The role of the insulin-like growth factor-1 system in breast cancer.

abstract：:Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cl...

journal_title：Molecular cancer

authors： Moossavi M,Parsamanesh N,Bahrami A,Atkin SL,Sahebkar A

更新日期：2018-11-17 00:00:00

abstract：BACKGROUND:In previously published studies, oncolytic adenovirus-mediated gene therapy has produced good results in targeting cancer cells. However, safety and efficacy, the two most important aspects in cancer therapy, remain serious challenges. The specific expression or deletion of replication related genes in an ad...

journal_title：Molecular cancer

authors： Xu HN,Huang WD,Cai Y,Ding M,Gu JF,Wei N,Sun LY,Cao X,Li HG,Zhang KJ,Liu XR,Liu XY

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:We have previously reported that expression of the Wnt antagonist genes SFRP1 and SFRP5 is frequently silenced by promoter hypermethylation in breast cancer. SFRP2 is a further Wnt inhibitor whose expression was recently found being downregulated in various malignancies. Here we investigated whether SFRP2 is...

journal_title：Molecular cancer

authors： Veeck J,Noetzel E,Bektas N,Jost E,Hartmann A,Knüchel R,Dahl E

更新日期：2008-11-06 00:00:00

abstract：BACKGROUND:TGF-β promotes tumor invasion and metastasis through inducing epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC). Circular RNAs (circRNAs) are recognized as functional non-coding RNAs involved in human cancers. However, whether and how circRNAs contribute to TGF-β-induced EMT and m...

journal_title：Molecular cancer

authors： Wang L,Tong X,Zhou Z,Wang S,Lei Z,Zhang T,Liu Z,Zeng Y,Li C,Zhao J,Su Z,Zhang C,Liu X,Xu G,Zhang HT

更新日期：2018-09-27 00:00:00

abstract：BACKGROUND:The disruption of normal gene regulation due to microRNA dysfunction is a common event in cancer pathogenesis. MicroRNA-27b is an example of an oncogenic miRNA, and it is frequently upregulated in breast cancer. MicroRNAs have been found to deregulate tumor metabolism, which typically manifests as heightened...

journal_title：Molecular cancer

authors： Eastlack SC,Dong S,Ivan C,Alahari SK

更新日期：2018-07-16 00:00:00

abstract：BACKGROUND:Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear hormone receptor superfamily and is highly expressed in many human tumors including breast cancer. PPARgamma has been identified as a potential target for breast cancer therapy based on the fact that its activation by syn...

journal_title：Molecular cancer

authors： Zaytseva YY,Wang X,Southard RC,Wallis NK,Kilgore MW

更新日期：2008-12-05 00:00:00

abstract：BACKGROUND:Hedgehog acyltransferase (Hhat) catalyzes the transfer of the fatty acid palmitate onto Sonic Hedgehog (Shh), a modification that is essential for Shh signaling activity. The Shh signaling pathway has been implicated in the progression of breast cancer. METHODS:To determine the functional significance of Hh...

journal_title：Molecular cancer

authors： Matevossian A,Resh MD

更新日期：2015-04-01 00:00:00

abstract：:Exosomes are extracellular vesicles released by many cell types and have been attributed for their roles in many diseases including cancer. Exosomes secreted by tumor cells and stromal cells are critical mediators of intercellular communication in tumor microenvironments. Long noncoding RNAs (lncRNAs) are selectively ...

journal_title：Molecular cancer

authors： Sun Z,Yang S,Zhou Q,Wang G,Song J,Li Z,Zhang Z,Xu J,Xia K,Chang Y,Liu J,Yuan W

更新日期：2018-04-20 00:00:00

abstract：:Cancer research has mainly focused on alterations of genes and proteins in cancer cells themselves that result in either gain-of-function in oncogenes or loss-of-function in tumour-suppressor genes. However, stromal variables within or around tumours, including blood and lymph vessels, stromal cells and various protei...

journal_title：Molecular cancer

authors： Sun XF,Zhang H

更新日期：2006-10-06 00:00:00

abstract：:The HER4 intracellular domain (4ICD) is a potent estrogen receptor (ERalpha) coactivator with activities in breast cancer and the developing mammary gland that appear to overlap with progesterone receptor (PgR). In fact, 4ICD has recently emerged as an important regulator and predictor of tamoxifen response, a role pr...

journal_title：Molecular cancer

authors： Rokicki J,Das PM,Giltnane JM,Wansbury O,Rimm DL,Howard BA,Jones FE

更新日期：2010-06-15 00:00:00

abstract：BACKGROUND:High expression of P-glycoprotein is one of the well-known mechanisms of chemoresistance in chondrosarcomas. However, the role of antiapoptotic proteins, a common mechanism responsible for chemoresistance in other tumors, has not been well studied in chondrosarcomas. We examined the importance of P-glycoprot...

journal_title：Molecular cancer

authors： Kim DW,Kim KO,Shin MJ,Ha JH,Seo SW,Yang J,Lee FY

更新日期：2009-05-15 00:00:00

abstract：:Exosomes have emerged as a novel approach for the treatment and diagnosis of cancer after RNA content was discovered in exosomes in 2007. As important meditators of intercellular communication, exosomes have become a strong focus of investigation for researchers in the past decade, as witnessed through the exponential...

journal_title：Molecular cancer

authors： Zhou R,Chen KK,Zhang J,Xiao B,Huang Z,Ju C,Sun J,Zhang F,Lv XB,Huang G

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:Salivary Adenoid cystic carcinoma (SACC) patients with local invasion and lung metastasis are often resistant to conventional therapy such as operation, chemotherapy and radiotherapy. To explore the underling mechanisms, we studied the roles of miRNA in regulating invasiveness of SACC cells. METHODS:MicroRN...

journal_title：Molecular cancer

authors： Sun L,Liu B,Lin Z,Yao Y,Chen Y,Li Y,Chen J,Yu D,Tang Z,Wang B,Zeng S,Fan S,Wang Y,Li Y,Song E,Li J

更新日期：2015-04-29 00:00:00

abstract：BACKGROUND:Darpp-32 and t-Darpp are expressed in several forms of breast cancer. Both are transcribed from the gene PPP1R1B via alternative promoters. In humans, Darpp-32 is expressed in both normal and malignant breast tissue, whereas t-Darpp has only been found in malignant breast tissue. The exact biological functio...

journal_title：Molecular cancer

authors： Christenson JL,Kane SE

更新日期：2014-08-15 00:00:00

abstract：BACKGROUND:Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with high mutational heterogeneity and a generally poor clinical outcome. Despite implicated roles of deregulated TP53, IGF-2 and Wnt signaling pathways, a clear genetic association or unique mutational link to the disease is still missing. Recent...

journal_title：Molecular cancer

authors： Korah R,Healy JM,Kunstman JW,Fonseca AL,Ameri AH,Prasad ML,Carling T

更新日期：2013-08-05 00:00:00

abstract：BACKGROUND:The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division. Deregulation of FOXM1 has been linked to a majority of human cancers. We previously showed that FOXM1 was upregulated in basal cell c...

journal_title：Molecular cancer

authors： Teh MT,Gemenetzidis E,Chaplin T,Young BD,Philpott MP

更新日期：2010-02-26 00:00:00

abstract：BACKGROUND:Reactive oxygen species contribute to normal thyroid function. The NRF2 oxidative response pathway is frequently and constitutively activated in multiple tumor types, including papillary thyroid carcinoma (PTC). Genetic mechanisms underlying NRF2 pathway activation in PTC are not fully understood. Thus, we a...

journal_title：Molecular cancer

authors： Martinez VD,Vucic EA,Pikor LA,Thu KL,Hubaux R,Lam WL

更新日期：2013-10-20 00:00:00

abstract：BACKGROUND:In addition to androgens, growth factors are also implicated in the development and neoplastic growth of the prostate gland. Prosaposin is a potent neurotrophic molecule. Homozygous inactivation of prosaposin in mice has led to the development of a number of abnormalities in the male reproductive system, inc...

journal_title：Molecular cancer

authors： Lee TJ,Sartor O,Luftig RB,Koochekpour S

更新日期：2004-11-17 00:00:00

abstract：BACKGROUND:The expression of the rodent phosphoinositide-specific phospholipase C delta-4 (PLCdelta4) has been found to be elevated upon mitogenic stimulation and expression analysis have linked the upregulation of PLCdelta4 expression with rapid proliferation in certain rat transformed cell lines. The human homologue ...

journal_title：Molecular cancer

authors： Leung DW,Tompkins C,Brewer J,Ball A,Coon M,Morris V,Waggoner D,Singer JW

更新日期：2004-05-13 00:00:00

abstract：:The early diagnosis of pancreatic cancer, as well as distinguishing between chronic pancreatitis and malignant pancreatic disease, remains still a clinical problem. Presently, there is no specific tumor marker for diagnosing pancreatic cancer. Mucin-associated marker like CA 19-9 are the most widely available pancreat...

journal_title：Molecular cancer

authors： Ringel J,Löhr M

更新日期：2003-01-07 00:00:00

abstract：BACKGROUND:The Hedgehog (HH) pathway promotes tumorigenesis in a diversity of cancers. Activation of the HH signaling pathway is caused by overexpression of HH ligands or mutations in the components of the HH/GLI1 cascade, which lead to increased transactivation of GLI transcription factors. Although negative kinase re...

journal_title：Molecular cancer

authors： Mizuarai S,Kawagishi A,Kotani H

更新日期：2009-07-06 00:00:00

abstract：BACKGROUND:Tumor-associated macrophages (TAMs) are the major component of tumor-infiltrating leukocytes. TAMs are heterogeneous, with distinct phenotypes influenced by the microenvironment surrounding tumor tissues, but relatively little is known about the key molecular in these cells that contribute to malignant pheno...

journal_title：Molecular cancer

authors： Yang M,Liu J,Shao J,Qin Y,Ji Q,Zhang X,Du J

更新日期：2014-03-02 00:00:00

abstract：BACKGROUND:Cholangiocarcinoma (CCA) has an abundance of tumor stroma which plays an important role in cancer progression via tumor-promoting signals. This study aims to explore the microRNA (miRNA) profile of CCA-associated fibroblasts (CCFs) and the roles of any identified miRNAs in CCA progression. METHODS:miRNA exp...

journal_title：Molecular cancer

authors： Utaijaratrasmi P,Vaeteewoottacharn K,Tsunematsu T,Jamjantra P,Wongkham S,Pairojkul C,Khuntikeo N,Ishimaru N,Sirivatanauksorn Y,Pongpaibul A,Thuwajit P,Thuwajit C,Kudo Y

更新日期：2018-01-18 00:00:00

abstract：BACKGROUND:Recognition of pathogens by immune receptors leads to activation of macrophages, dendritic cells, and lymphocytes. Signals are communicated to enhance expression of target molecules such as cytokines and adhesion molecules, depending on activation of various inducible transcription factors, among which the f...

journal_title：Molecular cancer

authors： Kracklauer MP,Schmidt C

更新日期：2003-11-05 00:00:00

abstract：BACKGROUND:Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic secretome delivering and trafficking for long-distance cell-to-cell communication. This stu...

journal_title：Molecular cancer

authors： Lin Q,Chen X,Meng F,Ogawa K,Li M,Song R,Zhang S,Zhang Z,Kong X,Xu Q,He F,Bai X,Sun B,Hung MC,Liu L,Wands J,Dong X

更新日期：2019-11-07 00:00:00

abstract：BACKGROUND:Triple negative breast cancer (TNBC) remains the most challenging breast cancer subtype so far. Specific therapeutic approaches have rarely achieved clinical improvements in treatment of TNBC patients and effective molecular biomarkers are largely unknown. METHODS:We used paired TNBC samples and high throug...

journal_title：Molecular cancer

authors： Li J,Ma M,Yang X,Zhang M,Luo J,Zhou H,Huang N,Xiao F,Lai B,Lv W,Zhang N

更新日期：2020-09-11 00:00:00

abstract：:Several studies of tumors have revealed substantial numbers of clonally expanded somatic mutations in mitochondrial DNA (mtDNA), not observed in adjacent intact tissues. These findings were interpreted as indicating the involvement of mtDNA mutations in tumorigenesis. Such comparisons, however, ignore an important con...

journal_title：Molecular cancer

authors： Khaidakov M,Shmookler Reis RJ

更新日期：2005-09-13 00:00:00

abstract：BACKGROUND:Granulosa cell tumors (GCTs) are relatively rare and are subtypes of the sex-cord stromal neoplasms. Methylation induced silencing in the promoters of genes such as tumor suppressor genes, DNA repair genes and pro-apoptotic genes is recognised as a critical factor in cancer development. METHODS:We examined ...

journal_title：Molecular cancer

authors： Dhillon VS,Shahid M,Husain SA

更新日期：2004-12-01 00:00:00

abstract：:Early detection of a premalignant or cancerous oral lesion promises to improve the survival and the morbidity of patients suffering from these conditions. Cytological study of oral cells is a non-aggressive technique that is well accepted by the patient, and is therefore an attractive option for the early diagnosis of...

journal_title：Molecular cancer

authors： Mehrotra R,Gupta A,Singh M,Ibrahim R

更新日期：2006-03-23 00:00:00

abstract：BACKGROUND:TGF-beta resistance often develops in breast cancer cells that in turn overproduce this cytokine to create a local immunosuppressive environment that fosters tumor growth and exacerbates the invasive and metastatic behavior of the tumor cells themselves. Smads-mediated cross-talk with the estrogen receptor h...

journal_title：Molecular cancer

authors： Ren Y,Wu L,Frost AR,Grizzle W,Cao X,Wan M

更新日期：2009-11-27 00:00:00