Oncogenic seRNA functional activation: a novel mechanism of tumorigenesis.

abstract：BACKGROUND:Certain types of potassium channels (known as Eag1, KCNH1, Kv10.1) are associated with the production of tumours in patients and in animals. We have now studied the expression pattern of the Eag1 channel in a large range of normal and tumour tissues from different collections utilising molecular biological a...

journal_title：Molecular cancer

authors： Hemmerlein B,Weseloh RM,Mello de Queiroz F,Knötgen H,Sánchez A,Rubio ME,Martin S,Schliephacke T,Jenke M,Heinz-Joachim-Radzun,Stühmer W,Pardo LA

更新日期：2006-10-05 00:00:00

abstract：INTRODUCTION:Tumor-initiating cells (TICs), aka "cancer stem cells", are believed to fuel tumors and to sustain therapy resistance and systemic metastasis. Breast cancer is the first human carcinoma in which a subpopulation of cells displaying a specific CD44+/CD24-/low/ESA+ antigenic phenotype was found to have TIC pr...

journal_title：Molecular cancer

authors： Leccia F,Del Vecchio L,Mariotti E,Di Noto R,Morel AP,Puisieux A,Salvatore F,Ansieau S

更新日期：2014-09-12 00:00:00

abstract：:At the moment, pancreatic cancer is among the deadliest gastrointestinal diseases, and pancreatic cancer growth is a complex biological process that is based on different kinds of genes. Exosomes are extracellular vesicles containing microRNAs (miRNAs), messenger RNA (mRNA), and proteins, they act as the most prominen...

journal_title：Molecular cancer

authors： Ariston Gabriel AN,Wang F,Jiao Q,Yvette U,Yang X,Al-Ameri SA,Du L,Wang YS,Wang C

更新日期：2020-08-27 00:00:00

abstract：BACKGROUND:Epigenetic control is essential for maintenance of tissue hierarchy and correct differentiation. In cancer, this hierarchical structure is altered and epigenetic control deregulated, but the relationship between these two phenomena is still unclear. CD133 is a marker for adult stem cells in various tissues a...

journal_title：Molecular cancer

authors： Pellacani D,Packer RJ,Frame FM,Oldridge EE,Berry PA,Labarthe MC,Stower MJ,Simms MS,Collins AT,Maitland NJ

更新日期：2011-07-29 00:00:00

abstract：BACKGROUND:Alterations of chromosome 8 and hypomethylation of LINE-1 retrotransposons are common alterations in advanced prostate carcinoma. In a former study including many metastatic cases, they strongly correlated with each other. To elucidate a possible interaction between the two alterations, we investigated their...

journal_title：Molecular cancer

authors： Schulz WA,Alexa A,Jung V,Hader C,Hoffmann MJ,Yamanaka M,Fritzsche S,Wlazlinski A,Müller M,Lengauer T,Engers R,Florl AR,Wullich B,Rahnenführer J

更新日期：2007-02-05 00:00:00

abstract：:Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) are heterogenous vesicles formed by budding of the cellular membrane, which are secreted in larger amounts by ...

journal_title：Molecular cancer

authors： Bian X,Xiao YT,Wu T,Yao M,Du L,Ren S,Wang J

更新日期：2019-03-30 00:00:00

abstract：:Cancer research has mainly focused on alterations of genes and proteins in cancer cells themselves that result in either gain-of-function in oncogenes or loss-of-function in tumour-suppressor genes. However, stromal variables within or around tumours, including blood and lymph vessels, stromal cells and various protei...

journal_title：Molecular cancer

authors： Sun XF,Zhang H

更新日期：2006-10-06 00:00:00

abstract：BACKGROUND:The poor prognosis of esophageal squamous cell carcinoma (ESCC) highlights the need for novel strategies against this disease. Our previous study suggested the involvement of CCL2 and tumor associated macrophages (TAMs) in esophageal carcinogenesis. Despite the recognition of TAMs as a promising target for c...

journal_title：Molecular cancer

authors： Yang H,Zhang Q,Xu M,Wang L,Chen X,Feng Y,Li Y,Zhang X,Cui W,Jia X

更新日期：2020-02-27 00:00:00

abstract：:Live animal imaging is becoming an increasingly common technique for accurate and quantitative assessment of tumor burden over time. Bioluminescence imaging systems rely on a bioluminescent signal from tumor cells, typically generated from expression of the firefly luciferase gene. However, previous reports have sugge...

journal_title：Molecular cancer

authors： Tiffen JC,Bailey CG,Ng C,Rasko JE,Holst J

更新日期：2010-11-22 00:00:00

abstract：BACKGROUND:Metastasis is the leading cause of death among breast cancer patients. Identifying key cellular factors controlling invasion and metastasis of breast cancer cells should pave the way to new therapeutic strategies efficiently interfering with the metastatic process. PAX2 (paired box 2) transcription factor is...

journal_title：Molecular cancer

authors： Beauchemin D,Lacombe C,Van Themsche C

更新日期：2011-12-14 00:00:00

abstract：BACKGROUND:Tumor spreading is the major threat for cancer patients. The recently published anti-cancer drug salinomycin raised hope for an improved treatment by targeting therapy-refractory cancer stem cells. However, an unambiguous role of salinomycin against cancer cell migration and metastasis formation remains elus...

journal_title：Molecular cancer

authors： Kopp F,Hermawan A,Oak PS,Herrmann A,Wagner E,Roidl A

更新日期：2014-01-27 00:00:00

abstract：BACKGROUND:Changes in glycogen metabolism is an essential feature among the various metabolic adaptations used by cancer cells to adjust to the conditions imposed by the tumor microenvironment. Our previous study showed that glycogen branching enzyme (GBE1) is downstream of the HIF1 pathway in hypoxia-conditioned lung ...

journal_title：Molecular cancer

authors： Li L,Yang L,Cheng S,Fan Z,Shen Z,Xue W,Zheng Y,Li F,Wang D,Zhang K,Lian J,Wang D,Zhu Z,Zhao J,Zhang Y

更新日期：2019-06-20 00:00:00

abstract：BACKGROUND:An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, was tested side-by-side with khat in a panel of acute myeloid leukemia cell lines to elucidate me...

journal_title：Molecular cancer

authors： Bredholt T,Dimba EA,Hagland HR,Wergeland L,Skavland J,Fossan KO,Tronstad KJ,Johannessen AC,Vintermyr OK,Gjertsen BT

更新日期：2009-11-13 00:00:00

abstract：BACKGROUND:SKI and SnoN proteins have been shown to inhibit TGF-β signaling, acting both as transcriptional co-repressors in the cell nucleus, and as sequestrators of SMAD proteins in the cytoplasm. TGF-β, on the other hand, induces rapid, proteasome-mediated, degradation of both proteins. How elevated SKI and SnoN pro...

journal_title：Molecular cancer

authors： Javelaud D,van Kempen L,Alexaki VI,Le Scolan E,Luo K,Mauviel A

更新日期：2011-01-06 00:00:00

abstract：:The concept that vegetables and fruits are relevant sources of cancer-preventive substances is strongly supported by population studies. Among others, cruciferous vegetables like broccoli, cabbage, cauliflower and Brussels sprouts are thought to affect the development of various types of cancers and especially prostat...

journal_title：Molecular cancer

authors： Appendino G,Bardelli A

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Hodgkin lymphoma (HL) and Anaplastic Large Cell Lymphoma (ALCL), are forms of malignant lymphoma defined by unique morphologic, immunophenotypic, genotypic, and clinical characteristics, but both overexpress CD30. We used sub-megabase resolution tiling (SMRT) array-based comparative genomic hybridization to ...

journal_title：Molecular cancer

authors： Fadlelmola FM,Zhou M,de Leeuw RJ,Dosanjh NS,Harmer K,Huntsman D,Lam WL,Banerjee D

更新日期：2008-01-07 00:00:00

abstract：BACKGROUND:Glioblastoma (GBM) is the most common and malignant primary intracranial human neoplasm. GBMs are characterized by the presence of extensive areas of necrosis and hypoxia. Hypoxia and its master regulator, hypoxia inducible factor 1 (HIF-1) play a key role in glioma invasion. RESULTS:To further elucidate th...

journal_title：Molecular cancer

authors： Méndez O,Zavadil J,Esencay M,Lukyanov Y,Santovasi D,Wang SC,Newcomb EW,Zagzag D

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Relapse due to chemoresistant residual disease is a major cause of death in acute myelogenous leukemia (AML). The present study was undertaken to elucidate the molecular mechanisms of chemoresistance by comparing differential gene expression in blasts from patients with resistant relapsing AML and chemosensi...

journal_title：Molecular cancer

authors： Huang TS,Myklebust LM,Kjarland E,Gjertsen BT,Pendino F,Bruserud Ø,Døskeland SO,Lillehaug JR

更新日期：2007-04-23 00:00:00

abstract：BACKGROUND:The tetraspanin CD63 is a highly N-glycosylated protein that is known to regulate cancer malignancy. However, the contribution of glycosylation of CD63 to cancer malignancy remains unclear. Previously, we reported that ribophorin II (RPN2), which is part of an N-oligosaccharyle transferase complex, is respon...

journal_title：Molecular cancer

authors： Tominaga N,Hagiwara K,Kosaka N,Honma K,Nakagama H,Ochiya T

更新日期：2014-05-31 00:00:00

abstract：BACKGROUND:The exposure of skin keratinocytes to Ultraviolet (UV) irradiation leads to Akt phosphorylation at Ser-473, which is important for the carcinogenic effects of excessive sun exposure. The present study investigated the underlying mechanism of Akt Ser-473 phosphorylation by UVB radiation. RESULTS:We found tha...

journal_title：Molecular cancer

authors： Tu Y,Ji C,Yang B,Yang Z,Gu H,Lu CC,Wang R,Su ZL,Chen B,Sun WL,Xia JP,Bi ZG,He L

更新日期：2013-12-24 00:00:00

abstract：BACKGROUND:As one of the most frequent chemical modifications in eukaryotic mRNAs, N6-methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing, and translation. Recently, the regulatory role of m6A in tumorigenesis has been increasingly recognized. However, dysregulation of m6A and its fu...

journal_title：Molecular cancer

authors： Yue B,Song C,Yang L,Cui R,Cheng X,Zhang Z,Zhao G

更新日期：2019-10-13 00:00:00

abstract：BACKGROUND:CADM1 encodes an immunoglobulin superfamily (IGSF) cell adhesion molecule. Inactivation of CADM1, either by promoter hypermethylation or loss of heterozygosity, has been reported in a wide variety of tumor types, thus it has been postulated as a tumor suppressor gene. FINDINGS:We show for the first time tha...

journal_title：Molecular cancer

authors： van der Weyden L,Arends MJ,Rust AG,Poulogiannis G,McIntyre RE,Adams DJ

更新日期：2012-05-03 00:00:00

abstract：BACKGROUND:Although the prognosis of gastric cancer patients have a favorable progression, there are some patients with unusual patterns of locoregional and systemic recurrence. Therefore, a better understanding of early molecular events of the disease is needed. Current evidences demonstrate that long noncoding RNAs (...

journal_title：Molecular cancer

authors： Liu YW,Xia R,Lu K,Xie M,Yang F,Sun M,De W,Wang C,Ji G

更新日期：2017-02-16 00:00:00

abstract：BACKGROUND:In addition to androgens, growth factors are also implicated in the development and neoplastic growth of the prostate gland. Prosaposin is a potent neurotrophic molecule. Homozygous inactivation of prosaposin in mice has led to the development of a number of abnormalities in the male reproductive system, inc...

journal_title：Molecular cancer

authors： Lee TJ,Sartor O,Luftig RB,Koochekpour S

更新日期：2004-11-17 00:00:00

abstract：:Autophagy is a highly conserved catabolic process that mediates degradation of pernicious or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and organelles. It can promote or suppress tumor development, so it is a "double-edged sword" in tumors that depends on the cell and tissue typ...

journal_title：Molecular cancer

authors： Chen HT,Liu H,Mao MJ,Tan Y,Mo XQ,Meng XJ,Cao MT,Zhong CY,Liu Y,Shan H,Jiang GM

更新日期：2019-05-24 00:00:00

abstract：:Early detection of a premalignant or cancerous oral lesion promises to improve the survival and the morbidity of patients suffering from these conditions. Cytological study of oral cells is a non-aggressive technique that is well accepted by the patient, and is therefore an attractive option for the early diagnosis of...

journal_title：Molecular cancer

authors： Mehrotra R,Gupta A,Singh M,Ibrahim R

更新日期：2006-03-23 00:00:00

abstract：BACKGROUND:Cholangiocarcinoma (CCA) has an abundance of tumor stroma which plays an important role in cancer progression via tumor-promoting signals. This study aims to explore the microRNA (miRNA) profile of CCA-associated fibroblasts (CCFs) and the roles of any identified miRNAs in CCA progression. METHODS:miRNA exp...

journal_title：Molecular cancer

authors： Utaijaratrasmi P,Vaeteewoottacharn K,Tsunematsu T,Jamjantra P,Wongkham S,Pairojkul C,Khuntikeo N,Ishimaru N,Sirivatanauksorn Y,Pongpaibul A,Thuwajit P,Thuwajit C,Kudo Y

更新日期：2018-01-18 00:00:00

abstract：:The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms. Here, we review recent findings regarding chromatin modifications and their relevance to cancer. ...

journal_title：Molecular cancer

authors： Ducasse M,Brown MA

更新日期：2006-11-08 00:00:00

abstract：BACKGROUND:The urokinase receptor (uPAR) mediates a diverse array of cellular processes including several events involved in prostate cancer metastasis. Many of these activities are initiated or enhanced by uPAR binding to its proteolytic ligand, urokinase (uPA). Our objective in this study was to generate and test an ...

journal_title：Molecular cancer

authors： Hasanuzzaman M,Kutner R,Agha-Mohammadi S,Reiser J,Sehgal I

更新日期：2007-05-17 00:00:00

abstract：BACKGROUND:Kinases downstream of growth factor receptors have been implicated in radioresistance and are, therefore, attractive targets to improve radiotherapy outcome in head and neck squamous cell carcinoma (HNSCC) patients. METHODS:An antibody-based array was used to quantify the expression levels of multiple phosp...

journal_title：Molecular cancer

authors： Stegeman H,Kaanders JH,Verheijen MM,Peeters WJ,Wheeler DL,Iida M,Grénman R,van der Kogel AJ,Span PN,Bussink J

更新日期：2013-11-05 00:00:00