Abstract：
:Graves' disease (GD) is the most prevalent cause of thyrotoxicosis in children. Because spontaneous and lasting resolution of this condition occurs in only a minority of patients, most pediatric patients with GD will need radioactive iodine treatment (131I) or thyroidectomy. Whereas the medication propylthiouracil (PTU) had been used in the past, only methimazole (MMI) should be now used in children, as PTU is associated with an unacceptable risk of liver failure. However, MMI may be associated minor and major side effects, which may be minimized using lower doses. An area of controversy involves the optimal duration of antithyroid drug (ATD) therapy. For some children, the prolonged use of antithyroid drugs is a valid approach, but for most, this will not increase the chance of remission. When 131I is administered, dosages should be greater than 150 uCi/gm of thyroid tissue, with higher dosages needed for larger glands. Considering that there will be low-level whole body radiation exposure associated with 131I, this treatment is viewed as controversial by some and should be avoided in young children. When surgery is performed, near-total or total thyroidectomy is the recommended procedure. Complications for thyroidectomy in children are considerably higher than in adults. Thus, an experienced thyroid surgeon is needed when children have surgery. Overall, when different treatment options for GD are considered, the benefits, risks and viewpoints of the family need to be considered and discussed in full.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Rivkees SAdoi
10.1007/s40618-016-0477-xsubject
Has Abstractpub_date
2016-11-01 00:00:00pages
1247-1257issue
11eissn
0391-4097issn
1720-8386pii
10.1007/s40618-016-0477-xjournal_volume
39pub_type
杂志文章,评审abstract：:Nine chronic male alcoholics presenting with hypogonadism but without overt liver failure were examined under baseline conditions and after acute injection of gonadotropin releasing hormone (GnRH, 100 micrograms iv) and thyrotropin releasing hormone (TRH, 200 micrograms iv), performed at 60 min of a 3-h infusion of sa...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF03348339
更新日期：1983-12-01 00:00:00
abstract：:The AA. studied the glycometabolic activity of prazosin, a hypotensive drug with an adrenergic blocking activity of alpha-1-selective type. Twenty-two moderately hypertensive subjects were studied. Their ages ranged from 37 to 57 years; 10 of the patients had non-insulin dependent diabetes mellitus. After overnight fa...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF03350608
更新日期：1983-06-01 00:00:00
abstract：BACKGROUND:Visfatin [pre-B cell colony- enhancing factor (PBEF)] is a cytokine highly expressed in visceral fat that exhibits insulin-mimetic properties. However, its role in insulin-resistant states, such as in metabolic syndrome (MetS), remains largely unknown. OBJECTIVE:To investigate the possible differences of pl...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346300
更新日期：2007-04-01 00:00:00
abstract：:Unfortunately, the author name and his affiliation were published in the original publication. They have now been removed. ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,已发布勘误
doi：10.1007/s40618-019-01012-x
更新日期：2019-02-01 00:00:00
abstract：:Ghrelin, a natural GH secretagogue, exerts remarkable endocrine and non-endocrine activities such as orexigenic effect and modulation of the endocrine and metabolic response to variations in energy balance. Ghrelin levels have been reported to be negatively associated to insulin secretion, enhanced in anorexia and red...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03344026
更新日期：2002-05-01 00:00:00
abstract：PURPOSE:Spinal cord injury (SCI) affects sexual health of both male and female, but little attention has been given to sexuality of SCI women. Similar to penile erection, vaginal lubrication represents a neurovascular event and then both denervation and vascular damage might contribute to its impairment. Nevertheless, ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-020-01185-w
更新日期：2020-07-01 00:00:00
abstract：PURPOSE:Hashimoto's thyroiditis (HT) is often associated with rheumatic disorders (arthritis, etc.), but many HT patients report non-specific rheumatic signs and symptoms in the absence of clinically evident rheumatic diseases. Aim of this study was to evaluate the prevalence of non-specific rheumatic manifestations (R...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-019-01083-w
更新日期：2020-01-01 00:00:00
abstract：:Long-acting im bromocriptine was administered to 7 patients with pituitary macroadenomas (4 acromegalics, 1 Nelson's syndrome and 2 prolactinomas), with good tolerance except during the first 24 h. During a 42-day period hormonal, CT-scan and visual field variations were followed. In acromegalics HGH decrease was not ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348130
更新日期：1987-06-01 00:00:00
abstract：:This report describes the results of the second part of the collaborative study organized by a working group sponsored by the Community Bureau of Reference of the European Community Commission. The whole study was designed to understand the causes of discrepancy among LH immunoassay methods. In the parent report we de...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章
doi：10.1007/BF03347727
更新日期：1994-06-01 00:00:00
abstract：:A 56-year-old woman with granulomas of gold thioglucose in her hips exhibited recurrent bouts of hypoglycemic attacks. The first attack occurred 2 years after the last injection of gold thioglucose, when large amounts of extractable insulin and human insulin-specific antibody were noted in her serum. Histological exam...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348654
更新日期：1992-01-01 00:00:00
abstract：:Fifty-seven (35.6%) of 160 patients with papillary thyroid carcinoma had lymph node metastases at the primary treatment. Children and adolescents were most frequently affected (69.2%), followed by the age group of 21-40-year olds (38.8%). Those older than 40 had the lowest incidence of lymph node metastases (29.6%; p ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346863
更新日期：1991-07-01 00:00:00
abstract：:In the literature, few studies analyze the effect of GH therapy on height, preferring a more indirect approach, where factors influencing the total pubertal and pre-pubertal growth in GH-deficient patients are evaluated and subsequently used to estimate the overall effect at the end of the therapy; unfortunately, this...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345420
更新日期：2012-02-01 00:00:00
abstract：:We report a case of pulmonary multinodular mucormycosis in a Type 1 diabetic patient with diabetic ketoacidosis. He had a history of 20-pack-year tobacco use. The initial chest roentgenogram and thorax tomography (after the treatment of diabetic ketoacidosis) revealed multiple nodular lesions with cavitation in the up...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347433
更新日期：2007-03-01 00:00:00
abstract：:Anorexia nervosa (AN) is a complex mental disorder presenting psychiatric and physical symptoms. Literature recognizes the role of several factors in the pathogenesis of this disorder, according to the biopsychosocial model. Many mechanisms are still partly unclear. Endocrine and metabolic alterations usually occur in...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/BF03347545
更新日期：2004-11-01 00:00:00
abstract：:A 50 year old man is described in whom primary hypothyroidism and isolated ACTH deficiency leading to adrenocortical insufficiency occurred simultaneously. Low thyroid hormone levels, elevated serum TSH values and high titers of antithyroid antibodies (ATA) were consistent with primary hypothyroidism. The diagnosis of...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348331
更新日期：1982-07-01 00:00:00
abstract：PURPOSE:Few examples of the involvement of a single gene in idiopathic short stature have been described until now. Our aim was to identify the causative gene of proportionate short stature in a large family showing co-segregation of the phenotype with the reciprocal translocation t(10;15)(q22;q24). METHODS:FISH mappi...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-017-0819-3
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:In our previous study, we introduced a rat model of polycystic ovary syndrome (PCOS) induced by prenatal exposure to a single dose of testosterone on embryonic day 20. In the current study, we aimed to investigate whether prenatal exposure to a single dose of testosterone could also induce metabolic disturbance...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-014-0198-y
更新日期：2015-05-01 00:00:00
abstract：:Cardiovascular problems have long been recognized as responsible for an increased morbidity and mortality in patients with acromegaly. The aim of the present study was to evaluate echocardiographically the prevalence of cardiomyopathy in a cohort of acromegalic patients and to analyze the results in relation to demogr...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349779
更新日期：1995-09-01 00:00:00
abstract：:Carbenoxolone is a derivative of glycyrrhetinic acid used for the treatment of peptic ulcer and gastritis, with salt and water retention a very common side-effect. To investigate this drug-induced pseudohyperaldosteronism we have studied 6 male volunteers before, during and after treatment with carbenoxolone for 7 day...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03350002
更新日期：1989-05-01 00:00:00
abstract：BACKGROUND:In obese subjects it has been shown that cortisol (F) contributes to the reduction in insulin sensitivity, suggesting a role in the development of the metabolic syndrome (MS). AIM:The aim of this retrospective study was to evaluate the relationship between F and components of MS in 1,027 obese children and ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-013-0014-0
更新日期：2014-01-01 00:00:00
abstract：:The effects of growth hormone-releasing hormone (GHRH) were studied on densely granulated somatotroph adenoma cells and sparsely granulated somatotroph adenoma cells in culture by measuring release of growth hormone (GH) as well as ultrastructural morphometrical parameters and comparing them with those of control aden...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03350727
更新日期：1989-07-01 00:00:00
abstract：:A dialyzable, thermostable inhibitor of normal thyroid peroxidase (TPO), with UV absorption maximum at 250-260 nm, was found in the digitonized, washed particulate fraction of two dyshormonogenetic goiters. No intrinsic TPO iodide-oxidation activity was detectable in either of these goiters, and their TPO iodination a...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349651
更新日期：1990-12-01 00:00:00
abstract：:Final height was evaluated in 47 patients with classical 21-hydroxylase treated since diagnosis, and in 29 patients with nonclassical (NC) 21-hydroxylase deficiency who had never been treated before reaching final adult height. Classical patients achieved final heights consistently below the mean for the general popul...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:The article "EStradiol and PRogesterone in In vitro ferTilization (ESPRIT): a multicenter study evaluating third‑ versus second‑generation estradiol and progesterone immunoassays. ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,已发布勘误
doi：10.1007/s40618-020-01295-5
更新日期：2020-09-01 00:00:00
abstract：:In order to investigate the effect of gender, age and level of obesity on body composition and anaerobic power output, and to test the hypothesis that variation in body composition affects muscle power output in obesity, a cohort of 377 subjects (112 males and 265 females, aged 18-75 yr) with different levels of obesi...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346280
更新日期：2004-10-01 00:00:00
abstract：:Many studies have shown that fat distribution influences metabolism independently of the effects of total body fat stores. The accumulation of fat in the abdominal area, particularly in the visceral fat compartment, seems to be associated with an increased risk to display complications such as insulin resistance, diab...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/BF03344051
更新日期：2002-11-01 00:00:00
abstract：OBJECTIVE:Focal thyroid incidentaloma (TI) occurs in a 2% of 18F-FDG PET/CT and about one-third of TIs is cancer. Due to the lack of evidence on the optimal management of TI, current guidelines suggest performing fine-needle aspiration cytology (FNA). The study aim was to evaluate the reliability of ACR-TIRADS, EU-TIRA...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-020-01244-2
更新日期：2020-11-01 00:00:00
abstract：:The regulation of GH secretion involves the harmonious integration of factors acting at the hypothalamic and pituitary levels summating to produce the peripheral patterns of intermittent GH secretion observed in man and experimental animals under physiologic and experimental conditions. SRIH and GHRH act primarily at ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：1989-01-01 00:00:00
abstract：:A 34-yr-old nulliparous black woman presented with hair loss, facial hirsutism, irregular menses and infertility associated with greatly increased serum total testosterone levels. The adrenal glands and the ovaries were normal on radiological and ultrasonographic investigation. Catheterization of the veins draining fr...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348033
更新日期：1997-12-01 00:00:00
abstract：:The present study investigated whether trophoblast, decidua and fetal membranes express nerve growth factor (NGF) mRNA and peptide. Tissue specimens were collected in the first and third trimester of pregnancy from women undergoing voluntary pregnancy interruption (no.= 6; from 8 to 12 gestational weeks) and from wome...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03344105
更新日期：2006-04-01 00:00:00
