Knock down of HIF-1alpha in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres.

abstract：:seRNA is a noncoding RNA (ncRNA) transcribed from active super-enhancer (SE), through which SE exerts biological functions and participates in various physiological and pathological processes. seRNA recruits cofactor, RNA polymerase II and mediator to constitute and stabilize chromatin loop SE and promoter region, whi...

journal_title：Molecular cancer

authors： Tan Y,Li Y,Tang F

更新日期：2020-04-11 00:00:00

abstract：BACKGROUND:Hypoxia inducible factor-1 alpha (HIF-1alpha) protein is rapidly degraded under normoxic conditions. When oxygen tensions fall HIF-1alpha protein stabilizes and transactivates genes involved in adaptation to hypoxic conditions. We have examined the normoxic expression of HIF-1alpha RNA and protein in normal ...

journal_title：Molecular cancer

authors： Mills CN,Joshi SS,Niles RM

更新日期：2009-11-17 00:00:00

abstract：BACKGROUND:Perturbation of DNA methylation is frequent in cancers and has emerged as an important mechanism involved in tumorigenesis. To determine how DNA methylation is modified in the genome of primary glioma, we used Methyl-DNA immunoprecipitation (MeDIP) and Nimblegen CpG promoter microarrays to identify different...

journal_title：Molecular cancer

authors： Zhang Z,Tang H,Wang Z,Zhang B,Liu W,Lu H,Xiao L,Liu X,Wang R,Li X,Wu M,Li G

更新日期：2011-09-30 00:00:00

abstract：BACKGROUND:miR-139-5p was identified to be significantly down-regulated in colon tumor tissues by miRNA array. We aimed to clarify its biological function, molecular mechanisms and direct target gene in colorectal cancer (CRC). METHODS:The biological function of miR-139-5p was examined by cell growth, cell cycle and a...

journal_title：Molecular cancer

authors： Zhang L,Dong Y,Zhu N,Tsoi H,Zhao Z,Wu CW,Wang K,Zheng S,Ng SS,Chan FK,Sung JJ,Yu J

更新日期：2014-05-26 00:00:00

abstract：BACKGROUND:Lung cancer is the most lethal cancer and almost 90% of lung cancer is due to cigarette smoking. Even though nicotine, one of the major ingredients of cigarette smoke and the causative agent for addiction, is not a carcinogen by itself, several investigators have shown that nicotine can induce cell prolifera...

journal_title：Molecular cancer

authors： Puliyappadamba VT,Cheriyan VT,Thulasidasan AK,Bava SV,Vinod BS,Prabhu PR,Varghese R,Bevin A,Venugopal S,Anto RJ

更新日期：2010-08-20 00:00:00

abstract：BACKGROUND:The cyclin D1 proto-oncogene is an important regulator of G1 to S-phase transition and an important cofactor for several transcription factors in numerous cell types. Studies on neonatal cardiomyocytes and postmitotic neurons indicate that the activity of cyclin D1 may be regulated through its cytoplasmic se...

journal_title：Molecular cancer

authors： Alao JP,Gamble SC,Stavropoulou AV,Pomeranz KM,Lam EW,Coombes RC,Vigushin DM

更新日期：2006-02-17 00:00:00

abstract：BACKGROUND:Ambiguity in malignant transformation of glioma has made prognostic diagnosis very challenging. Tumor malignant transformation is closely correlated with specific alterations of the metabolic profile. Exploration of the underlying metabolic alterations in glioma cells of different malignant degree is therefo...

journal_title：Molecular cancer

authors： Shao W,Gu J,Huang C,Liu D,Huang H,Huang Z,Lin Z,Yang W,Liu K,Lin D,Ji T

更新日期：2014-08-27 00:00:00

abstract：:Several studies of tumors have revealed substantial numbers of clonally expanded somatic mutations in mitochondrial DNA (mtDNA), not observed in adjacent intact tissues. These findings were interpreted as indicating the involvement of mtDNA mutations in tumorigenesis. Such comparisons, however, ignore an important con...

journal_title：Molecular cancer

authors： Khaidakov M,Shmookler Reis RJ

更新日期：2005-09-13 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) has one of the poorest prognoses among all cancers. Over the past several decades, investigators have made great advances in the research of PDAC pathogenesis. Importantly, identification of pancreatic cancer stem cells (PCSCs) in pancreatic cancer cases has increased our unders...

journal_title：Molecular cancer

authors： Quan M,Wang P,Cui J,Gao Y,Xie K

更新日期：2013-12-10 00:00:00

abstract：:Exosomes are extracellular vesicles released by many cell types and have been attributed for their roles in many diseases including cancer. Exosomes secreted by tumor cells and stromal cells are critical mediators of intercellular communication in tumor microenvironments. Long noncoding RNAs (lncRNAs) are selectively ...

journal_title：Molecular cancer

authors： Sun Z,Yang S,Zhou Q,Wang G,Song J,Li Z,Zhang Z,Xu J,Xia K,Chang Y,Liu J,Yuan W

更新日期：2018-04-20 00:00:00

abstract：:Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cl...

journal_title：Molecular cancer

authors： Moossavi M,Parsamanesh N,Bahrami A,Atkin SL,Sahebkar A

更新日期：2018-11-17 00:00:00

abstract：BACKGROUND:Although both circular RNAs (circRNAs) and autophagy are associated with the function of breast cancer (BC), whether circRNAs regulate BC progression via autophagy remains unknown. In this study, we aim to explore the regulatory mechanisms and the clinical significance of autophagy-associated circRNAs in BC....

journal_title：Molecular cancer

authors： Liang G,Ling Y,Mehrpour M,Saw PE,Liu Z,Tan W,Tian Z,Zhong W,Lin W,Luo Q,Lin Q,Li Q,Zhou Y,Hamai A,Codogno P,Li J,Song E,Gong C

更新日期：2020-03-25 00:00:00

abstract：BACKGROUND:As one of the most frequent chemical modifications in eukaryotic mRNAs, N6-methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing, and translation. Recently, the regulatory role of m6A in tumorigenesis has been increasingly recognized. However, dysregulation of m6A and its fu...

journal_title：Molecular cancer

authors： Yue B,Song C,Yang L,Cui R,Cheng X,Zhang Z,Zhao G

更新日期：2019-10-13 00:00:00

abstract：INTRODUCTION:Anaplastic thyroid carcinoma, which is one of the most aggressive, malignant tumors in humans, results in an extremely poor prognosis despite chemotherapy and radiotherapy. The present study was designed to evaluate therapeutic effects of radiation by glycerol on p53-mutant anaplastic thyroid carcinoma cel...

journal_title：Molecular cancer

authors： Ohnishi K,Ota I,Yane K,Takahashi A,Yuki K,Emoto M,Hosoi H,Ohnishi T

更新日期：2002-10-04 00:00:00

abstract：BACKGROUND:In the current study we investigated the role of caveolin-1 (cav-1) in pancreatic adenocarcinoma (PC) cell migration and invasion; initial steps in metastasis. Cav-1 is the major structural protein in caveolae; small Omega-shaped invaginations within the plasma membrane. Caveolae are involved in signal trans...

journal_title：Molecular cancer

authors： Lin M,DiVito MM,Merajver SD,Boyanapalli M,van Golen KL

更新日期：2005-06-21 00:00:00

abstract：BACKGROUND:Hypoxia can halt cell cycle progression of several cell types at the G1/S interface. The arrest needs to be overcome by cancer cells. We have previously shown that the hypoxia-inducible cellular oxygen sensor PHD3/EGLN3 enhances hypoxic cell cycle entry at the G1/S boundary. METHODS:We used PHD3 knockdown b...

journal_title：Molecular cancer

authors： Högel H,Miikkulainen P,Bino L,Jaakkola PM

更新日期：2015-07-30 00:00:00

abstract：:Cancer has become a major health issue worldwide, contributing to a high mortality rate. Tumor metastasis is attributed to the death of most patients. Epithelial-to-mesenchymal transition (EMT) plays a vital role in inducing metastasis. During EMT, epithelial cells lose their characteristics, such as cell-to-cell adhe...

journal_title：Molecular cancer

authors： Shang BQ,Li ML,Quan HY,Hou PF,Li ZW,Chu SF,Zheng JN,Bai J

更新日期：2019-09-16 00:00:00

abstract：BACKGROUND:In previously published studies, oncolytic adenovirus-mediated gene therapy has produced good results in targeting cancer cells. However, safety and efficacy, the two most important aspects in cancer therapy, remain serious challenges. The specific expression or deletion of replication related genes in an ad...

journal_title：Molecular cancer

authors： Xu HN,Huang WD,Cai Y,Ding M,Gu JF,Wei N,Sun LY,Cao X,Li HG,Zhang KJ,Liu XR,Liu XY

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Metastatic renal cell carcinoma (RCC) remains the leading cause of mortality in patients with clear cell RCC arising from mutations in the von Hippel Lindau (VHL) tumor suppressor. Successful RCC tumor suppression by VHL requires the negative regulation of hypoxia inducible factor alpha (HIF alpha) protein a...

journal_title：Molecular cancer

authors： Petrella BL,Brinckerhoff CE

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Tumor spreading is the major threat for cancer patients. The recently published anti-cancer drug salinomycin raised hope for an improved treatment by targeting therapy-refractory cancer stem cells. However, an unambiguous role of salinomycin against cancer cell migration and metastasis formation remains elus...

journal_title：Molecular cancer

authors： Kopp F,Hermawan A,Oak PS,Herrmann A,Wagner E,Roidl A

更新日期：2014-01-27 00:00:00

abstract：:Early detection of a premalignant or cancerous oral lesion promises to improve the survival and the morbidity of patients suffering from these conditions. Cytological study of oral cells is a non-aggressive technique that is well accepted by the patient, and is therefore an attractive option for the early diagnosis of...

journal_title：Molecular cancer

authors： Mehrotra R,Gupta A,Singh M,Ibrahim R

更新日期：2006-03-23 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumour (GIST) is the most common soft tissue sarcoma. The identification of the molecular mechanisms regulating GIST progression is vital for its treatment and prevention. Increasing reports have demonstrated that epigenetic alterations play critical roles in GIST development. Howeve...

journal_title：Molecular cancer

authors： Hu F,Li H,Liu L,Xu F,Lai S,Luo X,Hu J,Yang X

更新日期：2018-07-30 00:00:00

abstract：BACKGROUND:Human clear cell renal cell carcinoma (CRCC) remains resistant to therapies. Recent advances in Hypoxia Inducible Factors (HIF) molecular network led to targeted therapies, but unfortunately with only limited clinical significance. Elucidating the molecular processes involved in kidney tumorigenesis and resi...

journal_title：Molecular cancer

authors： Dormoy V,Danilin S,Lindner V,Thomas L,Rothhut S,Coquard C,Helwig JJ,Jacqmin D,Lang H,Massfelder T

更新日期：2009-12-16 00:00:00

abstract：BACKGROUND:Human or animals lacking either JAK3 or the common gamma chain (gammac) expression display severe combined immunodeficiency disease, indicating the crucial role of JAK3 in T-cell development and the homeostasis of the immune system. JAK3 has also been suggested to contribute to the pathogenesis of tumorigene...

journal_title：Molecular cancer

authors： Kim BH,Jee JG,Yin CH,Sandoval C,Jayabose S,Kitamura D,Bach EA,Baeg GH

更新日期：2010-02-11 00:00:00

abstract：BACKGROUND:Osteopontin (OPN) has been shown to play many roles in the progression of cancer. We have recently demonstrated the activation of Akt by OPN. Integrin-linked kinase and PI3-kinase are integral proteins in OPN/AKT pathway in PC3 cells. To investigate the role of the extracellular receptors in OPN signaling, w...

journal_title：Molecular cancer

authors： Robertson BW,Bonsal L,Chellaiah MA

更新日期：2010-09-26 00:00:00

abstract：BACKGROUND:CD44 is considered as 'a' metastasis associated gene, despite the fact that it is an umbrella term for a group of molecules produced from a single gene by alternative splicing. However, little consideration is given to the above in the literature of colorectal carcinomas as well as other tumour types, leadin...

journal_title：Molecular cancer

authors： Bánky B,Rásó-Barnett L,Barbai T,Tímár J,Becságh P,Rásó E

更新日期：2012-11-14 00:00:00

abstract：BACKGROUND:Breast cancer is one of the most common malignancies and the major cause of cancer-related death in women. Although the importance of PIWI-interacting RNAs (piRNAs) in cancer has been increasingly recognized, few studies have been explored the functional mechanism of piRNAs in breast cancer development and p...

journal_title：Molecular cancer

authors： Tan L,Mai D,Zhang B,Jiang X,Zhang J,Bai R,Ye Y,Li M,Pan L,Su J,Zheng Y,Liu Z,Zuo Z,Zhao Q,Li X,Huang X,Yang J,Tan W,Zheng J,Lin D

更新日期：2019-01-12 00:00:00

abstract：BACKGROUND:Perifosine, an alkylphospholipid tested in phase II clinical trials, modulates the extrinsic apoptotic pathway and cooperates with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to augment apoptosis. The current study focuses on revealing the mechanisms by which perifosine enhances TRAIL-ind...

journal_title：Molecular cancer

authors： Fu L,Lin YD,Elrod HA,Yue P,Oh Y,Li B,Tao H,Chen GZ,Shin DM,Khuri FR,Sun SY

更新日期：2010-12-20 00:00:00

abstract：BACKGROUND:High expression of P-glycoprotein is one of the well-known mechanisms of chemoresistance in chondrosarcomas. However, the role of antiapoptotic proteins, a common mechanism responsible for chemoresistance in other tumors, has not been well studied in chondrosarcomas. We examined the importance of P-glycoprot...

journal_title：Molecular cancer

authors： Kim DW,Kim KO,Shin MJ,Ha JH,Seo SW,Yang J,Lee FY

更新日期：2009-05-15 00:00:00

abstract：BACKGROUND:Minimal residual disease is the main issue of advanced ovarian cancer treatment. According to the literature and previous results, we hypothesized that Mesenchymal Stromal Cells (MSC) could support this minimal residual disease by protecting ovarian cancer cells (OCC) from chemotherapy. In vitro study confir...

journal_title：Molecular cancer

authors： Pasquier J,Gosset M,Geyl C,Hoarau-Véchot J,Chevrot A,Pocard M,Mirshahi M,Lis R,Rafii A,Touboul C

更新日期：2018-02-19 00:00:00