NC2213: a novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cells.

abstract：BACKGROUND:Although the prognosis of gastric cancer patients have a favorable progression, there are some patients with unusual patterns of locoregional and systemic recurrence. Therefore, a better understanding of early molecular events of the disease is needed. Current evidences demonstrate that long noncoding RNAs (...

journal_title：Molecular cancer

authors： Liu YW,Xia R,Lu K,Xie M,Yang F,Sun M,De W,Wang C,Ji G

更新日期：2017-02-16 00:00:00

abstract：BACKGROUND:Since tumor growth requires reactivation of telomerase (hTERT), this enzyme is a challenging target for drug development. Therefore, it is of great interest to identify telomerase expression and activity regulators. Retinoids are well-known inducers of granulocytic maturation associated with hTERT repression...

journal_title：Molecular cancer

authors： El Hajj J,Nguyen E,Liu Q,Bouyer C,Adriaenssens E,Hilal G,Ségal-Bendirdjian E

更新日期：2018-04-27 00:00:00

abstract：BACKGROUND:An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, was tested side-by-side with khat in a panel of acute myeloid leukemia cell lines to elucidate me...

journal_title：Molecular cancer

authors： Bredholt T,Dimba EA,Hagland HR,Wergeland L,Skavland J,Fossan KO,Tronstad KJ,Johannessen AC,Vintermyr OK,Gjertsen BT

更新日期：2009-11-13 00:00:00

abstract：BACKGROUND:Reovirus type 3 Dearing strain (ReoT3D) has an inherent propensity to preferentially infect and destroy cancer cells. The oncolytic activity of ReoT3D as a single agent has been demonstrated in vitro and in vivo against various cancers, including colon, pancreatic, ovarian and breast cancers. Its human safet...

journal_title：Molecular cancer

authors： Sei S,Mussio JK,Yang QE,Nagashima K,Parchment RE,Coffey MC,Shoemaker RH,Tomaszewski JE

更新日期：2009-07-14 00:00:00

abstract：:Recent advances in diagnosis and treatment are enabling a more targeted approach to treating lung cancers. Therapy targeting the specific oncogenic driver mutation could inhibit tumor progression and provide a favorable prognosis in clinical practice. Activating mutations of epidermal growth factor receptor (EGFR) in ...

journal_title：Molecular cancer

authors： Wu SG,Shih JY

更新日期：2018-02-19 00:00:00

abstract：BACKGROUND:Nilotinib is a tyrosine kinase inhibitor with high target specificity. Here, we characterized the effects of nilotinib for the first time on CD4+CD25+ regulatory T cells (Tregs) which regulate anti-tumor/leukemia immune responses. DESIGN AND METHODS:Carboxyfluorescein diacetate succinimidyl ester (CFSE) and...

journal_title：Molecular cancer

authors： Fei F,Yu Y,Schmitt A,Rojewski MT,Chen B,Greiner J,Götz M,Bunjes D,Schmitt M

更新日期：2010-01-29 00:00:00

abstract：BACKGROUND:PTEN is the second most mutated tumor suppressor gene other than p53. It suppresses tumorigenesis by dephosphorylating phosphatidylinositol (3,4,5)-triphosphate (PIP3) to phosphatidylinositol (4,5)-biphosphate (PIP2), thereby directly inhibiting phosphatidylinositol 3 kinase (PI3K)-mediated tumorigenic activ...

journal_title：Molecular cancer

authors： Fan C,He L,Kapoor A,Rybak AP,De Melo J,Cutz JC,Tang D

更新日期：2009-11-10 00:00:00

abstract：BACKGROUND:SOX2, a high mobility group (HMG)-box containing transcription factor, is a key regulator during development of the nervous system and a persistent marker of neural stem cells. Recent studies suggested a role of SOX2 in tumor progression. In our previous work we detected SOX2 in glioma cells and glioblastoma...

journal_title：Molecular cancer

authors： Oppel F,Müller N,Schackert G,Hendruschk S,Martin D,Geiger KD,Temme A

更新日期：2011-11-09 00:00:00

abstract：BACKGROUND:Glioblastomas (GBM) continue to remain one of the most dreaded tumours that are highly infiltrative in nature and easily preclude comprehensive surgical resection. GBMs pose an intricate etiology as they are being associated with a plethora of genetic and epigenetic lesions. Misregulation of the PI3 kinase p...

journal_title：Molecular cancer

authors： Nawaz Z,Patil V,Paul Y,Hegde AS,Arivazhagan A,Santosh V,Somasundaram K

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:SKI and SnoN proteins have been shown to inhibit TGF-β signaling, acting both as transcriptional co-repressors in the cell nucleus, and as sequestrators of SMAD proteins in the cytoplasm. TGF-β, on the other hand, induces rapid, proteasome-mediated, degradation of both proteins. How elevated SKI and SnoN pro...

journal_title：Molecular cancer

authors： Javelaud D,van Kempen L,Alexaki VI,Le Scolan E,Luo K,Mauviel A

更新日期：2011-01-06 00:00:00

abstract：BACKGROUND AND METHODS:Stem or progenitor cells from healthy tissues have the capacity to co-segregate their template DNA strands during mitosis. Here, we set out to test whether breast cancer cell lines also possess the ability to asymmetrically segregate their template DNA strands via non-random chromosome co-segrega...

journal_title：Molecular cancer

authors： Liu W,Jeganathan G,Amiri S,Morgan KM,Ryan BM,Pine SR

更新日期：2013-11-15 00:00:00

abstract：:Cells respond to hypoxia by shifting cellular processes from general housekeeping functions to activating specialized hypoxia-response pathways. Oxygen plays an important role in generating ATP to maintain a productive rate of protein synthesis in normoxia. In hypoxia, the rate of the canonical protein synthesis pathw...

journal_title：Molecular cancer

authors： Chee NT,Lohse I,Brothers SP

更新日期：2019-03-30 00:00:00

abstract：BACKGROUND:ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin motifs) is a member of the ADAMTS family of metalloproteases. Here, we investigated mRNA and protein levels of ADAMTS-1 in normal and neoplastic tissues using qPCR, immunohistochemistry and immunoblot analyses, and we addressed the role of ADAMT...

journal_title：Molecular cancer

authors： Freitas VM,do Amaral JB,Silva TA,Santos ES,Mangone FR,Pinheiro Jde J,Jaeger RG,Nagai MA,Machado-Santelli GM

更新日期：2013-01-05 00:00:00

abstract：BACKGROUND:The Hedgehog (HH) pathway promotes tumorigenesis in a diversity of cancers. Activation of the HH signaling pathway is caused by overexpression of HH ligands or mutations in the components of the HH/GLI1 cascade, which lead to increased transactivation of GLI transcription factors. Although negative kinase re...

journal_title：Molecular cancer

authors： Mizuarai S,Kawagishi A,Kotani H

更新日期：2009-07-06 00:00:00

abstract：BACKGROUND:Aberrant accumulation of beta-catenin plays an important role in a variety of human neoplasms. We recently reported accumulation of beta-catenin in parathyroid adenomas from patients with primary hyperparathyroidism (pHPT). In CTNNB1 exon 3, we detected a stabilizing mutation (S37A) in 3 out of 20 analyzed a...

journal_title：Molecular cancer

authors： Björklund P,Lindberg D,Akerström G,Westin G

更新日期：2008-06-09 00:00:00

abstract：:Gene fusions occur in up to 17% of solid tumours. Oncogenic kinases are often involved in such fusions. In lung cancer, almost 30% of patients carrying an activated oncogene show the fusion of a tyrosine kinase to an heterologous gene. Several genes are partner in the fusion with the three kinases ALK, ROS1 and RET in...

journal_title：Molecular cancer

authors： Cerrato A,Visconti R,Celetti A

更新日期：2018-02-19 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) is the number one cancer killer. Tumor-initiating cells (TICs) are responsible for tumor progression and recurrence. Emerging evidences suggest that small nucleolar RNAs (snoRNAs) play malfunctioning roles in lung tumorigenesis. This study aims to determine if snoRNAs have ...

journal_title：Molecular cancer

authors： Mannoor K,Shen J,Liao J,Liu Z,Jiang F

更新日期：2014-05-06 00:00:00

abstract：BACKGROUND:Interferon alpha (IFNα) is a well-established regulator of immunosuppression in head and neck squamous cell carcinoma (HNSCC), while the role of long noncoding RNAs (lncRNAs) in immunosuppression remains largely unknown. METHODS:Differentially expressed lncRNAs were screened under IFNα stimulation using lnc...

journal_title：Molecular cancer

authors： Ma H,Chang H,Yang W,Lu Y,Hu J,Jin S

更新日期：2020-01-06 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with high morbidity and mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation and related mechanisms has led researchers to focus on the microenvironment where pancreatic cancers develop. The anomalous proliferation ...

journal_title：Molecular cancer

authors： Thomas D,Radhakrishnan P

更新日期：2019-01-21 00:00:00

abstract：BACKGROUND:Pancreatic acinar cell carcinoma (ACC) is a rare tumor entity with an unfavorable prognosis. Recent whole-exome sequencing identified p53 mutations in a subset of human ACC. Activation of the mammalian target of rapamycin (mTOR) pathway is associated with various pancreatic neoplasms. We thus aimed at analyz...

journal_title：Molecular cancer

authors： Kong B,Cheng T,Qian C,Wu W,Steiger K,Cao J,Schlitter AM,Regel I,Raulefs S,Friess H,Erkan M,Esposito I,Kleeff J,Michalski CW

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:Human clear cell renal cell carcinoma (CRCC) remains resistant to therapies. Recent advances in Hypoxia Inducible Factors (HIF) molecular network led to targeted therapies, but unfortunately with only limited clinical significance. Elucidating the molecular processes involved in kidney tumorigenesis and resi...

journal_title：Molecular cancer

authors： Dormoy V,Danilin S,Lindner V,Thomas L,Rothhut S,Coquard C,Helwig JJ,Jacqmin D,Lang H,Massfelder T

更新日期：2009-12-16 00:00:00

abstract：:Bortezomib is a novel anti-cancer agent which has shown promising activity in non-small lung cancer (NSCLC) patients. However, only a subset of patients respond to this treatment. We show that NSCLC cell lines are differentially sensitive to bortezomib, IC50 values ranging from 5 to 83 nM. The apoptosis-inducing poten...

journal_title：Molecular cancer

authors： Voortman J,Checińska A,Giaccone G

更新日期：2007-11-17 00:00:00

abstract：BACKGROUND:Phospholipid phosphatase 4 (PPAPDC1A or PLPP4) has been demonstrated to be involved in the malignant process of many cancers. The purpose of this study was to investigate the clinical significance and biological roles of PLPP4 in lung carcinoma. METHODS:PLPP4 expression was examined in 8 paired lung carcino...

journal_title：Molecular cancer

authors： Zhang X,Zhang L,Lin B,Chai X,Li R,Liao Y,Deng X,Liu Q,Yang W,Cai Y,Zhou W,Lin Z,Huang W,Zhong M,Lei F,Wu J,Yu S,Li X,Li S,Li Y,Zeng J,Long W,Ren D,Huang Y

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:The role of TNF-alpha in affecting the fate of tumors is controversial, while some studies have reported apoptotic or necrotic effects of TNF-alpha, others provide evidence that endogenous TNF-alpha promotes growth and development of tumors. Understanding the mechanism(s) of TNF-alpha mediated growth arrest ...

journal_title：Molecular cancer

authors： Kumar PS,Shiras A,Das G,Jagtap JC,Prasad V,Shastry P

更新日期：2007-06-12 00:00:00

abstract：BACKGROUND:Epigenetic regulators play a critical role in the maintenance of specific chromatin domains in an active or repressed state. Disruption of epigenetic regulatory mechanisms is widespread in cancer cells and largely contributes to the transformation process through active repression of tumor suppressor genes. ...

journal_title：Molecular cancer

authors： Yeh CH,Bai XT,Moles R,Ratner L,Waldmann TA,Watanabe T,Nicot C

更新日期：2016-02-16 00:00:00

abstract：BACKGROUND:High expression of the long non-coding RNA nuclear-enriched abundant transcript 1 (NEAT1) in whole blood has been reported in colorectal cancer patients; however, its' clinical significance and origin are unclear. We evaluated the diagnostic and prognostic value, and origin of whole blood NEAT1 in colorectal...

journal_title：Molecular cancer

authors： Wu Y,Yang L,Zhao J,Li C,Nie J,Liu F,Zhuo C,Zheng Y,Li B,Wang Z,Xu Y

更新日期：2015-11-09 00:00:00

abstract：BACKGROUND:Among women worldwide, breast cancer is the most commonly diagnosed cancer, and the second leading cause of cancer-related deaths. Improved understanding of breast tumourigenesis may facilitate the development of more effective therapies. Peroxisome proliferator-activated receptor (PPAR)γ is a transcription ...

journal_title：Molecular cancer

authors： Apostoli AJ,Roche JM,Schneider MM,SenGupta SK,Di Lena MA,Rubino RE,Peterson NT,Nicol CJ

更新日期：2015-04-15 00:00:00

abstract：BACKGROUND:Granulosa cell tumors (GCTs) are relatively rare and are subtypes of the sex-cord stromal neoplasms. Methylation induced silencing in the promoters of genes such as tumor suppressor genes, DNA repair genes and pro-apoptotic genes is recognised as a critical factor in cancer development. METHODS:We examined ...

journal_title：Molecular cancer

authors： Dhillon VS,Shahid M,Husain SA

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Triple negative breast cancer (TNBC) remains the most challenging breast cancer subtype so far. Specific therapeutic approaches have rarely achieved clinical improvements in treatment of TNBC patients and effective molecular biomarkers are largely unknown. METHODS:We used paired TNBC samples and high throug...

journal_title：Molecular cancer

authors： Li J,Ma M,Yang X,Zhang M,Luo J,Zhou H,Huang N,Xiao F,Lai B,Lv W,Zhang N

更新日期：2020-09-11 00:00:00

abstract：:The HER4 intracellular domain (4ICD) is a potent estrogen receptor (ERalpha) coactivator with activities in breast cancer and the developing mammary gland that appear to overlap with progesterone receptor (PgR). In fact, 4ICD has recently emerged as an important regulator and predictor of tamoxifen response, a role pr...

journal_title：Molecular cancer

authors： Rokicki J,Das PM,Giltnane JM,Wansbury O,Rimm DL,Howard BA,Jones FE

更新日期：2010-06-15 00:00:00