Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled.

abstract：BACKGROUND:Though esophageal cancer is three to four times more common among males than females worldwide, this type of cancer still ranks in the top incidence among women, even more than the female specific cancer types. The occurrence is currently attributed to extrinsic factors, including tobacco use and alcohol con...

journal_title：Molecular cancer

authors： Li W,Zhang L,Guo B,Deng J,Wu S,Li F,Wang Y,Lu J,Zhou Y

更新日期：2019-02-08 00:00:00

abstract：BACKGROUND:Darpp-32 and t-Darpp are expressed in several forms of breast cancer. Both are transcribed from the gene PPP1R1B via alternative promoters. In humans, Darpp-32 is expressed in both normal and malignant breast tissue, whereas t-Darpp has only been found in malignant breast tissue. The exact biological functio...

journal_title：Molecular cancer

authors： Christenson JL,Kane SE

更新日期：2014-08-15 00:00:00

abstract：BACKGROUND:ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin motifs) is a member of the ADAMTS family of metalloproteases. Here, we investigated mRNA and protein levels of ADAMTS-1 in normal and neoplastic tissues using qPCR, immunohistochemistry and immunoblot analyses, and we addressed the role of ADAMT...

journal_title：Molecular cancer

authors： Freitas VM,do Amaral JB,Silva TA,Santos ES,Mangone FR,Pinheiro Jde J,Jaeger RG,Nagai MA,Machado-Santelli GM

更新日期：2013-01-05 00:00:00

abstract：BACKGROUND:Inactivation of the Fanconi anemia (FA) pathway through defects in one of 13 FA genes occurs at low frequency in various solid cancer entities among the general population. As FA pathway inactivation confers a distinct hypersensitivity towards DNA interstrand-crosslinking (ICL)-agents, FA defects represent r...

journal_title：Molecular cancer

authors： Palagyi A,Neveling K,Plinninger U,Ziesch A,Targosz BS,Denk GU,Ochs S,Rizzani A,Meier D,Thasler WE,Hanenberg H,De Toni EN,Bassermann F,Schäfer C,Göke B,Schindler D,Gallmeier E

更新日期：2010-05-28 00:00:00

abstract：BACKGROUND:miR-139-5p was identified to be significantly down-regulated in colon tumor tissues by miRNA array. We aimed to clarify its biological function, molecular mechanisms and direct target gene in colorectal cancer (CRC). METHODS:The biological function of miR-139-5p was examined by cell growth, cell cycle and a...

journal_title：Molecular cancer

authors： Zhang L,Dong Y,Zhu N,Tsoi H,Zhao Z,Wu CW,Wang K,Zheng S,Ng SS,Chan FK,Sung JJ,Yu J

更新日期：2014-05-26 00:00:00

abstract：BACKGROUND:Although the prognosis of gastric cancer patients have a favorable progression, there are some patients with unusual patterns of locoregional and systemic recurrence. Therefore, a better understanding of early molecular events of the disease is needed. Current evidences demonstrate that long noncoding RNAs (...

journal_title：Molecular cancer

authors： Liu YW,Xia R,Lu K,Xie M,Yang F,Sun M,De W,Wang C,Ji G

更新日期：2017-02-16 00:00:00

abstract：BACKGROUND:Breast cancer is the second leading cause of cancer related deaths among females worldwide. Berbamine (BER), a kind of bis-benzylisoquinoline alkaloid, has been used to treat clinical patients with inflammation and cancer for many years in China. The purpose of this study is to investigate the activity of BE...

journal_title：Molecular cancer

authors： Wang S,Liu Q,Zhang Y,Liu K,Yu P,Liu K,Luan J,Duan H,Lu Z,Wang F,Wu E,Yagasaki K,Zhang G

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:In addition to androgens, growth factors are also implicated in the development and neoplastic growth of the prostate gland. Prosaposin is a potent neurotrophic molecule. Homozygous inactivation of prosaposin in mice has led to the development of a number of abnormalities in the male reproductive system, inc...

journal_title：Molecular cancer

authors： Lee TJ,Sartor O,Luftig RB,Koochekpour S

更新日期：2004-11-17 00:00:00

abstract：:Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) are heterogenous vesicles formed by budding of the cellular membrane, which are secreted in larger amounts by ...

journal_title：Molecular cancer

authors： Bian X,Xiao YT,Wu T,Yao M,Du L,Ren S,Wang J

更新日期：2019-03-30 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with high morbidity and mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation and related mechanisms has led researchers to focus on the microenvironment where pancreatic cancers develop. The anomalous proliferation ...

journal_title：Molecular cancer

authors： Thomas D,Radhakrishnan P

更新日期：2019-01-21 00:00:00

abstract：BACKGROUND:Metastatic renal cell carcinoma (RCC) remains the leading cause of mortality in patients with clear cell RCC arising from mutations in the von Hippel Lindau (VHL) tumor suppressor. Successful RCC tumor suppression by VHL requires the negative regulation of hypoxia inducible factor alpha (HIF alpha) protein a...

journal_title：Molecular cancer

authors： Petrella BL,Brinckerhoff CE

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:SOX2, a high mobility group (HMG)-box containing transcription factor, is a key regulator during development of the nervous system and a persistent marker of neural stem cells. Recent studies suggested a role of SOX2 in tumor progression. In our previous work we detected SOX2 in glioma cells and glioblastoma...

journal_title：Molecular cancer

authors： Oppel F,Müller N,Schackert G,Hendruschk S,Martin D,Geiger KD,Temme A

更新日期：2011-11-09 00:00:00

abstract：:Since the publication of this work [1] and in response to a recent query that was brought to our attention in relation to the Western Blot in Figure 1(C) for NP2, protein lysates prepared around the same time as those presented in the manuscript in question, were run by SDS-PAGE under similar experimental conditions a...

journal_title：Molecular cancer

authors： Barr MP,Gray SG,Gately K,Hams E,Fallon PG,Davies AM,Richard DJ,Pidgeon GP,O'Byrne KJ

更新日期：2020-01-27 00:00:00

abstract：BACKGROUND:The Sonic hedgehog (Shh) signaling pathway plays an important role in cerebellar development, and mutations leading to hyperactive Shh signaling have been associated with certain forms of medulloblastoma, a common form of pediatric brain cancer. While the fundamentals of this pathway are known, the molecular...

journal_title：Molecular cancer

authors： Lee SJ,Litan A,Li Z,Graves B,Lindsey S,Barwe SP,Langhans SA

更新日期：2015-08-19 00:00:00

abstract：BACKGROUND:Recognition of pathogens by immune receptors leads to activation of macrophages, dendritic cells, and lymphocytes. Signals are communicated to enhance expression of target molecules such as cytokines and adhesion molecules, depending on activation of various inducible transcription factors, among which the f...

journal_title：Molecular cancer

authors： Kracklauer MP,Schmidt C

更新日期：2003-11-05 00:00:00

abstract：:Bortezomib is a novel anti-cancer agent which has shown promising activity in non-small lung cancer (NSCLC) patients. However, only a subset of patients respond to this treatment. We show that NSCLC cell lines are differentially sensitive to bortezomib, IC50 values ranging from 5 to 83 nM. The apoptosis-inducing poten...

journal_title：Molecular cancer

authors： Voortman J,Checińska A,Giaccone G

更新日期：2007-11-17 00:00:00

abstract：BACKGROUND:Constitutive activation of signal transducer and activator of transcription 3 (STAT3) has been linked with proliferation, survival, invasion and angiogenesis of a variety of human cancer cells, including hepatocellular carcinoma (HCC). Thus, novel agents that can suppress STAT3 activation have potential for ...

journal_title：Molecular cancer

authors： Sethi G,Chatterjee S,Rajendran P,Li F,Shanmugam MK,Wong KF,Kumar AP,Senapati P,Behera AK,Hui KM,Basha J,Natesh N,Luk JM,Kundu TK

更新日期：2014-03-21 00:00:00

abstract：BACKGROUND:To clarify the implications of cell-free nucleic acids (cfNA) in the plasma in neoplastic disease, it is necessary to determine the kinetics of their release into the circulation. METHODS:To quantify non-tumor and tumor DNA and RNA in the plasma of tumor-bearing rats and to correlate such levels with tumor ...

journal_title：Molecular cancer

authors： García-Olmo DC,Picazo MG,Toboso I,Asensio AI,García-Olmo D

更新日期：2013-02-04 00:00:00

abstract：BACKGROUND:Tumor spreading is the major threat for cancer patients. The recently published anti-cancer drug salinomycin raised hope for an improved treatment by targeting therapy-refractory cancer stem cells. However, an unambiguous role of salinomycin against cancer cell migration and metastasis formation remains elus...

journal_title：Molecular cancer

authors： Kopp F,Hermawan A,Oak PS,Herrmann A,Wagner E,Roidl A

更新日期：2014-01-27 00:00:00

abstract：:IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evid...

journal_title：Molecular cancer

authors： Christopoulos PF,Msaouel P,Koutsilieris M

更新日期：2015-02-15 00:00:00

abstract：BACKGROUND:MUC16 is a cell surface mucin expressed at high levels by epithelial ovarian tumors. Following proteolytic cleavage, cell surface MUC16 (csMUC16) is shed in the extracellular milieu and is detected in the serum of cancer patients as the tumor marker CA125. csMUC16 acts as an adhesion molecule and facilitates...

journal_title：Molecular cancer

authors： Belisle JA,Horibata S,Jennifer GA,Petrie S,Kapur A,André S,Gabius HJ,Rancourt C,Connor J,Paulson JC,Patankar MS

更新日期：2010-05-24 00:00:00

abstract：:MicroRNAs (miRNAs) are emerging as central players in shaping the biology of the Tumor Microenvironment (TME). They do so both by modulating their expression levels within the different cells of the TME and by being shuttled among different cell populations within exosomes and other extracellular vesicles. This review...

journal_title：Molecular cancer

authors： Frediani JN,Fabbri M

更新日期：2016-05-26 00:00:00

abstract：:Exosomes have emerged as a novel approach for the treatment and diagnosis of cancer after RNA content was discovered in exosomes in 2007. As important meditators of intercellular communication, exosomes have become a strong focus of investigation for researchers in the past decade, as witnessed through the exponential...

journal_title：Molecular cancer

authors： Zhou R,Chen KK,Zhang J,Xiao B,Huang Z,Ju C,Sun J,Zhang F,Lv XB,Huang G

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:Hypoxia can halt cell cycle progression of several cell types at the G1/S interface. The arrest needs to be overcome by cancer cells. We have previously shown that the hypoxia-inducible cellular oxygen sensor PHD3/EGLN3 enhances hypoxic cell cycle entry at the G1/S boundary. METHODS:We used PHD3 knockdown b...

journal_title：Molecular cancer

authors： Högel H,Miikkulainen P,Bino L,Jaakkola PM

更新日期：2015-07-30 00:00:00

abstract：BACKGROUND:Sigma-2 receptors are over-expressed in proliferating cancer cells, making an attractive target for the targeted treatment of pancreatic cancer. In this study, we investigated the role of the novel sigma-2 receptor ligand SW43 to induce apoptosis and augment standard chemotherapy. RESULTS:The binding affini...

journal_title：Molecular cancer

authors： Hornick JR,Xu J,Vangveravong S,Tu Z,Mitchem JB,Spitzer D,Goedegebuure P,Mach RH,Hawkins WG

更新日期：2010-11-22 00:00:00

abstract：BACKGROUND:Tumor recurrence and metastasis develop as a result of tumors' acquisition of anti-apoptotic mechanisms and therefore, it is necessary to develop novel effective therapeutics against metastatic cancers. In this study, we showed the differential TRAIL responsiveness of human prostate adenocarcinoma PC3 and hu...

journal_title：Molecular cancer

authors： Kim HB,Kim MJ,Kim DY,Lee JW,Bae JH,Kim DW,Kang CD,Kim SH

更新日期：2011-04-25 00:00:00

abstract：BACKGROUND:Deregulated circular RNAs (circRNAs) are associated with the development of cancer and therapy resistance. However, functional research of circRNAs mostly focus on potential miRNA or protein binding and more potential regulation of circRNA on host gene DNA in cancers are yet to be inspected. METHOD:We perfo...

journal_title：Molecular cancer

authors： Xu X,Zhang J,Tian Y,Gao Y,Dong X,Chen W,Yuan X,Yin W,Xu J,Chen K,He C,Wei L

更新日期：2020-08-24 00:00:00

abstract：BACKGROUND:An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, was tested side-by-side with khat in a panel of acute myeloid leukemia cell lines to elucidate me...

journal_title：Molecular cancer

authors： Bredholt T,Dimba EA,Hagland HR,Wergeland L,Skavland J,Fossan KO,Tronstad KJ,Johannessen AC,Vintermyr OK,Gjertsen BT

更新日期：2009-11-13 00:00:00

abstract：BACKGROUND:Survivin is a dual function protein. It inhibits the apoptosis of cells by inhibiting caspases, and also promotes cell growth by stabilizing microtubules during mitosis. Over-expression of survivin has been demonstrated to induce drug-resistance to various chemo-therapeutic agents such as cisplatin (DNA dama...

journal_title：Molecular cancer

authors： Cheung CH,Chen HH,Kuo CC,Chang CY,Coumar MS,Hsieh HP,Chang JY

更新日期：2009-07-03 00:00:00

abstract：BACKGROUND:In high grade gliomas, 1p19q codeletion and EGFR amplification are mutually exclusive and predictive of dramatically different outcomes. We performed a microarray gene expression study of four high grade gliomas with 1p19q codeletion and nine with EGFR amplification, identified by CGH-array. RESULTS:The two...

journal_title：Molecular cancer

authors： Ducray F,Idbaih A,de Reyniès A,Bièche I,Thillet J,Mokhtari K,Lair S,Marie Y,Paris S,Vidaud M,Hoang-Xuan K,Delattre O,Delattre JY,Sanson M

更新日期：2008-05-20 00:00:00