当前位置： SCI文献检索 > Molecular Cancer期刊下所有文献 > RASAL2 promotes tumor progression through LATS2/YAP1 axis of hippo signaling pathway in colorectal cancer.

RASAL2 promotes tumor progression through LATS2/YAP1 axis of hippo signaling pathway in colorectal cancer.

Abstract：

BACKGROUND:Patients with colorectal cancer (CRC) have a high incidence of regional and distant metastases. Although metastasis is the main cause of CRC-related death, its molecular mechanisms remain largely unknown. METHODS:Using array-CGH and expression microarray analyses, changes in DNA copy number and mRNA expression levels were investigated in human CRC samples. The mRNA expression level of RASAL2 was validated by qRT-PCR, and the protein expression was evaluated by western blot as well as immunohistochemistry in CRC cell lines and primary tumors. The functional role of RASAL2 in CRC was determined by MTT proliferation assay, monolayer and soft agar colony formation assays, cell cycle analysis, cell invasion and migration and in vivo study through siRNA/shRNA mediated knockdown and overexpression assays. Identification of RASAL2 involved in hippo pathway was achieved by expression microarray screening, double immunofluorescence staining and co-immunoprecipitation assays. RESULTS:Integrated genomic analysis identified copy number gains and upregulation of RASAL2 in metastatic CRC. RASAL2 encodes a RAS-GTPase-activating protein (RAS-GAP) and showed increased expression in CRC cell lines and clinical specimens. Higher RASAL2 expression was significantly correlated with lymph node involvement and distant metastasis in CRC patients. Moreover, we found that RASAL2 serves as an independent prognostic marker of overall survival in CRC patients. In vitro and in vivo functional studies revealed that RASAL2 promoted tumor progression in both KRAS/NRAS mutant and wild-type CRC cells. Knockdown of RASAL2 promoted YAP1 phosphorylation, cytoplasm retention and ubiquitination, therefore activating the hippo pathway through the LATS2/YAP1 axis. CONCLUSIONS:Our findings demonstrated the roles of RASAL2 in CRC tumorigenesis as well as metastasis, and RASAL2 exerts its oncogenic property through LATS2/YAP1 axis of hippo signaling pathway in CRC.

journal_name

Mol Cancer

journal_title

Molecular cancer

authors

Pan Y,Tong JHM,Lung RWM,Kang W,Kwan JSH,Chak WP,Tin KY,Chung LY,Wu F,Ng SSM,Mak TWC,Yu J,Lo KW,Chan AWH,To KF

doi

10.1186/s12943-018-0853-6

subject

Has Abstract

pub_date

2018-07-23 00:00:00

pages

102

issue

1

issn

1476-4598

pii

10.1186/s12943-018-0853-6

journal_volume

17

pub_type

杂志文章

相关文献

Molecular Cancer文献大全
  • Microrna-124 targets flotillin-1 to regulate proliferation and migration in breast cancer.

    abstract：BACKGROUND:MicroRNAs (miRNAs) have been documented as playing important roles in cancer development. In this study, we investigated the role of miR-124 in breast cancer and clarified the regulation of flotillin-1 (FLOT1) by miR-124. METHODS:The expression levels of miR-124 were examined in breast cancer cell lines and...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-12-163

    authors： Li L,Luo J,Wang B,Wang D,Xie X,Yuan L,Guo J,Xi S,Gao J,Lin X,Kong Y,Xu X,Tang H,Xie X,Liu M

    更新日期：2013-12-13 00:00:00

  • SLC/CCL21-mediated anti-tumor responses require IFNgamma, MIG/CXCL9 and IP-10/CXCL10.

    abstract：BACKGROUND:SLC/CCL21, normally expressed in high endothelial venules and in T cell zones of spleen and lymph nodes, strongly attracts T cells and dendritic cells (DC). We have previously shown that SLC/CCL21-mediated anti-tumor responses are accompanied by significant induction of IFNgamma and the CXC chemokines, monok...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-2-22

    authors： Sharma S,Yang SC,Hillinger S,Zhu LX,Huang M,Batra RK,Lin JF,Burdick MD,Strieter RM,Dubinett SM

    更新日期：2003-04-15 00:00:00

  • Role of hypoxia-induced exosomes in tumor biology.

    abstract：PURPOSE:Hypoxia is a major regulator of angiogenesis and always influences the release of exosomes in various types of tumors. The present review aimed to assess the role of hypoxia-induced exosomes in the tumor biology. METHODS:The relevant publications were retrieved from PubMed using keywords such as hypoxia, exoso...

    journal_title：Molecular cancer

    pub_type： 杂志文章,评审

    doi：10.1186/s12943-018-0869-y

    authors： Shao C,Yang F,Miao S,Liu W,Wang C,Shu Y,Shen H

    更新日期：2018-08-11 00:00:00

  • Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling.

    abstract：BACKGROUND:Patients with familial adenomatous polyposis (FAP) are at increased risk for the development of colorectal cancer. Surgery and chemoprevention are the most effective means to prevent cancer development. Thymoquinone (TQ) is considered the main compound of the volatile Nigella sativa seed oil and has been rep...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-12-41

    authors： Lang M,Borgmann M,Oberhuber G,Evstatiev R,Jimenez K,Dammann KW,Jambrich M,Khare V,Campregher C,Ristl R,Gasche C

    更新日期：2013-05-13 00:00:00

  • DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival.

    abstract：BACKGROUND:The exposure of skin keratinocytes to Ultraviolet (UV) irradiation leads to Akt phosphorylation at Ser-473, which is important for the carcinogenic effects of excessive sun exposure. The present study investigated the underlying mechanism of Akt Ser-473 phosphorylation by UVB radiation. RESULTS:We found tha...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-12-172

    authors： Tu Y,Ji C,Yang B,Yang Z,Gu H,Lu CC,Wang R,Su ZL,Chen B,Sun WL,Xia JP,Bi ZG,He L

    更新日期：2013-12-24 00:00:00

  • Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer.

    abstract：BACKGROUND:We have previously reported that expression of the Wnt antagonist genes SFRP1 and SFRP5 is frequently silenced by promoter hypermethylation in breast cancer. SFRP2 is a further Wnt inhibitor whose expression was recently found being downregulated in various malignancies. Here we investigated whether SFRP2 is...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-7-83

    authors： Veeck J,Noetzel E,Bektas N,Jost E,Hartmann A,Knüchel R,Dahl E

    更新日期：2008-11-06 00:00:00

  • Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression.

    abstract：:Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) are heterogenous vesicles formed by budding of the cellular membrane, which are secreted in larger amounts by ...

    journal_title：Molecular cancer

    pub_type： 杂志文章,评审

    doi：10.1186/s12943-019-0973-7

    authors： Bian X,Xiao YT,Wu T,Yao M,Du L,Ren S,Wang J

    更新日期：2019-03-30 00:00:00

  • Altered Ca2+ homeostasis in polymorphonuclear leukocytes from chronic myeloid leukaemia patients.

    abstract：BACKGROUND:In polymorphonuclear leukocytes (PMNL), mobilization of calcium ions is one of the early events triggered by binding of chemoattractant to its receptors. Besides chemotaxis, a variety of other functional responses are dependent on calcium ion mobilization. PMNL from chronic myeloid leukaemia (CML) patients t...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-5-65

    authors： Revankar CM,Advani SH,Naik NR

    更新日期：2006-11-27 00:00:00

  • Insulin-like growth factor-I gene therapy reverses morphologic changes and reduces hyperprolactinemia in experimental rat prolactinomas.

    abstract：BACKGROUND:The implementation of gene therapy for the treatment of pituitary tumors emerges as a promising complement to surgery and may have distinct advantages over radiotherapy for this type of tumors. Up to now, suicide gene therapy has been the main experimental approach explored to treat experimental pituitary tu...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-7-13

    authors： Console GM,Herenu CB,Camihort GA,Luna GC,Bracamonte MI,Morel GR,Goya RG

    更新日期：2008-01-25 00:00:00

  • METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner.

    abstract：BACKGROUND:METTL3 is known to be involved in all stages in the life cycle of RNA. It affects the tumor formation by the regulation the m6A modification in the mRNAs of critical oncogenes or tumor suppressors. In bladder cancer, METTL3 could promote the bladder cancer progression via AFF4/NF-κB/MYC signaling network by ...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/s12943-019-1036-9

    authors： Han J,Wang JZ,Yang X,Yu H,Zhou R,Lu HC,Yuan WB,Lu JC,Zhou ZJ,Lu Q,Wei JF,Yang H

    更新日期：2019-06-22 00:00:00

  • Invasion of ovarian cancer cells is induced byPITX2-mediated activation of TGF-β and Activin-A.

    abstract：BACKGROUND:Most ovarian cancers are highly invasive in nature and the high burden of metastatic disease make them a leading cause of mortality among all gynaecological malignancies. The homeodomain transcription factor, PITX2 is associated with cancer in different tissues. Our previous studies demonstrated increased PI...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/s12943-015-0433-y

    authors： Basu M,Bhattacharya R,Ray U,Mukhopadhyay S,Chatterjee U,Roy SS

    更新日期：2015-08-23 00:00:00

  • Role of the NLRP3 inflammasome in cancer.

    abstract：:Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cl...

    journal_title：Molecular cancer

    pub_type： 杂志文章,评审

    doi：10.1186/s12943-018-0900-3

    authors： Moossavi M,Parsamanesh N,Bahrami A,Atkin SL,Sahebkar A

    更新日期：2018-11-17 00:00:00

  • Effects of nilotinib on regulatory T cells: the dose matters.

    abstract：BACKGROUND:Nilotinib is a tyrosine kinase inhibitor with high target specificity. Here, we characterized the effects of nilotinib for the first time on CD4+CD25+ regulatory T cells (Tregs) which regulate anti-tumor/leukemia immune responses. DESIGN AND METHODS:Carboxyfluorescein diacetate succinimidyl ester (CFSE) and...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-9-22

    authors： Fei F,Yu Y,Schmitt A,Rojewski MT,Chen B,Greiner J,Götz M,Bunjes D,Schmitt M

    更新日期：2010-01-29 00:00:00

  • PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA.

    abstract：BACKGROUND:Breast cancer is one of the most common malignancies and the major cause of cancer-related death in women. Although the importance of PIWI-interacting RNAs (piRNAs) in cancer has been increasingly recognized, few studies have been explored the functional mechanism of piRNAs in breast cancer development and p...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/s12943-019-0940-3

    authors： Tan L,Mai D,Zhang B,Jiang X,Zhang J,Bai R,Ye Y,Li M,Pan L,Su J,Zheng Y,Liu Z,Zuo Z,Zhao Q,Li X,Huang X,Yang J,Tan W,Zheng J,Lin D

    更新日期：2019-01-12 00:00:00

  • Recent advances in understanding tumor stroma-mediated chemoresistance in breast cancer.

    abstract：:Although solid tumors comprise malignant cells, they also contain many different non-malignant cell types in their micro-environment. The cellular components of the tumor stroma consist of immune and endothelial cells combined with a heterogeneous population of stromal cells which include cancer-associated fibroblasts...

    journal_title：Molecular cancer

    pub_type： 杂志文章,评审

    doi：10.1186/s12943-019-0960-z

    authors： Plava J,Cihova M,Burikova M,Matuskova M,Kucerova L,Miklikova S

    更新日期：2019-03-30 00:00:00

  • Bevacizumab promotes venous thromboembolism through the induction of PAI-1 in a mouse xenograft model of human lung carcinoma.

    abstract：BACKGROUND:An increased incidence of venous thromboembolism (VTE) is associated with anti-vascular endothelial growth factor (VEGF) treatment in cancer. However, the mechanism underlying this effect remains elusive. In this study, we examined the effect of bevacizumab, a humanized monoclonal antibody against VEGF-A, on...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/s12943-015-0418-x

    authors： Chen N,Ren M,Li R,Deng X,Li Y,Yan K,Xiao L,Yang Y,Wang L,Luo M,Fay WP,Wu J

    更新日期：2015-07-29 00:00:00

  • Favorable outcome of patients with lung adenocarcinoma harboring POLE mutations and expressing high PD-L1.

    abstract：:Mutations in polymerase ε (POLE) confer favorable prognosis and outcomes in various cancer types, but their role in non-small cell lung cancer (NSCLC) is unknown. Utilizing the data of 513 patients with adenocarcinoma (LUAD) and 497 patients with squamous cell carcinoma (LUSC) from The Cancer Genome Atlas (TCGA) cohor...

    journal_title：Molecular cancer

    pub_type： 信件

    doi：10.1186/s12943-018-0832-y

    authors： Liu L,Ruiz J,O'Neill SS,Grant SC,Petty WJ,Yang M,Chen K,Topaloglu U,Pasche B,Zhang W

    更新日期：2018-04-12 00:00:00

  • Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells.

    abstract：BACKGROUND:The expression of the rodent phosphoinositide-specific phospholipase C delta-4 (PLCdelta4) has been found to be elevated upon mitogenic stimulation and expression analysis have linked the upregulation of PLCdelta4 expression with rapid proliferation in certain rat transformed cell lines. The human homologue ...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-3-15

    authors： Leung DW,Tompkins C,Brewer J,Ball A,Coon M,Morris V,Waggoner D,Singer JW

    更新日期：2004-05-13 00:00:00

  • IGFBP-rP1, a potential molecule associated with colon cancer differentiation.

    abstract：BACKGROUND:In our previous studies, we have demonstrated that insulin-like growth factor binding protein-related protein1 (IGFBP-rP1) played its potential tumor suppressor role in colon cancer cells through apoptosis and senescence induction. In this study, we will further uncover the role of IGFBP-rP1 in colon cancer ...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-9-281

    authors： Ruan W,Zhu S,Wang H,Xu F,Deng H,Ma Y,Lai M

    更新日期：2010-10-26 00:00:00

  • Higher FOXP3-TSDR demethylation rates in adjacent normal tissues in patients with colon cancer were associated with worse survival.

    abstract：BACKGROUND:The influence of natural regulatory T cells (nTregs) on the patients with colon cancer is unclear. Demethylated status of the Treg-specific demethylated region (TSDR) of the FOXP3 gene was reported to be a potential biomarker for the identification of nTregs. METHODS:The demethylation rate of the TSDR (TSDR...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-13-153

    authors： Zhuo C,Li Z,Xu Y,Wang Y,Li Q,Peng J,Zheng H,Wu P,Li B,Cai S

    更新日期：2014-06-18 00:00:00

  • Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis.

    abstract：BACKGROUND:Transforming Growth Factor beta (TGF-beta) plays an important role in tumor invasion and metastasis. We set out to investigate the possible clinical utility of TGF-beta antagonists in a human metastatic basal-like breast cancer model. We examined the effects of two types of the TGF-beta pathway antagonists (...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-9-122

    authors： Ganapathy V,Ge R,Grazioli A,Xie W,Banach-Petrosky W,Kang Y,Lonning S,McPherson J,Yingling JM,Biswas S,Mundy GR,Reiss M

    更新日期：2010-05-26 00:00:00

  • Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo.

    abstract：:Live animal imaging is becoming an increasingly common technique for accurate and quantitative assessment of tumor burden over time. Bioluminescence imaging systems rely on a bioluminescent signal from tumor cells, typically generated from expression of the firefly luciferase gene. However, previous reports have sugge...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-9-299

    authors： Tiffen JC,Bailey CG,Ng C,Rasko JE,Holst J

    更新日期：2010-11-22 00:00:00

  • Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes.

    abstract：BACKGROUND:The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division. Deregulation of FOXM1 has been linked to a majority of human cancers. We previously showed that FOXM1 was upregulated in basal cell c...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-9-45

    authors： Teh MT,Gemenetzidis E,Chaplin T,Young BD,Philpott MP

    更新日期：2010-02-26 00:00:00

  • A novel autoantibody test for the detection of pre-neoplastic lung lesions.

    abstract：BACKGROUND:Atypical adenomatous hyperplasia (AAH) and squamous cell dysplasia (SCD) are associated with the development of malignant lesions in the lung. Accurate diagnosis of AAH and SCD could facilitate earlier clinical intervention and provide useful information for assessing lung cancer risk in human populations. D...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-13-78

    authors： Lowe FJ,Shen W,Zu J,Li J,Wang H,Zhang X,Zhong L

    更新日期：2014-04-05 00:00:00

  • Knock down of HIF-1alpha in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres.

    abstract：BACKGROUND:Glioblastoma (GBM) is the most common and malignant primary intracranial human neoplasm. GBMs are characterized by the presence of extensive areas of necrosis and hypoxia. Hypoxia and its master regulator, hypoxia inducible factor 1 (HIF-1) play a key role in glioma invasion. RESULTS:To further elucidate th...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-9-133

    authors： Méndez O,Zavadil J,Esencay M,Lukyanov Y,Santovasi D,Wang SC,Newcomb EW,Zagzag D

    更新日期：2010-06-01 00:00:00

  • Amplification and overexpression of the ID4 gene at 6p22.3 in bladder cancer.

    abstract：BACKGROUND:Amplifications at 6p22.3 are prevalent in advanced stage bladder cancer (TCC). Previous studies have identified SOX4, CDKAL, and E2F3 as targets of this amplification and therefore potential oncogenes, but the more telomeric DEK gene too has been reported as overexpressed and amplified. We have therefore inv...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-4-16

    authors： Wu Q,Hoffmann MJ,Hartmann FH,Schulz WA

    更新日期：2005-05-05 00:00:00

  • MOZ-TIF2 repression of nuclear receptor-mediated transcription requires multiple domains in MOZ and in the CID domain of TIF2.

    abstract：BACKGROUND:Fusion of the MOZ and TIF2 genes by an inv (8) (p11q13) translocation has been identified in patients with acute mixed-lineage leukemia. Characterization of the molecular structure of the MOZ-TIF2 fusion protein suggested that the fusion protein would effect on nuclear receptor signaling. RESULTS:A series o...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-6-51

    authors： Yin H,Glass J,Blanchard KL

    更新日期：2007-08-13 00:00:00

  • Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression.

    abstract：BACKGROUND:Although both circular RNAs (circRNAs) and autophagy are associated with the function of breast cancer (BC), whether circRNAs regulate BC progression via autophagy remains unknown. In this study, we aim to explore the regulatory mechanisms and the clinical significance of autophagy-associated circRNAs in BC....

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/s12943-020-01152-2

    authors： Liang G,Ling Y,Mehrpour M,Saw PE,Liu Z,Tan W,Tian Z,Zhong W,Lin W,Luo Q,Lin Q,Li Q,Zhou Y,Hamai A,Codogno P,Li J,Song E,Gong C

    更新日期：2020-03-25 00:00:00

  • Phosphorylation of Ser78 of Hsp27 correlated with HER-2/neu status and lymph node positivity in breast cancer.

    abstract：BACKGROUND:Abnormal amplification/expression of HER-2/neu oncogene has been causally linked with tumorigenesis and metastasis in breast cancer and associated with shortened overall survival of patients. Recently, heat shock protein 27 (Hsp27) was reported to be highly expressed in HER-2/neu positive tumors and cell lin...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-6-52

    authors： Zhang D,Wong LL,Koay ES

    更新日期：2007-08-14 00:00:00

  • Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells.

    abstract：BACKGROUND:The expression level of osteopontin correlates with the metastatic potential of several tumors. Osteopontin is a well-characterized ligand for the alphavbeta3 integrin. The present study was undertaken to elucidate the possible role of osteopontin/alphavbeta3 signaling in prostate cancer cell migration. RES...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-6-18

    authors： Desai B,Rogers MJ,Chellaiah MA

    更新日期：2007-03-07 00:00:00