Regulation of the stem cell marker CD133 is independent of promoter hypermethylation in human epithelial differentiation and cancer.

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Molecular cancer

authors： Rong D,Lu C,Zhang B,Fu K,Zhao S,Tang W,Cao H

更新日期：2020-09-09 00:00:00

abstract：BACKGROUND:Taurine upregulated gene1 (TUG1) as a 7.1-kb lncRNA, has been shown to play an oncogenic role in various cancers. However, the biological functions of lncRNA TUG1 in small cell lung cancer (SCLC) remain unknown. The aim of this study is to explore the roles of TUG1 in cell growth and chemoresistance of SCLC ...

journal_title：Molecular cancer

authors： Niu Y,Ma F,Huang W,Fang S,Li M,Wei T,Guo L

更新日期：2017-01-09 00:00:00

abstract：BACKGROUND:The pre-leukemia transcription factor 3 (PBX) is part of the PBX family of transcription factors, which is known to regulate genes involved in differentiation of urogenital organs and steroidogenesis. This is of interest with regard to prostate cancer progression as regulation of steroidogenesis is one of th...

journal_title：Molecular cancer

authors： Ramberg H,Alshbib A,Berge V,Svindland A,Taskén KA

更新日期：2011-05-06 00:00:00

abstract：BACKGROUND:To clarify the implications of cell-free nucleic acids (cfNA) in the plasma in neoplastic disease, it is necessary to determine the kinetics of their release into the circulation. METHODS:To quantify non-tumor and tumor DNA and RNA in the plasma of tumor-bearing rats and to correlate such levels with tumor ...

journal_title：Molecular cancer

authors： García-Olmo DC,Picazo MG,Toboso I,Asensio AI,García-Olmo D

更新日期：2013-02-04 00:00:00

abstract：BACKGROUND:In polymorphonuclear leukocytes (PMNL), mobilization of calcium ions is one of the early events triggered by binding of chemoattractant to its receptors. Besides chemotaxis, a variety of other functional responses are dependent on calcium ion mobilization. PMNL from chronic myeloid leukaemia (CML) patients t...

journal_title：Molecular cancer

authors： Revankar CM,Advani SH,Naik NR

更新日期：2006-11-27 00:00:00

abstract：BACKGROUND:PTEN is the second most mutated tumor suppressor gene other than p53. It suppresses tumorigenesis by dephosphorylating phosphatidylinositol (3,4,5)-triphosphate (PIP3) to phosphatidylinositol (4,5)-biphosphate (PIP2), thereby directly inhibiting phosphatidylinositol 3 kinase (PI3K)-mediated tumorigenic activ...

journal_title：Molecular cancer

authors： Fan C,He L,Kapoor A,Rybak AP,De Melo J,Cutz JC,Tang D

更新日期：2009-11-10 00:00:00

abstract：BACKGROUND:Long non-coding RNAs (lncRNAs) have been identified as important epigenetic regulators that play critical roles in human cancers. However, the regulatory functions of lncRNAs in tumorigenesis remains to be elucidated. Here, we aimed to investigate the molecular mechanisms and potential clinical application o...

journal_title：Molecular cancer

authors： He X,Chai P,Li F,Zhang L,Zhou C,Yuan X,Li Y,Yang J,Luo Y,Ge S,Zhang H,Jia R,Fan X

更新日期：2020-07-15 00:00:00

abstract：BACKGROUND:Sorafenib, a kinase inhibitor active against various solid tumours, induces oxidative stress and ferroptosis, a new form of oxidative necrosis, in some cancer cells. Clinically-applicable biomarkers that reflect the impact of sorafenib on the redox metabolism of cancer cells are lacking. METHODS:We used gen...

journal_title：Molecular cancer

authors： Houessinon A,François C,Sauzay C,Louandre C,Mongelard G,Godin C,Bodeau S,Takahashi S,Saidak Z,Gutierrez L,Régimbeau JM,Barget N,Barbare JC,Ganne N,Chauffert B,Coriat R,Galmiche A

更新日期：2016-05-16 00:00:00

abstract：BACKGROUND:We previously identified TrkB as an oncogene involved in promoting metastasis in endometrial carcinoma (EC). Here, we sought to delineate the effect of changes in TrkB expression on the global profile of microRNAs (miRNAs) in EC cells and further investigated the correlation between the expression of certain...

journal_title：Molecular cancer

authors： Bao W,Wang HH,Tian FJ,He XY,Qiu MT,Wang JY,Zhang HJ,Wang LH,Wan XP

更新日期：2013-12-09 00:00:00

abstract：:Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important advances have been made in the biogenesis, regulation, localization, degradation and modification of circRNAs. CircRNAs exert biological functions by acting as tra...

journal_title：Molecular cancer

authors： Zhou WY,Cai ZR,Liu J,Wang DS,Ju HQ,Xu RH

更新日期：2020-12-14 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the major causes of mortality. ABT-263 is a newly synthesized, orally available Bcl-2/xL inhibitor that shows promising efficacy in HCC therapy. ABT-263 inhibits the anti-apoptotic activity of Bcl-2 and Bcl-xL, but not Mcl-1. Previous reports have shown that ABT-263 u...

journal_title：Molecular cancer

authors： Wang B,Ni Z,Dai X,Qin L,Li X,Xu L,Lian J,He F

更新日期：2014-04-30 00:00:00

abstract：BACKGROUND:The epithelial-to-mesenchymal transition (EMT) process results in a loss of cell-cell adhesion, increased cell mobility, and is crucial for enabling the metastasis of cancer cells. Recently, the enzyme SIRT1 has been implicated in a variety of physiological processes; however, its role in regulating oral can...

journal_title：Molecular cancer

authors： Chen IC,Chiang WF,Huang HH,Chen PF,Shen YY,Chiang HC

更新日期：2014-11-26 00:00:00

abstract：:Methionine aminopeptidase 2 (MetAP2) is a bifunctional protein that plays a critical role in the regulation of post-translational processing and protein synthesis. MetAP2 is overexpressed in human colon cancer. In this report we screened various MetAP2 inhibitors and treated HT29 cells with various concentrations of c...

journal_title：Molecular cancer

authors： Selvakumar P,Lakshmikuttyamma A,Das U,Pati HN,Dimmock JR,Sharma RK

更新日期：2009-08-24 00:00:00

abstract：BACKGROUND:Metastasis in medulloblastoma (MB) is associated with poor survival. Recent genetic studies revealed MB to comprise distinct molecular subgroups, including the sonic hedgehog (SHH) subgroup that exhibits a relatively high rate of progression. To identify targeted therapeutics against metastasis, a better und...

journal_title：Molecular cancer

authors： Yuan L,Zhang H,Liu J,Rubin JB,Cho YJ,Shu HK,Schniederjan M,MacDonald TJ

更新日期：2013-03-05 00:00:00

abstract：:The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms. Here, we review recent findings regarding chromatin modifications and their relevance to cancer. ...

journal_title：Molecular cancer

authors： Ducasse M,Brown MA

更新日期：2006-11-08 00:00:00

abstract：BACKGROUND:Platinum-containing chemotherapy produces specific DNA damage and is used to treat several human solid tumors. Tumors initially sensitive to platinum-based drugs frequently become resistant. Inhibition of DNA repair is a potential strategy to enhance cisplatin effectiveness. After cisplatin treatment, a bala...

journal_title：Molecular cancer

authors： Sand-Dejmek J,Adelmant G,Sobhian B,Calkins AS,Marto J,Iglehart DJ,Lazaro JB

更新日期：2011-06-16 00:00:00

abstract：BACKGROUND:MUC16 is a cell surface mucin expressed at high levels by epithelial ovarian tumors. Following proteolytic cleavage, cell surface MUC16 (csMUC16) is shed in the extracellular milieu and is detected in the serum of cancer patients as the tumor marker CA125. csMUC16 acts as an adhesion molecule and facilitates...

journal_title：Molecular cancer

authors： Belisle JA,Horibata S,Jennifer GA,Petrie S,Kapur A,André S,Gabius HJ,Rancourt C,Connor J,Paulson JC,Patankar MS

更新日期：2010-05-24 00:00:00

abstract：BACKGROUND:Anaplastic lymphoma kinase (ALK), which is a receptor tyrosine kinase, is essentially and transiently expressed in the developing nervous system. Recently, the deregulated expression of full-length ALK has been observed in some primary solid tumors, but little is known about its involvement in the tumorigene...

journal_title：Molecular cancer

authors： Inoue H,Hashimura M,Akiya M,Chiba R,Saegusa M

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:A maximum entropy approach is proposed to predict the cytotoxic effects of a panel of colchicine derivatives in several human cancer cell lines. Data was obtained from cytotoxicity assays performed with 21 drug molecules from the same family of colchicine compounds and correlate these results with independen...

journal_title：Molecular cancer

authors： Tseng CY,Mane JY,Winter P,Johnson L,Huzil T,Izbicka E,Luduena RF,Tuszynski JA

更新日期：2010-05-30 00:00:00

abstract：:Gene fusions occur in up to 17% of solid tumours. Oncogenic kinases are often involved in such fusions. In lung cancer, almost 30% of patients carrying an activated oncogene show the fusion of a tyrosine kinase to an heterologous gene. Several genes are partner in the fusion with the three kinases ALK, ROS1 and RET in...

journal_title：Molecular cancer

authors： Cerrato A,Visconti R,Celetti A

更新日期：2018-02-19 00:00:00

abstract：:The concept that vegetables and fruits are relevant sources of cancer-preventive substances is strongly supported by population studies. Among others, cruciferous vegetables like broccoli, cabbage, cauliflower and Brussels sprouts are thought to affect the development of various types of cancers and especially prostat...

journal_title：Molecular cancer

authors： Appendino G,Bardelli A

更新日期：2010-12-01 00:00:00

abstract：:Cells respond to hypoxia by shifting cellular processes from general housekeeping functions to activating specialized hypoxia-response pathways. Oxygen plays an important role in generating ATP to maintain a productive rate of protein synthesis in normoxia. In hypoxia, the rate of the canonical protein synthesis pathw...

journal_title：Molecular cancer

authors： Chee NT,Lohse I,Brothers SP

更新日期：2019-03-30 00:00:00

abstract：BACKGROUND:Lung cancer is the most lethal cancer and almost 90% of lung cancer is due to cigarette smoking. Even though nicotine, one of the major ingredients of cigarette smoke and the causative agent for addiction, is not a carcinogen by itself, several investigators have shown that nicotine can induce cell prolifera...

journal_title：Molecular cancer

authors： Puliyappadamba VT,Cheriyan VT,Thulasidasan AK,Bava SV,Vinod BS,Prabhu PR,Varghese R,Bevin A,Venugopal S,Anto RJ

更新日期：2010-08-20 00:00:00

abstract：BACKGROUND:The disruption of normal gene regulation due to microRNA dysfunction is a common event in cancer pathogenesis. MicroRNA-27b is an example of an oncogenic miRNA, and it is frequently upregulated in breast cancer. MicroRNAs have been found to deregulate tumor metabolism, which typically manifests as heightened...

journal_title：Molecular cancer

authors： Eastlack SC,Dong S,Ivan C,Alahari SK

更新日期：2018-07-16 00:00:00

abstract：:Live animal imaging is becoming an increasingly common technique for accurate and quantitative assessment of tumor burden over time. Bioluminescence imaging systems rely on a bioluminescent signal from tumor cells, typically generated from expression of the firefly luciferase gene. However, previous reports have sugge...

journal_title：Molecular cancer

authors： Tiffen JC,Bailey CG,Ng C,Rasko JE,Holst J

更新日期：2010-11-22 00:00:00

abstract：BACKGROUND:Perifosine, an alkylphospholipid tested in phase II clinical trials, modulates the extrinsic apoptotic pathway and cooperates with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to augment apoptosis. The current study focuses on revealing the mechanisms by which perifosine enhances TRAIL-ind...

journal_title：Molecular cancer

authors： Fu L,Lin YD,Elrod HA,Yue P,Oh Y,Li B,Tao H,Chen GZ,Shin DM,Khuri FR,Sun SY

更新日期：2010-12-20 00:00:00

abstract：BACKGROUND:Recent advances have revealed a significant contribution of chemokines and their receptors in tumor growth, survival after chemotherapy, and organ-specific metastasis. The CXC chemokine receptor-7 (CXCR7) is the latest chemokine receptor implicated in cancer. Although over expressed in breast cancer cell lin...

journal_title：Molecular cancer

authors： Salazar N,Muñoz D,Kallifatidis G,Singh RK,Jordà M,Lokeshwar BL

更新日期：2014-08-28 00:00:00

abstract：BACKGROUND:We have previously reported that expression of the Wnt antagonist genes SFRP1 and SFRP5 is frequently silenced by promoter hypermethylation in breast cancer. SFRP2 is a further Wnt inhibitor whose expression was recently found being downregulated in various malignancies. Here we investigated whether SFRP2 is...

journal_title：Molecular cancer

authors： Veeck J,Noetzel E,Bektas N,Jost E,Hartmann A,Knüchel R,Dahl E

更新日期：2008-11-06 00:00:00

abstract：BACKGROUND:Atypical adenomatous hyperplasia (AAH) and squamous cell dysplasia (SCD) are associated with the development of malignant lesions in the lung. Accurate diagnosis of AAH and SCD could facilitate earlier clinical intervention and provide useful information for assessing lung cancer risk in human populations. D...

journal_title：Molecular cancer

authors： Lowe FJ,Shen W,Zu J,Li J,Wang H,Zhang X,Zhong L

更新日期：2014-04-05 00:00:00

abstract：BACKGROUND:Fibroblast growth factors FGF-1 and FGF-2 are often upregulated in tumors, but tightly bound to heparan sulphate proteoglycans of the extracellular matrix (ECM). One mechanism of their bioactivation relies on the FGF-binding protein (FGF-BP) which, upon reversible binding to FGF-1 or -2, leads to their relea...

journal_title：Molecular cancer

authors： Schulze D,Plohmann P,Höbel S,Aigner A

更新日期：2011-11-23 00:00:00