当前位置： SCI文献检索 > Molecular Cancer期刊下所有文献 > A novel IFNα-induced long noncoding RNA negatively regulates immunosuppression by interrupting H3K27 acetylation in head and neck squamous cell carcinoma.

A novel IFNα-induced long noncoding RNA negatively regulates immunosuppression by interrupting H3K27 acetylation in head and neck squamous cell carcinoma.

Abstract：

BACKGROUND:Interferon alpha (IFNα) is a well-established regulator of immunosuppression in head and neck squamous cell carcinoma (HNSCC), while the role of long noncoding RNAs (lncRNAs) in immunosuppression remains largely unknown. METHODS:Differentially expressed lncRNAs were screened under IFNα stimulation using lncRNA sequencing. The role and mechanism of lncRNA in immunosuppression were investigated in HNSCC in vitro and in vivo. RESULTS:We identified a novel IFNα-induced upregulated lncRNA, lncMX1-215, in HNSCC. LncMX1-215 was primarily located in the cell nucleus. Ectopic expression of lncMX1-215 markedly inhibited expression of the IFNα-induced, immunosuppression-related molecules programmed cell death 1 ligand 1 (PD-L1) and galectin-9, and vice versa. Subsequently, histone deacetylase (HDAC) inhibitors promoted the expression of PD-L1 and galectin-9. Binding sites for H3K27 acetylation were found on PD-L1 and galectin-9 promoters. Mechanistically, we found that lncMX1-215 directly interacted with GCN5, a known H3K27 acetylase, to interrupt its binding to H3K27 acetylation. Clinically, negative correlations between lncMX1-215 and PD-L1 and galectin-9 expression were observed. Finally, overexpression of lncMX1-215 suppressed HNSCC proliferation and metastasis capacity in vitro and in vivo. CONCLUSIONS:Our results suggest that lncMX1-215 negatively regulates immunosuppression by interrupting GCN5/H3K27ac binding in HNSCC, thus providing novel insights into immune checkpoint blockade treatment.

journal_name

Mol Cancer

journal_title

Molecular cancer

authors

Ma H,Chang H,Yang W,Lu Y,Hu J,Jin S

doi

10.1186/s12943-019-1123-y

subject

Has Abstract

pub_date

2020-01-06 00:00:00

pages

4

issue

1

issn

1476-4598

pii

10.1186/s12943-019-1123-y

journal_volume

19

pub_type

杂志文章

相关文献

Molecular Cancer文献大全
  • Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling.

    abstract：BACKGROUND:Patients with familial adenomatous polyposis (FAP) are at increased risk for the development of colorectal cancer. Surgery and chemoprevention are the most effective means to prevent cancer development. Thymoquinone (TQ) is considered the main compound of the volatile Nigella sativa seed oil and has been rep...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-12-41

    authors： Lang M,Borgmann M,Oberhuber G,Evstatiev R,Jimenez K,Dammann KW,Jambrich M,Khare V,Campregher C,Ristl R,Gasche C

    更新日期：2013-05-13 00:00:00

  • Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer.

    abstract：BACKGROUND:Colorectal cancer is third most common malignancy and is the second most common cause of cancer-related death. The MUC1 heterodimeric protein is aberrantly overexpressed in colorectal cancer and has been linked to poor outcomes in this disease. Here, we investigate the effects of the MUC1-C subunit inhibitor...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/s12943-017-0608-9

    authors： Ahmad R,Alam M,Hasegawa M,Uchida Y,Al-Obaid O,Kharbanda S,Kufe D

    更新日期：2017-02-02 00:00:00

  • Dual effects of TGF-beta on ERalpha-mediated estrogenic transcriptional activity in breast cancer.

    abstract：BACKGROUND:TGF-beta resistance often develops in breast cancer cells that in turn overproduce this cytokine to create a local immunosuppressive environment that fosters tumor growth and exacerbates the invasive and metastatic behavior of the tumor cells themselves. Smads-mediated cross-talk with the estrogen receptor h...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-8-111

    authors： Ren Y,Wu L,Frost AR,Grizzle W,Cao X,Wan M

    更新日期：2009-11-27 00:00:00

  • SLC/CCL21-mediated anti-tumor responses require IFNgamma, MIG/CXCL9 and IP-10/CXCL10.

    abstract：BACKGROUND:SLC/CCL21, normally expressed in high endothelial venules and in T cell zones of spleen and lymph nodes, strongly attracts T cells and dendritic cells (DC). We have previously shown that SLC/CCL21-mediated anti-tumor responses are accompanied by significant induction of IFNgamma and the CXC chemokines, monok...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-2-22

    authors： Sharma S,Yang SC,Hillinger S,Zhu LX,Huang M,Batra RK,Lin JF,Burdick MD,Strieter RM,Dubinett SM

    更新日期：2003-04-15 00:00:00

  • Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile.

    abstract：BACKGROUND:In high grade gliomas, 1p19q codeletion and EGFR amplification are mutually exclusive and predictive of dramatically different outcomes. We performed a microarray gene expression study of four high grade gliomas with 1p19q codeletion and nine with EGFR amplification, identified by CGH-array. RESULTS:The two...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-7-41

    authors： Ducray F,Idbaih A,de Reyniès A,Bièche I,Thillet J,Mokhtari K,Lair S,Marie Y,Paris S,Vidaud M,Hoang-Xuan K,Delattre O,Delattre JY,Sanson M

    更新日期：2008-05-20 00:00:00

  • Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines.

    abstract：BACKGROUND:Kinases downstream of growth factor receptors have been implicated in radioresistance and are, therefore, attractive targets to improve radiotherapy outcome in head and neck squamous cell carcinoma (HNSCC) patients. METHODS:An antibody-based array was used to quantify the expression levels of multiple phosp...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-12-133

    authors： Stegeman H,Kaanders JH,Verheijen MM,Peeters WJ,Wheeler DL,Iida M,Grénman R,van der Kogel AJ,Span PN,Bussink J

    更新日期：2013-11-05 00:00:00

  • Thyroid cancers of follicular origin in a genomic light: in-depth overview of common and unique molecular marker candidates.

    abstract：:In recent years, thyroid malignances have become more prevalent, especially among women. The most common sporadic types of thyroid tumors of follicular origin include papillary, follicular and anaplastic thyroid carcinomas. Although modern diagnosis methods enable the identification of tumors of small diameter, tumor ...

    journal_title：Molecular cancer

    pub_type： 杂志文章,评审

    doi：10.1186/s12943-018-0866-1

    authors： Pstrąg N,Ziemnicka K,Bluyssen H,Wesoły J

    更新日期：2018-08-08 00:00:00

  • DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival.

    abstract：BACKGROUND:The exposure of skin keratinocytes to Ultraviolet (UV) irradiation leads to Akt phosphorylation at Ser-473, which is important for the carcinogenic effects of excessive sun exposure. The present study investigated the underlying mechanism of Akt Ser-473 phosphorylation by UVB radiation. RESULTS:We found tha...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-12-172

    authors： Tu Y,Ji C,Yang B,Yang Z,Gu H,Lu CC,Wang R,Su ZL,Chen B,Sun WL,Xia JP,Bi ZG,He L

    更新日期：2013-12-24 00:00:00

  • Next generation chimeric antigen receptor T cells: safety strategies to overcome toxicity.

    abstract：:Chimeric antigen receptor T (CAR-T) cell therapy is an emerging and effective cancer immunotherapy. Especially in hematological malignancies, CAR-T cells have achieved exciting results. Two Anti-CD19 CAR-T therapies have been approved for the treatment of CD19-positive leukemia or lymphoma. However, the application of...

    journal_title：Molecular cancer

    pub_type： 杂志文章,评审

    doi：10.1186/s12943-019-1057-4

    authors： Yu S,Yi M,Qin S,Wu K

    更新日期：2019-08-20 00:00:00

  • Cathepsin S-mediated autophagic flux in tumor-associated macrophages accelerate tumor development by promoting M2 polarization.

    abstract：BACKGROUND:Tumor-associated macrophages (TAMs) are the major component of tumor-infiltrating leukocytes. TAMs are heterogeneous, with distinct phenotypes influenced by the microenvironment surrounding tumor tissues, but relatively little is known about the key molecular in these cells that contribute to malignant pheno...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-13-43

    authors： Yang M,Liu J,Shao J,Qin Y,Ji Q,Zhang X,Du J

    更新日期：2014-03-02 00:00:00

  • RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy.

    abstract：BACKGROUND:The tetraspanin CD63 is a highly N-glycosylated protein that is known to regulate cancer malignancy. However, the contribution of glycosylation of CD63 to cancer malignancy remains unclear. Previously, we reported that ribophorin II (RPN2), which is part of an N-oligosaccharyle transferase complex, is respon...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-13-134

    authors： Tominaga N,Hagiwara K,Kosaka N,Honma K,Nakagama H,Ochiya T

    更新日期：2014-05-31 00:00:00

  • RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts.

    abstract：BACKGROUND:Incorrect segregation of whole chromosomes or parts of chromosome leads to aneuploidy commonly observed in cancer. The correct centrosome duplication, assuring assembly of a bipolar mitotic spindle, is essential for chromosome segregation fidelity and preventing aneuploidy. Alteration of p53 and pRb function...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-5-38

    authors： Iovino F,Lentini L,Amato A,Di Leonardo A

    更新日期：2006-09-20 00:00:00

  • Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action.

    abstract：BACKGROUND:Breast cancer is the second leading cause of cancer related deaths among females worldwide. Berbamine (BER), a kind of bis-benzylisoquinoline alkaloid, has been used to treat clinical patients with inflammation and cancer for many years in China. The purpose of this study is to investigate the activity of BE...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-8-81

    authors： Wang S,Liu Q,Zhang Y,Liu K,Yu P,Liu K,Luan J,Duan H,Lu Z,Wang F,Wu E,Yagasaki K,Zhang G

    更新日期：2009-10-01 00:00:00

  • Diagnostic, prognostic and predictive value of cell-free miRNAs in prostate cancer: a systematic review.

    abstract：:Prostate cancer, the second most frequently diagnosed cancer in males worldwide, is estimated to be diagnosed in 1.1 million men per year. Introduction of PSA testing substantially improved early detection of prostate cancer, however it also led to overdiagnosis and subsequent overtreatment of patients with an indolen...

    journal_title：Molecular cancer

    pub_type： 杂志文章,评审

    doi：10.1186/s12943-016-0523-5

    authors： Endzeliņš E,Melne V,Kalniņa Z,Lietuvietis V,Riekstiņa U,Llorente A,Linē A

    更新日期：2016-05-18 00:00:00

  • Role of PP2Calpha in cell growth, in radio- and chemosensitivity, and in tumorigenicity.

    abstract：BACKGROUND:PP2Calpha is the representative member of the type 2C family of protein phosphatases, and it has recently been implicated in the regulation of p53-, TGFbeta-, cyclin-dependent kinase- and apoptosis-signaling. To investigate the role of PP2Calpha in cell growth and in radio- and chemosensitivity, wild type an...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-6-65

    authors： Lammers T,Peschke P,Ehemann V,Debus J,Slobodin B,Lavi S,Huber P

    更新日期：2007-10-17 00:00:00

  • NC2213: a novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cells.

    abstract：:Methionine aminopeptidase 2 (MetAP2) is a bifunctional protein that plays a critical role in the regulation of post-translational processing and protein synthesis. MetAP2 is overexpressed in human colon cancer. In this report we screened various MetAP2 inhibitors and treated HT29 cells with various concentrations of c...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-8-65

    authors： Selvakumar P,Lakshmikuttyamma A,Das U,Pati HN,Dimmock JR,Sharma RK

    更新日期：2009-08-24 00:00:00

  • Epigenetic aberrations and cancer.

    abstract：:The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms. Here, we review recent findings regarding chromatin modifications and their relevance to cancer. ...

    journal_title：Molecular cancer

    pub_type： 杂志文章,评审

    doi：10.1186/1476-4598-5-60

    authors： Ducasse M,Brown MA

    更新日期：2006-11-08 00:00:00

  • Oncogenic KRAS promotes malignant brain tumors in zebrafish.

    abstract：BACKGROUND:Zebrafish have been used as a vertebrate model to study human cancers such as melanoma, rhabdomyosarcoma, liver cancer, and leukemia as well as for high-throughput screening of small molecules of therapeutic value. However, they are just emerging as a model for human brain tumors, which are among the most de...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/s12943-015-0288-2

    authors： Ju B,Chen W,Orr BA,Spitsbergen JM,Jia S,Eden CJ,Henson HE,Taylor MR

    更新日期：2015-02-03 00:00:00

  • LMP1-augmented kappa intron enhancer activity contributes to upregulation expression of Ig kappa light chain via NF-kappaB and AP-1 pathways in nasopharyngeal carcinoma cells.

    abstract：BACKGROUND:Expression of kappa gene is under the control of distinct cis-regulatory elements, including the kappa intron enhancer (iE kappa) and the kappa 3' enhancer (3'E kappa). The active enhancers and expression of immunoglobulin is generally considered to be restricted to B lymphocytes. However, accumulating evide...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-8-92

    authors： Liu H,Zheng H,Duan Z,Hu D,Li M,Liu S,Li Z,Deng X,Wang Z,Tang M,Shi Y,Yi W,Cao Y

    更新日期：2009-10-27 00:00:00

  • Down-regulation of PPARgamma1 suppresses cell growth and induces apoptosis in MCF-7 breast cancer cells.

    abstract：BACKGROUND:Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear hormone receptor superfamily and is highly expressed in many human tumors including breast cancer. PPARgamma has been identified as a potential target for breast cancer therapy based on the fact that its activation by syn...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-7-90

    authors： Zaytseva YY,Wang X,Southard RC,Wallis NK,Kilgore MW

    更新日期：2008-12-05 00:00:00

  • The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine.

    abstract：BACKGROUND:Sigma-2 receptors are over-expressed in proliferating cancer cells, making an attractive target for the targeted treatment of pancreatic cancer. In this study, we investigated the role of the novel sigma-2 receptor ligand SW43 to induce apoptosis and augment standard chemotherapy. RESULTS:The binding affini...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-9-298

    authors： Hornick JR,Xu J,Vangveravong S,Tu Z,Mitchem JB,Spitzer D,Goedegebuure P,Mach RH,Hawkins WG

    更新日期：2010-11-22 00:00:00

  • Tumor promoting effects of CD95 signaling in chemoresistant cells.

    abstract：BACKGROUND:CD95 is a death receptor controlling not only apoptotic pathways but also activating mechanisms promoting tumor growth. During the acquisition of chemoresistance to oxaliplatin there is a progressive loss of CD95 expression in colon cancer cells and a decreased ability of this receptor to induce cell death. ...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-9-161

    authors： Ametller E,García-Recio S,Costamagna D,Mayordomo C,Fernández-Nogueira P,Carbó N,Pastor-Arroyo EM,Gascón P,Almendro V

    更新日期：2010-06-23 00:00:00

  • Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1.

    abstract：BACKGROUND:CADM1 encodes an immunoglobulin superfamily (IGSF) cell adhesion molecule. Inactivation of CADM1, either by promoter hypermethylation or loss of heterozygosity, has been reported in a wide variety of tumor types, thus it has been postulated as a tumor suppressor gene. FINDINGS:We show for the first time tha...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-11-29

    authors： van der Weyden L,Arends MJ,Rust AG,Poulogiannis G,McIntyre RE,Adams DJ

    更新日期：2012-05-03 00:00:00

  • Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes.

    abstract：BACKGROUND:MUC16 is a cell surface mucin expressed at high levels by epithelial ovarian tumors. Following proteolytic cleavage, cell surface MUC16 (csMUC16) is shed in the extracellular milieu and is detected in the serum of cancer patients as the tumor marker CA125. csMUC16 acts as an adhesion molecule and facilitates...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-9-118

    authors： Belisle JA,Horibata S,Jennifer GA,Petrie S,Kapur A,André S,Gabius HJ,Rancourt C,Connor J,Paulson JC,Patankar MS

    更新日期：2010-05-24 00:00:00

  • Effects of AKT inhibitor therapy in response and resistance to BRAF inhibition in melanoma.

    abstract：BACKGROUND:The clinical use of BRAF inhibitors for treatment of metastatic melanoma is limited by the development of drug resistance. In this study we investigated whether co-targeting the MAPK and the PI3K-AKT pathway can prevent emergence of resistance or provide additional growth inhibitory effects in vitro. METHOD...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-13-83

    authors： Lassen A,Atefi M,Robert L,Wong DJ,Cerniglia M,Comin-Anduix B,Ribas A

    更新日期：2014-04-16 00:00:00

  • Tumor cell-derived PDGF-B potentiates mouse mesenchymal stem cells-pericytes transition and recruitment through an interaction with NRP-1.

    abstract：BACKGROUND:New blood vessel formation, or angiogenic switch, is an essential event in the development of solid tumors and their metastatic growth. Tumor blood vessel formation and remodeling is a complex and multi-step processes. The differentiation and recruitment of mural cells including vascular smooth muscle cells ...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-9-209

    authors： Dhar K,Dhar G,Majumder M,Haque I,Mehta S,Van Veldhuizen PJ,Banerjee SK,Banerjee S

    更新日期：2010-08-05 00:00:00

  • Broccoli, PTEN deletion and prostate cancer: where is the link?

    abstract：:The concept that vegetables and fruits are relevant sources of cancer-preventive substances is strongly supported by population studies. Among others, cruciferous vegetables like broccoli, cabbage, cauliflower and Brussels sprouts are thought to affect the development of various types of cancers and especially prostat...

    journal_title：Molecular cancer

    pub_type： 评论,杂志文章

    doi：10.1186/1476-4598-9-308

    authors： Appendino G,Bardelli A

    更新日期：2010-12-01 00:00:00

  • Correction to: Circular RNA circFGFR1 promotes progression and anti-PD-1 resistance by sponging miR-381-3p in non-small cell lung cancer cells.

    abstract：:After the publication of this work [1], an error was found in Fig. 1b. As described in the Results section that circ0084003 has 13 exons, it should be formed by 5-17 (13exons) exons, authors have described "formed by 5-19 exons". The authors extend their apology for the mistake caused by their action. With that mistak...

    journal_title：Molecular cancer

    pub_type： 已发布勘误

    doi：10.1186/s12943-020-1131-y

    authors： Zhang PF,Pei X,Li KS,Jin LN,Wang F,Wu J,Zhang XM

    更新日期：2020-02-01 00:00:00

  • Perforin-dependent direct cytotoxicity in natural killer cells induces considerable knockdown of spontaneous lung metastases and computer modelling-proven tumor cell dormancy in a HT29 human colon cancer xenograft mouse model.

    abstract：BACKGROUND:For long, natural killer (NK) cells have been suspected to play a critical role in suppressing the development of spontaneous metastases in cancer patients. Despite a wide range of studies it remains unclear so far to what extent primary tumor growth together with formation of distant metastases and NK cell ...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-13-244

    authors： Brodbeck T,Nehmann N,Bethge A,Wedemann G,Schumacher U

    更新日期：2014-11-05 00:00:00

  • METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner.

    abstract：BACKGROUND:METTL3 is known to be involved in all stages in the life cycle of RNA. It affects the tumor formation by the regulation the m6A modification in the mRNAs of critical oncogenes or tumor suppressors. In bladder cancer, METTL3 could promote the bladder cancer progression via AFF4/NF-κB/MYC signaling network by ...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/s12943-019-1036-9

    authors： Han J,Wang JZ,Yang X,Yu H,Zhou R,Lu HC,Yuan WB,Lu JC,Zhou ZJ,Lu Q,Wei JF,Yang H

    更新日期：2019-06-22 00:00:00