Abstract:
BACKGROUND:In contrast to tumor-suppressive apoptosis and autophagic cell death, necrosis promotes tumor progression by releasing the pro-inflammatory and tumor-promoting cytokine high mobility group box 1 (HMGB1), and its presence in tumor patients is associated with poor prognosis. Thus, necrosis has important clinical implications in tumor development; however, its molecular mechanism remains poorly understood. RESULTS:In the present study, we show that Distal-less 2 (Dlx-2), a homeobox gene of the Dlx family that is involved in embryonic development, is induced in cancer cell lines dependently of reactive oxygen species (ROS) in response to glucose deprivation (GD), one of the metabolic stresses occurring in solid tumors. Increased Dlx-2 expression was also detected in the inner regions, which experience metabolic stress, of human tumors and of a multicellular tumor spheroid, an in vitro model of solid tumors. Dlx-2 short hairpin RNA (shRNA) inhibited metabolic stress-induced increase in propidium iodide-positive cell population and HMGB1 and lactate dehydrogenase (LDH) release, indicating the important role(s) of Dlx-2 in metabolic stress-induced necrosis. Dlx-2 shRNA appeared to exert its anti-necrotic effects by preventing metabolic stress-induced increases in mitochondrial ROS, which are responsible for triggering necrosis. CONCLUSIONS:These results suggest that Dlx-2 may be involved in tumor progression via the regulation of metabolic stress-induced necrosis.
journal_name
Mol Cancerjournal_title
Molecular cancerauthors
Lee SY,Jeon HM,Kim CH,Ju MK,Bae HS,Park HG,Lim SC,Han SI,Kang HSdoi
10.1186/1476-4598-10-113subject
Has Abstractpub_date
2011-09-14 00:00:00pages
113issn
1476-4598pii
1476-4598-10-113journal_volume
10pub_type
杂志文章相关文献
Molecular Cancer文献大全abstract:BACKGROUND:SOX2, a high mobility group (HMG)-box containing transcription factor, is a key regulator during development of the nervous system and a persistent marker of neural stem cells. Recent studies suggested a role of SOX2 in tumor progression. In our previous work we detected SOX2 in glioma cells and glioblastoma...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-137
更新日期:2011-11-09 00:00:00
abstract::Bortezomib is a novel anti-cancer agent which has shown promising activity in non-small lung cancer (NSCLC) patients. However, only a subset of patients respond to this treatment. We show that NSCLC cell lines are differentially sensitive to bortezomib, IC50 values ranging from 5 to 83 nM. The apoptosis-inducing poten...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-6-73
更新日期:2007-11-17 00:00:00
abstract:BACKGROUND:High expression of P-glycoprotein is one of the well-known mechanisms of chemoresistance in chondrosarcomas. However, the role of antiapoptotic proteins, a common mechanism responsible for chemoresistance in other tumors, has not been well studied in chondrosarcomas. We examined the importance of P-glycoprot...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-8-28
更新日期:2009-05-15 00:00:00
abstract:BACKGROUND:TGF-β promotes tumor invasion and metastasis through inducing epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC). Circular RNAs (circRNAs) are recognized as functional non-coding RNAs involved in human cancers. However, whether and how circRNAs contribute to TGF-β-induced EMT and m...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-018-0889-7
更新日期:2018-09-27 00:00:00
abstract::This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1186/s12943-015-0389-y. ...
journal_title:Molecular cancer
pub_type: 杂志文章,撤回出版物
doi:10.1186/s12943-020-01242-1
更新日期:2020-08-15 00:00:00
abstract:BACKGROUND:Hypermethylation of promotor CpG islands is a common mechanism that inactivates tumor suppressor genes in cancer. Genes belonging to the RASSF gene family have frequently been reported as epigenetically silenced by promotor methylation in human cancers. Two members of this gene family, RASSF1A and RASSF5A ha...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-11-40
更新日期:2012-06-13 00:00:00
abstract::The mammalian target of rapamycin (mTOR), which exists in two functionally distinct complexes, mTORC1 and mTORC2 plays an important role in tumor growth. Whereas the role of mTORC1 has been well characterized in this process, little is known about the functions of mTORC2 in cancer progression. In this study, we explor...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-57
更新日期:2010-03-12 00:00:00
abstract:BACKGROUND:The Sonic hedgehog (Shh) signaling pathway plays an important role in cerebellar development, and mutations leading to hyperactive Shh signaling have been associated with certain forms of medulloblastoma, a common form of pediatric brain cancer. While the fundamentals of this pathway are known, the molecular...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-015-0430-1
更新日期:2015-08-19 00:00:00
abstract::The HER4 intracellular domain (4ICD) is a potent estrogen receptor (ERalpha) coactivator with activities in breast cancer and the developing mammary gland that appear to overlap with progesterone receptor (PgR). In fact, 4ICD has recently emerged as an important regulator and predictor of tamoxifen response, a role pr...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-150
更新日期:2010-06-15 00:00:00
abstract:BACKGROUND:The tetraspanin CD63 is a highly N-glycosylated protein that is known to regulate cancer malignancy. However, the contribution of glycosylation of CD63 to cancer malignancy remains unclear. Previously, we reported that ribophorin II (RPN2), which is part of an N-oligosaccharyle transferase complex, is respon...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-134
更新日期:2014-05-31 00:00:00
abstract:BACKGROUND:Breast cancer is the second leading cause of cancer related deaths among females worldwide. Berbamine (BER), a kind of bis-benzylisoquinoline alkaloid, has been used to treat clinical patients with inflammation and cancer for many years in China. The purpose of this study is to investigate the activity of BE...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-8-81
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:In our previous studies, we have demonstrated that insulin-like growth factor binding protein-related protein1 (IGFBP-rP1) played its potential tumor suppressor role in colon cancer cells through apoptosis and senescence induction. In this study, we will further uncover the role of IGFBP-rP1 in colon cancer ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-281
更新日期:2010-10-26 00:00:00
abstract:BACKGROUND:Tumor spreading is the major threat for cancer patients. The recently published anti-cancer drug salinomycin raised hope for an improved treatment by targeting therapy-refractory cancer stem cells. However, an unambiguous role of salinomycin against cancer cell migration and metastasis formation remains elus...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-16
更新日期:2014-01-27 00:00:00
abstract:BACKGROUND:Although chemotherapy represents a predominant anti-cancer therapeutic modality, drug treatment efficacy is often limited due to the development of resistant tumor cells. The pregnane X receptor (PXR) affects chemotherapeutic effects by regulating targets involved in drug metabolism and transportation, but t...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-017-0641-8
更新日期:2017-03-29 00:00:00
abstract:BACKGROUND:The expression of the rodent phosphoinositide-specific phospholipase C delta-4 (PLCdelta4) has been found to be elevated upon mitogenic stimulation and expression analysis have linked the upregulation of PLCdelta4 expression with rapid proliferation in certain rat transformed cell lines. The human homologue ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-3-15
更新日期:2004-05-13 00:00:00
abstract::Mutations in polymerase ε (POLE) confer favorable prognosis and outcomes in various cancer types, but their role in non-small cell lung cancer (NSCLC) is unknown. Utilizing the data of 513 patients with adenocarcinoma (LUAD) and 497 patients with squamous cell carcinoma (LUSC) from The Cancer Genome Atlas (TCGA) cohor...
journal_title:Molecular cancer
pub_type: 信件
doi:10.1186/s12943-018-0832-y
更新日期:2018-04-12 00:00:00
abstract:BACKGROUND:Sharing the common neuroectodermal origin, melanoma and neuroblastoma are tumors widely diffused among adult and children, respectively. Clinical prognosis of aggressive neuroectodermal cancers remains dismal, therefore the search for novel therapies against such tumors is warranted. Curcumin is a phytochemi...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-137
更新日期:2010-06-03 00:00:00
abstract::Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) are heterogenous vesicles formed by budding of the cellular membrane, which are secreted in larger amounts by ...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-019-0973-7
更新日期:2019-03-30 00:00:00
abstract:BACKGROUND:As one of the most frequent chemical modifications in eukaryotic mRNAs, N6-methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing, and translation. Recently, the regulatory role of m6A in tumorigenesis has been increasingly recognized. However, dysregulation of m6A and its fu...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-019-1065-4
更新日期:2019-10-13 00:00:00
abstract:BACKGROUND:Glioblastoma (GBM) is the most common and malignant primary intracranial human neoplasm. GBMs are characterized by the presence of extensive areas of necrosis and hypoxia. Hypoxia and its master regulator, hypoxia inducible factor 1 (HIF-1) play a key role in glioma invasion. RESULTS:To further elucidate th...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-133
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Chromosomal aberrations of BCL11A at 2p16.1 have been reported in a variety of B-cell malignancies and its deficiency in mice leads to a profound block in B-cell development. RESULTS:Alternative pre-mRNA splicing of BCL11A produces multiple isoforms sharing a common N-terminus. The most abundant isoform we ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-5-18
更新日期:2006-05-16 00:00:00
abstract:BACKGROUND:The pre-leukemia transcription factor 3 (PBX) is part of the PBX family of transcription factors, which is known to regulate genes involved in differentiation of urogenital organs and steroidogenesis. This is of interest with regard to prostate cancer progression as regulation of steroidogenesis is one of th...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-50
更新日期:2011-05-06 00:00:00
abstract:BACKGROUND:Hodgkin lymphoma (HL) and Anaplastic Large Cell Lymphoma (ALCL), are forms of malignant lymphoma defined by unique morphologic, immunophenotypic, genotypic, and clinical characteristics, but both overexpress CD30. We used sub-megabase resolution tiling (SMRT) array-based comparative genomic hybridization to ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-7-2
更新日期:2008-01-07 00:00:00
abstract:BACKGROUND:microRNAs (miRNAs) play both oncogenic and oncostatic roles in leukemia. However, the molecular details underlying miRNA-mediated regulation of their target genes in pediatric B- and T-cell acute lymphoblastic leukemias (ALLs) remain unclear. The present study investigated the relationship between miR-2909 a...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-175
更新日期:2014-07-18 00:00:00
abstract:BACKGROUND:Ambiguity in malignant transformation of glioma has made prognostic diagnosis very challenging. Tumor malignant transformation is closely correlated with specific alterations of the metabolic profile. Exploration of the underlying metabolic alterations in glioma cells of different malignant degree is therefo...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-197
更新日期:2014-08-27 00:00:00
abstract:BACKGROUND:TPC-1 is a papillary thyroid carcinoma (PTC)-derived cell line that spontaneously expresses the oncogene RET/PTC1. TPC-1 treated with the RET/PTC1 inhibitor RPI-1 displayed a cytostatic and reversible inhibition of cell proliferation and a strong activation of focal adhesion kinase (FAK). As dasatinib inhibi...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-278
更新日期:2010-10-18 00:00:00
abstract:BACKGROUND:Cancer/testis (CT) genes have expression normally restricted to the testis, but become activated during oncogenesis, so they have excellent potential as cancer-specific biomarkers. Evidence is starting to emerge to indicate that they also provide function(s) in the oncogenic programme. Human TEX19 is a recen...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-017-0653-4
更新日期:2017-04-26 00:00:00
abstract:BACKGROUND:Aurora-A is an oncogenic kinase playing well-documented roles in mitotic spindle organisation. We previously found that Aurora-A inactivation yields the formation of spindles with fragmented poles that can drive chromosome mis-segregation. Here we have addressed the mechanism through which Aurora-A activity ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-131
更新日期:2011-10-19 00:00:00
abstract:BACKGROUND:Lung cancer in nonsmokers tends to be driven by a single somatic mutation or a gene fusion. KIF5B-RET fusion is an oncogene identified in non-small cell lung cancers. In this study, we verified the oncogenic activity of KIF5B-RET fusion and investigated how KIF5B-RET activates the specific signaling pathways...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-176
更新日期:2014-07-21 00:00:00
abstract:BACKGROUND:METTL3 is known to be involved in all stages in the life cycle of RNA. It affects the tumor formation by the regulation the m6A modification in the mRNAs of critical oncogenes or tumor suppressors. In bladder cancer, METTL3 could promote the bladder cancer progression via AFF4/NF-κB/MYC signaling network by ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-019-1036-9
更新日期:2019-06-22 00:00:00