The MUC gene family: their role in diagnosis and early detection of pancreatic cancer.

abstract：BACKGROUND:Aberrant accumulation of beta-catenin plays an important role in a variety of human neoplasms. We recently reported accumulation of beta-catenin in parathyroid adenomas from patients with primary hyperparathyroidism (pHPT). In CTNNB1 exon 3, we detected a stabilizing mutation (S37A) in 3 out of 20 analyzed a...

journal_title：Molecular cancer

authors： Björklund P,Lindberg D,Akerström G,Westin G

更新日期：2008-06-09 00:00:00

abstract：BACKGROUND:The human genome encodes thousands of unique long non-coding RNAs (lncRNAs), and these transcripts are emerging as critical regulators of gene expression and cell fate. However, the transcriptional regulation of their expression is not fully understood. The pivotal transcription factor E2F1 which can induce ...

journal_title：Molecular cancer

authors： Feldstein O,Nizri T,Doniger T,Jacob J,Rechavi G,Ginsberg D

更新日期：2013-10-29 00:00:00

abstract：BACKGROUND:We previously identified TrkB as an oncogene involved in promoting metastasis in endometrial carcinoma (EC). Here, we sought to delineate the effect of changes in TrkB expression on the global profile of microRNAs (miRNAs) in EC cells and further investigated the correlation between the expression of certain...

journal_title：Molecular cancer

authors： Bao W,Wang HH,Tian FJ,He XY,Qiu MT,Wang JY,Zhang HJ,Wang LH,Wan XP

更新日期：2013-12-09 00:00:00

abstract：:In recent years, thyroid malignances have become more prevalent, especially among women. The most common sporadic types of thyroid tumors of follicular origin include papillary, follicular and anaplastic thyroid carcinomas. Although modern diagnosis methods enable the identification of tumors of small diameter, tumor ...

journal_title：Molecular cancer

authors： Pstrąg N,Ziemnicka K,Bluyssen H,Wesoły J

更新日期：2018-08-08 00:00:00

abstract：BACKGROUND:Pancreatic acinar cell carcinoma (ACC) is a rare tumor entity with an unfavorable prognosis. Recent whole-exome sequencing identified p53 mutations in a subset of human ACC. Activation of the mammalian target of rapamycin (mTOR) pathway is associated with various pancreatic neoplasms. We thus aimed at analyz...

journal_title：Molecular cancer

authors： Kong B,Cheng T,Qian C,Wu W,Steiger K,Cao J,Schlitter AM,Regel I,Raulefs S,Friess H,Erkan M,Esposito I,Kleeff J,Michalski CW

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:Minimal residual disease is the main issue of advanced ovarian cancer treatment. According to the literature and previous results, we hypothesized that Mesenchymal Stromal Cells (MSC) could support this minimal residual disease by protecting ovarian cancer cells (OCC) from chemotherapy. In vitro study confir...

journal_title：Molecular cancer

authors： Pasquier J,Gosset M,Geyl C,Hoarau-Véchot J,Chevrot A,Pocard M,Mirshahi M,Lis R,Rafii A,Touboul C

更新日期：2018-02-19 00:00:00

abstract：BACKGROUND:High expression of P-glycoprotein is one of the well-known mechanisms of chemoresistance in chondrosarcomas. However, the role of antiapoptotic proteins, a common mechanism responsible for chemoresistance in other tumors, has not been well studied in chondrosarcomas. We examined the importance of P-glycoprot...

journal_title：Molecular cancer

authors： Kim DW,Kim KO,Shin MJ,Ha JH,Seo SW,Yang J,Lee FY

更新日期：2009-05-15 00:00:00

abstract：BACKGROUND:The implementation of gene therapy for the treatment of pituitary tumors emerges as a promising complement to surgery and may have distinct advantages over radiotherapy for this type of tumors. Up to now, suicide gene therapy has been the main experimental approach explored to treat experimental pituitary tu...

journal_title：Molecular cancer

authors： Console GM,Herenu CB,Camihort GA,Luna GC,Bracamonte MI,Morel GR,Goya RG

更新日期：2008-01-25 00:00:00

abstract：BACKGROUND:As one of the most frequent chemical modifications in eukaryotic mRNAs, N6-methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing, and translation. Recently, the regulatory role of m6A in tumorigenesis has been increasingly recognized. However, dysregulation of m6A and its fu...

journal_title：Molecular cancer

authors： Yue B,Song C,Yang L,Cui R,Cheng X,Zhang Z,Zhao G

更新日期：2019-10-13 00:00:00

abstract：BACKGROUND:Tumor spreading is the major threat for cancer patients. The recently published anti-cancer drug salinomycin raised hope for an improved treatment by targeting therapy-refractory cancer stem cells. However, an unambiguous role of salinomycin against cancer cell migration and metastasis formation remains elus...

journal_title：Molecular cancer

authors： Kopp F,Hermawan A,Oak PS,Herrmann A,Wagner E,Roidl A

更新日期：2014-01-27 00:00:00

abstract：:MicroRNAs (miRNAs) are emerging as central players in shaping the biology of the Tumor Microenvironment (TME). They do so both by modulating their expression levels within the different cells of the TME and by being shuttled among different cell populations within exosomes and other extracellular vesicles. This review...

journal_title：Molecular cancer

authors： Frediani JN,Fabbri M

更新日期：2016-05-26 00:00:00

abstract：BACKGROUND:The clinical efficacy of camptothecin (CPT), a drug specifically targeting topoisomerase I (TopoI), is under evaluation for the treatment of malignant gliomas. Due to the high unresponsiveness of these tumours to chemotherapy, it would be very important to study the signalling network that drives camptotheci...

journal_title：Molecular cancer

authors： Morandi E,Severini C,Quercioli D,D'Ario G,Perdichizzi S,Capri M,Farruggia G,Mascolo MG,Horn W,Vaccari M,Serra R,Colacci A,Silingardi P

更新日期：2008-08-11 00:00:00

abstract：BACKGROUND:TGF-β promotes tumor invasion and metastasis through inducing epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC). Circular RNAs (circRNAs) are recognized as functional non-coding RNAs involved in human cancers. However, whether and how circRNAs contribute to TGF-β-induced EMT and m...

journal_title：Molecular cancer

authors： Wang L,Tong X,Zhou Z,Wang S,Lei Z,Zhang T,Liu Z,Zeng Y,Li C,Zhao J,Su Z,Zhang C,Liu X,Xu G,Zhang HT

更新日期：2018-09-27 00:00:00

abstract：BACKGROUND:SOX2, a high mobility group (HMG)-box containing transcription factor, is a key regulator during development of the nervous system and a persistent marker of neural stem cells. Recent studies suggested a role of SOX2 in tumor progression. In our previous work we detected SOX2 in glioma cells and glioblastoma...

journal_title：Molecular cancer

authors： Oppel F,Müller N,Schackert G,Hendruschk S,Martin D,Geiger KD,Temme A

更新日期：2011-11-09 00:00:00

abstract：BACKGROUND:Since tumor growth requires reactivation of telomerase (hTERT), this enzyme is a challenging target for drug development. Therefore, it is of great interest to identify telomerase expression and activity regulators. Retinoids are well-known inducers of granulocytic maturation associated with hTERT repression...

journal_title：Molecular cancer

authors： El Hajj J,Nguyen E,Liu Q,Bouyer C,Adriaenssens E,Hilal G,Ségal-Bendirdjian E

更新日期：2018-04-27 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor (EGFR), a well-known oncogenic driver, contributes to the initiation and progression of a wide range of cancer types. Aberrant lipid metabolism including highly produced monounsaturated fatty acids (MUFA) is recognized as a hallmark of cancer. However, how EGFR regulates MUFA...

journal_title：Molecular cancer

authors： Zhang J,Song F,Zhao X,Jiang H,Wu X,Wang B,Zhou M,Tian M,Shi B,Wang H,Jia Y,Wang H,Pan X,Li Z

更新日期：2017-07-19 00:00:00

abstract：BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies. Neovascularization during tumorigenesis supplies oxygen and nutrients to proliferative tumor cells, and serves as a conduit for migration. Targeting oncogenes involved in angiogenesis is needed to treat organ-confined and local...

journal_title：Molecular cancer

authors： Chen Y,Wang D,Peng H,Chen X,Han X,Yu J,Wang W,Liang L,Liu Z,Zheng Y,Hu J,Yang L,Li J,Zhou H,Cui X,Li F

更新日期：2019-01-04 00:00:00

abstract：BACKGROUND:Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear hormone receptor superfamily and is highly expressed in many human tumors including breast cancer. PPARgamma has been identified as a potential target for breast cancer therapy based on the fact that its activation by syn...

journal_title：Molecular cancer

authors： Zaytseva YY,Wang X,Southard RC,Wallis NK,Kilgore MW

更新日期：2008-12-05 00:00:00

abstract：BACKGROUND:Metastasis accounts for the majority of deaths from cancer. Although tumor microenvironment has been shown to have a significant impact on the initiation and/or promotion of metastasis, the mechanism remains elusive. We previously reported that HCT-8 colon cancer cells underwent a phenotypic transition from ...

journal_title：Molecular cancer

authors： Tang X,Kuhlenschmidt TB,Li Q,Ali S,Lezmi S,Chen H,Pires-Alves M,Laegreid WW,Saif TA,Kuhlenschmidt MS

更新日期：2014-05-29 00:00:00

abstract：INTRODUCTION:Anaplastic thyroid carcinoma, which is one of the most aggressive, malignant tumors in humans, results in an extremely poor prognosis despite chemotherapy and radiotherapy. The present study was designed to evaluate therapeutic effects of radiation by glycerol on p53-mutant anaplastic thyroid carcinoma cel...

journal_title：Molecular cancer

authors： Ohnishi K,Ota I,Yane K,Takahashi A,Yuki K,Emoto M,Hosoi H,Ohnishi T

更新日期：2002-10-04 00:00:00

abstract：:Exosomes have emerged as a novel approach for the treatment and diagnosis of cancer after RNA content was discovered in exosomes in 2007. As important meditators of intercellular communication, exosomes have become a strong focus of investigation for researchers in the past decade, as witnessed through the exponential...

journal_title：Molecular cancer

authors： Zhou R,Chen KK,Zhang J,Xiao B,Huang Z,Ju C,Sun J,Zhang F,Lv XB,Huang G

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide, and the biology of this cancer remains poorly understood. Recent evidence indicates that long non-coding RNAs (lncRNAs) are found to be dysregulated in a variety of cancers, including HCC. Taurine Up-regulated Gene...

journal_title：Molecular cancer

authors： Huang MD,Chen WM,Qi FZ,Sun M,Xu TP,Ma P,Shu YQ

更新日期：2015-09-04 00:00:00

abstract：BACKGROUND:Neurofibromatosis type 1 (NF1) is the most common hereditary neurocutaneous disorder and it is associated with an elevated risk for malignant tumors of tissues derived from neural crest cells. The NF1 gene is considered a tumor suppressor gene and inactivation of both copies can be found in NF1-associated be...

journal_title：Molecular cancer

authors： Rübben A,Bausch B,Nikkels A

更新日期：2006-09-10 00:00:00

abstract：BACKGROUND:A maximum entropy approach is proposed to predict the cytotoxic effects of a panel of colchicine derivatives in several human cancer cell lines. Data was obtained from cytotoxicity assays performed with 21 drug molecules from the same family of colchicine compounds and correlate these results with independen...

journal_title：Molecular cancer

authors： Tseng CY,Mane JY,Winter P,Johnson L,Huzil T,Izbicka E,Luduena RF,Tuszynski JA

更新日期：2010-05-30 00:00:00

abstract：:Since the publication of this work [1] and in response to a recent query that was brought to our attention in relation to the Western Blot in Figure 1(C) for NP2, protein lysates prepared around the same time as those presented in the manuscript in question, were run by SDS-PAGE under similar experimental conditions a...

journal_title：Molecular cancer

authors： Barr MP,Gray SG,Gately K,Hams E,Fallon PG,Davies AM,Richard DJ,Pidgeon GP,O'Byrne KJ

更新日期：2020-01-27 00:00:00

abstract：:Prostate cancer, the second most frequently diagnosed cancer in males worldwide, is estimated to be diagnosed in 1.1 million men per year. Introduction of PSA testing substantially improved early detection of prostate cancer, however it also led to overdiagnosis and subsequent overtreatment of patients with an indolen...

journal_title：Molecular cancer

authors： Endzeliņš E,Melne V,Kalniņa Z,Lietuvietis V,Riekstiņa U,Llorente A,Linē A

更新日期：2016-05-18 00:00:00

abstract：BACKGROUND:Perifosine, an alkylphospholipid tested in phase II clinical trials, modulates the extrinsic apoptotic pathway and cooperates with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to augment apoptosis. The current study focuses on revealing the mechanisms by which perifosine enhances TRAIL-ind...

journal_title：Molecular cancer

authors： Fu L,Lin YD,Elrod HA,Yue P,Oh Y,Li B,Tao H,Chen GZ,Shin DM,Khuri FR,Sun SY

更新日期：2010-12-20 00:00:00

abstract：BACKGROUND:In polymorphonuclear leukocytes (PMNL), mobilization of calcium ions is one of the early events triggered by binding of chemoattractant to its receptors. Besides chemotaxis, a variety of other functional responses are dependent on calcium ion mobilization. PMNL from chronic myeloid leukaemia (CML) patients t...

journal_title：Molecular cancer

authors： Revankar CM,Advani SH,Naik NR

更新日期：2006-11-27 00:00:00

abstract：BACKGROUND:The dioxin (AhR) receptor can have oncogenic or tumor suppressor activities depending on the phenotype of the target cell. We have shown that AhR knockdown promotes melanoma primary tumorigenesis and lung metastasis in the mouse and that human metastatic melanomas had reduced AhR levels with respect to benig...

journal_title：Molecular cancer

authors： Contador-Troca M,Alvarez-Barrientos A,Merino JM,Morales-Hernández A,Rodríguez MI,Rey-Barroso J,Barrasa E,Cerezo-Guisado MI,Catalina-Fernández I,Sáenz-Santamaría J,Oliver FJ,Fernandez-Salguero PM

更新日期：2015-08-05 00:00:00

abstract：BACKGROUND:Epigenetic regulators play a critical role in the maintenance of specific chromatin domains in an active or repressed state. Disruption of epigenetic regulatory mechanisms is widespread in cancer cells and largely contributes to the transformation process through active repression of tumor suppressor genes. ...

journal_title：Molecular cancer

authors： Yeh CH,Bai XT,Moles R,Ratner L,Waldmann TA,Watanabe T,Nicot C

更新日期：2016-02-16 00:00:00