The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines.

abstract：BACKGROUND:Sharing the common neuroectodermal origin, melanoma and neuroblastoma are tumors widely diffused among adult and children, respectively. Clinical prognosis of aggressive neuroectodermal cancers remains dismal, therefore the search for novel therapies against such tumors is warranted. Curcumin is a phytochemi...

journal_title：Molecular cancer

authors： Pisano M,Pagnan G,Dettori MA,Cossu S,Caffa I,Sassu I,Emionite L,Fabbri D,Cilli M,Pastorino F,Palmieri G,Delogu G,Ponzoni M,Rozzo C

更新日期：2010-06-03 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) has one of the poorest prognoses among all cancers. Over the past several decades, investigators have made great advances in the research of PDAC pathogenesis. Importantly, identification of pancreatic cancer stem cells (PCSCs) in pancreatic cancer cases has increased our unders...

journal_title：Molecular cancer

authors： Quan M,Wang P,Cui J,Gao Y,Xie K

更新日期：2013-12-10 00:00:00

abstract：:Monoclonal antibodies represent some of the most promising molecular targeted immunotherapies. However, understanding mechanisms by which tumors evade elimination by the immune system of the host presents a significant challenge for developing effective cancer immunotherapies. The interaction of cancer cells with the ...

journal_title：Molecular cancer

authors： Klinke DJ 2nd

更新日期：2010-09-15 00:00:00

abstract：BACKGROUND:To clarify the implications of cell-free nucleic acids (cfNA) in the plasma in neoplastic disease, it is necessary to determine the kinetics of their release into the circulation. METHODS:To quantify non-tumor and tumor DNA and RNA in the plasma of tumor-bearing rats and to correlate such levels with tumor ...

journal_title：Molecular cancer

authors： García-Olmo DC,Picazo MG,Toboso I,Asensio AI,García-Olmo D

更新日期：2013-02-04 00:00:00

abstract：BACKGROUND:Salivary Adenoid cystic carcinoma (SACC) patients with local invasion and lung metastasis are often resistant to conventional therapy such as operation, chemotherapy and radiotherapy. To explore the underling mechanisms, we studied the roles of miRNA in regulating invasiveness of SACC cells. METHODS:MicroRN...

journal_title：Molecular cancer

authors： Sun L,Liu B,Lin Z,Yao Y,Chen Y,Li Y,Chen J,Yu D,Tang Z,Wang B,Zeng S,Fan S,Wang Y,Li Y,Song E,Li J

更新日期：2015-04-29 00:00:00

abstract：BACKGROUND:Acute lymphoblastic leukemia (ALL) is the most common hematological malignancy affecting children. Despite significant progress and success in the treatment of ALL, a significant number of children continue to relapse and for them, outcome remains poor. Therefore, the search for novel therapeutic approaches ...

journal_title：Molecular cancer

authors： Sengupta TK,Leclerc GM,Hsieh-Kinser TT,Leclerc GJ,Singh I,Barredo JC

更新日期：2007-07-10 00:00:00

abstract：BACKGROUND:Glycochenodeoxycholate (GCDA) is one of the major human bile salts. Bile salts stimulate cell survival and proliferation through the mitogen-activated protein kinase, but the downstream signaling mechanism(s) remains enigmatic. Mcl-1 is an antiapoptotic molecule of the Bcl2 family that is extensively overexp...

journal_title：Molecular cancer

authors： Liao M,Zhao J,Wang T,Duan J,Zhang Y,Deng X

更新日期：2011-04-20 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumour (GIST) is the most common soft tissue sarcoma. The identification of the molecular mechanisms regulating GIST progression is vital for its treatment and prevention. Increasing reports have demonstrated that epigenetic alterations play critical roles in GIST development. Howeve...

journal_title：Molecular cancer

authors： Hu F,Li H,Liu L,Xu F,Lai S,Luo X,Hu J,Yang X

更新日期：2018-07-30 00:00:00

abstract：BACKGROUND:Platinum-containing chemotherapy produces specific DNA damage and is used to treat several human solid tumors. Tumors initially sensitive to platinum-based drugs frequently become resistant. Inhibition of DNA repair is a potential strategy to enhance cisplatin effectiveness. After cisplatin treatment, a bala...

journal_title：Molecular cancer

authors： Sand-Dejmek J,Adelmant G,Sobhian B,Calkins AS,Marto J,Iglehart DJ,Lazaro JB

更新日期：2011-06-16 00:00:00

abstract：:Because circulating microRNAs (miRNAs) have drawn a great deal of attention as promising novel cancer diagnostics and prognostic biomarkers, we sought to identify serum miRNAs significantly associated with outcome in glioblastoma patients. To do this, we performed global miRNA profiling in serum samples from 106 prima...

journal_title：Molecular cancer

authors： Zhao H,Shen J,Hodges TR,Song R,Fuller GN,Heimberger AB

更新日期：2017-03-11 00:00:00

abstract：BACKGROUND:Pancreatic cancer is a highly lethal disease and has the worst prognosis of any major malignancy. G protein-coupled receptor GPR87 is reported to be overexpressed in multiple cancers. The clinical significance and biological role of GPR87 in pancreatic cancer, however, remain to be established. METHODS:GPR8...

journal_title：Molecular cancer

authors： Wang L,Zhou W,Zhong Y,Huo Y,Fan P,Zhan S,Xiao J,Jin X,Gou S,Yin T,Wu H,Liu T

更新日期：2017-03-14 00:00:00

abstract：BACKGROUND:Lung cancer is the most lethal cancer and almost 90% of lung cancer is due to cigarette smoking. Even though nicotine, one of the major ingredients of cigarette smoke and the causative agent for addiction, is not a carcinogen by itself, several investigators have shown that nicotine can induce cell prolifera...

journal_title：Molecular cancer

authors： Puliyappadamba VT,Cheriyan VT,Thulasidasan AK,Bava SV,Vinod BS,Prabhu PR,Varghese R,Bevin A,Venugopal S,Anto RJ

更新日期：2010-08-20 00:00:00

abstract：BACKGROUND:Although the prognosis of gastric cancer patients have a favorable progression, there are some patients with unusual patterns of locoregional and systemic recurrence. Therefore, a better understanding of early molecular events of the disease is needed. Current evidences demonstrate that long noncoding RNAs (...

journal_title：Molecular cancer

authors： Liu YW,Xia R,Lu K,Xie M,Yang F,Sun M,De W,Wang C,Ji G

更新日期：2017-02-16 00:00:00

abstract：:Gene fusions occur in up to 17% of solid tumours. Oncogenic kinases are often involved in such fusions. In lung cancer, almost 30% of patients carrying an activated oncogene show the fusion of a tyrosine kinase to an heterologous gene. Several genes are partner in the fusion with the three kinases ALK, ROS1 and RET in...

journal_title：Molecular cancer

authors： Cerrato A,Visconti R,Celetti A

更新日期：2018-02-19 00:00:00

abstract：BACKGROUND:Aberrant expression of microRNAs in different human cancer types has been widely reported. MiR-218 acts as a tumor suppressor in diverse human cancer types impacting regulation of multiple genes in oncogenic pathways. Here, we evaluated the expression and function of miR-218 in human lung cancer and ALDH pos...

journal_title：Molecular cancer

authors： Yang Y,Ding L,Hu Q,Xia J,Sun J,Wang X,Xiong H,Gurbani D,Li L,Liu Y,Liu A

更新日期：2017-08-22 00:00:00

abstract：BACKGROUND:SLC/CCL21, normally expressed in high endothelial venules and in T cell zones of spleen and lymph nodes, strongly attracts T cells and dendritic cells (DC). We have previously shown that SLC/CCL21-mediated anti-tumor responses are accompanied by significant induction of IFNgamma and the CXC chemokines, monok...

journal_title：Molecular cancer

authors： Sharma S,Yang SC,Hillinger S,Zhu LX,Huang M,Batra RK,Lin JF,Burdick MD,Strieter RM,Dubinett SM

更新日期：2003-04-15 00:00:00

abstract：BACKGROUND:New blood vessel formation, or angiogenic switch, is an essential event in the development of solid tumors and their metastatic growth. Tumor blood vessel formation and remodeling is a complex and multi-step processes. The differentiation and recruitment of mural cells including vascular smooth muscle cells ...

journal_title：Molecular cancer

authors： Dhar K,Dhar G,Majumder M,Haque I,Mehta S,Van Veldhuizen PJ,Banerjee SK,Banerjee S

更新日期：2010-08-05 00:00:00

abstract：BACKGROUND:Interferon alpha (IFNα) is a well-established regulator of immunosuppression in head and neck squamous cell carcinoma (HNSCC), while the role of long noncoding RNAs (lncRNAs) in immunosuppression remains largely unknown. METHODS:Differentially expressed lncRNAs were screened under IFNα stimulation using lnc...

journal_title：Molecular cancer

authors： Ma H,Chang H,Yang W,Lu Y,Hu J,Jin S

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Fibroblast growth factors FGF-1 and FGF-2 are often upregulated in tumors, but tightly bound to heparan sulphate proteoglycans of the extracellular matrix (ECM). One mechanism of their bioactivation relies on the FGF-binding protein (FGF-BP) which, upon reversible binding to FGF-1 or -2, leads to their relea...

journal_title：Molecular cancer

authors： Schulze D,Plohmann P,Höbel S,Aigner A

更新日期：2011-11-23 00:00:00

abstract：:Exosomes have emerged as a novel approach for the treatment and diagnosis of cancer after RNA content was discovered in exosomes in 2007. As important meditators of intercellular communication, exosomes have become a strong focus of investigation for researchers in the past decade, as witnessed through the exponential...

journal_title：Molecular cancer

authors： Zhou R,Chen KK,Zhang J,Xiao B,Huang Z,Ju C,Sun J,Zhang F,Lv XB,Huang G

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:Akt/PKB is a serine/threonine kinase that has attracted much attention because of its central role in regulating cell proliferation, survival, motility and angiogenesis. Activation of Akt in breast cancer portends aggressive tumour behaviour, resistance to hormone-, chemo-, and radiotherapy-induced apoptosis...

journal_title：Molecular cancer

authors： Pecorari L,Marin O,Silvestri C,Candini O,Rossi E,Guerzoni C,Cattelani S,Mariani SA,Corradini F,Ferrari-Amorotti G,Cortesi L,Bussolari R,Raschellà G,Federico MR,Calabretta B

更新日期：2009-08-03 00:00:00

abstract：BACKGROUND:The clinical use of BRAF inhibitors for treatment of metastatic melanoma is limited by the development of drug resistance. In this study we investigated whether co-targeting the MAPK and the PI3K-AKT pathway can prevent emergence of resistance or provide additional growth inhibitory effects in vitro. METHOD...

journal_title：Molecular cancer

authors： Lassen A,Atefi M,Robert L,Wong DJ,Cerniglia M,Comin-Anduix B,Ribas A

更新日期：2014-04-16 00:00:00

abstract：BACKGROUND:Although chemotherapy represents a predominant anti-cancer therapeutic modality, drug treatment efficacy is often limited due to the development of resistant tumor cells. The pregnane X receptor (PXR) affects chemotherapeutic effects by regulating targets involved in drug metabolism and transportation, but t...

journal_title：Molecular cancer

authors： Dong Y,Wang Z,Xie GF,Li C,Zuo WW,Meng G,Xu CP,Li JJ

更新日期：2017-03-29 00:00:00

abstract：BACKGROUND:New therapies are urgently needed for patients with small cell lung cancer (SCLC). Chemotherapy and targeted therapies, including the Bcl-2 inhibitor ABT-737, may induce tumor cell autophagy. Autophagy can promote survival of cancer cells under stress and comprise a pathway of escape from cytotoxic therapies...

journal_title：Molecular cancer

authors： Zinn RL,Gardner EE,Dobromilskaya I,Murphy S,Marchionni L,Hann CL,Rudin CM

更新日期：2013-03-02 00:00:00

abstract：BACKGROUND:Aberrant accumulation of beta-catenin plays an important role in a variety of human neoplasms. We recently reported accumulation of beta-catenin in parathyroid adenomas from patients with primary hyperparathyroidism (pHPT). In CTNNB1 exon 3, we detected a stabilizing mutation (S37A) in 3 out of 20 analyzed a...

journal_title：Molecular cancer

authors： Björklund P,Lindberg D,Akerström G,Westin G

更新日期：2008-06-09 00:00:00

abstract：BACKGROUND:Although both circular RNAs (circRNAs) and autophagy are associated with the function of breast cancer (BC), whether circRNAs regulate BC progression via autophagy remains unknown. In this study, we aim to explore the regulatory mechanisms and the clinical significance of autophagy-associated circRNAs in BC....

journal_title：Molecular cancer

authors： Liang G,Ling Y,Mehrpour M,Saw PE,Liu Z,Tan W,Tian Z,Zhong W,Lin W,Luo Q,Lin Q,Li Q,Zhou Y,Hamai A,Codogno P,Li J,Song E,Gong C

更新日期：2020-03-25 00:00:00

abstract：BACKGROUND:Hodgkin lymphoma (HL) and Anaplastic Large Cell Lymphoma (ALCL), are forms of malignant lymphoma defined by unique morphologic, immunophenotypic, genotypic, and clinical characteristics, but both overexpress CD30. We used sub-megabase resolution tiling (SMRT) array-based comparative genomic hybridization to ...

journal_title：Molecular cancer

authors： Fadlelmola FM,Zhou M,de Leeuw RJ,Dosanjh NS,Harmer K,Huntsman D,Lam WL,Banerjee D

更新日期：2008-01-07 00:00:00

abstract：:Methionine aminopeptidase 2 (MetAP2) is a bifunctional protein that plays a critical role in the regulation of post-translational processing and protein synthesis. MetAP2 is overexpressed in human colon cancer. In this report we screened various MetAP2 inhibitors and treated HT29 cells with various concentrations of c...

journal_title：Molecular cancer

authors： Selvakumar P,Lakshmikuttyamma A,Das U,Pati HN,Dimmock JR,Sharma RK

更新日期：2009-08-24 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide, and the biology of this cancer remains poorly understood. Recent evidence indicates that long non-coding RNAs (lncRNAs) are found to be dysregulated in a variety of cancers, including HCC. Taurine Up-regulated Gene...

journal_title：Molecular cancer

authors： Huang MD,Chen WM,Qi FZ,Sun M,Xu TP,Ma P,Shu YQ

更新日期：2015-09-04 00:00:00

abstract：INTRODUCTION:ERBB3, one of the four members of the ErbB family of receptor tyrosine kinases, plays an important role in breast cancer etiology and progression. In the present study, we aimed to identify novel miRNAs that can potentially target ERBB3 and their biological functions. METHOD:The expression levels of miR-1...

journal_title：Molecular cancer

authors： Yan X,Chen X,Liang H,Deng T,Chen W,Zhang S,Liu M,Gao X,Liu Y,Zhao C,Wang X,Wang N,Li J,Liu R,Zen K,Zhang CY,Liu B,Ba Y

更新日期：2014-09-24 00:00:00