Long non-coding RNA TUG1 is up-regulated in hepatocellular carcinoma and promotes cell growth and apoptosis by epigenetically silencing of KLF2.

abstract：BACKGROUND:To clarify the implications of cell-free nucleic acids (cfNA) in the plasma in neoplastic disease, it is necessary to determine the kinetics of their release into the circulation. METHODS:To quantify non-tumor and tumor DNA and RNA in the plasma of tumor-bearing rats and to correlate such levels with tumor ...

journal_title：Molecular cancer

authors： García-Olmo DC,Picazo MG,Toboso I,Asensio AI,García-Olmo D

更新日期：2013-02-04 00:00:00

abstract：BACKGROUND:MicroRNA-10b (miR-10b) has a prominent role in regulating tumor invasion and metastasis by targeting the HOXD10 transcriptional repressor and has been found up-regulated in several tumor types. METHODS:We evaluated the expression of miR-10b in paired tumor and normal specimens obtained from a prospective co...

journal_title：Molecular cancer

authors： Parrella P,Barbano R,Pasculli B,Fontana A,Copetti M,Valori VM,Poeta ML,Perrone G,Righi D,Castelvetere M,Coco M,Balsamo T,Morritti M,Pellegrini F,Onetti-Muda A,Maiello E,Murgo R,Fazio VM

更新日期：2014-06-04 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are involved in cancer development and progression, acting as tumor suppressors or oncogenes. Our previous studies have revealed that miR-148a and miR-152 are significantly down-regulated in gastrointestinal cancers. Interestingly, miR-148b has the same "seed sequences" as miR-148a and miR...

journal_title：Molecular cancer

authors： Song YX,Yue ZY,Wang ZN,Xu YY,Luo Y,Xu HM,Zhang X,Jiang L,Xing CZ,Zhang Y

更新日期：2011-01-04 00:00:00

abstract：BACKGROUND:Chromosomal aberrations of BCL11A at 2p16.1 have been reported in a variety of B-cell malignancies and its deficiency in mice leads to a profound block in B-cell development. RESULTS:Alternative pre-mRNA splicing of BCL11A produces multiple isoforms sharing a common N-terminus. The most abundant isoform we ...

journal_title：Molecular cancer

authors： Liu H,Ippolito GC,Wall JK,Niu T,Probst L,Lee BS,Pulford K,Banham AH,Stockwin L,Shaffer AL,Staudt LM,Das C,Dyer MJ,Tucker PW

更新日期：2006-05-16 00:00:00

abstract：:Sema4D, also known as CD100, is a protein belonging to class IV semaphorin. Its physiologic roles in the immune and nervous systems have been extensively explored. However, the roles of Sema4D have extended beyond these traditionally studied territories. Via interaction with its high affinity receptor Plexin-B1, Sema4...

journal_title：Molecular cancer

authors： Ch'ng ES,Kumanogoh A

更新日期：2010-09-21 00:00:00

abstract：BACKGROUND:Pituitary tumor transforming gene (pttg) is a novel oncogene that is expressed at higher level in most of the tumors analyzed to date compared to normal tissues. Nevertheless, its expression in prolactinomas and its relation with the pituitary dopamine receptor 2 (D2R) are not well defined. We sought to dete...

journal_title：Molecular cancer

authors： Cristina C,Díaz-Torga GS,Goya RG,Kakar SS,Perez-Millán MI,Passos VQ,Giannella-Neto D,Bronstein MD,Becu-Villalobos D

更新日期：2007-01-12 00:00:00

abstract：BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is highly malignant with highly invasive and metastatic capabilities and poor prognosis. It is believed that the ESCC cancer stem-like cells (ECSLCs) are critical for tumorigenicity, invasion and metastasis of ESCC. However, the properties of ECSLCs vary with differe...

journal_title：Molecular cancer

authors： Liu Q,Cui X,Yu X,Bian BS,Qian F,Hu XG,Ji CD,Yang L,Ren Y,Cui W,Zhang X,Zhang P,Wang JM,Cui YH,Bian XW

更新日期：2017-04-21 00:00:00

abstract：BACKGROUND:Patients with colorectal cancer (CRC) have a high incidence of regional and distant metastases. Although metastasis is the main cause of CRC-related death, its molecular mechanisms remain largely unknown. METHODS:Using array-CGH and expression microarray analyses, changes in DNA copy number and mRNA express...

journal_title：Molecular cancer

authors： Pan Y,Tong JHM,Lung RWM,Kang W,Kwan JSH,Chak WP,Tin KY,Chung LY,Wu F,Ng SSM,Mak TWC,Yu J,Lo KW,Chan AWH,To KF

更新日期：2018-07-23 00:00:00

abstract：BACKGROUND:The clinical efficacy of camptothecin (CPT), a drug specifically targeting topoisomerase I (TopoI), is under evaluation for the treatment of malignant gliomas. Due to the high unresponsiveness of these tumours to chemotherapy, it would be very important to study the signalling network that drives camptotheci...

journal_title：Molecular cancer

authors： Morandi E,Severini C,Quercioli D,D'Ario G,Perdichizzi S,Capri M,Farruggia G,Mascolo MG,Horn W,Vaccari M,Serra R,Colacci A,Silingardi P

更新日期：2008-08-11 00:00:00

abstract：BACKGROUND:Recent advances have revealed a significant contribution of chemokines and their receptors in tumor growth, survival after chemotherapy, and organ-specific metastasis. The CXC chemokine receptor-7 (CXCR7) is the latest chemokine receptor implicated in cancer. Although over expressed in breast cancer cell lin...

journal_title：Molecular cancer

authors： Salazar N,Muñoz D,Kallifatidis G,Singh RK,Jordà M,Lokeshwar BL

更新日期：2014-08-28 00:00:00

abstract：BACKGROUND:Cancer is the result of a multistep process of genomic alterations, including mutations in key regulatory proteins that result in loss of balanced gene expression and subsequent malignant transformation. Throughout the various stages of colorectal carcinoma (CRC), complex genetic alterations occur, of which ...

journal_title：Molecular cancer

authors： Gaur S,Chen L,Ann V,Lin WC,Wang Y,Chang VH,Hsu NY,Shia HS,Yen Y

更新日期：2014-02-04 00:00:00

abstract：BACKGROUND:ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin motifs) is a member of the ADAMTS family of metalloproteases. Here, we investigated mRNA and protein levels of ADAMTS-1 in normal and neoplastic tissues using qPCR, immunohistochemistry and immunoblot analyses, and we addressed the role of ADAMT...

journal_title：Molecular cancer

authors： Freitas VM,do Amaral JB,Silva TA,Santos ES,Mangone FR,Pinheiro Jde J,Jaeger RG,Nagai MA,Machado-Santelli GM

更新日期：2013-01-05 00:00:00

abstract：BACKGROUND:miR-139-5p was identified to be significantly down-regulated in colon tumor tissues by miRNA array. We aimed to clarify its biological function, molecular mechanisms and direct target gene in colorectal cancer (CRC). METHODS:The biological function of miR-139-5p was examined by cell growth, cell cycle and a...

journal_title：Molecular cancer

authors： Zhang L,Dong Y,Zhu N,Tsoi H,Zhao Z,Wu CW,Wang K,Zheng S,Ng SS,Chan FK,Sung JJ,Yu J

更新日期：2014-05-26 00:00:00

abstract：BACKGROUND:Salivary Adenoid cystic carcinoma (SACC) patients with local invasion and lung metastasis are often resistant to conventional therapy such as operation, chemotherapy and radiotherapy. To explore the underling mechanisms, we studied the roles of miRNA in regulating invasiveness of SACC cells. METHODS:MicroRN...

journal_title：Molecular cancer

authors： Sun L,Liu B,Lin Z,Yao Y,Chen Y,Li Y,Chen J,Yu D,Tang Z,Wang B,Zeng S,Fan S,Wang Y,Li Y,Song E,Li J

更新日期：2015-04-29 00:00:00

abstract：BACKGROUND:CD44 is considered as 'a' metastasis associated gene, despite the fact that it is an umbrella term for a group of molecules produced from a single gene by alternative splicing. However, little consideration is given to the above in the literature of colorectal carcinomas as well as other tumour types, leadin...

journal_title：Molecular cancer

authors： Bánky B,Rásó-Barnett L,Barbai T,Tímár J,Becságh P,Rásó E

更新日期：2012-11-14 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumour (GIST) is the most common soft tissue sarcoma. The identification of the molecular mechanisms regulating GIST progression is vital for its treatment and prevention. Increasing reports have demonstrated that epigenetic alterations play critical roles in GIST development. Howeve...

journal_title：Molecular cancer

authors： Hu F,Li H,Liu L,Xu F,Lai S,Luo X,Hu J,Yang X

更新日期：2018-07-30 00:00:00

abstract：BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is a highly lethal cancer that contains cellular and functional heterogeneity. Previously, we enriched a subpopulation of highly tumorigenic head and neck cancer initiating cells (HN-CICs) from HNSCC. However, the molecular mechanisms by which to govern the chara...

journal_title：Molecular cancer

authors： Wu MJ,Jan CI,Tsay YG,Yu YH,Huang CY,Lin SC,Liu CJ,Chen YS,Lo JF,Yu CC

更新日期：2010-10-27 00:00:00

abstract：:Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important advances have been made in the biogenesis, regulation, localization, degradation and modification of circRNAs. CircRNAs exert biological functions by acting as tra...

journal_title：Molecular cancer

authors： Zhou WY,Cai ZR,Liu J,Wang DS,Ju HQ,Xu RH

更新日期：2020-12-14 00:00:00

abstract：BACKGROUND:As an important means of communication, exosomes play an important role in the development of hepatocellular carcinoma (HCC). METHODS:Bioinformatics analysis, dual-luciferase reporter assays, methylation-specific quantitative PCR, and ChIP-PCR analysis were used to gain insight into the underlying mechanism...

journal_title：Molecular cancer

authors： Cao LQ,Yang XW,Chen YB,Zhang DW,Jiang XF,Xue P

更新日期：2019-10-27 00:00:00

abstract：BACKGROUND:The clinical use of BRAF inhibitors for treatment of metastatic melanoma is limited by the development of drug resistance. In this study we investigated whether co-targeting the MAPK and the PI3K-AKT pathway can prevent emergence of resistance or provide additional growth inhibitory effects in vitro. METHOD...

journal_title：Molecular cancer

authors： Lassen A,Atefi M,Robert L,Wong DJ,Cerniglia M,Comin-Anduix B,Ribas A

更新日期：2014-04-16 00:00:00

abstract：BACKGROUND:Aberrant expression of microRNAs in different human cancer types has been widely reported. MiR-218 acts as a tumor suppressor in diverse human cancer types impacting regulation of multiple genes in oncogenic pathways. Here, we evaluated the expression and function of miR-218 in human lung cancer and ALDH pos...

journal_title：Molecular cancer

authors： Yang Y,Ding L,Hu Q,Xia J,Sun J,Wang X,Xiong H,Gurbani D,Li L,Liu Y,Liu A

更新日期：2017-08-22 00:00:00

abstract：BACKGROUND:The tumor cell lysate-pulsed, dendritic cell (DC)-based cancer vaccine approaches are being actively evaluated for application to cancer immunotherapy, hopefully at a personalized medicine base. There is apparently an emerging technical problem however, the lack of highly efficacious potency in activation of...

journal_title：Molecular cancer

authors： Lin TJ,Lin HT,Chang WT,Mitapalli S P,Hsiao PW,Yin SY,Yang NS

更新日期：2015-09-24 00:00:00

abstract：BACKGROUND:High expression of the long non-coding RNA nuclear-enriched abundant transcript 1 (NEAT1) in whole blood has been reported in colorectal cancer patients; however, its' clinical significance and origin are unclear. We evaluated the diagnostic and prognostic value, and origin of whole blood NEAT1 in colorectal...

journal_title：Molecular cancer

authors： Wu Y,Yang L,Zhao J,Li C,Nie J,Liu F,Zhuo C,Zheng Y,Li B,Wang Z,Xu Y

更新日期：2015-11-09 00:00:00

abstract：INTRODUCTION:Tumor-initiating cells (TICs), aka "cancer stem cells", are believed to fuel tumors and to sustain therapy resistance and systemic metastasis. Breast cancer is the first human carcinoma in which a subpopulation of cells displaying a specific CD44+/CD24-/low/ESA+ antigenic phenotype was found to have TIC pr...

journal_title：Molecular cancer

authors： Leccia F,Del Vecchio L,Mariotti E,Di Noto R,Morel AP,Puisieux A,Salvatore F,Ansieau S

更新日期：2014-09-12 00:00:00

abstract：BACKGROUND:A maximum entropy approach is proposed to predict the cytotoxic effects of a panel of colchicine derivatives in several human cancer cell lines. Data was obtained from cytotoxicity assays performed with 21 drug molecules from the same family of colchicine compounds and correlate these results with independen...

journal_title：Molecular cancer

authors： Tseng CY,Mane JY,Winter P,Johnson L,Huzil T,Izbicka E,Luduena RF,Tuszynski JA

更新日期：2010-05-30 00:00:00

abstract：:Exosomes have emerged as a novel approach for the treatment and diagnosis of cancer after RNA content was discovered in exosomes in 2007. As important meditators of intercellular communication, exosomes have become a strong focus of investigation for researchers in the past decade, as witnessed through the exponential...

journal_title：Molecular cancer

authors： Zhou R,Chen KK,Zhang J,Xiao B,Huang Z,Ju C,Sun J,Zhang F,Lv XB,Huang G

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:Lung cancer is one of the most prevalent neoplasias in developed countries. Advances in patient survival have been limited and the identification of prognostic molecules is needed. Resistance to treatment is strongly related to tumor cell adhesion to the extracellular matrix and alterations in the quantity a...

journal_title：Molecular cancer

authors： Irigoyen M,Pajares MJ,Agorreta J,Ponz-Sarvisé M,Salvo E,Lozano MD,Pío R,Gil-Bazo I,Rouzaut A

更新日期：2010-05-28 00:00:00

abstract：BACKGROUND:Targeted therapies have improved therapeutic options of treating renal cell carcinoma (RCC). However, drug response is temporary due to resistance development. METHODS:Functional and molecular changes in RCC Caki-1 cells, after acquired resistance to the mammalian target of rapamycin (mTOR)-inhibitor everol...

journal_title：Molecular cancer

authors： Juengel E,Nowaz S,Makarevi J,Natsheh I,Werner I,Nelson K,Reiter M,Tsaur I,Mani J,Harder S,Bartsch G,Haferkamp A,Blaheta RA

更新日期：2014-06-16 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive type of primary brain tumours. Anti-angiogenic therapies (AAT), such as bevacizumab, have been developed to target the tumour blood supply. However, GBM presents mechanisms of escape from AAT activity, including a speculated direct effect of AAT on GBM cells. Furthermore, beva...

journal_title：Molecular cancer

authors： Simon T,Pinioti S,Schellenberger P,Rajeeve V,Wendler F,Cutillas PR,King A,Stebbing J,Giamas G

更新日期：2018-08-31 00:00:00

abstract：BACKGROUND:Relapse due to chemoresistant residual disease is a major cause of death in acute myelogenous leukemia (AML). The present study was undertaken to elucidate the molecular mechanisms of chemoresistance by comparing differential gene expression in blasts from patients with resistant relapsing AML and chemosensi...

journal_title：Molecular cancer

authors： Huang TS,Myklebust LM,Kjarland E,Gjertsen BT,Pendino F,Bruserud Ø,Døskeland SO,Lillehaug JR

更新日期：2007-04-23 00:00:00