Abstract:
:The concept that vegetables and fruits are relevant sources of cancer-preventive substances is strongly supported by population studies. Among others, cruciferous vegetables like broccoli, cabbage, cauliflower and Brussels sprouts are thought to affect the development of various types of cancers and especially prostate tumors. Yet, the identification of the molecular mechanisms by which the 'active' compounds contained in these vegetables mediate their anticancer activity has historically lagged behind. Accordingly, direct laboratory evidence of how individual nutrients affect cancer genes and the pathways they control remains the major obstacle to progress in this research field. Here we review a recent report investigating the interaction between sulforaphane, a dietary isothiocyanate derived from broccoli, and expression of the PTEN tumor suppressor gene in pre malignant prostate tissue.
journal_name
Mol Cancerjournal_title
Molecular cancerauthors
Appendino G,Bardelli Adoi
10.1186/1476-4598-9-308subject
Has Abstractpub_date
2010-12-01 00:00:00pages
308issn
1476-4598pii
1476-4598-9-308journal_volume
9pub_type
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