Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression.

abstract：PURPOSE:Hypoxia is a major regulator of angiogenesis and always influences the release of exosomes in various types of tumors. The present review aimed to assess the role of hypoxia-induced exosomes in the tumor biology. METHODS:The relevant publications were retrieved from PubMed using keywords such as hypoxia, exoso...

journal_title：Molecular cancer

authors： Shao C,Yang F,Miao S,Liu W,Wang C,Shu Y,Shen H

更新日期：2018-08-11 00:00:00

abstract：:The HER4 intracellular domain (4ICD) is a potent estrogen receptor (ERalpha) coactivator with activities in breast cancer and the developing mammary gland that appear to overlap with progesterone receptor (PgR). In fact, 4ICD has recently emerged as an important regulator and predictor of tamoxifen response, a role pr...

journal_title：Molecular cancer

authors： Rokicki J,Das PM,Giltnane JM,Wansbury O,Rimm DL,Howard BA,Jones FE

更新日期：2010-06-15 00:00:00

abstract：:Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cl...

journal_title：Molecular cancer

authors： Moossavi M,Parsamanesh N,Bahrami A,Atkin SL,Sahebkar A

更新日期：2018-11-17 00:00:00

abstract：:Methionine aminopeptidase 2 (MetAP2) is a bifunctional protein that plays a critical role in the regulation of post-translational processing and protein synthesis. MetAP2 is overexpressed in human colon cancer. In this report we screened various MetAP2 inhibitors and treated HT29 cells with various concentrations of c...

journal_title：Molecular cancer

authors： Selvakumar P,Lakshmikuttyamma A,Das U,Pati HN,Dimmock JR,Sharma RK

更新日期：2009-08-24 00:00:00

abstract：BACKGROUND:Zebrafish have been used as a vertebrate model to study human cancers such as melanoma, rhabdomyosarcoma, liver cancer, and leukemia as well as for high-throughput screening of small molecules of therapeutic value. However, they are just emerging as a model for human brain tumors, which are among the most de...

journal_title：Molecular cancer

authors： Ju B,Chen W,Orr BA,Spitsbergen JM,Jia S,Eden CJ,Henson HE,Taylor MR

更新日期：2015-02-03 00:00:00

abstract：BACKGROUND:Sigma-2 receptors are over-expressed in proliferating cancer cells, making an attractive target for the targeted treatment of pancreatic cancer. In this study, we investigated the role of the novel sigma-2 receptor ligand SW43 to induce apoptosis and augment standard chemotherapy. RESULTS:The binding affini...

journal_title：Molecular cancer

authors： Hornick JR,Xu J,Vangveravong S,Tu Z,Mitchem JB,Spitzer D,Goedegebuure P,Mach RH,Hawkins WG

更新日期：2010-11-22 00:00:00

abstract：BACKGROUND:Cellular senescence is a state of irreversible cell growth arrest and senescence cells permanently lose proliferation potential. Induction of cellular senescence might be a novel therapy for cancer cells. TRIB2 has been reported to participate in regulating proliferation and drug resistance of various cancer...

journal_title：Molecular cancer

authors： Hou Z,Guo K,Sun X,Hu F,Chen Q,Luo X,Wang G,Hu J,Sun L

更新日期：2018-12-12 00:00:00

abstract：BACKGROUND:Differential mRNA splicing and alternative promoter usage of the TP73 gene results in the expression of multiple NH2-truncated isoforms that act as oncogenes. Abundant levels of these p73 variants in a variety of human cancers correlated with adverse clinical prognosis and response failure to conventional th...

journal_title：Molecular cancer

authors： Emmrich S,Wang W,John K,Li W,Pützer BM

更新日期：2009-08-11 00:00:00

abstract：INTRODUCTION:ERBB3, one of the four members of the ErbB family of receptor tyrosine kinases, plays an important role in breast cancer etiology and progression. In the present study, we aimed to identify novel miRNAs that can potentially target ERBB3 and their biological functions. METHOD:The expression levels of miR-1...

journal_title：Molecular cancer

authors： Yan X,Chen X,Liang H,Deng T,Chen W,Zhang S,Liu M,Gao X,Liu Y,Zhao C,Wang X,Wang N,Li J,Liu R,Zen K,Zhang CY,Liu B,Ba Y

更新日期：2014-09-24 00:00:00

abstract：BACKGROUND:The Sonic hedgehog (Shh) signaling pathway plays an important role in cerebellar development, and mutations leading to hyperactive Shh signaling have been associated with certain forms of medulloblastoma, a common form of pediatric brain cancer. While the fundamentals of this pathway are known, the molecular...

journal_title：Molecular cancer

authors： Lee SJ,Litan A,Li Z,Graves B,Lindsey S,Barwe SP,Langhans SA

更新日期：2015-08-19 00:00:00

abstract：:Since the publication of this work [1] and in response to a recent query that was brought to our attention in relation to the Western Blot in Figure 1(C) for NP2, protein lysates prepared around the same time as those presented in the manuscript in question, were run by SDS-PAGE under similar experimental conditions a...

journal_title：Molecular cancer

authors： Barr MP,Gray SG,Gately K,Hams E,Fallon PG,Davies AM,Richard DJ,Pidgeon GP,O'Byrne KJ

更新日期：2020-01-27 00:00:00

abstract：BACKGROUND:In the current study we investigated the role of caveolin-1 (cav-1) in pancreatic adenocarcinoma (PC) cell migration and invasion; initial steps in metastasis. Cav-1 is the major structural protein in caveolae; small Omega-shaped invaginations within the plasma membrane. Caveolae are involved in signal trans...

journal_title：Molecular cancer

authors： Lin M,DiVito MM,Merajver SD,Boyanapalli M,van Golen KL

更新日期：2005-06-21 00:00:00

abstract：BACKGROUND:The human genome encodes thousands of unique long non-coding RNAs (lncRNAs), and these transcripts are emerging as critical regulators of gene expression and cell fate. However, the transcriptional regulation of their expression is not fully understood. The pivotal transcription factor E2F1 which can induce ...

journal_title：Molecular cancer

authors： Feldstein O,Nizri T,Doniger T,Jacob J,Rechavi G,Ginsberg D

更新日期：2013-10-29 00:00:00

abstract：:By nature, scientists contribute to our understanding of nature and ourselves. As communities undergo significant changes, new challenges are presented. Here, we offer alternative views on recent changes in society. ...

journal_title：Molecular cancer

authors： Christian LM,Naqvi HR,Schmidt C,Covarrubias D,Mathur S

更新日期：2008-07-17 00:00:00

abstract：BACKGROUND:Hedgehog acyltransferase (Hhat) catalyzes the transfer of the fatty acid palmitate onto Sonic Hedgehog (Shh), a modification that is essential for Shh signaling activity. The Shh signaling pathway has been implicated in the progression of breast cancer. METHODS:To determine the functional significance of Hh...

journal_title：Molecular cancer

authors： Matevossian A,Resh MD

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Metabolic plasticity has been increasingly thought to be a determinant of tumor growth and metastasis. MACC1, a transcriptional regulator of MET, was recognized as an oncogene in gastric cancer (GC); however, its transcriptional or post-translational regulation was not clear. We previously reported the metab...

journal_title：Molecular cancer

authors： Zhao Y,Liu Y,Lin L,Huang Q,He W,Zhang S,Dong S,Wen Z,Rao J,Liao W,Shi M

更新日期：2018-03-06 00:00:00

abstract：BACKGROUND:The poor prognosis of esophageal squamous cell carcinoma (ESCC) highlights the need for novel strategies against this disease. Our previous study suggested the involvement of CCL2 and tumor associated macrophages (TAMs) in esophageal carcinogenesis. Despite the recognition of TAMs as a promising target for c...

journal_title：Molecular cancer

authors： Yang H,Zhang Q,Xu M,Wang L,Chen X,Feng Y,Li Y,Zhang X,Cui W,Jia X

更新日期：2020-02-27 00:00:00

abstract：BACKGROUND:N6-methyladenosine (m6A) emerges as one of the most important modification of RNA. Bladder cancer is a common cancer type in developed countries, and hundreds of thousands of bladder cancer patients die every year. MATERIALS AND METHODS:There are various cells in bladder tumor bulk, and a small population c...

journal_title：Molecular cancer

authors： Gu C,Wang Z,Zhou N,Li G,Kou Y,Luo Y,Wang Y,Yang J,Tian F

更新日期：2019-11-25 00:00:00

abstract：:Recent studies have shown that on one hand, tumors need to obtain a sufficient energy supply, and on the other hand they must evade the body's immune surveillance. Because of their metabolic reprogramming characteristics, tumors can modify the physicochemical properties of the microenvironment, which in turn affects t...

journal_title：Molecular cancer

authors： Wang YA,Li XL,Mo YZ,Fan CM,Tang L,Xiong F,Guo C,Xiang B,Zhou M,Ma J,Huang X,Wu X,Li Y,Li GY,Zeng ZY,Xiong W

更新日期：2018-11-26 00:00:00

abstract：BACKGROUND:Relapse due to chemoresistant residual disease is a major cause of death in acute myelogenous leukemia (AML). The present study was undertaken to elucidate the molecular mechanisms of chemoresistance by comparing differential gene expression in blasts from patients with resistant relapsing AML and chemosensi...

journal_title：Molecular cancer

authors： Huang TS,Myklebust LM,Kjarland E,Gjertsen BT,Pendino F,Bruserud Ø,Døskeland SO,Lillehaug JR

更新日期：2007-04-23 00:00:00

abstract：BACKGROUND:In our previous studies, we have demonstrated that insulin-like growth factor binding protein-related protein1 (IGFBP-rP1) played its potential tumor suppressor role in colon cancer cells through apoptosis and senescence induction. In this study, we will further uncover the role of IGFBP-rP1 in colon cancer ...

journal_title：Molecular cancer

authors： Ruan W,Zhu S,Wang H,Xu F,Deng H,Ma Y,Lai M

更新日期：2010-10-26 00:00:00

abstract：BACKGROUND:Hypermethylation of promotor CpG islands is a common mechanism that inactivates tumor suppressor genes in cancer. Genes belonging to the RASSF gene family have frequently been reported as epigenetically silenced by promotor methylation in human cancers. Two members of this gene family, RASSF1A and RASSF5A ha...

journal_title：Molecular cancer

authors： Djos A,Martinsson T,Kogner P,Carén H

更新日期：2012-06-13 00:00:00

abstract：:At the moment, pancreatic cancer is among the deadliest gastrointestinal diseases, and pancreatic cancer growth is a complex biological process that is based on different kinds of genes. Exosomes are extracellular vesicles containing microRNAs (miRNAs), messenger RNA (mRNA), and proteins, they act as the most prominen...

journal_title：Molecular cancer

authors： Ariston Gabriel AN,Wang F,Jiao Q,Yvette U,Yang X,Al-Ameri SA,Du L,Wang YS,Wang C

更新日期：2020-08-27 00:00:00

abstract：BACKGROUND:TGF-beta resistance often develops in breast cancer cells that in turn overproduce this cytokine to create a local immunosuppressive environment that fosters tumor growth and exacerbates the invasive and metastatic behavior of the tumor cells themselves. Smads-mediated cross-talk with the estrogen receptor h...

journal_title：Molecular cancer

authors： Ren Y,Wu L,Frost AR,Grizzle W,Cao X,Wan M

更新日期：2009-11-27 00:00:00

abstract：:Mutations in polymerase ε (POLE) confer favorable prognosis and outcomes in various cancer types, but their role in non-small cell lung cancer (NSCLC) is unknown. Utilizing the data of 513 patients with adenocarcinoma (LUAD) and 497 patients with squamous cell carcinoma (LUSC) from The Cancer Genome Atlas (TCGA) cohor...

journal_title：Molecular cancer

authors： Liu L,Ruiz J,O'Neill SS,Grant SC,Petty WJ,Yang M,Chen K,Topaloglu U,Pasche B,Zhang W

更新日期：2018-04-12 00:00:00

abstract：BACKGROUND:Hodgkin lymphoma (HL) and Anaplastic Large Cell Lymphoma (ALCL), are forms of malignant lymphoma defined by unique morphologic, immunophenotypic, genotypic, and clinical characteristics, but both overexpress CD30. We used sub-megabase resolution tiling (SMRT) array-based comparative genomic hybridization to ...

journal_title：Molecular cancer

authors： Fadlelmola FM,Zhou M,de Leeuw RJ,Dosanjh NS,Harmer K,Huntsman D,Lam WL,Banerjee D

更新日期：2008-01-07 00:00:00

abstract：BACKGROUND:Cancer is the result of a multistep process of genomic alterations, including mutations in key regulatory proteins that result in loss of balanced gene expression and subsequent malignant transformation. Throughout the various stages of colorectal carcinoma (CRC), complex genetic alterations occur, of which ...

journal_title：Molecular cancer

authors： Gaur S,Chen L,Ann V,Lin WC,Wang Y,Chang VH,Hsu NY,Shia HS,Yen Y

更新日期：2014-02-04 00:00:00

abstract：BACKGROUND:As an important means of communication, exosomes play an important role in the development of hepatocellular carcinoma (HCC). METHODS:Bioinformatics analysis, dual-luciferase reporter assays, methylation-specific quantitative PCR, and ChIP-PCR analysis were used to gain insight into the underlying mechanism...

journal_title：Molecular cancer

authors： Cao LQ,Yang XW,Chen YB,Zhang DW,Jiang XF,Xue P

更新日期：2019-10-27 00:00:00

abstract：BACKGROUND:Certain types of potassium channels (known as Eag1, KCNH1, Kv10.1) are associated with the production of tumours in patients and in animals. We have now studied the expression pattern of the Eag1 channel in a large range of normal and tumour tissues from different collections utilising molecular biological a...

journal_title：Molecular cancer

authors： Hemmerlein B,Weseloh RM,Mello de Queiroz F,Knötgen H,Sánchez A,Rubio ME,Martin S,Schliephacke T,Jenke M,Heinz-Joachim-Radzun,Stühmer W,Pardo LA

更新日期：2006-10-05 00:00:00

abstract：BACKGROUND:Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with high mutational heterogeneity and a generally poor clinical outcome. Despite implicated roles of deregulated TP53, IGF-2 and Wnt signaling pathways, a clear genetic association or unique mutational link to the disease is still missing. Recent...

journal_title：Molecular cancer

authors： Korah R,Healy JM,Kunstman JW,Fonseca AL,Ameri AH,Prasad ML,Carling T

更新日期：2013-08-05 00:00:00