A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12.

abstract：BACKGROUND:Amplifications at 6p22.3 are prevalent in advanced stage bladder cancer (TCC). Previous studies have identified SOX4, CDKAL, and E2F3 as targets of this amplification and therefore potential oncogenes, but the more telomeric DEK gene too has been reported as overexpressed and amplified. We have therefore inv...

journal_title：Molecular cancer

authors： Wu Q,Hoffmann MJ,Hartmann FH,Schulz WA

更新日期：2005-05-05 00:00:00

abstract：:Cancer has become a major health issue worldwide, contributing to a high mortality rate. Tumor metastasis is attributed to the death of most patients. Epithelial-to-mesenchymal transition (EMT) plays a vital role in inducing metastasis. During EMT, epithelial cells lose their characteristics, such as cell-to-cell adhe...

journal_title：Molecular cancer

authors： Shang BQ,Li ML,Quan HY,Hou PF,Li ZW,Chu SF,Zheng JN,Bai J

更新日期：2019-09-16 00:00:00

abstract：BACKGROUND:Alterations of chromosome 8 and hypomethylation of LINE-1 retrotransposons are common alterations in advanced prostate carcinoma. In a former study including many metastatic cases, they strongly correlated with each other. To elucidate a possible interaction between the two alterations, we investigated their...

journal_title：Molecular cancer

authors： Schulz WA,Alexa A,Jung V,Hader C,Hoffmann MJ,Yamanaka M,Fritzsche S,Wlazlinski A,Müller M,Lengauer T,Engers R,Florl AR,Wullich B,Rahnenführer J

更新日期：2007-02-05 00:00:00

abstract：BACKGROUND:Antisense (AS) induced down-regulation of uPAR in ACCS adenoid-cyctic carcinoma cells decreased the cellular adhesion and invasion on various extracellular matrices. Additionally, ACCS-AS cells showed an increased EGFR expression and other behavioral similarities to NA-SCC, a typical highly proliferative but...

journal_title：Molecular cancer

authors： Abu-Ali S,Fotovati A,Shirasuna K

更新日期：2008-06-03 00:00:00

abstract：BACKGROUND:Epigenetic regulators play a critical role in the maintenance of specific chromatin domains in an active or repressed state. Disruption of epigenetic regulatory mechanisms is widespread in cancer cells and largely contributes to the transformation process through active repression of tumor suppressor genes. ...

journal_title：Molecular cancer

authors： Yeh CH,Bai XT,Moles R,Ratner L,Waldmann TA,Watanabe T,Nicot C

更新日期：2016-02-16 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Molecular cancer

authors： Rong D,Lu C,Zhang B,Fu K,Zhao S,Tang W,Cao H

更新日期：2020-09-09 00:00:00

abstract：BACKGROUND:Cancer is the result of a multistep process of genomic alterations, including mutations in key regulatory proteins that result in loss of balanced gene expression and subsequent malignant transformation. Throughout the various stages of colorectal carcinoma (CRC), complex genetic alterations occur, of which ...

journal_title：Molecular cancer

authors： Gaur S,Chen L,Ann V,Lin WC,Wang Y,Chang VH,Hsu NY,Shia HS,Yen Y

更新日期：2014-02-04 00:00:00

abstract：INTRODUCTION:Anaplastic thyroid carcinoma, which is one of the most aggressive, malignant tumors in humans, results in an extremely poor prognosis despite chemotherapy and radiotherapy. The present study was designed to evaluate therapeutic effects of radiation by glycerol on p53-mutant anaplastic thyroid carcinoma cel...

journal_title：Molecular cancer

authors： Ohnishi K,Ota I,Yane K,Takahashi A,Yuki K,Emoto M,Hosoi H,Ohnishi T

更新日期：2002-10-04 00:00:00

abstract：BACKGROUND:Pancreatic cancer is a highly lethal disease and has the worst prognosis of any major malignancy. G protein-coupled receptor GPR87 is reported to be overexpressed in multiple cancers. The clinical significance and biological role of GPR87 in pancreatic cancer, however, remain to be established. METHODS:GPR8...

journal_title：Molecular cancer

authors： Wang L,Zhou W,Zhong Y,Huo Y,Fan P,Zhan S,Xiao J,Jin X,Gou S,Yin T,Wu H,Liu T

更新日期：2017-03-14 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary tumor in the central nervous system. One of the most widely used chemotherapeutic drugs for GBM is temozolomide, which is a DNA-alkylating agent and its efficacy is dependent on MGMT methylation status. Little progress in improving the p...

journal_title：Molecular cancer

authors： Zhao HF,Wang J,Shao W,Wu CP,Chen ZP,To ST,Li WP

更新日期：2017-06-07 00:00:00

abstract：BACKGROUND:In our previous studies, we have demonstrated that insulin-like growth factor binding protein-related protein1 (IGFBP-rP1) played its potential tumor suppressor role in colon cancer cells through apoptosis and senescence induction. In this study, we will further uncover the role of IGFBP-rP1 in colon cancer ...

journal_title：Molecular cancer

authors： Ruan W,Zhu S,Wang H,Xu F,Deng H,Ma Y,Lai M

更新日期：2010-10-26 00:00:00

abstract：BACKGROUND:Cholangiocarcinoma (CCA) has an abundance of tumor stroma which plays an important role in cancer progression via tumor-promoting signals. This study aims to explore the microRNA (miRNA) profile of CCA-associated fibroblasts (CCFs) and the roles of any identified miRNAs in CCA progression. METHODS:miRNA exp...

journal_title：Molecular cancer

authors： Utaijaratrasmi P,Vaeteewoottacharn K,Tsunematsu T,Jamjantra P,Wongkham S,Pairojkul C,Khuntikeo N,Ishimaru N,Sirivatanauksorn Y,Pongpaibul A,Thuwajit P,Thuwajit C,Kudo Y

更新日期：2018-01-18 00:00:00

abstract：BACKGROUND:Neuroblastoma is responsible for 15% of all childhood cancer deaths. Despite advances in treatment and disease management, the overall 5-year survival rates remain poor in high-risk disease (25-40%). MiR-497 was previously identified by our laboratory as a member of a miRNA expression signature, predictive o...

journal_title：Molecular cancer

authors： Creevey L,Ryan J,Harvey H,Bray IM,Meehan M,Khan AR,Stallings RL

更新日期：2013-03-26 00:00:00

abstract：:Chimeric antigen receptor T (CAR-T) cell therapy is an emerging and effective cancer immunotherapy. Especially in hematological malignancies, CAR-T cells have achieved exciting results. Two Anti-CD19 CAR-T therapies have been approved for the treatment of CD19-positive leukemia or lymphoma. However, the application of...

journal_title：Molecular cancer

authors： Yu S,Yi M,Qin S,Wu K

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:Circular RNAs (circRNAs) are a new type of non-coding RNAs and their functions in gastric cancer (GC) remain unclear. Recent studies have revealed that circRNAs play an important role in cancer development and certain types of pathological responses, acting as microRNA (miRNA) sponges to regulate gene expres...

journal_title：Molecular cancer

authors： Liu H,Liu Y,Bian Z,Zhang J,Zhang R,Chen X,Huang Y,Wang Y,Zhu J

更新日期：2018-10-18 00:00:00

abstract：:Tumor metabolism is a thrilling discipline that focuses on mechanisms used by cancer cells to earn crucial building blocks and energy to preserve growth and overcome resistance to various treatment modalities. At the same time, therapies directed specifically against aberrant signalling pathways driven by protein tyro...

journal_title：Molecular cancer

authors： Poliaková M,Aebersold DM,Zimmer Y,Medová M

更新日期：2018-02-19 00:00:00

abstract：BACKGROUND:Transforming Growth Factor beta (TGF-beta) plays an important role in tumor invasion and metastasis. We set out to investigate the possible clinical utility of TGF-beta antagonists in a human metastatic basal-like breast cancer model. We examined the effects of two types of the TGF-beta pathway antagonists (...

journal_title：Molecular cancer

authors： Ganapathy V,Ge R,Grazioli A,Xie W,Banach-Petrosky W,Kang Y,Lonning S,McPherson J,Yingling JM,Biswas S,Mundy GR,Reiss M

更新日期：2010-05-26 00:00:00

abstract：:Cancer is a leading cause of death worldwide, particularly because of its high mortality rate in patients who are diagnosed at late stages. Conventional biomarkers originating from blood are widely used for cancer diagnosis, but their low sensitivity and specificity limit their widespread application in cancer screeni...

journal_title：Molecular cancer

authors： Wang S,Zhang K,Tan S,Xin J,Yuan Q,Xu H,Xu X,Liang Q,Christiani DC,Wang M,Liu L,Du M

更新日期：2021-01-11 00:00:00

abstract：:The mammalian target of rapamycin (mTOR), which exists in two functionally distinct complexes, mTORC1 and mTORC2 plays an important role in tumor growth. Whereas the role of mTORC1 has been well characterized in this process, little is known about the functions of mTORC2 in cancer progression. In this study, we explor...

journal_title：Molecular cancer

authors： Roulin D,Cerantola Y,Dormond-Meuwly A,Demartines N,Dormond O

更新日期：2010-03-12 00:00:00

abstract：:Cell lines are still a tool of choice for many fields of biomedical research, including oncology. Although cancer is a very complex disease, many discoveries have been made using monocultures of established cell lines. Therefore, the proper use of in vitro models is crucial to enhance our understanding of cancer. Ther...

journal_title：Molecular cancer

authors： Brodaczewska KK,Szczylik C,Fiedorowicz M,Porta C,Czarnecka AM

更新日期：2016-12-19 00:00:00

abstract：:Since the publication of this work [1] and in response to a recent query that was brought to our attention in relation to the Western Blot in Figure 1(C) for NP2, protein lysates prepared around the same time as those presented in the manuscript in question, were run by SDS-PAGE under similar experimental conditions a...

journal_title：Molecular cancer

authors： Barr MP,Gray SG,Gately K,Hams E,Fallon PG,Davies AM,Richard DJ,Pidgeon GP,O'Byrne KJ

更新日期：2020-01-27 00:00:00

abstract：BACKGROUND:Metastatic renal cell carcinoma (RCC) remains the leading cause of mortality in patients with clear cell RCC arising from mutations in the von Hippel Lindau (VHL) tumor suppressor. Successful RCC tumor suppression by VHL requires the negative regulation of hypoxia inducible factor alpha (HIF alpha) protein a...

journal_title：Molecular cancer

authors： Petrella BL,Brinckerhoff CE

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:The IκB kinase (IKK) complex, comprising the two enzymes IKKα and IKKβ, is the main activator of the inflammatory transcription factor NF-κB, which is constitutively active in many cancers. While several connections between NF-κB signaling and the oncogene c-Myc have been shown, functional links between the ...

journal_title：Molecular cancer

authors： Moser B,Hochreiter B,Basílio J,Gleitsmann V,Panhuber A,Pardo-Garcia A,Hoesel B,Salzmann M,Resch U,Noreen M,Schmid JA

更新日期：2021-01-18 00:00:00

abstract：BACKGROUND:Perturbation of DNA methylation is frequent in cancers and has emerged as an important mechanism involved in tumorigenesis. To determine how DNA methylation is modified in the genome of primary glioma, we used Methyl-DNA immunoprecipitation (MeDIP) and Nimblegen CpG promoter microarrays to identify different...

journal_title：Molecular cancer

authors： Zhang Z,Tang H,Wang Z,Zhang B,Liu W,Lu H,Xiao L,Liu X,Wang R,Li X,Wu M,Li G

更新日期：2011-09-30 00:00:00

abstract：BACKGROUND:Interferon Regulatory Factor 5 is a transcription factor that regulates the expression of genes involved in the response to viral infection and in the stimulation of the immune system. Moreover, multiple studies have demonstrated that it negatively regulates cell growth and oncogenesis, favoring cell differe...

journal_title：Molecular cancer

authors： Massimino M,Vigneri P,Fallica M,Fidilio A,Aloisi A,Frasca F,Manzella L

更新日期：2012-04-16 00:00:00

abstract：INTRODUCTION:ERBB3, one of the four members of the ErbB family of receptor tyrosine kinases, plays an important role in breast cancer etiology and progression. In the present study, we aimed to identify novel miRNAs that can potentially target ERBB3 and their biological functions. METHOD:The expression levels of miR-1...

journal_title：Molecular cancer

authors： Yan X,Chen X,Liang H,Deng T,Chen W,Zhang S,Liu M,Gao X,Liu Y,Zhao C,Wang X,Wang N,Li J,Liu R,Zen K,Zhang CY,Liu B,Ba Y

更新日期：2014-09-24 00:00:00

abstract：BACKGROUND:Akt/PKB is a serine/threonine kinase that has attracted much attention because of its central role in regulating cell proliferation, survival, motility and angiogenesis. Activation of Akt in breast cancer portends aggressive tumour behaviour, resistance to hormone-, chemo-, and radiotherapy-induced apoptosis...

journal_title：Molecular cancer

authors： Pecorari L,Marin O,Silvestri C,Candini O,Rossi E,Guerzoni C,Cattelani S,Mariani SA,Corradini F,Ferrari-Amorotti G,Cortesi L,Bussolari R,Raschellà G,Federico MR,Calabretta B

更新日期：2009-08-03 00:00:00

abstract：BACKGROUND:Fusion of the MOZ and TIF2 genes by an inv (8) (p11q13) translocation has been identified in patients with acute mixed-lineage leukemia. Characterization of the molecular structure of the MOZ-TIF2 fusion protein suggested that the fusion protein would effect on nuclear receptor signaling. RESULTS:A series o...

journal_title：Molecular cancer

authors： Yin H,Glass J,Blanchard KL

更新日期：2007-08-13 00:00:00

abstract：BACKGROUND:Medulloblastoma is the most common type of malignant brain tumor that afflicts children. Although recent advances in chemotherapy and radiation have improved outcomes, high-risk patients do poorly with significant morbidity. METHODS:To identify new molecular targets, we performed an integrated genomic analy...

journal_title：Molecular cancer

authors： Harris PS,Venkataraman S,Alimova I,Birks DK,Balakrishnan I,Cristiano B,Donson AM,Dubuc AM,Taylor MD,Foreman NK,Reigan P,Vibhakar R

更新日期：2014-03-24 00:00:00

abstract：:The concept that vegetables and fruits are relevant sources of cancer-preventive substances is strongly supported by population studies. Among others, cruciferous vegetables like broccoli, cabbage, cauliflower and Brussels sprouts are thought to affect the development of various types of cancers and especially prostat...

journal_title：Molecular cancer

authors： Appendino G,Bardelli A

更新日期：2010-12-01 00:00:00