Abstract:
:The aim of the study was to examine the effects of strenuous training on the hypothalamic- pituitary-adrenal axis activity. Exercise tests and saliva collections for analysis of awakening cortisol response (ACR) and midnight cortisol were performed before and after a 7-day period of intensified training in a group of 15 soccer players. Intensified training resulted in a performance decrement as shown by the pre-post-training changes in maximal values of counter movement jump (CMJ) height (p=0.008). Cortisol assessment during the first 30 min after awakening showed significant increases both before and after the 7-day period and post-training ACR higher than pre-training ACR (p<0.001). Midnight cortisol also significantly increased after training (mean+/-SD, before: 3.0+/-0.7 nmol/l vs after: 5.9+/-3.3 nmol/l; p=0.017). The analysis of individual data showed an important inter-individual variability in the pre-post-training changes: several subjects increased post-awakening peak of cortisol, rate of cortisol increase from awakening to peak, and area under the curve (AUC) values, whereas other subjects showed no training-related increases. Significant correlations were observed between pre-post-training change in CMJ and in the following variables: awakening cortisol (r=0.74), post-awakening peak of cortisol (r=0.81), rate of cortisol increase (r=0.75), and AUC (r=0.79). Briefly, the lower the performance decrease, the higher the training-associated ACR increase. These data could indicate that a dysregulated adaptation to exercise occurred in athletes who experienced a higher performance decrease after training and lower (or absent) hormonal changes. Future studies are needed to elucidate the physiological determinants which underlie the exercise-elicited changes in ACR and in midnight cortisol levels and their value in predicting impaired adaptations to exercise.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Minetto MA,Lanfranco F,Tibaudi A,Baldi M,Termine A,Ghigo Edoi
10.1007/BF03345561subject
Has Abstractpub_date
2008-01-01 00:00:00pages
16-24issue
1eissn
0391-4097issn
1720-8386pii
4392journal_volume
31pub_type
临床试验,杂志文章abstract:PURPOSE:Leptin is associated with cardiovascular risk factors (e.g. hypertension, insulin resistance, kidney disease and excess body weight). Experimental studies showed that leptin might affect serum uric acid, by modulation of the uric acid excretion. However, there are few observational data on the relationship betw...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-019-01140-4
更新日期:2020-05-01 00:00:00
abstract::Over the last decade, there has been an alarming increase of Type 2 diabetes mellitus (T2DM) in youths, concomitant with the rise of obesity in this age group. T2DM is a progressive disease with a gradual increase in insulin resistance associated later with a decline in insulin secretion with fasting hyperglycemia. Pr...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/BF03347581
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:Aim of this study is to report on basal clinical phenotype and follow up after diagnosis, of patients with 17beta-hydroxysteroid-dehydrogenase type 3 (17beta-HSD3) deficiency in Italy. SETTING:Pediatric Endocrine Departments, University Hospitals. PATIENTS:The cases of 5 Italian subjects affected by 17beta-...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03345738
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Results of circulating Ghrelin levels in hyper- or hypothyroidism are conflicting and only overt thyroid dysfunction has been evaluated. AIM:To evaluate in a large number of patients with thyroid disfunction whether: a) hyper- and hypothyroidism (clinical or subclinical) are associated with variations in bo...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03345683
更新日期:2009-01-01 00:00:00
abstract::During a systematic study of women with idiopathic galactorrhea, we observed several patients with normal random serum prolactin (PRL) levels and normal menses, but abnormal sellar tomograms characteristic of a pituitary adenoma. To test the hypothesis that these women might have intermittent PRL hypersecretion, we st...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348450
更新日期:1984-10-01 00:00:00
abstract::Two radioimmunological techniques for the measurement of anti-alpha-galactosyl (anti-Gal) antibodies were developed and we demonstrated that this antibody is present in the serum of most untreated patients with Graves' disease, thyroid-associated ophthalmopathy (TAO) and autoimmune thyroiditis. Thyrotropin-binding inh...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349806
更新日期:1995-11-01 00:00:00
abstract:AIM:We aimed to investigate serum nesfatin-1 level in girls with premature thelarche (PT) and its relationship with anthropometric parameters and leptin, which are involved in the initiation of pubertal process. SUBJECTS-METHODS:Non-obese girls who presented with the complaint of early (2-8 years) and isolated breast ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-015-0277-8
更新日期:2015-08-01 00:00:00
abstract::We evaluated the oral calcium-loading test (OCLT) in diagnosing normocalcemic primary hyperparathyroidism. Calcium and PTH levels were measured before, 60, 120 and 180 min after oral 1 g of calcium gluconolactate administration in 102 consecutive females with high circulating PTH levels, and 25 controls. Patients were...
journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章
doi:10.1007/BF03345180
更新日期:2003-04-01 00:00:00
abstract:PURPOSE:An increased aggressiveness of familial papillary thyroid carcinoma (FPTC) compared with sporadic form has been reported. On the contrary, the biological behavior of familial microPTC (FmPTC) is still debated. To assess if familial diseases should be considered as a negative prognostic factor in mPTC, the clini...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-019-01039-0
更新日期:2019-10-01 00:00:00
abstract:CONTEXT:The latest guidelines of the 4th International Workshop on Asymptomatic Primary Hyperparathyroidism (aPHPT) reintroduced hypercalciuria (i.e. urinary calcium > 400 mg/day) as criterion for surgery. However, the value of hypercalciuria as a predictor of nephrolithiasis and the correct cut-off values still need t...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-019-01162-y
更新日期:2020-05-01 00:00:00
abstract::GH secretion in acromegaly was studied in 8 patients before and during treatment with SMS 201-995, a somatostatin analogue, 100 micrograms twice daily, by evaluating GH day profiles and GH suppressibility after oral glucose tolerance tests (OGTT). Normalization of GH secretion, estimated by OGTT, was only observed in ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350758
更新日期:1989-09-01 00:00:00
abstract::Final height was evaluated in 47 patients with classical 21-hydroxylase treated since diagnosis, and in 29 patients with nonclassical (NC) 21-hydroxylase deficiency who had never been treated before reaching final adult height. Classical patients achieved final heights consistently below the mean for the general popul...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::The present study investigated whether trophoblast, decidua and fetal membranes express nerve growth factor (NGF) mRNA and peptide. Tissue specimens were collected in the first and third trimester of pregnancy from women undergoing voluntary pregnancy interruption (no.= 6; from 8 to 12 gestational weeks) and from wome...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03344105
更新日期:2006-04-01 00:00:00
abstract::Rats bearing mammosomatotropic tumors have raised insulin but lowered glucose concentrations. To determine if growth hormone (GH) secreted by these tumors causes insulin antagonism, pancreatic suppression tests utilizing infusions (per kg per min) of glucose (8 mg), insulin (200 ng) and somatostatin (1.4 micrograms) f...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346996
更新日期:1987-12-01 00:00:00
abstract::Basal IGF-I levels and the GH response to at least two among provocative stimuli such as clonidine (CLO, Catapresan, 150 mcg/m2 p.o.), GHRH (1 mcg/kg i.v.)+arginine (ARG, 0.5 g/kg i.v. infusion during 30 min) and GHRH+pyridostigmine (PD, Mestinon cpr 60 mg p.o.) have been evaluated in 43 children with Prader-Willi syn...
journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章
doi:10.1007/BF03343684
更新日期:2000-02-01 00:00:00
abstract::The 24-h profiles of plasma cortisol (F), 11-beta-hydroxyandrostenedione (11OHAD), androstenedione (AD), dehydroisoandrosterone (DHEA) and testosterone (T) were obtained simultaneously in 11 normal males sampled at 15-min intervals. The data were submitted to a detailed quantitative analysis including the estimation o...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348129
更新日期:1987-06-01 00:00:00
abstract:PURPOSE:We did a meta-analysis with meta-regression to evaluate the relationship between hemoglobin A1c (A1C) reduction and the primary CV outcome of cardiovascular outcome trials (CVOTs). METHODS:We used a random effects meta-analysis of the 12 CVOTs to quantify the effect of A1C reduction on major cardiovascular eve...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,meta分析
doi:10.1007/s40618-019-01047-0
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Glucagon-like peptide-1 (GLP-1) and its potent analog, exendin-4, are well known to inhibit β- cell apoptosis and promote β-cell proliferation. Meanwhile, cytokines, such as interleukin-1β (IL-1β), stimulate inducible nitric oxide synthase (iNOS) expression and nitric oxide overproduction leading to β-cell d...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/8938
更新日期:2013-11-01 00:00:00
abstract::Ketoacidosis is a metabolic alteration caused by absolute or relative insulin deficiency and oversecretion of glucagon. Prompt diagnosis and rapid initiation of treatment are mandatory to avoid the complications and fatal outcome. Reduction of plasma glucose to levels within acceptable limits, block of ketogenesis, re...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Many hirsute women may present a form of functional ovarian hyperandrogenism (FOH), since they show an exaggerated 17-hydroxyprogesterone (17-OHP) response to GnRH agonists administration. As the failure of dexamethasone to reduce testosterone levels may be indicative of an ovarian source of androgen secretion, we eva...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03343965
更新日期:2002-01-01 00:00:00
abstract::Several cases of ovarian neoplasms resulting in Cushing's syndrome due to ectopic secretion of ACTH or ectopic secretion of F have been reported. Tumors producing ACTH include adenocarcinoma, androblastoma, Sertoli cell carcinoma, carcinoid tumor and teratoma. Cortisol secretion has been reported in ovarian steroid ce...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/BF03344020
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:The coexistence of insulin and ACTH hypersecretion in the same patient is extremely rare. A diabetic patient with a pancreatic endocrine tumor (PET) co-secreting insulin and ACTH is even rarer and has never been described. The combination of these two endocrine syndromes results in a peculiar clinical pictur...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347062
更新日期:2011-03-01 00:00:00
abstract::The differential diagnosis of an osteoblastic vertebral lesion (ivory vertebra) includes metastatic prostate cancer, lung cancer, lymphoma, osteosarcoma and Paget's disease. We report a case of a man who was initially diagnosed with Paget's disease on vertebral biopsy. He failed to respond to conventional bisphosphate...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03343770
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) are well-recognized complications of obesity. This study was designed to evaluate the role of the UCP1 -3826 A>G polymorphism, adiponectin levels, leptin/adiponectin ratio (L/A), and main biochemical parameters in 102 unrelated se...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346500
更新日期:2009-06-01 00:00:00
abstract::Because women affected by polycystic ovary syndrome (PCOS) present an increased cardiovascular risk, the safety of estroprogestin treatment is debated and contrasting data have been reported. However, cardiovascular risk is not the same in all PCOS women and individual cardiovascular risk should be assessed before sta...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.3275/8882
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:In our previous study, we introduced a rat model of polycystic ovary syndrome (PCOS) induced by prenatal exposure to a single dose of testosterone on embryonic day 20. In the current study, we aimed to investigate whether prenatal exposure to a single dose of testosterone could also induce metabolic disturbance...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-014-0198-y
更新日期:2015-05-01 00:00:00
abstract::The present study was performed in 30 patients who needed steroid therapy: courses of triamcinolone or DTM 8-15 given orally lasted 30 days. In 15 of these patients glucoactive corticosteroids were administered in combination with 5 micrograms/day of 25OH-vitamin D3 (25OHD3). 47Calcium oral test and 99mTc-MDP kinetics...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348448
更新日期:1984-10-01 00:00:00
abstract::GH may exert direct growth-promoting and metabolic actions on target tissues, but most of its effects are mediated by circulating (endocrine) or local (auto-/paracrine) IGF-I. The GH/IGF-I system has an important role in cardiac development and in maintaining the structure and function of the heart. A subgroup of chil...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03345590
更新日期:2008-03-01 00:00:00
abstract::Keratoconus is a bilateral non-inflammatory corneal ectasia with an incidence of approximately 1 per 2000 in the general population. The etiology of keratoconus is multifactorial, although not completely understood. Several clinical observations suggest that thyroid gland dysfunction is associated with keratoconus pat...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03345600
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Protein tyrosine phosphatase (PTP)- 1B, encoded by the PTPN1 gene, negatively regulates insulin signaling by dephosphorylating the phosphotyrosine residues of the insulin receptor kinase activation segment. Several rare single nucleotide polymorphisms (SNP) have been linked to diseases accompanying insulin r...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346629
更新日期:2010-07-01 00:00:00