Potent anti-tumor effects of a dual specific oncolytic adenovirus expressing apoptin in vitro and in vivo.

abstract：BACKGROUND:MicroRNAs (miRNAs) are involved in cancer development and progression, acting as tumor suppressors or oncogenes. Our previous studies have revealed that miR-148a and miR-152 are significantly down-regulated in gastrointestinal cancers. Interestingly, miR-148b has the same "seed sequences" as miR-148a and miR...

journal_title：Molecular cancer

authors： Song YX,Yue ZY,Wang ZN,Xu YY,Luo Y,Xu HM,Zhang X,Jiang L,Xing CZ,Zhang Y

更新日期：2011-01-04 00:00:00

abstract：BACKGROUND:The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division. Deregulation of FOXM1 has been linked to a majority of human cancers. We previously showed that FOXM1 was upregulated in basal cell c...

journal_title：Molecular cancer

authors： Teh MT,Gemenetzidis E,Chaplin T,Young BD,Philpott MP

更新日期：2010-02-26 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide, and the biology of this cancer remains poorly understood. Recent evidence indicates that long non-coding RNAs (lncRNAs) are found to be dysregulated in a variety of cancers, including HCC. Taurine Up-regulated Gene...

journal_title：Molecular cancer

authors： Huang MD,Chen WM,Qi FZ,Sun M,Xu TP,Ma P,Shu YQ

更新日期：2015-09-04 00:00:00

abstract：:Since the publication of this work [1] and in response to a recent query that was brought to our attention in relation to the Western Blot in Figure 1(C) for NP2, protein lysates prepared around the same time as those presented in the manuscript in question, were run by SDS-PAGE under similar experimental conditions a...

journal_title：Molecular cancer

authors： Barr MP,Gray SG,Gately K,Hams E,Fallon PG,Davies AM,Richard DJ,Pidgeon GP,O'Byrne KJ

更新日期：2020-01-27 00:00:00

abstract：BACKGROUND:Medulloblastoma is the most common type of malignant brain tumor that afflicts children. Although recent advances in chemotherapy and radiation have improved outcomes, high-risk patients do poorly with significant morbidity. METHODS:To identify new molecular targets, we performed an integrated genomic analy...

journal_title：Molecular cancer

authors： Harris PS,Venkataraman S,Alimova I,Birks DK,Balakrishnan I,Cristiano B,Donson AM,Dubuc AM,Taylor MD,Foreman NK,Reigan P,Vibhakar R

更新日期：2014-03-24 00:00:00

abstract：:Several studies of tumors have revealed substantial numbers of clonally expanded somatic mutations in mitochondrial DNA (mtDNA), not observed in adjacent intact tissues. These findings were interpreted as indicating the involvement of mtDNA mutations in tumorigenesis. Such comparisons, however, ignore an important con...

journal_title：Molecular cancer

authors： Khaidakov M,Shmookler Reis RJ

更新日期：2005-09-13 00:00:00

abstract：:Recent advances in diagnosis and treatment are enabling a more targeted approach to treating lung cancers. Therapy targeting the specific oncogenic driver mutation could inhibit tumor progression and provide a favorable prognosis in clinical practice. Activating mutations of epidermal growth factor receptor (EGFR) in ...

journal_title：Molecular cancer

authors： Wu SG,Shih JY

更新日期：2018-02-19 00:00:00

abstract：BACKGROUND:The pre-leukemia transcription factor 3 (PBX) is part of the PBX family of transcription factors, which is known to regulate genes involved in differentiation of urogenital organs and steroidogenesis. This is of interest with regard to prostate cancer progression as regulation of steroidogenesis is one of th...

journal_title：Molecular cancer

authors： Ramberg H,Alshbib A,Berge V,Svindland A,Taskén KA

更新日期：2011-05-06 00:00:00

abstract：BACKGROUND:The exposure of skin keratinocytes to Ultraviolet (UV) irradiation leads to Akt phosphorylation at Ser-473, which is important for the carcinogenic effects of excessive sun exposure. The present study investigated the underlying mechanism of Akt Ser-473 phosphorylation by UVB radiation. RESULTS:We found tha...

journal_title：Molecular cancer

authors： Tu Y,Ji C,Yang B,Yang Z,Gu H,Lu CC,Wang R,Su ZL,Chen B,Sun WL,Xia JP,Bi ZG,He L

更新日期：2013-12-24 00:00:00

abstract：BACKGROUND:High expression of the long non-coding RNA nuclear-enriched abundant transcript 1 (NEAT1) in whole blood has been reported in colorectal cancer patients; however, its' clinical significance and origin are unclear. We evaluated the diagnostic and prognostic value, and origin of whole blood NEAT1 in colorectal...

journal_title：Molecular cancer

authors： Wu Y,Yang L,Zhao J,Li C,Nie J,Liu F,Zhuo C,Zheng Y,Li B,Wang Z,Xu Y

更新日期：2015-11-09 00:00:00

abstract：BACKGROUND:Survivin is a dual function protein. It inhibits the apoptosis of cells by inhibiting caspases, and also promotes cell growth by stabilizing microtubules during mitosis. Over-expression of survivin has been demonstrated to induce drug-resistance to various chemo-therapeutic agents such as cisplatin (DNA dama...

journal_title：Molecular cancer

authors： Cheung CH,Chen HH,Kuo CC,Chang CY,Coumar MS,Hsieh HP,Chang JY

更新日期：2009-07-03 00:00:00

abstract：BACKGROUND:Alterations of chromosome 8 and hypomethylation of LINE-1 retrotransposons are common alterations in advanced prostate carcinoma. In a former study including many metastatic cases, they strongly correlated with each other. To elucidate a possible interaction between the two alterations, we investigated their...

journal_title：Molecular cancer

authors： Schulz WA,Alexa A,Jung V,Hader C,Hoffmann MJ,Yamanaka M,Fritzsche S,Wlazlinski A,Müller M,Lengauer T,Engers R,Florl AR,Wullich B,Rahnenführer J

更新日期：2007-02-05 00:00:00

abstract：BACKGROUND:Metastasis in medulloblastoma (MB) is associated with poor survival. Recent genetic studies revealed MB to comprise distinct molecular subgroups, including the sonic hedgehog (SHH) subgroup that exhibits a relatively high rate of progression. To identify targeted therapeutics against metastasis, a better und...

journal_title：Molecular cancer

authors： Yuan L,Zhang H,Liu J,Rubin JB,Cho YJ,Shu HK,Schniederjan M,MacDonald TJ

更新日期：2013-03-05 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignant tumours with a poor prognosis worldwide. While early stage tumours can be treated with curative approaches such as liver transplantation or surgical resection, these are only suitable for a minority of patients. Those with advanced stage disease are on...

journal_title：Molecular cancer

authors： Huo X,Han S,Wu G,Latchoumanin O,Zhou G,Hebbard L,George J,Qiao L

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:Although both circular RNAs (circRNAs) and autophagy are associated with the function of breast cancer (BC), whether circRNAs regulate BC progression via autophagy remains unknown. In this study, we aim to explore the regulatory mechanisms and the clinical significance of autophagy-associated circRNAs in BC....

journal_title：Molecular cancer

authors： Liang G,Ling Y,Mehrpour M,Saw PE,Liu Z,Tan W,Tian Z,Zhong W,Lin W,Luo Q,Lin Q,Li Q,Zhou Y,Hamai A,Codogno P,Li J,Song E,Gong C

更新日期：2020-03-25 00:00:00

abstract：BACKGROUND:We previously identified TrkB as an oncogene involved in promoting metastasis in endometrial carcinoma (EC). Here, we sought to delineate the effect of changes in TrkB expression on the global profile of microRNAs (miRNAs) in EC cells and further investigated the correlation between the expression of certain...

journal_title：Molecular cancer

authors： Bao W,Wang HH,Tian FJ,He XY,Qiu MT,Wang JY,Zhang HJ,Wang LH,Wan XP

更新日期：2013-12-09 00:00:00

abstract：BACKGROUND:In recent years, circular RNAs (circRNAs), a new star of non-coding RNA, have been emerged as vital regulators and gained much attention for involvement of initiation and progression of diverse kinds of human diseases, especially cancer. However, regulatory role, clinical significance and underlying mechanis...

journal_title：Molecular cancer

authors： Yang R,Xing L,Zheng X,Sun Y,Wang X,Chen J

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:Changes in glycogen metabolism is an essential feature among the various metabolic adaptations used by cancer cells to adjust to the conditions imposed by the tumor microenvironment. Our previous study showed that glycogen branching enzyme (GBE1) is downstream of the HIF1 pathway in hypoxia-conditioned lung ...

journal_title：Molecular cancer

authors： Li L,Yang L,Cheng S,Fan Z,Shen Z,Xue W,Zheng Y,Li F,Wang D,Zhang K,Lian J,Wang D,Zhu Z,Zhao J,Zhang Y

更新日期：2019-06-20 00:00:00

abstract：:Autophagy is a highly conserved catabolic process that mediates degradation of pernicious or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and organelles. It can promote or suppress tumor development, so it is a "double-edged sword" in tumors that depends on the cell and tissue typ...

journal_title：Molecular cancer

authors： Chen HT,Liu H,Mao MJ,Tan Y,Mo XQ,Meng XJ,Cao MT,Zhong CY,Liu Y,Shan H,Jiang GM

更新日期：2019-05-24 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) is highly invasive and aggressive and lacks specific molecular targets to improve the prognosis. MiR-25-3p promotes proliferation of many tumors and its role and underlying mechanisms in TNBC remain to be well elucidated. METHODS:Differential expression of miR-25-3p in T...

journal_title：Molecular cancer

authors： Chen H,Pan H,Qian Y,Zhou W,Liu X

更新日期：2018-01-08 00:00:00

abstract：BACKGROUND:Constitutive activation of signal transducer and activator of transcription 3 (STAT3) has been linked with proliferation, survival, invasion and angiogenesis of a variety of human cancer cells, including hepatocellular carcinoma (HCC). Thus, novel agents that can suppress STAT3 activation have potential for ...

journal_title：Molecular cancer

authors： Sethi G,Chatterjee S,Rajendran P,Li F,Shanmugam MK,Wong KF,Kumar AP,Senapati P,Behera AK,Hui KM,Basha J,Natesh N,Luk JM,Kundu TK

更新日期：2014-03-21 00:00:00

abstract：BACKGROUND:SLC/CCL21, normally expressed in high endothelial venules and in T cell zones of spleen and lymph nodes, strongly attracts T cells and dendritic cells (DC). We have previously shown that SLC/CCL21-mediated anti-tumor responses are accompanied by significant induction of IFNgamma and the CXC chemokines, monok...

journal_title：Molecular cancer

authors： Sharma S,Yang SC,Hillinger S,Zhu LX,Huang M,Batra RK,Lin JF,Burdick MD,Strieter RM,Dubinett SM

更新日期：2003-04-15 00:00:00

abstract：BACKGROUND:Reactive oxygen species contribute to normal thyroid function. The NRF2 oxidative response pathway is frequently and constitutively activated in multiple tumor types, including papillary thyroid carcinoma (PTC). Genetic mechanisms underlying NRF2 pathway activation in PTC are not fully understood. Thus, we a...

journal_title：Molecular cancer

authors： Martinez VD,Vucic EA,Pikor LA,Thu KL,Hubaux R,Lam WL

更新日期：2013-10-20 00:00:00

abstract：BACKGROUND:PP2Calpha is the representative member of the type 2C family of protein phosphatases, and it has recently been implicated in the regulation of p53-, TGFbeta-, cyclin-dependent kinase- and apoptosis-signaling. To investigate the role of PP2Calpha in cell growth and in radio- and chemosensitivity, wild type an...

journal_title：Molecular cancer

authors： Lammers T,Peschke P,Ehemann V,Debus J,Slobodin B,Lavi S,Huber P

更新日期：2007-10-17 00:00:00

abstract：BACKGROUND:CD44 is considered as 'a' metastasis associated gene, despite the fact that it is an umbrella term for a group of molecules produced from a single gene by alternative splicing. However, little consideration is given to the above in the literature of colorectal carcinomas as well as other tumour types, leadin...

journal_title：Molecular cancer

authors： Bánky B,Rásó-Barnett L,Barbai T,Tímár J,Becságh P,Rásó E

更新日期：2012-11-14 00:00:00

abstract：BACKGROUND:Glycochenodeoxycholate (GCDA) is one of the major human bile salts. Bile salts stimulate cell survival and proliferation through the mitogen-activated protein kinase, but the downstream signaling mechanism(s) remains enigmatic. Mcl-1 is an antiapoptotic molecule of the Bcl2 family that is extensively overexp...

journal_title：Molecular cancer

authors： Liao M,Zhao J,Wang T,Duan J,Zhang Y,Deng X

更新日期：2011-04-20 00:00:00

abstract：:The early diagnosis of pancreatic cancer, as well as distinguishing between chronic pancreatitis and malignant pancreatic disease, remains still a clinical problem. Presently, there is no specific tumor marker for diagnosing pancreatic cancer. Mucin-associated marker like CA 19-9 are the most widely available pancreat...

journal_title：Molecular cancer

authors： Ringel J,Löhr M

更新日期：2003-01-07 00:00:00

abstract：:Although solid tumors comprise malignant cells, they also contain many different non-malignant cell types in their micro-environment. The cellular components of the tumor stroma consist of immune and endothelial cells combined with a heterogeneous population of stromal cells which include cancer-associated fibroblasts...

journal_title：Molecular cancer

authors： Plava J,Cihova M,Burikova M,Matuskova M,Kucerova L,Miklikova S

更新日期：2019-03-30 00:00:00

abstract：BACKGROUND:Metastasis accounts for the majority of deaths from cancer. Although tumor microenvironment has been shown to have a significant impact on the initiation and/or promotion of metastasis, the mechanism remains elusive. We previously reported that HCT-8 colon cancer cells underwent a phenotypic transition from ...

journal_title：Molecular cancer

authors： Tang X,Kuhlenschmidt TB,Li Q,Ali S,Lezmi S,Chen H,Pires-Alves M,Laegreid WW,Saif TA,Kuhlenschmidt MS

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear hormone receptor superfamily and is highly expressed in many human tumors including breast cancer. PPARgamma has been identified as a potential target for breast cancer therapy based on the fact that its activation by syn...

journal_title：Molecular cancer

authors： Zaytseva YY,Wang X,Southard RC,Wallis NK,Kilgore MW

更新日期：2008-12-05 00:00:00