Abstract:
BACKGROUND:Aberrant accumulation of beta-catenin plays an important role in a variety of human neoplasms. We recently reported accumulation of beta-catenin in parathyroid adenomas from patients with primary hyperparathyroidism (pHPT). In CTNNB1 exon 3, we detected a stabilizing mutation (S37A) in 3 out of 20 analyzed adenomas. The aim of the present study was to determine the frequency and zygosity of mutations in CTNNB1 exon 3, and beta-catenin accumulation in a large series of parathyroid adenomas of Swedish patients. RESULTS:The mutation S37A (TCT > GCT) was detected by direct DNA sequencing of PCR fragments in 6 out of 104 sporadic parathyroid adenomas (5.8%). Taking our previous study into account, a total of 9 out of 124 (7.3%) adenomas displayed the same mutation. The mutations were homozygous by DNA sequencing, restriction enzyme cleavage, and gene copy number determination using the GeneChip 500 K Mapping Array Set. All tumors analyzed by immunohistochemistry, including those with mutation, displayed aberrant beta-catenin accumulation. Western blotting revealed a slightly higher expression level of beta-catenin and nonphosphorylated active beta-catenin in tumors with mutation compared to those without. Presence of the mutation was not related to distinct clinical characteristics. CONCLUSION:Aberrant accumulation of beta-catenin is very common in parathyroid tumors, and is caused by stabilizing homozygous mutation in 7.3% of Swedish pHPT patients.
journal_name
Mol Cancerjournal_title
Molecular cancerauthors
Björklund P,Lindberg D,Akerström G,Westin Gdoi
10.1186/1476-4598-7-53subject
Has Abstractpub_date
2008-06-09 00:00:00pages
53issn
1476-4598pii
1476-4598-7-53journal_volume
7pub_type
杂志文章相关文献
Molecular Cancer文献大全abstract:BACKGROUND:PP2Calpha is the representative member of the type 2C family of protein phosphatases, and it has recently been implicated in the regulation of p53-, TGFbeta-, cyclin-dependent kinase- and apoptosis-signaling. To investigate the role of PP2Calpha in cell growth and in radio- and chemosensitivity, wild type an...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-6-65
更新日期:2007-10-17 00:00:00
abstract:BACKGROUND:Gefitinib is a tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR) especially effective in tumors with activating EGFR gene mutations while EGFR wild-type non small cell lung cancer (NSCLC) patients at present do not benefit from this treatment.The primary site of gefitinib metabol...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-143
更新日期:2011-11-23 00:00:00
abstract:BACKGROUND:Although both circular RNAs (circRNAs) and autophagy are associated with the function of breast cancer (BC), whether circRNAs regulate BC progression via autophagy remains unknown. In this study, we aim to explore the regulatory mechanisms and the clinical significance of autophagy-associated circRNAs in BC....
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-020-01152-2
更新日期:2020-03-25 00:00:00
abstract:BACKGROUND:Differential mRNA splicing and alternative promoter usage of the TP73 gene results in the expression of multiple NH2-truncated isoforms that act as oncogenes. Abundant levels of these p73 variants in a variety of human cancers correlated with adverse clinical prognosis and response failure to conventional th...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-8-61
更新日期:2009-08-11 00:00:00
abstract:BACKGROUND:Gastrointestinal stromal tumour (GIST) is the most common soft tissue sarcoma. The identification of the molecular mechanisms regulating GIST progression is vital for its treatment and prevention. Increasing reports have demonstrated that epigenetic alterations play critical roles in GIST development. Howeve...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-018-0861-6
更新日期:2018-07-30 00:00:00
abstract::Exosomes have emerged as a novel approach for the treatment and diagnosis of cancer after RNA content was discovered in exosomes in 2007. As important meditators of intercellular communication, exosomes have become a strong focus of investigation for researchers in the past decade, as witnessed through the exponential...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-018-0823-z
更新日期:2018-03-20 00:00:00
abstract:BACKGROUND:Previous reports have suggested that the VEGF receptor neuropilin-1 (NRP-1) is expressed in a singly dispersed subpopulation of cells in the normal colonic epithelium, but that expression becomes dysregulated during colorectal carcinogenesis, with higher levels in tumour suggestive of a poor prognosis. We no...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-27
更新日期:2011-03-14 00:00:00
abstract:BACKGROUND:Neuroblastoma is responsible for 15% of all childhood cancer deaths. Despite advances in treatment and disease management, the overall 5-year survival rates remain poor in high-risk disease (25-40%). MiR-497 was previously identified by our laboratory as a member of a miRNA expression signature, predictive o...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-12-23
更新日期:2013-03-26 00:00:00
abstract:BACKGROUND:In addition to androgens, growth factors are also implicated in the development and neoplastic growth of the prostate gland. Prosaposin is a potent neurotrophic molecule. Homozygous inactivation of prosaposin in mice has led to the development of a number of abnormalities in the male reproductive system, inc...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-3-31
更新日期:2004-11-17 00:00:00
abstract:BACKGROUND:As an important means of communication, exosomes play an important role in the development of hepatocellular carcinoma (HCC). METHODS:Bioinformatics analysis, dual-luciferase reporter assays, methylation-specific quantitative PCR, and ChIP-PCR analysis were used to gain insight into the underlying mechanism...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-019-1075-2
更新日期:2019-10-27 00:00:00
abstract:BACKGROUND:Triple-negative breast cancer (TNBC) is highly invasive and aggressive and lacks specific molecular targets to improve the prognosis. MiR-25-3p promotes proliferation of many tumors and its role and underlying mechanisms in TNBC remain to be well elucidated. METHODS:Differential expression of miR-25-3p in T...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-017-0754-0
更新日期:2018-01-08 00:00:00
abstract:BACKGROUND:Truncated dopamine and cyclic-AMP-regulated phosphoprotein (t-DARPP) is frequently overexpressed in gastrointestinal malignancies. In this study, we examined the role of t-DARPP in regulating β-catenin. RESULTS:The pTopFlash construct that contains multiple TCF/LEF-binding sites was used as a measure of β-c...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-32
更新日期:2011-03-29 00:00:00
abstract::Long-noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200 nucleotides and do not code for proteins. However, this class of RNAs plays pivotal regulatory roles. The mechanism of their action is highly complex. Mounting evidence shows that lncRNAs can regulate cancer onset and progression in a va...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-017-0699-3
更新日期:2017-07-24 00:00:00
abstract:BACKGROUND:Among women worldwide, breast cancer is the most commonly diagnosed cancer, and the second leading cause of cancer-related deaths. Improved understanding of breast tumourigenesis may facilitate the development of more effective therapies. Peroxisome proliferator-activated receptor (PPAR)γ is a transcription ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-015-0347-8
更新日期:2015-04-15 00:00:00
abstract:BACKGROUND:Hodgkin lymphoma (HL) and Anaplastic Large Cell Lymphoma (ALCL), are forms of malignant lymphoma defined by unique morphologic, immunophenotypic, genotypic, and clinical characteristics, but both overexpress CD30. We used sub-megabase resolution tiling (SMRT) array-based comparative genomic hybridization to ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-7-2
更新日期:2008-01-07 00:00:00
abstract:BACKGROUND:Acute lymphoblastic leukemia (ALL) is the most common hematological malignancy affecting children. Despite significant progress and success in the treatment of ALL, a significant number of children continue to relapse and for them, outcome remains poor. Therefore, the search for novel therapeutic approaches ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-6-46
更新日期:2007-07-10 00:00:00
abstract:BACKGROUND:As one of the most frequent chemical modifications in eukaryotic mRNAs, N6-methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing, and translation. Recently, the regulatory role of m6A in tumorigenesis has been increasingly recognized. However, dysregulation of m6A and its fu...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-019-1065-4
更新日期:2019-10-13 00:00:00
abstract:BACKGROUND:Metastatic renal cell carcinoma (RCC) remains the leading cause of mortality in patients with clear cell RCC arising from mutations in the von Hippel Lindau (VHL) tumor suppressor. Successful RCC tumor suppression by VHL requires the negative regulation of hypoxia inducible factor alpha (HIF alpha) protein a...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-5-66
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:Perifosine, an alkylphospholipid tested in phase II clinical trials, modulates the extrinsic apoptotic pathway and cooperates with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to augment apoptosis. The current study focuses on revealing the mechanisms by which perifosine enhances TRAIL-ind...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-315
更新日期:2010-12-20 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant diseases worldwide. It is refractory to conventional treatments, and consequently has a documented 5-year survival rate as low as 7%. Increasing evidence indicates that activated pancreatic stellate cells (PSCs), one of the stromal components ...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-018-0815-z
更新日期:2018-02-19 00:00:00
abstract:BACKGROUND:Pituitary tumor transforming gene (pttg) is a novel oncogene that is expressed at higher level in most of the tumors analyzed to date compared to normal tissues. Nevertheless, its expression in prolactinomas and its relation with the pituitary dopamine receptor 2 (D2R) are not well defined. We sought to dete...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-6-4
更新日期:2007-01-12 00:00:00
abstract::Glioblastoma (GBM) is the most aggressive type of primary brain tumours. Anti-angiogenic therapies (AAT), such as bevacizumab, have been developed to target the tumour blood supply. However, GBM presents mechanisms of escape from AAT activity, including a speculated direct effect of AAT on GBM cells. Furthermore, beva...
journal_title:Molecular cancer
pub_type: 信件
doi:10.1186/s12943-018-0878-x
更新日期:2018-08-31 00:00:00
abstract:BACKGROUND:An increasing number of studies support the presence of stem-like cells in human malignancies. These cells are primarily responsible for tumor initiation and thus considered as a potential target to eradicate tumors. CD133 has been identified as an important cell surface marker to enrich the stem-like popula...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-39
更新日期:2010-02-19 00:00:00
abstract:BACKGROUND:Nilotinib is a tyrosine kinase inhibitor with high target specificity. Here, we characterized the effects of nilotinib for the first time on CD4+CD25+ regulatory T cells (Tregs) which regulate anti-tumor/leukemia immune responses. DESIGN AND METHODS:Carboxyfluorescein diacetate succinimidyl ester (CFSE) and...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-22
更新日期:2010-01-29 00:00:00
abstract:BACKGROUND:Lung cancer is the most lethal cancer and almost 90% of lung cancer is due to cigarette smoking. Even though nicotine, one of the major ingredients of cigarette smoke and the causative agent for addiction, is not a carcinogen by itself, several investigators have shown that nicotine can induce cell prolifera...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-220
更新日期:2010-08-20 00:00:00
abstract:BACKGROUND:The dioxin (AhR) receptor can have oncogenic or tumor suppressor activities depending on the phenotype of the target cell. We have shown that AhR knockdown promotes melanoma primary tumorigenesis and lung metastasis in the mouse and that human metastatic melanomas had reduced AhR levels with respect to benig...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-015-0419-9
更新日期:2015-08-05 00:00:00
abstract::Cancer has become a major health issue worldwide, contributing to a high mortality rate. Tumor metastasis is attributed to the death of most patients. Epithelial-to-mesenchymal transition (EMT) plays a vital role in inducing metastasis. During EMT, epithelial cells lose their characteristics, such as cell-to-cell adhe...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-019-1071-6
更新日期:2019-09-16 00:00:00
abstract:BACKGROUND:Glycochenodeoxycholate (GCDA) is one of the major human bile salts. Bile salts stimulate cell survival and proliferation through the mitogen-activated protein kinase, but the downstream signaling mechanism(s) remains enigmatic. Mcl-1 is an antiapoptotic molecule of the Bcl2 family that is extensively overexp...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-44
更新日期:2011-04-20 00:00:00
abstract:BACKGROUND:Atypical adenomatous hyperplasia (AAH) and squamous cell dysplasia (SCD) are associated with the development of malignant lesions in the lung. Accurate diagnosis of AAH and SCD could facilitate earlier clinical intervention and provide useful information for assessing lung cancer risk in human populations. D...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-78
更新日期:2014-04-05 00:00:00
abstract:BACKGROUND:Estrogen receptor-positive (ER+) breast cancers represent approximately two-thirds of all breast cancers and have a sustained risk of late disease recurrence. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors have shown significant efficacy in ER+ breast cancer. However, their effects are still limited by ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-020-01210-9
更新日期:2020-05-11 00:00:00