CCL2/CCL5 secreted by the stroma induce IL-6/PYK2 dependent chemoresistance in ovarian cancer.

abstract：BACKGROUND:Osteopontin (OPN) has been shown to play many roles in the progression of cancer. We have recently demonstrated the activation of Akt by OPN. Integrin-linked kinase and PI3-kinase are integral proteins in OPN/AKT pathway in PC3 cells. To investigate the role of the extracellular receptors in OPN signaling, w...

journal_title：Molecular cancer

authors： Robertson BW,Bonsal L,Chellaiah MA

更新日期：2010-09-26 00:00:00

abstract：BACKGROUND:Atypical adenomatous hyperplasia (AAH) and squamous cell dysplasia (SCD) are associated with the development of malignant lesions in the lung. Accurate diagnosis of AAH and SCD could facilitate earlier clinical intervention and provide useful information for assessing lung cancer risk in human populations. D...

journal_title：Molecular cancer

authors： Lowe FJ,Shen W,Zu J,Li J,Wang H,Zhang X,Zhong L

更新日期：2014-04-05 00:00:00

abstract：:The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms. Here, we review recent findings regarding chromatin modifications and their relevance to cancer. ...

journal_title：Molecular cancer

authors： Ducasse M,Brown MA

更新日期：2006-11-08 00:00:00

abstract：BACKGROUND:CADM1 encodes an immunoglobulin superfamily (IGSF) cell adhesion molecule. Inactivation of CADM1, either by promoter hypermethylation or loss of heterozygosity, has been reported in a wide variety of tumor types, thus it has been postulated as a tumor suppressor gene. FINDINGS:We show for the first time tha...

journal_title：Molecular cancer

authors： van der Weyden L,Arends MJ,Rust AG,Poulogiannis G,McIntyre RE,Adams DJ

更新日期：2012-05-03 00:00:00

abstract：BACKGROUND:The expression of the rodent phosphoinositide-specific phospholipase C delta-4 (PLCdelta4) has been found to be elevated upon mitogenic stimulation and expression analysis have linked the upregulation of PLCdelta4 expression with rapid proliferation in certain rat transformed cell lines. The human homologue ...

journal_title：Molecular cancer

authors： Leung DW,Tompkins C,Brewer J,Ball A,Coon M,Morris V,Waggoner D,Singer JW

更新日期：2004-05-13 00:00:00

abstract：BACKGROUND:Hypoxia inducible factor-1 alpha (HIF-1alpha) protein is rapidly degraded under normoxic conditions. When oxygen tensions fall HIF-1alpha protein stabilizes and transactivates genes involved in adaptation to hypoxic conditions. We have examined the normoxic expression of HIF-1alpha RNA and protein in normal ...

journal_title：Molecular cancer

authors： Mills CN,Joshi SS,Niles RM

更新日期：2009-11-17 00:00:00

abstract：BACKGROUND:Sigma-2 receptors are over-expressed in proliferating cancer cells, making an attractive target for the targeted treatment of pancreatic cancer. In this study, we investigated the role of the novel sigma-2 receptor ligand SW43 to induce apoptosis and augment standard chemotherapy. RESULTS:The binding affini...

journal_title：Molecular cancer

authors： Hornick JR,Xu J,Vangveravong S,Tu Z,Mitchem JB,Spitzer D,Goedegebuure P,Mach RH,Hawkins WG

更新日期：2010-11-22 00:00:00

abstract：BACKGROUND:N6-methyladenosine (m6A) emerges as one of the most important modification of RNA. Bladder cancer is a common cancer type in developed countries, and hundreds of thousands of bladder cancer patients die every year. MATERIALS AND METHODS:There are various cells in bladder tumor bulk, and a small population c...

journal_title：Molecular cancer

authors： Gu C,Wang Z,Zhou N,Li G,Kou Y,Luo Y,Wang Y,Yang J,Tian F

更新日期：2019-11-25 00:00:00

abstract：:Cancer has become a major health issue worldwide, contributing to a high mortality rate. Tumor metastasis is attributed to the death of most patients. Epithelial-to-mesenchymal transition (EMT) plays a vital role in inducing metastasis. During EMT, epithelial cells lose their characteristics, such as cell-to-cell adhe...

journal_title：Molecular cancer

authors： Shang BQ,Li ML,Quan HY,Hou PF,Li ZW,Chu SF,Zheng JN,Bai J

更新日期：2019-09-16 00:00:00

abstract：BACKGROUND:Glioblastoma (GBM) is the most common and malignant primary intracranial human neoplasm. GBMs are characterized by the presence of extensive areas of necrosis and hypoxia. Hypoxia and its master regulator, hypoxia inducible factor 1 (HIF-1) play a key role in glioma invasion. RESULTS:To further elucidate th...

journal_title：Molecular cancer

authors： Méndez O,Zavadil J,Esencay M,Lukyanov Y,Santovasi D,Wang SC,Newcomb EW,Zagzag D

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Cholangiocarcinoma (CCA) has an abundance of tumor stroma which plays an important role in cancer progression via tumor-promoting signals. This study aims to explore the microRNA (miRNA) profile of CCA-associated fibroblasts (CCFs) and the roles of any identified miRNAs in CCA progression. METHODS:miRNA exp...

journal_title：Molecular cancer

authors： Utaijaratrasmi P,Vaeteewoottacharn K,Tsunematsu T,Jamjantra P,Wongkham S,Pairojkul C,Khuntikeo N,Ishimaru N,Sirivatanauksorn Y,Pongpaibul A,Thuwajit P,Thuwajit C,Kudo Y

更新日期：2018-01-18 00:00:00

abstract：BACKGROUND:In the current study we investigated the role of caveolin-1 (cav-1) in pancreatic adenocarcinoma (PC) cell migration and invasion; initial steps in metastasis. Cav-1 is the major structural protein in caveolae; small Omega-shaped invaginations within the plasma membrane. Caveolae are involved in signal trans...

journal_title：Molecular cancer

authors： Lin M,DiVito MM,Merajver SD,Boyanapalli M,van Golen KL

更新日期：2005-06-21 00:00:00

abstract：BACKGROUND:METTL3 is known to be involved in all stages in the life cycle of RNA. It affects the tumor formation by the regulation the m6A modification in the mRNAs of critical oncogenes or tumor suppressors. In bladder cancer, METTL3 could promote the bladder cancer progression via AFF4/NF-κB/MYC signaling network by ...

journal_title：Molecular cancer

authors： Han J,Wang JZ,Yang X,Yu H,Zhou R,Lu HC,Yuan WB,Lu JC,Zhou ZJ,Lu Q,Wei JF,Yang H

更新日期：2019-06-22 00:00:00

abstract：:Cancer is a leading cause of death worldwide, particularly because of its high mortality rate in patients who are diagnosed at late stages. Conventional biomarkers originating from blood are widely used for cancer diagnosis, but their low sensitivity and specificity limit their widespread application in cancer screeni...

journal_title：Molecular cancer

authors： Wang S,Zhang K,Tan S,Xin J,Yuan Q,Xu H,Xu X,Liang Q,Christiani DC,Wang M,Liu L,Du M

更新日期：2021-01-11 00:00:00

abstract：:IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evid...

journal_title：Molecular cancer

authors： Christopoulos PF,Msaouel P,Koutsilieris M

更新日期：2015-02-15 00:00:00

abstract：BACKGROUND:High expression of the long non-coding RNA nuclear-enriched abundant transcript 1 (NEAT1) in whole blood has been reported in colorectal cancer patients; however, its' clinical significance and origin are unclear. We evaluated the diagnostic and prognostic value, and origin of whole blood NEAT1 in colorectal...

journal_title：Molecular cancer

authors： Wu Y,Yang L,Zhao J,Li C,Nie J,Liu F,Zhuo C,Zheng Y,Li B,Wang Z,Xu Y

更新日期：2015-11-09 00:00:00

abstract：BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is a highly lethal cancer that contains cellular and functional heterogeneity. Previously, we enriched a subpopulation of highly tumorigenic head and neck cancer initiating cells (HN-CICs) from HNSCC. However, the molecular mechanisms by which to govern the chara...

journal_title：Molecular cancer

authors： Wu MJ,Jan CI,Tsay YG,Yu YH,Huang CY,Lin SC,Liu CJ,Chen YS,Lo JF,Yu CC

更新日期：2010-10-27 00:00:00

abstract：BACKGROUND:In recent years, circular RNAs (circRNAs), a new star of non-coding RNA, have been emerged as vital regulators and gained much attention for involvement of initiation and progression of diverse kinds of human diseases, especially cancer. However, regulatory role, clinical significance and underlying mechanis...

journal_title：Molecular cancer

authors： Yang R,Xing L,Zheng X,Sun Y,Wang X,Chen J

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:As an important means of communication, exosomes play an important role in the development of hepatocellular carcinoma (HCC). METHODS:Bioinformatics analysis, dual-luciferase reporter assays, methylation-specific quantitative PCR, and ChIP-PCR analysis were used to gain insight into the underlying mechanism...

journal_title：Molecular cancer

authors： Cao LQ,Yang XW,Chen YB,Zhang DW,Jiang XF,Xue P

更新日期：2019-10-27 00:00:00

abstract：BACKGROUND:The epigenetic regulation of immune response has been demonstrated in recent studies. Nonetheless, potential roles of RNA N6-methyladenosine (m6A) modification in tumor microenvironment (TME) cell infiltration remain unknown. METHODS:We comprehensively evaluated the m6A modification patterns of 1938 gastric...

journal_title：Molecular cancer

authors： Zhang B,Wu Q,Li B,Wang D,Wang L,Zhou YL

更新日期：2020-03-12 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the major causes of mortality. ABT-263 is a newly synthesized, orally available Bcl-2/xL inhibitor that shows promising efficacy in HCC therapy. ABT-263 inhibits the anti-apoptotic activity of Bcl-2 and Bcl-xL, but not Mcl-1. Previous reports have shown that ABT-263 u...

journal_title：Molecular cancer

authors： Wang B,Ni Z,Dai X,Qin L,Li X,Xu L,Lian J,He F

更新日期：2014-04-30 00:00:00

abstract：BACKGROUND:Anaplastic lymphoma kinase (ALK), which is a receptor tyrosine kinase, is essentially and transiently expressed in the developing nervous system. Recently, the deregulated expression of full-length ALK has been observed in some primary solid tumors, but little is known about its involvement in the tumorigene...

journal_title：Molecular cancer

authors： Inoue H,Hashimura M,Akiya M,Chiba R,Saegusa M

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor (EGFR), a well-known oncogenic driver, contributes to the initiation and progression of a wide range of cancer types. Aberrant lipid metabolism including highly produced monounsaturated fatty acids (MUFA) is recognized as a hallmark of cancer. However, how EGFR regulates MUFA...

journal_title：Molecular cancer

authors： Zhang J,Song F,Zhao X,Jiang H,Wu X,Wang B,Zhou M,Tian M,Shi B,Wang H,Jia Y,Wang H,Pan X,Li Z

更新日期：2017-07-19 00:00:00

abstract：BACKGROUND:Glycochenodeoxycholate (GCDA) is one of the major human bile salts. Bile salts stimulate cell survival and proliferation through the mitogen-activated protein kinase, but the downstream signaling mechanism(s) remains enigmatic. Mcl-1 is an antiapoptotic molecule of the Bcl2 family that is extensively overexp...

journal_title：Molecular cancer

authors： Liao M,Zhao J,Wang T,Duan J,Zhang Y,Deng X

更新日期：2011-04-20 00:00:00

abstract：BACKGROUND:Many human cancer cells express filamin A (FLNA), an actin-binding structural protein that interacts with a diverse set of cell signaling proteins, but little is known about the biological importance of FLNA in tumor development. FLNA is also expressed in endothelial cells, which may be important for tumor a...

journal_title：Molecular cancer

authors： Nallapalli RK,Ibrahim MX,Zhou AX,Bandaru S,Sunkara SN,Redfors B,Pazooki D,Zhang Y,Borén J,Cao Y,Bergo MO,Akyürek LM

更新日期：2012-08-02 00:00:00

abstract：BACKGROUND:Reovirus type 3 Dearing strain (ReoT3D) has an inherent propensity to preferentially infect and destroy cancer cells. The oncolytic activity of ReoT3D as a single agent has been demonstrated in vitro and in vivo against various cancers, including colon, pancreatic, ovarian and breast cancers. Its human safet...

journal_title：Molecular cancer

authors： Sei S,Mussio JK,Yang QE,Nagashima K,Parchment RE,Coffey MC,Shoemaker RH,Tomaszewski JE

更新日期：2009-07-14 00:00:00

abstract：:Sema4D, also known as CD100, is a protein belonging to class IV semaphorin. Its physiologic roles in the immune and nervous systems have been extensively explored. However, the roles of Sema4D have extended beyond these traditionally studied territories. Via interaction with its high affinity receptor Plexin-B1, Sema4...

journal_title：Molecular cancer

authors： Ch'ng ES,Kumanogoh A

更新日期：2010-09-21 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) is highly invasive and aggressive and lacks specific molecular targets to improve the prognosis. MiR-25-3p promotes proliferation of many tumors and its role and underlying mechanisms in TNBC remain to be well elucidated. METHODS:Differential expression of miR-25-3p in T...

journal_title：Molecular cancer

authors： Chen H,Pan H,Qian Y,Zhou W,Liu X

更新日期：2018-01-08 00:00:00

abstract：BACKGROUND:Insulin enhancer binding protein-1 (ISL-1), a LIM-homeodomain transcription factor, is essential for the heart, motor neuron and pancreas development. Recently, ISL-1 has been found in some types of human cancers. However, how ISL-1 exerts the role in tumor development is not clear. METHODS AND RESULTS:The ...

journal_title：Molecular cancer

authors： Zhang Q,Yang Z,Jia Z,Liu C,Guo C,Lu H,Chen P,Ma K,Wang W,Zhou C

更新日期：2014-07-29 00:00:00

abstract：BACKGROUND:Oncolytic virotherapy is an attractive drug platform of cancer gene therapy, but efficacy and specificity are important prerequisites for success of such strategies. Previous studies determined that Apoptin is a p53 independent, bcl-2 insensitive apoptotic protein with the ability to specifically induce apop...

journal_title：Molecular cancer

authors： Li X,Liu Y,Wen Z,Li C,Lu H,Tian M,Jin K,Sun L,Gao P,Yang E,Xu X,Kan S,Wang Z,Wang Y,Jin N

更新日期：2010-01-20 00:00:00