Abstract:
:Exosomes are extracellular vesicles released by many cell types and have been attributed for their roles in many diseases including cancer. Exosomes secreted by tumor cells and stromal cells are critical mediators of intercellular communication in tumor microenvironments. Long noncoding RNAs (lncRNAs) are selectively sorted into exosomes and can regulate cancer onset and progression in a variety of ways. In this review, we summarize the characteristics of exosomal lncRNAs and their dysregulation in multiple types of cancer. We provide an overview of current research on exosomal lncRNAs in tumor microenvironments, especially the functions of exosomal lncRNAs in regulating tumor biology. A deeper understanding of the role of exosomal lncRNAs in the tumor microenvironment may help provide new diagnostic and prognostic markers for cancer.
journal_name
Mol Cancerjournal_title
Molecular cancerauthors
Sun Z,Yang S,Zhou Q,Wang G,Song J,Li Z,Zhang Z,Xu J,Xia K,Chang Y,Liu J,Yuan Wdoi
10.1186/s12943-018-0831-zsubject
Has Abstractpub_date
2018-04-20 00:00:00pages
82issue
1issn
1476-4598pii
10.1186/s12943-018-0831-zjournal_volume
17pub_type
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