Clinicopathological significance of stromal variables: angiogenesis, lymphangiogenesis, inflammatory infiltration, MMP and PINCH in colorectal carcinomas.

abstract：BACKGROUND:Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic secretome delivering and trafficking for long-distance cell-to-cell communication. This stu...

journal_title：Molecular cancer

authors： Lin Q,Chen X,Meng F,Ogawa K,Li M,Song R,Zhang S,Zhang Z,Kong X,Xu Q,He F,Bai X,Sun B,Hung MC,Liu L,Wands J,Dong X

更新日期：2019-11-07 00:00:00

abstract：BACKGROUND:To clarify the implications of cell-free nucleic acids (cfNA) in the plasma in neoplastic disease, it is necessary to determine the kinetics of their release into the circulation. METHODS:To quantify non-tumor and tumor DNA and RNA in the plasma of tumor-bearing rats and to correlate such levels with tumor ...

journal_title：Molecular cancer

authors： García-Olmo DC,Picazo MG,Toboso I,Asensio AI,García-Olmo D

更新日期：2013-02-04 00:00:00

abstract：BACKGROUND:CADM1 encodes an immunoglobulin superfamily (IGSF) cell adhesion molecule. Inactivation of CADM1, either by promoter hypermethylation or loss of heterozygosity, has been reported in a wide variety of tumor types, thus it has been postulated as a tumor suppressor gene. FINDINGS:We show for the first time tha...

journal_title：Molecular cancer

authors： van der Weyden L,Arends MJ,Rust AG,Poulogiannis G,McIntyre RE,Adams DJ

更新日期：2012-05-03 00:00:00

abstract：BACKGROUND:Metastasis accounts for the majority of deaths from cancer. Although tumor microenvironment has been shown to have a significant impact on the initiation and/or promotion of metastasis, the mechanism remains elusive. We previously reported that HCT-8 colon cancer cells underwent a phenotypic transition from ...

journal_title：Molecular cancer

authors： Tang X,Kuhlenschmidt TB,Li Q,Ali S,Lezmi S,Chen H,Pires-Alves M,Laegreid WW,Saif TA,Kuhlenschmidt MS

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:Transforming Growth Factor beta (TGF-beta) plays an important role in tumor invasion and metastasis. We set out to investigate the possible clinical utility of TGF-beta antagonists in a human metastatic basal-like breast cancer model. We examined the effects of two types of the TGF-beta pathway antagonists (...

journal_title：Molecular cancer

authors： Ganapathy V,Ge R,Grazioli A,Xie W,Banach-Petrosky W,Kang Y,Lonning S,McPherson J,Yingling JM,Biswas S,Mundy GR,Reiss M

更新日期：2010-05-26 00:00:00

abstract：BACKGROUND:In previously published studies, oncolytic adenovirus-mediated gene therapy has produced good results in targeting cancer cells. However, safety and efficacy, the two most important aspects in cancer therapy, remain serious challenges. The specific expression or deletion of replication related genes in an ad...

journal_title：Molecular cancer

authors： Xu HN,Huang WD,Cai Y,Ding M,Gu JF,Wei N,Sun LY,Cao X,Li HG,Zhang KJ,Liu XR,Liu XY

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Pancreatic acinar cell carcinoma (ACC) is a rare tumor entity with an unfavorable prognosis. Recent whole-exome sequencing identified p53 mutations in a subset of human ACC. Activation of the mammalian target of rapamycin (mTOR) pathway is associated with various pancreatic neoplasms. We thus aimed at analyz...

journal_title：Molecular cancer

authors： Kong B,Cheng T,Qian C,Wu W,Steiger K,Cao J,Schlitter AM,Regel I,Raulefs S,Friess H,Erkan M,Esposito I,Kleeff J,Michalski CW

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:The Hedgehog (HH) pathway promotes tumorigenesis in a diversity of cancers. Activation of the HH signaling pathway is caused by overexpression of HH ligands or mutations in the components of the HH/GLI1 cascade, which lead to increased transactivation of GLI transcription factors. Although negative kinase re...

journal_title：Molecular cancer

authors： Mizuarai S,Kawagishi A,Kotani H

更新日期：2009-07-06 00:00:00

abstract：BACKGROUND:The epithelial-to-mesenchymal transition (EMT) process results in a loss of cell-cell adhesion, increased cell mobility, and is crucial for enabling the metastasis of cancer cells. Recently, the enzyme SIRT1 has been implicated in a variety of physiological processes; however, its role in regulating oral can...

journal_title：Molecular cancer

authors： Chen IC,Chiang WF,Huang HH,Chen PF,Shen YY,Chiang HC

更新日期：2014-11-26 00:00:00

abstract：BACKGROUND:Certain types of potassium channels (known as Eag1, KCNH1, Kv10.1) are associated with the production of tumours in patients and in animals. We have now studied the expression pattern of the Eag1 channel in a large range of normal and tumour tissues from different collections utilising molecular biological a...

journal_title：Molecular cancer

authors： Hemmerlein B,Weseloh RM,Mello de Queiroz F,Knötgen H,Sánchez A,Rubio ME,Martin S,Schliephacke T,Jenke M,Heinz-Joachim-Radzun,Stühmer W,Pardo LA

更新日期：2006-10-05 00:00:00

abstract：BACKGROUND:Pituitary tumor transforming gene (pttg) is a novel oncogene that is expressed at higher level in most of the tumors analyzed to date compared to normal tissues. Nevertheless, its expression in prolactinomas and its relation with the pituitary dopamine receptor 2 (D2R) are not well defined. We sought to dete...

journal_title：Molecular cancer

authors： Cristina C,Díaz-Torga GS,Goya RG,Kakar SS,Perez-Millán MI,Passos VQ,Giannella-Neto D,Bronstein MD,Becu-Villalobos D

更新日期：2007-01-12 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the major causes of mortality. ABT-263 is a newly synthesized, orally available Bcl-2/xL inhibitor that shows promising efficacy in HCC therapy. ABT-263 inhibits the anti-apoptotic activity of Bcl-2 and Bcl-xL, but not Mcl-1. Previous reports have shown that ABT-263 u...

journal_title：Molecular cancer

authors： Wang B,Ni Z,Dai X,Qin L,Li X,Xu L,Lian J,He F

更新日期：2014-04-30 00:00:00

abstract：:At the moment, pancreatic cancer is among the deadliest gastrointestinal diseases, and pancreatic cancer growth is a complex biological process that is based on different kinds of genes. Exosomes are extracellular vesicles containing microRNAs (miRNAs), messenger RNA (mRNA), and proteins, they act as the most prominen...

journal_title：Molecular cancer

authors： Ariston Gabriel AN,Wang F,Jiao Q,Yvette U,Yang X,Al-Ameri SA,Du L,Wang YS,Wang C

更新日期：2020-08-27 00:00:00

abstract：BACKGROUND:Tumor cells produce various cytokines and chemokines that attract leukocytes. Leukocytes can amplify parenchymal innate immune responses, and have been shown to contribute to tumor promotion. Neutrophils are among the first cells to arrive at sites of inflammation, and the increased number of tumor-associate...

journal_title：Molecular cancer

authors： Gong L,Cumpian AM,Caetano MS,Ochoa CE,De la Garza MM,Lapid DJ,Mirabolfathinejad SG,Dickey BF,Zhou Q,Moghaddam SJ

更新日期：2013-12-09 00:00:00

abstract：:Prostate cancer, the second most frequently diagnosed cancer in males worldwide, is estimated to be diagnosed in 1.1 million men per year. Introduction of PSA testing substantially improved early detection of prostate cancer, however it also led to overdiagnosis and subsequent overtreatment of patients with an indolen...

journal_title：Molecular cancer

authors： Endzeliņš E,Melne V,Kalniņa Z,Lietuvietis V,Riekstiņa U,Llorente A,Linē A

更新日期：2016-05-18 00:00:00

abstract：BACKGROUND:Circular RNAs (circRNAs) are a new type of non-coding RNAs and their functions in gastric cancer (GC) remain unclear. Recent studies have revealed that circRNAs play an important role in cancer development and certain types of pathological responses, acting as microRNA (miRNA) sponges to regulate gene expres...

journal_title：Molecular cancer

authors： Liu H,Liu Y,Bian Z,Zhang J,Zhang R,Chen X,Huang Y,Wang Y,Zhu J

更新日期：2018-10-18 00:00:00

abstract：BACKGROUND:The IκB kinase (IKK) complex, comprising the two enzymes IKKα and IKKβ, is the main activator of the inflammatory transcription factor NF-κB, which is constitutively active in many cancers. While several connections between NF-κB signaling and the oncogene c-Myc have been shown, functional links between the ...

journal_title：Molecular cancer

authors： Moser B,Hochreiter B,Basílio J,Gleitsmann V,Panhuber A,Pardo-Garcia A,Hoesel B,Salzmann M,Resch U,Noreen M,Schmid JA

更新日期：2021-01-18 00:00:00

abstract：:This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1186/s12943-015-0389-y. ...

journal_title：Molecular cancer

authors： Bendinelli P,Maroni P,Matteucci E,Desiderio MA

更新日期：2020-08-15 00:00:00

abstract：BACKGROUND:Most ovarian cancers are highly invasive in nature and the high burden of metastatic disease make them a leading cause of mortality among all gynaecological malignancies. The homeodomain transcription factor, PITX2 is associated with cancer in different tissues. Our previous studies demonstrated increased PI...

journal_title：Molecular cancer

authors： Basu M,Bhattacharya R,Ray U,Mukhopadhyay S,Chatterjee U,Roy SS

更新日期：2015-08-23 00:00:00

abstract：BACKGROUND:TPC-1 is a papillary thyroid carcinoma (PTC)-derived cell line that spontaneously expresses the oncogene RET/PTC1. TPC-1 treated with the RET/PTC1 inhibitor RPI-1 displayed a cytostatic and reversible inhibition of cell proliferation and a strong activation of focal adhesion kinase (FAK). As dasatinib inhibi...

journal_title：Molecular cancer

authors： Caccia D,Miccichè F,Cassinelli G,Mondellini P,Casalini P,Bongarzone I

更新日期：2010-10-18 00:00:00

abstract：:After the publication of this work [1], an error was found in Fig. 1b. As described in the Results section that circ0084003 has 13 exons, it should be formed by 5-17 (13exons) exons, authors have described "formed by 5-19 exons". The authors extend their apology for the mistake caused by their action. With that mistak...

journal_title：Molecular cancer

authors： Zhang PF,Pei X,Li KS,Jin LN,Wang F,Wu J,Zhang XM

更新日期：2020-02-01 00:00:00

abstract：:Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) are heterogenous vesicles formed by budding of the cellular membrane, which are secreted in larger amounts by ...

journal_title：Molecular cancer

authors： Bian X,Xiao YT,Wu T,Yao M,Du L,Ren S,Wang J

更新日期：2019-03-30 00:00:00

abstract：:Because circulating microRNAs (miRNAs) have drawn a great deal of attention as promising novel cancer diagnostics and prognostic biomarkers, we sought to identify serum miRNAs significantly associated with outcome in glioblastoma patients. To do this, we performed global miRNA profiling in serum samples from 106 prima...

journal_title：Molecular cancer

authors： Zhao H,Shen J,Hodges TR,Song R,Fuller GN,Heimberger AB

更新日期：2017-03-11 00:00:00

abstract：BACKGROUND:New therapies are urgently needed for patients with small cell lung cancer (SCLC). Chemotherapy and targeted therapies, including the Bcl-2 inhibitor ABT-737, may induce tumor cell autophagy. Autophagy can promote survival of cancer cells under stress and comprise a pathway of escape from cytotoxic therapies...

journal_title：Molecular cancer

authors： Zinn RL,Gardner EE,Dobromilskaya I,Murphy S,Marchionni L,Hann CL,Rudin CM

更新日期：2013-03-02 00:00:00

abstract：BACKGROUND:For long, natural killer (NK) cells have been suspected to play a critical role in suppressing the development of spontaneous metastases in cancer patients. Despite a wide range of studies it remains unclear so far to what extent primary tumor growth together with formation of distant metastases and NK cell ...

journal_title：Molecular cancer

authors： Brodbeck T,Nehmann N,Bethge A,Wedemann G,Schumacher U

更新日期：2014-11-05 00:00:00

abstract：BACKGROUND:The poor prognosis of esophageal squamous cell carcinoma (ESCC) highlights the need for novel strategies against this disease. Our previous study suggested the involvement of CCL2 and tumor associated macrophages (TAMs) in esophageal carcinogenesis. Despite the recognition of TAMs as a promising target for c...

journal_title：Molecular cancer

authors： Yang H,Zhang Q,Xu M,Wang L,Chen X,Feng Y,Li Y,Zhang X,Cui W,Jia X

更新日期：2020-02-27 00:00:00

abstract：BACKGROUND:The tumor cell lysate-pulsed, dendritic cell (DC)-based cancer vaccine approaches are being actively evaluated for application to cancer immunotherapy, hopefully at a personalized medicine base. There is apparently an emerging technical problem however, the lack of highly efficacious potency in activation of...

journal_title：Molecular cancer

authors： Lin TJ,Lin HT,Chang WT,Mitapalli S P,Hsiao PW,Yin SY,Yang NS

更新日期：2015-09-24 00:00:00

abstract：BACKGROUND:Among women worldwide, breast cancer is the most commonly diagnosed cancer, and the second leading cause of cancer-related deaths. Improved understanding of breast tumourigenesis may facilitate the development of more effective therapies. Peroxisome proliferator-activated receptor (PPAR)γ is a transcription ...

journal_title：Molecular cancer

authors： Apostoli AJ,Roche JM,Schneider MM,SenGupta SK,Di Lena MA,Rubino RE,Peterson NT,Nicol CJ

更新日期：2015-04-15 00:00:00

abstract：BACKGROUND:Laryngeal squamous cell carcinoma (LSCC) is the second most common malignant tumor in head and neck. Autophagy and circular RNAs (circRNAs) play critical roles in cancer progression and chemoresistance. However, the function and mechanism of circRNA in autophagy regulation of LSCC remain unclear. METHODS:Th...

journal_title：Molecular cancer

authors： Gao W,Guo H,Niu M,Zheng X,Zhang Y,Xue X,Bo Y,Guan X,Li Z,Guo Y,He L,Zhang Y,Li L,Cao J,Wu Y

更新日期：2020-11-24 00:00:00

abstract：BACKGROUND:Constitutive activation of signal transducer and activator of transcription 3 (STAT3) has been linked with proliferation, survival, invasion and angiogenesis of a variety of human cancer cells, including hepatocellular carcinoma (HCC). Thus, novel agents that can suppress STAT3 activation have potential for ...

journal_title：Molecular cancer

authors： Sethi G,Chatterjee S,Rajendran P,Li F,Shanmugam MK,Wong KF,Kumar AP,Senapati P,Behera AK,Hui KM,Basha J,Natesh N,Luk JM,Kundu TK

更新日期：2014-03-21 00:00:00