Abstract：
:Necrotizing Enterocolitis (NEC) is associated with prematurity, enteral feedings, and enteral dysbiosis. Accordingly, we hypothesized that along with nutritional variability, metabolic dysfunction would be associated with NEC onset. Methods: We queried a multicenter longitudinal database that included 995 preterm infants (<32 weeks gestation) and included 73 cases of NEC. Dried blood spot samples were obtained on day of life 1, 7, 28, and 42. Metabolite data from each time point included 72 amino acid (AA) and acylcarnitine (AC) measures. Nutrition data were averaged at each of the same time points. Odds ratios and 95% confidence intervals were calculated using samples obtained prior to NEC diagnosis and adjusted for potential confounding variables. Nutritional and metabolic data were plotted longitudinally to determine relationship to NEC onset. Results: Day 1 analyte levels of alanine, phenylalanine, free carnitine, C16, arginine, C14:1/C16, and citrulline/phenylalanine were associated with the subsequent development of NEC. Over time, differences in individual analyte levels associated with NEC onset shifted from predominantly AAs at birth to predominantly ACs by day 42. Subjects who developed NEC received significantly lower weight-adjusted total calories (p < 0.001) overall, a trend that emerged by day of life 7 (p = 0.020), and persisted until day of life 28 (p < 0.001) and 42 (p < 0.001). Conclusion: Premature infants demonstrate metabolic differences at birth. Metabolite abnormalities progress in parallel to significant differences in nutritional delivery signifying metabolic dysfunction in premature newborns prior to NEC onset. These observations provide new insights to potential contributing pathophysiology of NEC and opportunity for clinical care-based prevention.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Sinclair TJ,Ye C,Chen Y,Zhang D,Li T,Ling XB,Cohen HJ,Shaw GM,Stevenson DK,Chace D,Clark RH,Sylvester KGdoi
10.3390/nu12051275subject
Has Abstractpub_date
2020-04-30 00:00:00issue
5issn
2072-6643pii
nu12051275journal_volume
12pub_type
杂志文章相关文献
Nutrients文献大全abstract：:Due to the high estimated prevalence of magnesium deficiency, there is a need for a rapid, non-invasive assessment tool that could be used by patients and clinicians to confirm suspected hypomagnesemia and substantiate laboratory testing. This study analyzed data from four large observational studies of hypomagnesemia...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12072062
更新日期：2020-07-11 00:00:00
abstract：:Dietary polyphenols are multi-target compounds that have been considered promising candidates in strategies for the mitigation of neurological diseases, acting particularly through reduction of microglia-driven neuroinflammation. In this study, an anthocyanin-rich extract obtained from Portuguese blueberries was subje...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12123670
更新日期：2020-11-28 00:00:00
abstract：:The fatty acid (FA) composition of red blood cell (RBC) membrane phospholipids of cancer patients can reflect tumor status, dietary intakes, and cancer type or therapy. However, the characteristic membrane profiles have so far not yet defined as a potential biomarker to monitor disease evolution. The present work prov...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10121853
更新日期：2018-12-01 00:00:00
abstract：:Based on a nationally representative sample of young Mexican women aged 20 to 49 years (n = 3260), we sought to explore whether cardiovascular risk factors and acute myocardial infarction (AMI) were associated with vitamin D deficiency (VDD, defined as 25-OH-D <50 nmol/L). To this end, we obtained sociodemographic, se...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11061211
更新日期：2019-05-28 00:00:00
abstract：:Preschool Mexican children consume 7% of their total energy intake from processed breakfast cereals. This study characterized the nutritional quality and labelling (claims and Guideline Daily Amount (GDA)) of the packaged breakfast cereals available in the Mexican market. Photographs of all breakfast cereals available...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9080884
更新日期：2017-08-16 00:00:00
abstract：:Some temporary double enterostomies (DES) or entero-atmospheric fistulas (EAF) have high output and are responsible for Type 2 intestinal failure. Intravenous supplementations (IVS) for parenteral nutrition and hydration compensate for intestinal losses. Chyme reinfusion (CR) artificially restores continuity pending s...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12051376
更新日期：2020-05-11 00:00:00
abstract：:The central and peripheral effects of caffeine remain debatable. We verified whether increases in endurance performance after caffeine ingestion occurred together with changes in primary motor cortex (MC) and prefrontal cortex (PFC) activation, neuromuscular efficiency (NME), and electroencephalography-electromyograph...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11102471
更新日期：2019-10-15 00:00:00
abstract：:Metabolic syndrome (MetS) is a growing problem worldwide in adolescents. This study compared two sample populations of young people in Spain and China, and analyzed the association of birth weight and breastfeeding duration with MetS. A cross-sectional study was conducted in adolescents (10-15 years old); 1150 Chinese...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11071568
更新日期：2019-07-11 00:00:00
abstract：:Long-term alcohol abuse is associated with poorer cognitive performance. However, the associations between light and moderate drinking and cognitive performance are less clear. We assessed this association via cross-sectional and longitudinal analyses in a sample of 702 Dutch students. At baseline, alcohol consumption...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12010200
更新日期：2020-01-13 00:00:00
abstract：:Medical nutrition therapy for the management of diabetes plays an important role in preventing diabetes complications and managing metabolic control. However, little is known about actual eating habits of individuals with type 2 diabetic mellitus (T2DM), especially in Japan. Therefore, we sought to (1) assess the diet...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu5072276
更新日期：2013-06-26 00:00:00
abstract：:Endurance exercise training can increase intestinal permeability which may contribute to the development of gastrointestinal symptoms in some athletes. Bovine colostrum (BC) supplementation reduces intestinal permeability induced by non-steroidal anti-inflammatory drugs. This study aimed to determine whether BC could ...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu1020224
更新日期：2009-02-01 00:00:00
abstract：:The present study compares the effects of two dietary strawberry extracts rich in monomeric (ME) or dimeric (DE) ellagitannins (ETs) on gastrointestinal, blood and tissue biomarkers in Wistar rats fed high-fructose diets. Both strawberry extracts beneficially affect the antioxidant status and lipid profile of the live...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10040445
更新日期：2018-04-04 00:00:00
abstract：:Premature and high-risk infants require accurate delivery of nutrients to promote appropriate growth. Continuous enteral feeding methods may result in significant fat and micronutrient loss. This study evaluated fat loss in enteral nutrition using current strategies for providing high-risk infants fortified human milk...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7021174
更新日期：2015-02-11 00:00:00
abstract：:Food intake biomarkers (FIBs) can reflect the intake of specific foods or dietary patterns (DP). DP for successful aging (SA) has been widely studied. However, the relationship between SA and DP characterized by FIBs still needs further exploration as the candidate markers are scarce. Thus, 1H-nuclear magnetic resonan...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12102900
更新日期：2020-09-23 00:00:00
abstract：:Obesity has recently risen and become a serious health concern in Korea according to the westernized diet and altered lifestyle. Hence, there is a growing interest in the supplementation of phytochemicals to find a safe and effective functional ingredient to treat obesity. Spergularia marina Griseb (SM) has traditiona...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12020336
更新日期：2020-01-27 00:00:00
abstract：:Metabolomics provide an unbiased tool for exploring the modulation of the human metabolome in response to food intake. This study applied metabolomics to capture the postprandial metabolic response to breakfast meals corresponding to vegan (VE), lacto ovo-vegetarian (LOV), and omnivore (OM) diets. In a cross over desi...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu10081063
更新日期：2018-08-10 00:00:00
abstract：:Dear Editor-in-Chief, [...]. ...
journal_title：Nutrients
pub_type： 社论
doi：10.3390/nu11071600
更新日期：2019-07-15 00:00:00
abstract：:Interventions to promote healthy pregnancy in women with obesity by improving diet quality have been widely unsuccessful. We hypothesized that diet quality is determined by eating behaviors, but evidence in women with obesity is lacking. We evaluated diet quality and eating behavior in 56 women with obesity (mean ± SE...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11071446
更新日期：2019-06-26 00:00:00
abstract：:This study evaluates the progressive participation of enzymes involved in lipolysis and lipogenesis, leading to adipocyte hypertrophy in a metabolic syndrome (MS) rat model caused by chronic consumption of 30% sucrose in drinking water. A total of 70 male Wistar rats were divided into two groups: C and MS. Each of the...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11071529
更新日期：2019-07-05 00:00:00
abstract：:Brain neurons form synapses throughout the life span. This process is initiated by neuronal depolarization, however the numbers of synapses thus formed depend on brain levels of three key nutrients-uridine, the omega-3 fatty acid DHA, and choline. Given together, these nutrients accelerate formation of synaptic membra...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu6041701
更新日期：2014-04-23 00:00:00
abstract：:This cross-sectional study addressed the relationship between coffee consumption and periodontitis in patients during the maintenance phase of periodontal treatment. A total of 414 periodontitis patients in the maintenance phase of periodontal treatment completed a questionnaire including items related to coffee intak...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu6104476
更新日期：2014-10-21 00:00:00
abstract：:The importance of gut microbiota in health and disease is being highlighted by numerous research groups worldwide. Atherosclerosis, the leading cause of heart disease and stroke, is responsible for about 50% of all cardiovascular deaths. Recently, gut dysbiosis has been identified as a remarkable factor to be consider...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12030605
更新日期：2020-02-26 00:00:00
abstract：:Neurological dementias such as Alzheimer's disease and Lewy body dementia are thought to be caused in part by the formation and deposition of characteristic insoluble fibrils of polypeptides such as amyloid beta (Aβ), Tau, and/or α-synuclein (αSyn). In this context, it is critical to suppress and remove such aggregate...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113480
更新日期：2020-11-13 00:00:00
abstract：:Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, implicated in both poor quality of life and negative health outcomes. One central question surrounding frailty is whether phenotypic frailty is associated with the cognitive impairment during aging. Using spontaneous behavioral tests...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11040715
更新日期：2019-03-27 00:00:00
abstract：:The Feeding Infants and Toddlers Study (FITS) is the largest survey of dietary intake among infants and young children in the United States. Dietary patterns in early childhood are a key component of prevention of diet-related chronic diseases, yet little is known about how food consumption patterns of infants and you...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11112807
更新日期：2019-11-17 00:00:00
abstract：:The purpose of this study was to explore the effect of the frequency of participation in horticultural activity types on psychological well-being and fruit and vegetable intake. The study sought to understand the mediating effect of psychological well-being between the frequency of types of horticultural activities an...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113296
更新日期：2020-10-28 00:00:00
abstract：:Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11081790
更新日期：2019-08-02 00:00:00
abstract：:No study has concurrently measured changes in free-living whole body protein metabolism and exercise performance during recovery from an acute bout of resistance exercise. We aimed to determine if whey protein ingestion enhances whole body net protein balance and recovery of exercise performance during overnight (10 h...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu9070735
更新日期：2017-07-11 00:00:00
abstract：:Geriatric patients with hip fractures often experience overlap in problems related to nutrition, including undernutrition, sarcopenia, and frailty. Such problems are powerful predictors of adverse responses, although few healthcare professionals are aware of them and therefore do not implement effective interventions....
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12123743
更新日期：2020-12-04 00:00:00
abstract：:Several diet-derived compounds have been reported to exert antioxidant, anti-proliferative and anti-angiogenic effects in numerous cancers and could be beneficial in cancer prevention. Olive oil production involves the generation of an aqueous phase defined as olive mill wastewater (OMWW), a polluting effluent rich in...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12040903
更新日期：2020-03-26 00:00:00
