, follicle-stimulating hormone and prolactin in man.

    abstract::Serum testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin (PRL) responses to exposure to sea-level altitude (LA) were examined in 13 eugonadal males, age 21-22 yr, 3 and 5 days after residing at LA and on the second day of return to basal altitude 90 days later. After 3 days at the...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350195

    authors: Ajlouni KM,Sliman NA,Najdawi A,Abu-Hajir MM,Arnaout MA

    更新日期:1988-09-01 00:00:00

  • False-positive diagnosis of adrenal pheochromocytoma on iodine-123-MIBG scan.

    abstract::1-123 metaiodobenzylguanidine (1-123 MIBG) scintigraphy is known for its high specificity in detecting pheochromocytoma and other tumors of neural crest origin. In this rare case report, we describe a definite adrenocortical adenoma that demonstrated false-positive uptake at I-123 MIBG scintigraphy and a remarkable ac...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348046

    authors: Letizia C,De Toma G,Massa R,Corsi A,Caliumi C,Subioli S,D'Erasmo E

    更新日期:1998-12-01 00:00:00

  • Cadmium exposure alters steroid receptors and proinflammatory cytokine levels in endothelial cells in vitro: a potential mechanism of endocrine disruptor atherogenic effect.

    abstract:BACKGROUND:Cadmium (Cd) is a widespread environmental pollutant that causes alterations in human health acting as endocrine disruptor. Recent data suggest that cardiovascular system might be a contamination target tissue, since Cd is found in atheromatic plaques. Thus, the purpose of this study was to evaluate the cons...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-018-0982-1

    authors: Fittipaldi S,Bimonte VM,Soricelli A,Aversa A,Lenzi A,Greco EA,Migliaccio S

    更新日期:2019-06-01 00:00:00

  • Study of the family of a patient with male-limited precocious puberty (MPP) due to T1193C transition in exon 11 of LH receptor gene.

    abstract::Molecular diagnostics of the LHR gene was conducted in a 5-year-old boy with clinical symptoms and hormonal profile typical of precocious puberty. His parents and 4 sisters were also diagnosed. Single-strand conformation polymorphism analysis under temperature gradient conditions (Multitemperature SSCP) of 3 overlappi...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03344001

    authors: Ignacak M,Starzyk J,Dziatkowiak H,Trzeciak WH

    更新日期:2002-03-01 00:00:00

  • The TRH induced PRL release in patients with autonomous thyroid nodules before and after surgical treatment.

    abstract::Total and free thyroid hormones (T3, T4, FT3, FT4), TSH and PRL were determined in basal conditions and after stimulation with TRH in 32 patients affected by autonomous thyroid nodules before and after nodulectomy and in 24 control subjects. Only 7 patients were clinically thyrotoxic and thyroid hormone concentrations...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350607

    authors: Langer M,Costanza C,Casu AR,Rassu S,Madeddu G

    更新日期:1983-06-01 00:00:00

  • From inflammation to sexual dysfunctions: a journey through diabetes, obesity, and metabolic syndrome.

    abstract::Metabolic diseases are associated with chronic low-grade inflammation, which has been indicated as a potential mediator of endothelial dysfunction and cardiovascular disease. Visceral adiposity is thought to be the starting condition of the inflammatory state through the release of inflammatory cytokines, including TN...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-018-0872-6

    authors: Maiorino MI,Bellastella G,Giugliano D,Esposito K

    更新日期:2018-11-01 00:00:00

  • An exception to the rule: ectopic ACTH production from functional neuroendocrine tissue in an ovarian dermoid cyst.

    abstract::Ectopic ACTH production accounts for 15% of Cushing's syndrome presentations and is characterized by the presence of an excess of ACTH precursors. However in the case presented here ectopic ACTH production was from functional pituitary tissue within an ovarian dermoid cyst. Endocrine investigations showed that the pro...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03343930

    authors: Watson J,Taylor M,Pampiglione J,Rasbridge S,Armitage M

    更新日期:2001-11-01 00:00:00

  • Influence of the neonatal suppression of TSH production (neonatal hyperthyroidism) on response to TSH in adulthood.

    abstract::Six-day treatment of neonatal rats with T3 or T4 resulted in a considerable depression of T4 production in response to exogenous TSH in adulthood. This supports the hypothetical conclusion that hormonal imprinting, i.e. the presence of the hormone and its interaction with the cell during the period of receptor maturat...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348561

    authors: Csaba G,Nagy SU

    更新日期:1985-12-01 00:00:00

  • Cardiac structure and functions in patients with asymptomatic primary hyperparathyroidism.

    abstract:BACKGROUND:The data about cardiovascular (CV) changes in patients with asymptomatic primary hyperparathyroidism (PHPT) are scarce. AIM:The aim of this study is to compare cardiac structure and functions in patients with asymptomatic PHPT and controls by using tissue Doppler echocardiography. SUBJECTS AND METHODS:Thir...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/8961

    authors: Aktas Yılmaz B,Akyel A,Kan E,Ercin U,Tavil Y,Bilgihan A,Cakır N,Arslan M,Balos Toruner F

    更新日期:2013-11-01 00:00:00

  • Intrinsic abnormality of thyroid cells from a patient with a Brobdingnagian goiter.

    abstract::Thyrocytes from normal and goitrous portions of the thyroid gland from a patient with an enormous (635 gm) goiter were cultured in media, and their relative abilities to uptake thymidine, synthesize DNA, and secrete Tg and T4 were assessed. Tg, T4 and the ratio Tg/T4 in media at 72 h were 120 micrograms/dl, 1.6 microg...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348184

    authors: Tseng YC,Burman KD,Baker JR Jr,D'Avis J,Wartofsky L

    更新日期:1987-10-01 00:00:00

  • Erectile dysfunction: symptom or disease?

    abstract::Erectile dysfunction (ED) has been defined by the National Institute of Health (NIH) as the inability to achieve and/or to maintain an erection for a sufficiently long period of time so as to permit satisfactory sexual intercourse. ED affects millions of men throughout the world and could have a negative influence on ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/BF03350917

    authors: Foresta C,Caretta N,Aversa A,Bettocchi C,Corona G,Mariani S,Rossato M

    更新日期:2004-01-01 00:00:00

  • Impact of short-term treatment with benzodiazepines and imidazopyridines on glucose metabolism in healthy subjects.

    abstract:AIM:In the last years there has been a progressive reduction of the average duration of sleep and an increase in the incidence of sleep disturbances. At the same time, an increase of the incidence of the metabolic syndrome has been described, partly attributable to the progressive worsening of dietary habits and the in...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s40618-013-0016-y

    authors: Gramaglia E,Ramella Gigliardi V,Olivetti I,Tomelini M,Belcastro S,Calvi E,Dotta A,Ghigo E,Benso A,Broglio F

    更新日期:2014-02-01 00:00:00

  • An assessment of genetic markers as predictors of bone turnover in healthy adults.

    abstract::In 1992 a significant relationship between bone turnover and the vitamin D receptor (VDR) genotype was reported in Australian subjects of UK-Irish decent. Since then, several groups have investigated the relationship between VDR and other bone-related genotypes, bone mass and bone turnover in several populations. Howe...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF03343853

    authors: Sheehan D,Bennett T,Cashman KD

    更新日期:2001-04-01 00:00:00

  • Seasonal plasma profiles of testosterone and androstenedione in the Gentile di Puglia ram in southern Italy.

    abstract::Seasonal plasma testosterone and androstenedione levels were determined by radioimmunoassay in the Gentile di Puglia ram. Androstenedione remains steady throughout the years, while testosterone shows seasonal changes. Testosterone is at high levels in winter, spring and summer and drops to a low concentration in autum...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348490

    authors: Dell'Aquila S,Crasto A,Alberico G,Varriale B,Pelosi A,Pierantoni R

    更新日期:1985-06-01 00:00:00

  • Decrease of thyroid antibodies during pregnancy.

    abstract::The behavior of serum anti-thyroglobulin (Abs-Tg) and antimicrosomal antibodies (Abs-Mc) was examined during and after normal pregnancies. The antibodies titer decreases as pregnancy progresses; they cross the placenta and are present in the fetal serum. Infants' thyroid function is not affected by this transplacentar...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349385

    authors: D'Armiento M,Salabé H,Vetrano G,Scucchia M,Pachi A

    更新日期:1980-10-01 00:00:00

  • Synthetic growth hormone-releasing hormone (GHRH 1-44) in the differential diagnosis between hypothalamic and pituitary GH deficiency.

    abstract::GH response to an iv bolus of growth-hormone-releasing hormone (GHRH 1-44, 2 micrograms/kg iv) was evaluated in 17 prepubertal children with total GH deficiency (GHD), 6 with partial GHD and in 7 prepubertal normal but short children tested as control. GH response to conventional pharmacological (insulin and arginine ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346976

    authors: Bozzola M,Tatò L,Cisternino M,Nava C,Valtorta A,Chiesa M,Severi F,Gaburro D

    更新日期:1986-12-01 00:00:00

  • Cardiovascular outcome trials and major cardiovascular events: does glucose matter? A systematic review with meta-analysis.

    abstract:PURPOSE:We did a meta-analysis with meta-regression to evaluate the relationship between hemoglobin A1c (A1C) reduction and the primary CV outcome of cardiovascular outcome trials (CVOTs). METHODS:We used a random effects meta-analysis of the 12 CVOTs to quantify the effect of A1C reduction on major cardiovascular eve...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,meta分析

    doi:10.1007/s40618-019-01047-0

    authors: Giugliano D,Chiodini P,Maiorino MI,Bellastella G,Esposito K

    更新日期:2019-10-01 00:00:00

  • Gene variants associated to malignant thyroid disease in familial adenomatous polyposis: a novel APC germline mutation.

    abstract:BACKGROUND AND AIM:Familial adenomatous polyposis (FAP) is an autosomal inherited syndrome characterized by hundreds to thousands colorectal adenomatous polyps with oncological transformation lifetime risk of 100%. FAP is mainly associated with mutations in APC (autosomal dominant inheritance) or MUTYH (autosomal reces...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346656

    authors: Martayan A,Sanchez-Mete L,Baldelli R,Falvo E,Barnabei A,Conti L,Giacomini P,Appetecchia M,Stigliano V

    更新日期:2010-10-01 00:00:00

  • Adiponectin expression and metabolic markers in obesity and Type 2 diabetes.

    abstract:BACKGROUND:Adiponectin has emerged over the last decade as a key adipokine linking obesity, insulin resistance, and Type 2 diabetes. However, the molecular mechanisms controlling adiponectin expression in adipose tissue are not fully elucidated. Furthermore, increasing evidence indicates that peroxisome proliferator-ac...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347056

    authors: Kouidhi S,Jarboui S,Marrakchi R,Froidevaux MS,Seugnet I,Abid H,Bchir F,Brahem M,Demeneix B,Guissouma H,Elgaaied AB

    更新日期:2011-02-01 00:00:00

  • Vitamin D deficiency and primary hyperparathyroidism.

    abstract::Vitamin D via its receptor has essential actions on parathyroid cells, inhibiting PTH secretion, and parathyroid cell proliferation. While the effects of vitamin D depletion in the pathogenesis of secondary hyperparathyroidism in elderly individuals or in the occurrence of parathyroid hyperplasia in patients with rena...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:

    authors: Nuti R,Merlotti D,Gennari L

    更新日期:2011-07-01 00:00:00

  • Exendin-4 protects murine MIN6 pancreatic β-cells from interleukin-1β-induced apoptosis via the NF-κB pathway.

    abstract:BACKGROUND:Glucagon-like peptide-1 (GLP-1) and its potent analog, exendin-4, are well known to inhibit β- cell apoptosis and promote β-cell proliferation. Meanwhile, cytokines, such as interleukin-1β (IL-1β), stimulate inducible nitric oxide synthase (iNOS) expression and nitric oxide overproduction leading to β-cell d...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/8938

    authors: Liu XH,Wang YP,Wang LX,Chen Z,Liu XY,Liu LB

    更新日期:2013-11-01 00:00:00

  • Effects of somatostatin in a case of severe hypoglycemia due to nesidioblastosis.

    abstract::The Authors have studied the effects of somatostatin (SRIF) treatment in an infant affected by hypoglycemia due to nesidioblastosis. During iv infusion with SRIF we observed a marked increase of blood glucose levels; concomitantly insulin secretion was almost completely suppressed. In contrast, during treatment with p...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350454

    authors: Roti E,Ghinelli C,Bandini P,Del Rossi C,Emanuele R,Robuschi G,Gnudi A

    更新日期:1981-04-01 00:00:00

  • Thyroid function tests in acute viral hepatitis: relative reduction in serum thyroxine levels due to T4-TBG binding inhibitors in patients with severe liver cell necrosis.

    abstract::Thyroid function tests were evaluated in 34 patients with acute viral hepatitis (AVH) and in 38 healthy controls (C). As expected, AVH patients displayed a significant increase in T4, rT3 and TBG serum levels with respect to C, while FT4 and TSH concentrations were similar. A positive correlation between TBG and T4 wa...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349947

    authors: Pagliacci MC,Pelicci G,Francisci D,Giammartino C,Fedeli L,Stagni G,Nicoletti I

    更新日期:1989-03-01 00:00:00

  • Serum free thyroid hormones in T3-toxicosis: a study of 35 patients.

    abstract::Few data are available on serum free thyroid hormone concentration in patients with T3-toxicosis. In this study total and free T4 and T3 and TBG were evaluated in 35 subjects with T3-toxicosis, including 12 with untreated Graves' disease, 5 Graves' patients on methimazole treatment, 13 with autonomous adenoma, 3 with ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350562

    authors: Ferrari C,Romussi M,Rampini P,Benco R,Boghen M,Paracchi A,Frezzati S

    更新日期:1983-02-01 00:00:00

  • Regional distribution of nuclear T3 receptors in rat brain and evidence for preferential localization in neurons.

    abstract::We examined the distribution of nuclear T3 in mature rat brain with the aim of determining specific targets of thyroid hormones within this tissue. Saturation experiments, performed in 9 different structures of the brain and in 4 parts of the cortex, revealed the presence of a single class of binding sites with a mean...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348511

    authors: Ruel J,Faure R,Dussault JH

    更新日期:1985-08-01 00:00:00

  • Serum 25 hydroxyvitamin D in employees of a Middle Eastern university hospital.

    abstract:BACKGROUND:The Middle East registers the highest rate of vitamin D deficiency worldwide. In Lebanon, previous studies looked at this deficiency in schoolchildren, university students, young adults and postmenopausal women. However, no previous study was performed in hospital workers. The objective of our study was to e...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-014-0061-1

    authors: Gannagé-Yared MH,Helou E,Zaraket V,Abi Akl S,Antonios L,Moussalli ML,Wakim S

    更新日期:2014-06-01 00:00:00

  • Incidence of congenital hypothyroidism in the Autonomous Province of Bolzano: benefit of increased iodine intake.

    abstract:PURPOSE:Although a nation-wide salt iodization program on voluntary basis was implemented in 2005, many areas in our country are still characterized by mild iodine deficiency. Differently from the rest of Italy, an efficient program of iodine prophylaxis was implemented in 1981 in the Autonomous Province of Bolzano. Th...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-014-0206-2

    authors: Olivieri A,Radetti G,Medda E,Italian Study Group for Congenital Hypothyroidism.

    更新日期:2015-02-01 00:00:00