Alterations in circulating thyroid hormones and thyroxine-binding globulin levels during diabetic ketoacidosis.

Abstract:

:During diabetic ketoacidosis, in 17 adult patients, significant decreases in serum TBG and total T4 levels were observed, without significant alteration of the T4 to TBG binding property. In addition, serum free T4 (FT4) was moderately elevated and the TSH response to TRH was markedly blunted. No correlation, however, was found between TSH blunting and FT4 elevation. Correlation of these serum anomalies required at least 5 days of adequate control of the diabetes. Thus, diabetic ketoacidosis in euthyroid patients is characterized by multiple alterations in thyroid function parameters and caution is recommended in the interpretation of thyroid tests during and in the days following this severe metabolic disorder.

journal_name

J Endocrinol Invest

authors

Glinoer D,Naeije R,Golstein J,Fernandez-Deville M,Vanhaelst L

doi

10.1007/BF03348220

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

67-9

issue

1

eissn

0391-4097

issn

1720-8386

journal_volume

3

pub_type

杂志文章
  • Decrease of thyroid antibodies during pregnancy.

    abstract::The behavior of serum anti-thyroglobulin (Abs-Tg) and antimicrosomal antibodies (Abs-Mc) was examined during and after normal pregnancies. The antibodies titer decreases as pregnancy progresses; they cross the placenta and are present in the fetal serum. Infants' thyroid function is not affected by this transplacentar...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349385

    authors: D'Armiento M,Salabé H,Vetrano G,Scucchia M,Pachi A

    更新日期:1980-10-01 00:00:00

  • Measurement of cAMP accumulation in Chinese hamster ovary cells transfected with the recombinant human TSH receptor (CHO-R): a new bioassay for human thyrotropin.

    abstract::Circulating TSH bioactivity may vary in several clinical and experimental conditions. Since the reliability of the current methods for the measurement of TSH bioactivity is limited, a new bioassay based on cAMP accumulation in Chinese Hamster Ovary cells transfected with recombinant human TSH receptor (CHO-R) was set ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348894

    authors: Persani L,Tonacchera M,Beck-Peccoz P,Vitti P,Mammoli C,Chiovato L,Elisei R,Faglia G,Ludgate M,Vassart G

    更新日期:1993-07-01 00:00:00

  • Amplification of LH response to LHRH by dopamine infusion in eugonadal women.

    abstract::Although the role of biogenic amines in the regulation of gonadotropin release has been studied extensively, the precise role of dopamine (DA) in stimulating LHRH and/or LH release is still controversial. In the present study 6 eugonadal women, aged 20-30, were given an LHRH infusion on day 6 of the menstrual cycle an...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349415

    authors: Pucci E,Franchi F,Kicovic PM,Sgrilli R,Barletta D,Argenio GF,Gasperi M,Bernini GP,Luisi M

    更新日期:1981-01-01 00:00:00

  • Correction to: EStradiol and PRogesterone in In vitro ferTilization (ESPRIT): a multicenter study evaluating third‑ versus second‑generation estradiol and progesterone immunoassays.

    abstract::The article "EStradiol and PRogesterone in In vitro ferTilization (ESPRIT): a multicenter study evaluating third‑ versus second‑generation estradiol and progesterone immunoassays. ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s40618-020-01295-5

    authors: Polyzos NP,Anckaert E,Drakopoulos P,Tournaye H,Schiettecatte J,Donner H,Bobba G,Miles G,Verhagen-Kamerbeek WDJ,Bosch E

    更新日期:2020-09-01 00:00:00

  • Glucose and insulin suppression of plasma free fatty acids in obese subjects with normal glucose tolerance or mild, newly diagnosed type 2 (non-insulin-dependent) diabetes.

    abstract::The in vivo suppressive effect of glucose and insulin on plasma free fatty acid concentrations was investigated in obese subjects with (n = 6) and without (n = 6) Type 2 (non-insulin-dependent) diabetes mellitus during a 4h-hyperglycemic glucose clamp (about 11.2 mmol/l). Somatostatin was infused (250 micrograms/h) du...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348582

    authors: Zancanaro C,Cigolini M,Bonora E,Moghetti P,Querena M,Muggeo M

    更新日期:1990-01-01 00:00:00

  • Extensive spherical amyloid deposition presenting as a pituitary tumor.

    abstract::A 71-yr-old man was admitted for further evaluation and trans-sphenoidal surgery of a pituitary tumor. He complained of impotence and decreased libido over a period of about 40 yr. Thirty-eight yr ago he was treated for bilateral gynecomastia with galactorrhea. Endocrinological investigation at presentation revealed o...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345219

    authors: Wiesli P,Brändle M,Brandner S,Kollias SS,Bernays RL

    更新日期:2003-06-01 00:00:00

  • Everything you ever wanted to know about phosphodiesterase 5 inhibitors and the heart (but never dared ask): How do they work?

    abstract:INTRODUCTION:Phosphodiesterase 5 inhibitors (PDE5i) were developed while investigating novel treatments for coronary artery disease, but their andrological side effects shifted their indication toward the management of erectile dysfunction. Although PDE5i are now also indicated for pulmonary arterial hypertension and t...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-015-0339-y

    authors: Pofi R,Gianfrilli D,Badagliacca R,Di Dato C,Venneri MA,Giannetta E

    更新日期:2016-02-01 00:00:00

  • Metastases to the thyroid gland: review of incidence, clinical presentation, diagnostic problems and surgery, our experience.

    abstract:PURPOSE:Metastases to the thyroid gland are uncommon and they represent 1-3% of all thyroid malignancy. The aim of this study is to analyze the diagnostic problems and the role of surgery in metastatic lesions to the thyroid. METHODS:We retrospectively analyzed all patients who had undergone thyroidectomy at our Cente...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-020-01282-w

    authors: Battistella E,Pomba L,Mattara G,Franzato B,Toniato A

    更新日期:2020-11-01 00:00:00

  • Administration of glutathione in patients with type 2 diabetes mellitus increases the platelet constitutive nitric oxide synthase activity and reduces PAI-1.

    abstract::Several studies suggest that nitric oxide (NO) production is impaired in diabetes mellitus. Reduced levels of NO could contribute to cardiovascular mortality. Furthermore, NO synthesis is impaired in glutathione (GSH)-depleted human umbilical vein endothelial cells and GSH is reduced in patients with type 2 diabetes m...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03343806

    authors: Martina V,Bruno GA,Zumpano E,Origlia C,Quaranta L,Pescarmona GP

    更新日期:2001-01-01 00:00:00

  • Sex-dependency of hepatic alcohol metabolizing enzymes.

    abstract::In mature female rats the administration of testosterone led to a striking reduction of hepatic alcohol dehydrogenase activity, whereas the hepatic microsomal ethanol oxidizing system as well as catalase were both increased in activity under these experimental conditions. Conversely, estradiol left the activities of a...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348330

    authors: Teschke R,Wiese B

    更新日期:1982-07-01 00:00:00

  • Minimally invasive video-assisted parathyroidectomy. Initial experience in a General Surgery Department.

    abstract:BACKGROUND:The aim of this study is to analyze our preliminary results from minimally invasive video-assisted parathyroidectomy (MIVAP) and demonstrate the feasibility of MIVAP also in non-referral centers. MATERIAL AND METHODS:During a period from June 2005 to January 2008, in the General Surgery Department of Univer...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345701

    authors: Dobrinja C,Trevisan G,Liguori G

    更新日期:2009-02-01 00:00:00

  • New insights into vitamin D regulation: is there a role for alkaline phosphatase?

    abstract:PURPOSE:The diagnosis of vitamin D deficiency is based on the determination of total plasma 25-hydroxyvitamin D (25-OHD) concentrations, but the regulation of vitamin D 25-hydroxylation is not a major consideration and very little information is available on this activity. To check what factors could interfere with the...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-021-01503-w

    authors: Bellastella G,Scappaticcio L,Longo M,Carotenuto R,Carbone C,Caruso P,Maio A,Paglionico VA,Vietri MT,Maiorino MI,Esposito K

    更新日期:2021-01-25 00:00:00

  • Adult subjects with Prader-Willi syndrome show more low-grade systemic inflammation than matched obese subjects.

    abstract:AIM:Adult subjects with Prader-Willi syndrome (PWS) may show several conditions that are associated with an activation of innate immunity such as obesity, deficient GH secretion or hypogonadism. Our aim was to study whether obese adult PWS subjects show an additional low-grade systemic inflammation (LGSI) in relation t...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345585

    authors: Caixàs A,Giménez-Palop O,Broch M,Vilardell C,Megía A,Simón I,Giménez-Pérez G,Mauricio D,Vendrell J,Richart C,González-Clemente JM

    更新日期:2008-02-01 00:00:00

  • Degree of catecholamine hypersecretion is the most important determinant of intra-operative hemodynamic outcomes in pheochromocytoma.

    abstract::Pheochromocytoma resection is often complicated by intra-operative hypertension and post-resection hypotension. Factors associated with these hemodynamic alterations are not well defined. The aim of this study was to analyse the clinical-laboratory features associated with hemodynamic parameters during pheochromocytom...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346458

    authors: Kramer CK,Leitão CB,Azevedo MJ,Canani LH,Maia AL,Czepielewski M,Paggi A,Rodrigues TC,Silveiro SP,Friedman R,Gross JL

    更新日期:2009-03-01 00:00:00

  • Associations between serum uric acid and adipokines, markers of inflammation, and endothelial dysfunction.

    abstract:AIM:Serum uric acid is associated with the metabolic syndrome and its components, while its relationship with cardiovascular disease is controversial. The aim of the study was to evaluate the association between uric acid and adipokines, markers of inflammation, oxidative stress, and endothelial dysfunction, which are ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346397

    authors: Bo S,Gambino R,Durazzo M,Ghione F,Musso G,Gentile L,Cassader M,Cavallo-Perin P,Pagano G

    更新日期:2008-06-01 00:00:00

  • Spot urinary iodine concentration as a measure of dietary iodine, evaluated in over 3800 young male subjects undergoing medical check-up preliminary to military enrolment in Piemonte and Aosta Valley (Italy).

    abstract::The aim of the study was to assess iodine status in over 3800 young male subjects aged 18, living in 6 different provinces of Piemonte and in Aosta Valley, Italy. A cross-sectional study on 3837 young male subjects undergoing medical evaluation preliminary to military enrolment was performed. Spot urine samples were o...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349155

    authors: Fonzo D,Germano L,Gallone G,Migliardi M

    更新日期:2003-12-01 00:00:00

  • Malignant pancreatic oncocytoma. An unusual cause of organic hypoglycemia.

    abstract::A case of malignant islet-cell tumor with oncocytic features occurring in a 54-year-old woman with symptoms of organic hypoglycemia is reported. The tumor was composed of ribbons of cells arranged in an endocrine pattern. The cytoplasm of these cells was eosinophilic and finely granular. Ultrastructurally, the cells c...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/BF03348712

    authors: Sadoul JL,Saint-Paul MC,Hoffman P,Plazza M,Birtwisle Y,Freychet P,Loubiere R

    更新日期:1992-03-01 00:00:00

  • Clinical and genetic characteristics of familial hypercholesterolemia patients with type 2 diabetes.

    abstract:PURPOSE:Though type 2 diabetes mellitus (T2DM) is an important and independent risk factor for coronary artery disease (CAD) in the general population, the impact of T2DM on CAD in patients with familial hypercholesterolemia (FH) is less understood. Thus, the current study aimed to examine the features of FH patients w...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-018-0959-0

    authors: Sun D,Cao YX,You XD,Zhou BY,Li S,Guo YL,Zhang Y,Wu NQ,Zhu CG,Gao Y,Dong QT,Liu G,Dong Q,Li JJ

    更新日期:2019-05-01 00:00:00

  • The impact of prenatal exposure to a single dose of testosterone on insulin resistance, glucose tolerance and lipid profile of female rat's offspring in adulthood.

    abstract:PURPOSE:In our previous study, we introduced a rat model of polycystic ovary syndrome (PCOS) induced by prenatal exposure to a single dose of testosterone on embryonic day 20. In the current study, we aimed to investigate whether prenatal exposure to a single dose of testosterone could also induce metabolic disturbance...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-014-0198-y

    authors: Noroozzadeh M,Ramezani Tehrani F,Sedaghat K,Godini A,Azizi F

    更新日期:2015-05-01 00:00:00

  • Molecular heterogeneity of a Graves' thyroid-infiltrating T cell population rich in CD8+ and gamma delta+ T cells.

    abstract::We report here on the isolation and repertoire characterization of a Graves' thyroid T cell population which, unlike most Graves' thyroid T cell isolates reported before, was rich in CD4-CD8- T cells (16%, all TcR gamma delta+) and CD8+ T cells (75%) [TcR alpha beta+ (59%) and TcR gamma delta+ (16%)]. Only 7% of the i...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348958

    authors: Santamaria P,Lewis C,Barbosa JJ

    更新日期:1993-12-01 00:00:00

  • Prevalence of overweight/obesity, abdominal obesity and metabolic syndrome and atypical cardiometabolic phenotypes in the adult Romanian population: PREDATORR study.

    abstract:PURPOSE:The objectives were to assess the prevalence of overweight/obesity, abdominal obesity and metabolic syndrome (MetS), and to evaluate the characteristics of the metabolically unhealthy lean (MUHL) and metabolically healthy overweight/obese (MHO) phenotypes in a Romanian population-based sample from the PREDATORR...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-016-0470-4

    authors: Popa S,Moţa M,Popa A,Moţa E,Serafinceanu C,Guja C,Catrinoiu D,Hâncu N,Lichiardopol R,Bala C,Popa A,Roman G,Radulian G,Timar R,Mihai B

    更新日期:2016-09-01 00:00:00

  • Long-term safety and efficacy of Omnitrope® in adults with growth hormone deficiency: Italian interim analysis of the PATRO Adults study.

    abstract:PURPOSE:To report the long-term effectiveness and safety of the recombinant human growth hormone Omnitrope®, a somatropin biosimilar to Genotropin®, in Italian patients with growth hormone deficiency (GHD) enrolled in the PATRO Adults study. METHODS:The PATRO Adults study is an ongoing observational, longitudinal, non...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s40618-016-0604-8

    authors: Ferone D,Profka E,Gasco V,Ambrosio MR,Colao A,Di Somma C,Puxeddu E,Arnaldi G,Pagano C,Zecchi E,Pietropoli A,Beck-Peccoz P

    更新日期:2017-06-01 00:00:00

  • Rising incidence of type 1 diabetes in Belgrade children aged 0-14 years in the period from 1982 to 2005.

    abstract:BACKGROUND:Type 1 diabetes (T1DM) is an autoimmune disease in which both genetic and environmental factors play a role in the etiology. AIM:The aim of this study was to analyze the incidence of T1DM. METHODS:A retrospective technique was used to register all newly diagnosed cases of T1DM in Belgrade (Serbia) children...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,多中心研究

    doi:10.3275/8619

    authors: Sipetic S,Maksimovic J,Vlajinac H,Ratkov I,Sajic S,Zdravkovic D,Sipetic T

    更新日期:2013-05-01 00:00:00

  • Pituitary and bilateral adrenal enlargement: an unusual presentation of hepatocellular carcinoma.

    abstract::Pituitary metastases account for about 1% of operated pituitary lesions. Most derive from primaries in the breast or lung. Pituitary metastases from hepatocellular carcinoma (HCC) have rarely been reported. We describe a patient in whom headache and left external ophthalmoplegia were the only presenting signs of a cli...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347227

    authors: Hirsch D,Benbassat CA,Drozd T,Okon E,Blum I

    更新日期:2005-05-01 00:00:00

  • A reappraisal of the role of methimazole and other factors on the efficacy and outcome of radioiodine therapy of Graves' hyperthyroidism.

    abstract::The outcome of radioiodine therapy of Graves' hyperthyroidism was retrospectively evaluated in 274 consecutive patients treated from 1975 to 1984. At 1-yr follow-up, permanent hypothyroidism occurred in 36.9% of patients and the cumulative incidence of hypothyroidism progressively increased up to 79.3% after 7-10 yr. ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348615

    authors: Marcocci C,Gianchecchi D,Masini I,Golia F,Ceccarelli C,Bracci E,Fenzi GF,Pinchera A

    更新日期:1990-06-01 00:00:00

  • The treatment with growth hormone receptor antagonist in acromegaly: effect on vascular structure and function in patients resistant to somatostatin analogues.

    abstract:BACKGROUND:Acromegaly is known to be associated to vascular damage characterized by an increase of vascular wall thickness and an impairment of vascular function. AIM:The aim of this study was to evaluate the effect of medical treatment with the GH receptor antagonist pegvisomant on vascular structure and function in ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346667

    authors: De Martino MC,Auriemma RS,Brevetti G,Vitale G,Schiano V,Galdiero M,Grasso L,Lombardi G,Colao A,Pivonello R

    更新日期:2010-10-01 00:00:00

  • The use of ultrasensitive thyroglobulin assays reduces but does not abolish the need for TSH stimulation in patients with differentiated thyroid carcinoma.

    abstract::Measurement of serum Tg using ultrasensitive assays is proposed to replace TSH-stimulated Tg measurement in the follow-up of differentiated thyroid cancer (DTC). Aim of our study was to verify this possibility using two ultrasensitive Tg assays. We selected 215 DTC patients with undetectable (<1 ng/ml) basal serum Tg ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/7571

    authors: Castagna MG,Tala Jury HP,Cipri C,Belardini V,Fioravanti C,Pasqui L,Sestini F,Theodoropoulou A,Pacini F

    更新日期:2011-09-01 00:00:00

  • Galactosylhydroxylysine and pyridinium cross links in monitoring the bone response to hormone replacement therapy.

    abstract::Aim of the study was to compare urinary galactosyl-hydroxylysine (GHyl), deoxypyridinoline (D-Pyr) and pyridinoline (Pyr) before and after 5 to 9 months of hormone replacement therapy (HRT) in postmenopausal women. The urinary markers were measured by HPLC in the second void of fasting samples and were expressed as ra...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349858

    authors: Marabini R,Sirtori P,Chionna R,Barzizza L,Rubinacci A

    更新日期:1996-03-01 00:00:00

  • Principles and clinical applications of liquid chromatography - tandem mass spectrometry for the determination of adrenal and gonadal steroid hormones.

    abstract::Liquid-chromatography - tandem mass spectrometry (LC-MS/MS) is becoming the method of choice for clinical steroid analysis. In most instances, it has the advantage of higher sensitivity, better reproducibility and greater specificity than commercial immunoassay techniques. The method requires only minimal sample prepa...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.3275/7843

    authors: Kulle AE,Welzel M,Holterhus PM,Riepe FG

    更新日期:2011-10-01 00:00:00

  • Surgical management of secondary hyperparathyroidism: how to effectively reduce recurrence at the time of primary surgery.

    abstract:BACKGROUND:Successful parathyroidectomy (PTX) often results in a dramatic drop in the parathyroid hormone (PTH) levels, relieves the patient from clinical symptoms, and reduces mortality. Although PTX is generally a successful treatment for progressive secondary hyperparathyroidism (SHPT) patients subjected to surgery,...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-015-0410-8

    authors: Xu D,Yin Y,Hou L,Dai W

    更新日期:2016-05-01 00:00:00