Asymmetric segregation of template DNA strands in basal-like human breast cancer cell lines.

abstract：BACKGROUND:Expression of kappa gene is under the control of distinct cis-regulatory elements, including the kappa intron enhancer (iE kappa) and the kappa 3' enhancer (3'E kappa). The active enhancers and expression of immunoglobulin is generally considered to be restricted to B lymphocytes. However, accumulating evide...

journal_title：Molecular cancer

authors： Liu H,Zheng H,Duan Z,Hu D,Li M,Liu S,Li Z,Deng X,Wang Z,Tang M,Shi Y,Yi W,Cao Y

更新日期：2009-10-27 00:00:00

abstract：BACKGROUND:The clinical efficacy of camptothecin (CPT), a drug specifically targeting topoisomerase I (TopoI), is under evaluation for the treatment of malignant gliomas. Due to the high unresponsiveness of these tumours to chemotherapy, it would be very important to study the signalling network that drives camptotheci...

journal_title：Molecular cancer

authors： Morandi E,Severini C,Quercioli D,D'Ario G,Perdichizzi S,Capri M,Farruggia G,Mascolo MG,Horn W,Vaccari M,Serra R,Colacci A,Silingardi P

更新日期：2008-08-11 00:00:00

abstract：BACKGROUND:The tumor cell lysate-pulsed, dendritic cell (DC)-based cancer vaccine approaches are being actively evaluated for application to cancer immunotherapy, hopefully at a personalized medicine base. There is apparently an emerging technical problem however, the lack of highly efficacious potency in activation of...

journal_title：Molecular cancer

authors： Lin TJ,Lin HT,Chang WT,Mitapalli S P,Hsiao PW,Yin SY,Yang NS

更新日期：2015-09-24 00:00:00

abstract：BACKGROUND:Interferon alpha (IFNα) is a well-established regulator of immunosuppression in head and neck squamous cell carcinoma (HNSCC), while the role of long noncoding RNAs (lncRNAs) in immunosuppression remains largely unknown. METHODS:Differentially expressed lncRNAs were screened under IFNα stimulation using lnc...

journal_title：Molecular cancer

authors： Ma H,Chang H,Yang W,Lu Y,Hu J,Jin S

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Akt/PKB is a serine/threonine kinase that has attracted much attention because of its central role in regulating cell proliferation, survival, motility and angiogenesis. Activation of Akt in breast cancer portends aggressive tumour behaviour, resistance to hormone-, chemo-, and radiotherapy-induced apoptosis...

journal_title：Molecular cancer

authors： Pecorari L,Marin O,Silvestri C,Candini O,Rossi E,Guerzoni C,Cattelani S,Mariani SA,Corradini F,Ferrari-Amorotti G,Cortesi L,Bussolari R,Raschellà G,Federico MR,Calabretta B

更新日期：2009-08-03 00:00:00

abstract：BACKGROUND:Gefitinib is a tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR) especially effective in tumors with activating EGFR gene mutations while EGFR wild-type non small cell lung cancer (NSCLC) patients at present do not benefit from this treatment.The primary site of gefitinib metabol...

journal_title：Molecular cancer

authors： Alfieri RR,Galetti M,Tramonti S,Andreoli R,Mozzoni P,Cavazzoni A,Bonelli M,Fumarola C,La Monica S,Galvani E,De Palma G,Mutti A,Mor M,Tiseo M,Mari E,Ardizzoni A,Petronini PG

更新日期：2011-11-23 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignant tumours with a poor prognosis worldwide. While early stage tumours can be treated with curative approaches such as liver transplantation or surgical resection, these are only suitable for a minority of patients. Those with advanced stage disease are on...

journal_title：Molecular cancer

authors： Huo X,Han S,Wu G,Latchoumanin O,Zhou G,Hebbard L,George J,Qiao L

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:Osteopontin (OPN) has been shown to play many roles in the progression of cancer. We have recently demonstrated the activation of Akt by OPN. Integrin-linked kinase and PI3-kinase are integral proteins in OPN/AKT pathway in PC3 cells. To investigate the role of the extracellular receptors in OPN signaling, w...

journal_title：Molecular cancer

authors： Robertson BW,Bonsal L,Chellaiah MA

更新日期：2010-09-26 00:00:00

abstract：BACKGROUND:Recent advances have revealed a significant contribution of chemokines and their receptors in tumor growth, survival after chemotherapy, and organ-specific metastasis. The CXC chemokine receptor-7 (CXCR7) is the latest chemokine receptor implicated in cancer. Although over expressed in breast cancer cell lin...

journal_title：Molecular cancer

authors： Salazar N,Muñoz D,Kallifatidis G,Singh RK,Jordà M,Lokeshwar BL

更新日期：2014-08-28 00:00:00

abstract：BACKGROUND:Glioblastoma (GBM) is the most common and malignant primary intracranial human neoplasm. GBMs are characterized by the presence of extensive areas of necrosis and hypoxia. Hypoxia and its master regulator, hypoxia inducible factor 1 (HIF-1) play a key role in glioma invasion. RESULTS:To further elucidate th...

journal_title：Molecular cancer

authors： Méndez O,Zavadil J,Esencay M,Lukyanov Y,Santovasi D,Wang SC,Newcomb EW,Zagzag D

更新日期：2010-06-01 00:00:00

abstract：:Long-noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200 nucleotides and do not code for proteins. However, this class of RNAs plays pivotal regulatory roles. The mechanism of their action is highly complex. Mounting evidence shows that lncRNAs can regulate cancer onset and progression in a va...

journal_title：Molecular cancer

authors： Fan C,Tang Y,Wang J,Xiong F,Guo C,Wang Y,Zhang S,Gong Z,Wei F,Yang L,He Y,Zhou M,Li X,Li G,Xiong W,Zeng Z

更新日期：2017-07-24 00:00:00

abstract：BACKGROUND:RNA interference (RNAi), a newly developed method in which RNA molecules inhibit gene expression, has recently received considerable research attention. In the development of RNAi-based therapies, nanoparticles, which have distinctive size effects along with facile modification strategies and are capable of ...

journal_title：Molecular cancer

authors： Xin Y,Huang M,Guo WW,Huang Q,Zhang LZ,Jiang G

更新日期：2017-07-28 00:00:00

abstract：BACKGROUND:Phospholipid phosphatase 4 (PPAPDC1A or PLPP4) has been demonstrated to be involved in the malignant process of many cancers. The purpose of this study was to investigate the clinical significance and biological roles of PLPP4 in lung carcinoma. METHODS:PLPP4 expression was examined in 8 paired lung carcino...

journal_title：Molecular cancer

authors： Zhang X,Zhang L,Lin B,Chai X,Li R,Liao Y,Deng X,Liu Q,Yang W,Cai Y,Zhou W,Lin Z,Huang W,Zhong M,Lei F,Wu J,Yu S,Li X,Li S,Li Y,Zeng J,Long W,Ren D,Huang Y

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:Epigenetic control is essential for maintenance of tissue hierarchy and correct differentiation. In cancer, this hierarchical structure is altered and epigenetic control deregulated, but the relationship between these two phenomena is still unclear. CD133 is a marker for adult stem cells in various tissues a...

journal_title：Molecular cancer

authors： Pellacani D,Packer RJ,Frame FM,Oldridge EE,Berry PA,Labarthe MC,Stower MJ,Simms MS,Collins AT,Maitland NJ

更新日期：2011-07-29 00:00:00

abstract：BACKGROUND:Co-Activator Arginine Methyltransferase 1(CARM1) is an Estrogen Receptor (ER) cofactor that remodels chromatin for gene regulation via methylation of Histone3. We investigated CARM1 levels and localization across breast cancer tumors in a cohort of patients of either European or African ancestry. METHODS:We...

journal_title：Molecular cancer

authors： Davis MB,Liu X,Wang S,Reeves J,Khramtsov A,Huo D,Olopade OI

更新日期：2013-05-10 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) is highly invasive and aggressive and lacks specific molecular targets to improve the prognosis. MiR-25-3p promotes proliferation of many tumors and its role and underlying mechanisms in TNBC remain to be well elucidated. METHODS:Differential expression of miR-25-3p in T...

journal_title：Molecular cancer

authors： Chen H,Pan H,Qian Y,Zhou W,Liu X

更新日期：2018-01-08 00:00:00

abstract：BACKGROUND:Platinum-containing chemotherapy produces specific DNA damage and is used to treat several human solid tumors. Tumors initially sensitive to platinum-based drugs frequently become resistant. Inhibition of DNA repair is a potential strategy to enhance cisplatin effectiveness. After cisplatin treatment, a bala...

journal_title：Molecular cancer

authors： Sand-Dejmek J,Adelmant G,Sobhian B,Calkins AS,Marto J,Iglehart DJ,Lazaro JB

更新日期：2011-06-16 00:00:00

abstract：:Infection with Human papillomaviruses (HPVs) leads to the development of a wide-range of cancers, accounting for 5% of all human cancers. A prominent example is cervical cancer, one of the leading causes of cancer death in women worldwide. It has been well established that tumor development and progression induced by ...

journal_title：Molecular cancer

authors： Zhang L,Wu J,Ling MT,Zhao L,Zhao KN

更新日期：2015-04-17 00:00:00

abstract：BACKGROUND:The influence of natural regulatory T cells (nTregs) on the patients with colon cancer is unclear. Demethylated status of the Treg-specific demethylated region (TSDR) of the FOXP3 gene was reported to be a potential biomarker for the identification of nTregs. METHODS:The demethylation rate of the TSDR (TSDR...

journal_title：Molecular cancer

authors： Zhuo C,Li Z,Xu Y,Wang Y,Li Q,Peng J,Zheng H,Wu P,Li B,Cai S

更新日期：2014-06-18 00:00:00

abstract：BACKGROUND:In contrast to tumor-suppressive apoptosis and autophagic cell death, necrosis promotes tumor progression by releasing the pro-inflammatory and tumor-promoting cytokine high mobility group box 1 (HMGB1), and its presence in tumor patients is associated with poor prognosis. Thus, necrosis has important clinic...

journal_title：Molecular cancer

authors： Lee SY,Jeon HM,Kim CH,Ju MK,Bae HS,Park HG,Lim SC,Han SI,Kang HS

更新日期：2011-09-14 00:00:00

abstract：BACKGROUND:Changes in glycogen metabolism is an essential feature among the various metabolic adaptations used by cancer cells to adjust to the conditions imposed by the tumor microenvironment. Our previous study showed that glycogen branching enzyme (GBE1) is downstream of the HIF1 pathway in hypoxia-conditioned lung ...

journal_title：Molecular cancer

authors： Li L,Yang L,Cheng S,Fan Z,Shen Z,Xue W,Zheng Y,Li F,Wang D,Zhang K,Lian J,Wang D,Zhu Z,Zhao J,Zhang Y

更新日期：2019-06-20 00:00:00

abstract：:Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important advances have been made in the biogenesis, regulation, localization, degradation and modification of circRNAs. CircRNAs exert biological functions by acting as tra...

journal_title：Molecular cancer

authors： Zhou WY,Cai ZR,Liu J,Wang DS,Ju HQ,Xu RH

更新日期：2020-12-14 00:00:00

abstract：BACKGROUND:Zebrafish have been used as a vertebrate model to study human cancers such as melanoma, rhabdomyosarcoma, liver cancer, and leukemia as well as for high-throughput screening of small molecules of therapeutic value. However, they are just emerging as a model for human brain tumors, which are among the most de...

journal_title：Molecular cancer

authors： Ju B,Chen W,Orr BA,Spitsbergen JM,Jia S,Eden CJ,Henson HE,Taylor MR

更新日期：2015-02-03 00:00:00

abstract：BACKGROUND:Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with high mutational heterogeneity and a generally poor clinical outcome. Despite implicated roles of deregulated TP53, IGF-2 and Wnt signaling pathways, a clear genetic association or unique mutational link to the disease is still missing. Recent...

journal_title：Molecular cancer

authors： Korah R,Healy JM,Kunstman JW,Fonseca AL,Ameri AH,Prasad ML,Carling T

更新日期：2013-08-05 00:00:00

abstract：BACKGROUND:Although chemotherapy represents a predominant anti-cancer therapeutic modality, drug treatment efficacy is often limited due to the development of resistant tumor cells. The pregnane X receptor (PXR) affects chemotherapeutic effects by regulating targets involved in drug metabolism and transportation, but t...

journal_title：Molecular cancer

authors： Dong Y,Wang Z,Xie GF,Li C,Zuo WW,Meng G,Xu CP,Li JJ

更新日期：2017-03-29 00:00:00

abstract：BACKGROUND:Human or animals lacking either JAK3 or the common gamma chain (gammac) expression display severe combined immunodeficiency disease, indicating the crucial role of JAK3 in T-cell development and the homeostasis of the immune system. JAK3 has also been suggested to contribute to the pathogenesis of tumorigene...

journal_title：Molecular cancer

authors： Kim BH,Jee JG,Yin CH,Sandoval C,Jayabose S,Kitamura D,Bach EA,Baeg GH

更新日期：2010-02-11 00:00:00

abstract：BACKGROUND:Although both circular RNAs (circRNAs) and autophagy are associated with the function of breast cancer (BC), whether circRNAs regulate BC progression via autophagy remains unknown. In this study, we aim to explore the regulatory mechanisms and the clinical significance of autophagy-associated circRNAs in BC....

journal_title：Molecular cancer

authors： Liang G,Ling Y,Mehrpour M,Saw PE,Liu Z,Tan W,Tian Z,Zhong W,Lin W,Luo Q,Lin Q,Li Q,Zhou Y,Hamai A,Codogno P,Li J,Song E,Gong C

更新日期：2020-03-25 00:00:00

abstract：BACKGROUND:PTEN is the second most mutated tumor suppressor gene other than p53. It suppresses tumorigenesis by dephosphorylating phosphatidylinositol (3,4,5)-triphosphate (PIP3) to phosphatidylinositol (4,5)-biphosphate (PIP2), thereby directly inhibiting phosphatidylinositol 3 kinase (PI3K)-mediated tumorigenic activ...

journal_title：Molecular cancer

authors： Fan C,He L,Kapoor A,Rybak AP,De Melo J,Cutz JC,Tang D

更新日期：2009-11-10 00:00:00

abstract：:Since the publication of this work [1] and in response to a recent query that was brought to our attention in relation to the Western Blot in Figure 1(C) for NP2, protein lysates prepared around the same time as those presented in the manuscript in question, were run by SDS-PAGE under similar experimental conditions a...

journal_title：Molecular cancer

authors： Barr MP,Gray SG,Gately K,Hams E,Fallon PG,Davies AM,Richard DJ,Pidgeon GP,O'Byrne KJ

更新日期：2020-01-27 00:00:00

abstract：BACKGROUND:SOX2, a high mobility group (HMG)-box containing transcription factor, is a key regulator during development of the nervous system and a persistent marker of neural stem cells. Recent studies suggested a role of SOX2 in tumor progression. In our previous work we detected SOX2 in glioma cells and glioblastoma...

journal_title：Molecular cancer

authors： Oppel F,Müller N,Schackert G,Hendruschk S,Martin D,Geiger KD,Temme A

更新日期：2011-11-09 00:00:00