Correction to: Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer.

abstract：BACKGROUND:The human microbial pathogen Helicobacter pylori resides in the stomach of about fifty percent of the world's population and represents a risk factor for chronic gastritis, peptic ulcers and, in rare cases, gastric cancer. Alterations of the Wnt/beta-catenin signaling pathway have been described in almost ev...

journal_title：Molecular cancer

authors： Gnad T,Feoktistova M,Leverkus M,Lendeckel U,Naumann M

更新日期：2010-02-05 00:00:00

abstract：BACKGROUND:Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear hormone receptor superfamily and is highly expressed in many human tumors including breast cancer. PPARgamma has been identified as a potential target for breast cancer therapy based on the fact that its activation by syn...

journal_title：Molecular cancer

authors： Zaytseva YY,Wang X,Southard RC,Wallis NK,Kilgore MW

更新日期：2008-12-05 00:00:00

abstract：BACKGROUND:The tetraspanin CD63 is a highly N-glycosylated protein that is known to regulate cancer malignancy. However, the contribution of glycosylation of CD63 to cancer malignancy remains unclear. Previously, we reported that ribophorin II (RPN2), which is part of an N-oligosaccharyle transferase complex, is respon...

journal_title：Molecular cancer

authors： Tominaga N,Hagiwara K,Kosaka N,Honma K,Nakagama H,Ochiya T

更新日期：2014-05-31 00:00:00

abstract：BACKGROUND:In previously published studies, oncolytic adenovirus-mediated gene therapy has produced good results in targeting cancer cells. However, safety and efficacy, the two most important aspects in cancer therapy, remain serious challenges. The specific expression or deletion of replication related genes in an ad...

journal_title：Molecular cancer

authors： Xu HN,Huang WD,Cai Y,Ding M,Gu JF,Wei N,Sun LY,Cao X,Li HG,Zhang KJ,Liu XR,Liu XY

更新日期：2011-11-01 00:00:00

abstract：:Cancer has become a major health issue worldwide, contributing to a high mortality rate. Tumor metastasis is attributed to the death of most patients. Epithelial-to-mesenchymal transition (EMT) plays a vital role in inducing metastasis. During EMT, epithelial cells lose their characteristics, such as cell-to-cell adhe...

journal_title：Molecular cancer

authors： Shang BQ,Li ML,Quan HY,Hou PF,Li ZW,Chu SF,Zheng JN,Bai J

更新日期：2019-09-16 00:00:00

abstract：BACKGROUND:Many human cancer cells express filamin A (FLNA), an actin-binding structural protein that interacts with a diverse set of cell signaling proteins, but little is known about the biological importance of FLNA in tumor development. FLNA is also expressed in endothelial cells, which may be important for tumor a...

journal_title：Molecular cancer

authors： Nallapalli RK,Ibrahim MX,Zhou AX,Bandaru S,Sunkara SN,Redfors B,Pazooki D,Zhang Y,Borén J,Cao Y,Bergo MO,Akyürek LM

更新日期：2012-08-02 00:00:00

abstract：BACKGROUND:To clarify the implications of cell-free nucleic acids (cfNA) in the plasma in neoplastic disease, it is necessary to determine the kinetics of their release into the circulation. METHODS:To quantify non-tumor and tumor DNA and RNA in the plasma of tumor-bearing rats and to correlate such levels with tumor ...

journal_title：Molecular cancer

authors： García-Olmo DC,Picazo MG,Toboso I,Asensio AI,García-Olmo D

更新日期：2013-02-04 00:00:00

abstract：BACKGROUND:Anaplastic lymphoma kinase (ALK), which is a receptor tyrosine kinase, is essentially and transiently expressed in the developing nervous system. Recently, the deregulated expression of full-length ALK has been observed in some primary solid tumors, but little is known about its involvement in the tumorigene...

journal_title：Molecular cancer

authors： Inoue H,Hashimura M,Akiya M,Chiba R,Saegusa M

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:Deregulated circular RNAs (circRNAs) are associated with the development of cancer and therapy resistance. However, functional research of circRNAs mostly focus on potential miRNA or protein binding and more potential regulation of circRNA on host gene DNA in cancers are yet to be inspected. METHOD:We perfo...

journal_title：Molecular cancer

authors： Xu X,Zhang J,Tian Y,Gao Y,Dong X,Chen W,Yuan X,Yin W,Xu J,Chen K,He C,Wei L

更新日期：2020-08-24 00:00:00

abstract：:Sema4D, also known as CD100, is a protein belonging to class IV semaphorin. Its physiologic roles in the immune and nervous systems have been extensively explored. However, the roles of Sema4D have extended beyond these traditionally studied territories. Via interaction with its high affinity receptor Plexin-B1, Sema4...

journal_title：Molecular cancer

authors： Ch'ng ES,Kumanogoh A

更新日期：2010-09-21 00:00:00

abstract：BACKGROUND:Epigenetic control is essential for maintenance of tissue hierarchy and correct differentiation. In cancer, this hierarchical structure is altered and epigenetic control deregulated, but the relationship between these two phenomena is still unclear. CD133 is a marker for adult stem cells in various tissues a...

journal_title：Molecular cancer

authors： Pellacani D,Packer RJ,Frame FM,Oldridge EE,Berry PA,Labarthe MC,Stower MJ,Simms MS,Collins AT,Maitland NJ

更新日期：2011-07-29 00:00:00

abstract：:The concept that vegetables and fruits are relevant sources of cancer-preventive substances is strongly supported by population studies. Among others, cruciferous vegetables like broccoli, cabbage, cauliflower and Brussels sprouts are thought to affect the development of various types of cancers and especially prostat...

journal_title：Molecular cancer

authors： Appendino G,Bardelli A

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Recognition of pathogens by immune receptors leads to activation of macrophages, dendritic cells, and lymphocytes. Signals are communicated to enhance expression of target molecules such as cytokines and adhesion molecules, depending on activation of various inducible transcription factors, among which the f...

journal_title：Molecular cancer

authors： Kracklauer MP,Schmidt C

更新日期：2003-11-05 00:00:00

abstract：BACKGROUND:Phospholipid phosphatase 4 (PPAPDC1A or PLPP4) has been demonstrated to be involved in the malignant process of many cancers. The purpose of this study was to investigate the clinical significance and biological roles of PLPP4 in lung carcinoma. METHODS:PLPP4 expression was examined in 8 paired lung carcino...

journal_title：Molecular cancer

authors： Zhang X,Zhang L,Lin B,Chai X,Li R,Liao Y,Deng X,Liu Q,Yang W,Cai Y,Zhou W,Lin Z,Huang W,Zhong M,Lei F,Wu J,Yu S,Li X,Li S,Li Y,Zeng J,Long W,Ren D,Huang Y

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:Glioblastomas (GBM) continue to remain one of the most dreaded tumours that are highly infiltrative in nature and easily preclude comprehensive surgical resection. GBMs pose an intricate etiology as they are being associated with a plethora of genetic and epigenetic lesions. Misregulation of the PI3 kinase p...

journal_title：Molecular cancer

authors： Nawaz Z,Patil V,Paul Y,Hegde AS,Arivazhagan A,Santosh V,Somasundaram K

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:CD95 is a death receptor controlling not only apoptotic pathways but also activating mechanisms promoting tumor growth. During the acquisition of chemoresistance to oxaliplatin there is a progressive loss of CD95 expression in colon cancer cells and a decreased ability of this receptor to induce cell death. ...

journal_title：Molecular cancer

authors： Ametller E,García-Recio S,Costamagna D,Mayordomo C,Fernández-Nogueira P,Carbó N,Pastor-Arroyo EM,Gascón P,Almendro V

更新日期：2010-06-23 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant diseases worldwide. It is refractory to conventional treatments, and consequently has a documented 5-year survival rate as low as 7%. Increasing evidence indicates that activated pancreatic stellate cells (PSCs), one of the stromal components ...

journal_title：Molecular cancer

authors： Fu Y,Liu S,Zeng S,Shen H

更新日期：2018-02-19 00:00:00

abstract：BACKGROUND:Zebrafish have been used as a vertebrate model to study human cancers such as melanoma, rhabdomyosarcoma, liver cancer, and leukemia as well as for high-throughput screening of small molecules of therapeutic value. However, they are just emerging as a model for human brain tumors, which are among the most de...

journal_title：Molecular cancer

authors： Ju B,Chen W,Orr BA,Spitsbergen JM,Jia S,Eden CJ,Henson HE,Taylor MR

更新日期：2015-02-03 00:00:00

abstract：BACKGROUND:The tumor cell lysate-pulsed, dendritic cell (DC)-based cancer vaccine approaches are being actively evaluated for application to cancer immunotherapy, hopefully at a personalized medicine base. There is apparently an emerging technical problem however, the lack of highly efficacious potency in activation of...

journal_title：Molecular cancer

authors： Lin TJ,Lin HT,Chang WT,Mitapalli S P,Hsiao PW,Yin SY,Yang NS

更新日期：2015-09-24 00:00:00

abstract：BACKGROUND:Sharing the common neuroectodermal origin, melanoma and neuroblastoma are tumors widely diffused among adult and children, respectively. Clinical prognosis of aggressive neuroectodermal cancers remains dismal, therefore the search for novel therapies against such tumors is warranted. Curcumin is a phytochemi...

journal_title：Molecular cancer

authors： Pisano M,Pagnan G,Dettori MA,Cossu S,Caffa I,Sassu I,Emionite L,Fabbri D,Cilli M,Pastorino F,Palmieri G,Delogu G,Ponzoni M,Rozzo C

更新日期：2010-06-03 00:00:00

abstract：BACKGROUND:N6-methyladenosine (m6A) emerges as one of the most important modification of RNA. Bladder cancer is a common cancer type in developed countries, and hundreds of thousands of bladder cancer patients die every year. MATERIALS AND METHODS:There are various cells in bladder tumor bulk, and a small population c...

journal_title：Molecular cancer

authors： Gu C,Wang Z,Zhou N,Li G,Kou Y,Luo Y,Wang Y,Yang J,Tian F

更新日期：2019-11-25 00:00:00

abstract：BACKGROUND:Insulin enhancer binding protein-1 (ISL-1), a LIM-homeodomain transcription factor, is essential for the heart, motor neuron and pancreas development. Recently, ISL-1 has been found in some types of human cancers. However, how ISL-1 exerts the role in tumor development is not clear. METHODS AND RESULTS:The ...

journal_title：Molecular cancer

authors： Zhang Q,Yang Z,Jia Z,Liu C,Guo C,Lu H,Chen P,Ma K,Wang W,Zhou C

更新日期：2014-07-29 00:00:00

abstract：BACKGROUND:METTL3 is known to be involved in all stages in the life cycle of RNA. It affects the tumor formation by the regulation the m6A modification in the mRNAs of critical oncogenes or tumor suppressors. In bladder cancer, METTL3 could promote the bladder cancer progression via AFF4/NF-κB/MYC signaling network by ...

journal_title：Molecular cancer

authors： Han J,Wang JZ,Yang X,Yu H,Zhou R,Lu HC,Yuan WB,Lu JC,Zhou ZJ,Lu Q,Wei JF,Yang H

更新日期：2019-06-22 00:00:00

abstract：BACKGROUND:Glycochenodeoxycholate (GCDA) is one of the major human bile salts. Bile salts stimulate cell survival and proliferation through the mitogen-activated protein kinase, but the downstream signaling mechanism(s) remains enigmatic. Mcl-1 is an antiapoptotic molecule of the Bcl2 family that is extensively overexp...

journal_title：Molecular cancer

authors： Liao M,Zhao J,Wang T,Duan J,Zhang Y,Deng X

更新日期：2011-04-20 00:00:00

abstract：BACKGROUND:The Ras-association family (RASSF) of tumour suppressor genes (TSGs) contains 10 members that encode proteins containing Ras-association (RA) domains. Several members of the RASSF family are frequently epigenetically inactivated in cancer, however, their role in leukaemia has remained largely uninvestigated....

journal_title：Molecular cancer

authors： Hesson LB,Dunwell TL,Cooper WN,Catchpoole D,Brini AT,Chiaramonte R,Griffiths M,Chalmers AD,Maher ER,Latif F

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Reovirus type 3 Dearing strain (ReoT3D) has an inherent propensity to preferentially infect and destroy cancer cells. The oncolytic activity of ReoT3D as a single agent has been demonstrated in vitro and in vivo against various cancers, including colon, pancreatic, ovarian and breast cancers. Its human safet...

journal_title：Molecular cancer

authors： Sei S,Mussio JK,Yang QE,Nagashima K,Parchment RE,Coffey MC,Shoemaker RH,Tomaszewski JE

更新日期：2009-07-14 00:00:00

abstract：:Exosomes are extracellular vesicles released by many cell types and have been attributed for their roles in many diseases including cancer. Exosomes secreted by tumor cells and stromal cells are critical mediators of intercellular communication in tumor microenvironments. Long noncoding RNAs (lncRNAs) are selectively ...

journal_title：Molecular cancer

authors： Sun Z,Yang S,Zhou Q,Wang G,Song J,Li Z,Zhang Z,Xu J,Xia K,Chang Y,Liu J,Yuan W

更新日期：2018-04-20 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary tumor in the central nervous system. One of the most widely used chemotherapeutic drugs for GBM is temozolomide, which is a DNA-alkylating agent and its efficacy is dependent on MGMT methylation status. Little progress in improving the p...

journal_title：Molecular cancer

authors： Zhao HF,Wang J,Shao W,Wu CP,Chen ZP,To ST,Li WP

更新日期：2017-06-07 00:00:00

abstract：BACKGROUND:Sorafenib, a kinase inhibitor active against various solid tumours, induces oxidative stress and ferroptosis, a new form of oxidative necrosis, in some cancer cells. Clinically-applicable biomarkers that reflect the impact of sorafenib on the redox metabolism of cancer cells are lacking. METHODS:We used gen...

journal_title：Molecular cancer

authors： Houessinon A,François C,Sauzay C,Louandre C,Mongelard G,Godin C,Bodeau S,Takahashi S,Saidak Z,Gutierrez L,Régimbeau JM,Barget N,Barbare JC,Ganne N,Chauffert B,Coriat R,Galmiche A

更新日期：2016-05-16 00:00:00

abstract：:Cell lines are still a tool of choice for many fields of biomedical research, including oncology. Although cancer is a very complex disease, many discoveries have been made using monocultures of established cell lines. Therefore, the proper use of in vitro models is crucial to enhance our understanding of cancer. Ther...

journal_title：Molecular cancer

authors： Brodaczewska KK,Szczylik C,Fiedorowicz M,Porta C,Czarnecka AM

更新日期：2016-12-19 00:00:00