Correction to: Circular RNA circFGFR1 promotes progression and anti-PD-1 resistance by sponging miR-381-3p in non-small cell lung cancer cells.

abstract：BACKGROUND:Increasing evidence supports the role of small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs) as master gene regulators at the epigenetic modification level. However, the underlying mechanism of these functional ncRNAs in colorectal cancer (CRC) has not been well investigated. METHODS:The dysre...

journal_title：Molecular cancer

authors： Wu H,Qin W,Lu S,Wang X,Zhang J,Sun T,Hu X,Li Y,Chen Q,Wang Y,Zhao H,Piao H,Zhang R,Wei M

更新日期：2020-05-22 00:00:00

abstract：BACKGROUND:Truncated dopamine and cyclic-AMP-regulated phosphoprotein (t-DARPP) is frequently overexpressed in gastrointestinal malignancies. In this study, we examined the role of t-DARPP in regulating β-catenin. RESULTS:The pTopFlash construct that contains multiple TCF/LEF-binding sites was used as a measure of β-c...

journal_title：Molecular cancer

authors： Vangamudi B,Zhu S,Soutto M,Belkhiri A,El-Rifai W

更新日期：2011-03-29 00:00:00

abstract：BACKGROUND:Osteopontin (OPN) has been shown to play many roles in the progression of cancer. We have recently demonstrated the activation of Akt by OPN. Integrin-linked kinase and PI3-kinase are integral proteins in OPN/AKT pathway in PC3 cells. To investigate the role of the extracellular receptors in OPN signaling, w...

journal_title：Molecular cancer

authors： Robertson BW,Bonsal L,Chellaiah MA

更新日期：2010-09-26 00:00:00

abstract：BACKGROUND:To clarify the implications of cell-free nucleic acids (cfNA) in the plasma in neoplastic disease, it is necessary to determine the kinetics of their release into the circulation. METHODS:To quantify non-tumor and tumor DNA and RNA in the plasma of tumor-bearing rats and to correlate such levels with tumor ...

journal_title：Molecular cancer

authors： García-Olmo DC,Picazo MG,Toboso I,Asensio AI,García-Olmo D

更新日期：2013-02-04 00:00:00

abstract：BACKGROUND:Although both circular RNAs (circRNAs) and autophagy are associated with the function of breast cancer (BC), whether circRNAs regulate BC progression via autophagy remains unknown. In this study, we aim to explore the regulatory mechanisms and the clinical significance of autophagy-associated circRNAs in BC....

journal_title：Molecular cancer

authors： Liang G,Ling Y,Mehrpour M,Saw PE,Liu Z,Tan W,Tian Z,Zhong W,Lin W,Luo Q,Lin Q,Li Q,Zhou Y,Hamai A,Codogno P,Li J,Song E,Gong C

更新日期：2020-03-25 00:00:00

abstract：BACKGROUND:Human clear cell renal cell carcinoma (CRCC) remains resistant to therapies. Recent advances in Hypoxia Inducible Factors (HIF) molecular network led to targeted therapies, but unfortunately with only limited clinical significance. Elucidating the molecular processes involved in kidney tumorigenesis and resi...

journal_title：Molecular cancer

authors： Dormoy V,Danilin S,Lindner V,Thomas L,Rothhut S,Coquard C,Helwig JJ,Jacqmin D,Lang H,Massfelder T

更新日期：2009-12-16 00:00:00

abstract：:The early diagnosis of pancreatic cancer, as well as distinguishing between chronic pancreatitis and malignant pancreatic disease, remains still a clinical problem. Presently, there is no specific tumor marker for diagnosing pancreatic cancer. Mucin-associated marker like CA 19-9 are the most widely available pancreat...

journal_title：Molecular cancer

authors： Ringel J,Löhr M

更新日期：2003-01-07 00:00:00

abstract：BACKGROUND:Hodgkin lymphoma (HL) and Anaplastic Large Cell Lymphoma (ALCL), are forms of malignant lymphoma defined by unique morphologic, immunophenotypic, genotypic, and clinical characteristics, but both overexpress CD30. We used sub-megabase resolution tiling (SMRT) array-based comparative genomic hybridization to ...

journal_title：Molecular cancer

authors： Fadlelmola FM,Zhou M,de Leeuw RJ,Dosanjh NS,Harmer K,Huntsman D,Lam WL,Banerjee D

更新日期：2008-01-07 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) have been documented as playing important roles in cancer development. In this study, we investigated the role of miR-124 in breast cancer and clarified the regulation of flotillin-1 (FLOT1) by miR-124. METHODS:The expression levels of miR-124 were examined in breast cancer cell lines and...

journal_title：Molecular cancer

authors： Li L,Luo J,Wang B,Wang D,Xie X,Yuan L,Guo J,Xi S,Gao J,Lin X,Kong Y,Xu X,Tang H,Xie X,Liu M

更新日期：2013-12-13 00:00:00

abstract：BACKGROUND:Alterations of chromosome 8 and hypomethylation of LINE-1 retrotransposons are common alterations in advanced prostate carcinoma. In a former study including many metastatic cases, they strongly correlated with each other. To elucidate a possible interaction between the two alterations, we investigated their...

journal_title：Molecular cancer

authors： Schulz WA,Alexa A,Jung V,Hader C,Hoffmann MJ,Yamanaka M,Fritzsche S,Wlazlinski A,Müller M,Lengauer T,Engers R,Florl AR,Wullich B,Rahnenführer J

更新日期：2007-02-05 00:00:00

abstract：BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is a highly lethal cancer that contains cellular and functional heterogeneity. Previously, we enriched a subpopulation of highly tumorigenic head and neck cancer initiating cells (HN-CICs) from HNSCC. However, the molecular mechanisms by which to govern the chara...

journal_title：Molecular cancer

authors： Wu MJ,Jan CI,Tsay YG,Yu YH,Huang CY,Lin SC,Liu CJ,Chen YS,Lo JF,Yu CC

更新日期：2010-10-27 00:00:00

abstract：BACKGROUND:Ambiguity in malignant transformation of glioma has made prognostic diagnosis very challenging. Tumor malignant transformation is closely correlated with specific alterations of the metabolic profile. Exploration of the underlying metabolic alterations in glioma cells of different malignant degree is therefo...

journal_title：Molecular cancer

authors： Shao W,Gu J,Huang C,Liu D,Huang H,Huang Z,Lin Z,Yang W,Liu K,Lin D,Ji T

更新日期：2014-08-27 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with high morbidity and mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation and related mechanisms has led researchers to focus on the microenvironment where pancreatic cancers develop. The anomalous proliferation ...

journal_title：Molecular cancer

authors： Thomas D,Radhakrishnan P

更新日期：2019-01-21 00:00:00

abstract：BACKGROUND:Pancreatic acinar cell carcinoma (ACC) is a rare tumor entity with an unfavorable prognosis. Recent whole-exome sequencing identified p53 mutations in a subset of human ACC. Activation of the mammalian target of rapamycin (mTOR) pathway is associated with various pancreatic neoplasms. We thus aimed at analyz...

journal_title：Molecular cancer

authors： Kong B,Cheng T,Qian C,Wu W,Steiger K,Cao J,Schlitter AM,Regel I,Raulefs S,Friess H,Erkan M,Esposito I,Kleeff J,Michalski CW

更新日期：2015-12-18 00:00:00

abstract：:The mammalian target of rapamycin (mTOR), which exists in two functionally distinct complexes, mTORC1 and mTORC2 plays an important role in tumor growth. Whereas the role of mTORC1 has been well characterized in this process, little is known about the functions of mTORC2 in cancer progression. In this study, we explor...

journal_title：Molecular cancer

authors： Roulin D,Cerantola Y,Dormond-Meuwly A,Demartines N,Dormond O

更新日期：2010-03-12 00:00:00

abstract：BACKGROUND:A maximum entropy approach is proposed to predict the cytotoxic effects of a panel of colchicine derivatives in several human cancer cell lines. Data was obtained from cytotoxicity assays performed with 21 drug molecules from the same family of colchicine compounds and correlate these results with independen...

journal_title：Molecular cancer

authors： Tseng CY,Mane JY,Winter P,Johnson L,Huzil T,Izbicka E,Luduena RF,Tuszynski JA

更新日期：2010-05-30 00:00:00

abstract：BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is highly malignant with highly invasive and metastatic capabilities and poor prognosis. It is believed that the ESCC cancer stem-like cells (ECSLCs) are critical for tumorigenicity, invasion and metastasis of ESCC. However, the properties of ECSLCs vary with differe...

journal_title：Molecular cancer

authors： Liu Q,Cui X,Yu X,Bian BS,Qian F,Hu XG,Ji CD,Yang L,Ren Y,Cui W,Zhang X,Zhang P,Wang JM,Cui YH,Bian XW

更新日期：2017-04-21 00:00:00

abstract：BACKGROUND:Medulloblastoma is the most common type of malignant brain tumor that afflicts children. Although recent advances in chemotherapy and radiation have improved outcomes, high-risk patients do poorly with significant morbidity. METHODS:To identify new molecular targets, we performed an integrated genomic analy...

journal_title：Molecular cancer

authors： Harris PS,Venkataraman S,Alimova I,Birks DK,Balakrishnan I,Cristiano B,Donson AM,Dubuc AM,Taylor MD,Foreman NK,Reigan P,Vibhakar R

更新日期：2014-03-24 00:00:00

abstract：:Mutations in polymerase ε (POLE) confer favorable prognosis and outcomes in various cancer types, but their role in non-small cell lung cancer (NSCLC) is unknown. Utilizing the data of 513 patients with adenocarcinoma (LUAD) and 497 patients with squamous cell carcinoma (LUSC) from The Cancer Genome Atlas (TCGA) cohor...

journal_title：Molecular cancer

authors： Liu L,Ruiz J,O'Neill SS,Grant SC,Petty WJ,Yang M,Chen K,Topaloglu U,Pasche B,Zhang W

更新日期：2018-04-12 00:00:00

abstract：BACKGROUND:Akt/PKB is a serine/threonine kinase that has attracted much attention because of its central role in regulating cell proliferation, survival, motility and angiogenesis. Activation of Akt in breast cancer portends aggressive tumour behaviour, resistance to hormone-, chemo-, and radiotherapy-induced apoptosis...

journal_title：Molecular cancer

authors： Pecorari L,Marin O,Silvestri C,Candini O,Rossi E,Guerzoni C,Cattelani S,Mariani SA,Corradini F,Ferrari-Amorotti G,Cortesi L,Bussolari R,Raschellà G,Federico MR,Calabretta B

更新日期：2009-08-03 00:00:00

abstract：BACKGROUND:Human or animals lacking either JAK3 or the common gamma chain (gammac) expression display severe combined immunodeficiency disease, indicating the crucial role of JAK3 in T-cell development and the homeostasis of the immune system. JAK3 has also been suggested to contribute to the pathogenesis of tumorigene...

journal_title：Molecular cancer

authors： Kim BH,Jee JG,Yin CH,Sandoval C,Jayabose S,Kitamura D,Bach EA,Baeg GH

更新日期：2010-02-11 00:00:00

abstract：BACKGROUND:Cancer/testis (CT) genes have expression normally restricted to the testis, but become activated during oncogenesis, so they have excellent potential as cancer-specific biomarkers. Evidence is starting to emerge to indicate that they also provide function(s) in the oncogenic programme. Human TEX19 is a recen...

journal_title：Molecular cancer

authors： Planells-Palop V,Hazazi A,Feichtinger J,Jezkova J,Thallinger G,Alsiwiehri NO,Almutairi M,Parry L,Wakeman JA,McFarlane RJ

更新日期：2017-04-26 00:00:00

abstract：BACKGROUND:In polymorphonuclear leukocytes (PMNL), mobilization of calcium ions is one of the early events triggered by binding of chemoattractant to its receptors. Besides chemotaxis, a variety of other functional responses are dependent on calcium ion mobilization. PMNL from chronic myeloid leukaemia (CML) patients t...

journal_title：Molecular cancer

authors： Revankar CM,Advani SH,Naik NR

更新日期：2006-11-27 00:00:00

abstract：BACKGROUND:Hedgehog acyltransferase (Hhat) catalyzes the transfer of the fatty acid palmitate onto Sonic Hedgehog (Shh), a modification that is essential for Shh signaling activity. The Shh signaling pathway has been implicated in the progression of breast cancer. METHODS:To determine the functional significance of Hh...

journal_title：Molecular cancer

authors： Matevossian A,Resh MD

更新日期：2015-04-01 00:00:00

abstract：:Cancer is a leading cause of death worldwide, particularly because of its high mortality rate in patients who are diagnosed at late stages. Conventional biomarkers originating from blood are widely used for cancer diagnosis, but their low sensitivity and specificity limit their widespread application in cancer screeni...

journal_title：Molecular cancer

authors： Wang S,Zhang K,Tan S,Xin J,Yuan Q,Xu H,Xu X,Liang Q,Christiani DC,Wang M,Liu L,Du M

更新日期：2021-01-11 00:00:00

abstract：BACKGROUND:SKI and SnoN proteins have been shown to inhibit TGF-β signaling, acting both as transcriptional co-repressors in the cell nucleus, and as sequestrators of SMAD proteins in the cytoplasm. TGF-β, on the other hand, induces rapid, proteasome-mediated, degradation of both proteins. How elevated SKI and SnoN pro...

journal_title：Molecular cancer

authors： Javelaud D,van Kempen L,Alexaki VI,Le Scolan E,Luo K,Mauviel A

更新日期：2011-01-06 00:00:00

abstract：BACKGROUND:Lung cancer is one of the most prevalent neoplasias in developed countries. Advances in patient survival have been limited and the identification of prognostic molecules is needed. Resistance to treatment is strongly related to tumor cell adhesion to the extracellular matrix and alterations in the quantity a...

journal_title：Molecular cancer

authors： Irigoyen M,Pajares MJ,Agorreta J,Ponz-Sarvisé M,Salvo E,Lozano MD,Pío R,Gil-Bazo I,Rouzaut A

更新日期：2010-05-28 00:00:00

abstract：BACKGROUND:The expression of the rodent phosphoinositide-specific phospholipase C delta-4 (PLCdelta4) has been found to be elevated upon mitogenic stimulation and expression analysis have linked the upregulation of PLCdelta4 expression with rapid proliferation in certain rat transformed cell lines. The human homologue ...

journal_title：Molecular cancer

authors： Leung DW,Tompkins C,Brewer J,Ball A,Coon M,Morris V,Waggoner D,Singer JW

更新日期：2004-05-13 00:00:00

abstract：BACKGROUND:The clinical use of BRAF inhibitors for treatment of metastatic melanoma is limited by the development of drug resistance. In this study we investigated whether co-targeting the MAPK and the PI3K-AKT pathway can prevent emergence of resistance or provide additional growth inhibitory effects in vitro. METHOD...

journal_title：Molecular cancer

authors： Lassen A,Atefi M,Robert L,Wong DJ,Cerniglia M,Comin-Anduix B,Ribas A

更新日期：2014-04-16 00:00:00

abstract：BACKGROUND:The Hedgehog (HH) pathway promotes tumorigenesis in a diversity of cancers. Activation of the HH signaling pathway is caused by overexpression of HH ligands or mutations in the components of the HH/GLI1 cascade, which lead to increased transactivation of GLI transcription factors. Although negative kinase re...

journal_title：Molecular cancer

authors： Mizuarai S,Kawagishi A,Kotani H

更新日期：2009-07-06 00:00:00