Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces.

abstract：BACKGROUND:To test if the expression of Smad1-8 mRNAs were predictive of survival in patients with oral squamous cell carcinoma (SCC). PATIENTS AND METHODS:We analyzed, prospectively, the expression of Smad1-8, by means of Ribonuclease Protection Assay in 48 primary, operable, oral SCC. In addition, 21 larynx, 10 orop...

journal_title：Molecular cancer

authors： Mangone FR,Walder F,Maistro S,Pasini FS,Lehn CN,Carvalho MB,Brentani MM,Snitcovsky I,Federico MH

更新日期：2010-05-12 00:00:00

abstract：BACKGROUND:The Sonic hedgehog (Shh) signaling pathway plays an important role in cerebellar development, and mutations leading to hyperactive Shh signaling have been associated with certain forms of medulloblastoma, a common form of pediatric brain cancer. While the fundamentals of this pathway are known, the molecular...

journal_title：Molecular cancer

authors： Lee SJ,Litan A,Li Z,Graves B,Lindsey S,Barwe SP,Langhans SA

更新日期：2015-08-19 00:00:00

abstract：BACKGROUND:Differential mRNA splicing and alternative promoter usage of the TP73 gene results in the expression of multiple NH2-truncated isoforms that act as oncogenes. Abundant levels of these p73 variants in a variety of human cancers correlated with adverse clinical prognosis and response failure to conventional th...

journal_title：Molecular cancer

authors： Emmrich S,Wang W,John K,Li W,Pützer BM

更新日期：2009-08-11 00:00:00

abstract：:Exosomes are extracellular vesicles released by many cell types and have been attributed for their roles in many diseases including cancer. Exosomes secreted by tumor cells and stromal cells are critical mediators of intercellular communication in tumor microenvironments. Long noncoding RNAs (lncRNAs) are selectively ...

journal_title：Molecular cancer

authors： Sun Z,Yang S,Zhou Q,Wang G,Song J,Li Z,Zhang Z,Xu J,Xia K,Chang Y,Liu J,Yuan W

更新日期：2018-04-20 00:00:00

abstract：:The mammalian target of rapamycin (mTOR), which exists in two functionally distinct complexes, mTORC1 and mTORC2 plays an important role in tumor growth. Whereas the role of mTORC1 has been well characterized in this process, little is known about the functions of mTORC2 in cancer progression. In this study, we explor...

journal_title：Molecular cancer

authors： Roulin D,Cerantola Y,Dormond-Meuwly A,Demartines N,Dormond O

更新日期：2010-03-12 00:00:00

abstract：BACKGROUND:Pituitary tumor transforming gene (pttg) is a novel oncogene that is expressed at higher level in most of the tumors analyzed to date compared to normal tissues. Nevertheless, its expression in prolactinomas and its relation with the pituitary dopamine receptor 2 (D2R) are not well defined. We sought to dete...

journal_title：Molecular cancer

authors： Cristina C,Díaz-Torga GS,Goya RG,Kakar SS,Perez-Millán MI,Passos VQ,Giannella-Neto D,Bronstein MD,Becu-Villalobos D

更新日期：2007-01-12 00:00:00

abstract：INTRODUCTION:Tumor-initiating cells (TICs), aka "cancer stem cells", are believed to fuel tumors and to sustain therapy resistance and systemic metastasis. Breast cancer is the first human carcinoma in which a subpopulation of cells displaying a specific CD44+/CD24-/low/ESA+ antigenic phenotype was found to have TIC pr...

journal_title：Molecular cancer

authors： Leccia F,Del Vecchio L,Mariotti E,Di Noto R,Morel AP,Puisieux A,Salvatore F,Ansieau S

更新日期：2014-09-12 00:00:00

abstract：:In recent years, thyroid malignances have become more prevalent, especially among women. The most common sporadic types of thyroid tumors of follicular origin include papillary, follicular and anaplastic thyroid carcinomas. Although modern diagnosis methods enable the identification of tumors of small diameter, tumor ...

journal_title：Molecular cancer

authors： Pstrąg N,Ziemnicka K,Bluyssen H,Wesoły J

更新日期：2018-08-08 00:00:00

abstract：BACKGROUND:Increasing evidence supports the role of small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs) as master gene regulators at the epigenetic modification level. However, the underlying mechanism of these functional ncRNAs in colorectal cancer (CRC) has not been well investigated. METHODS:The dysre...

journal_title：Molecular cancer

authors： Wu H,Qin W,Lu S,Wang X,Zhang J,Sun T,Hu X,Li Y,Chen Q,Wang Y,Zhao H,Piao H,Zhang R,Wei M

更新日期：2020-05-22 00:00:00

abstract：BACKGROUND:TPC-1 is a papillary thyroid carcinoma (PTC)-derived cell line that spontaneously expresses the oncogene RET/PTC1. TPC-1 treated with the RET/PTC1 inhibitor RPI-1 displayed a cytostatic and reversible inhibition of cell proliferation and a strong activation of focal adhesion kinase (FAK). As dasatinib inhibi...

journal_title：Molecular cancer

authors： Caccia D,Miccichè F,Cassinelli G,Mondellini P,Casalini P,Bongarzone I

更新日期：2010-10-18 00:00:00

abstract：:Several studies of tumors have revealed substantial numbers of clonally expanded somatic mutations in mitochondrial DNA (mtDNA), not observed in adjacent intact tissues. These findings were interpreted as indicating the involvement of mtDNA mutations in tumorigenesis. Such comparisons, however, ignore an important con...

journal_title：Molecular cancer

authors： Khaidakov M,Shmookler Reis RJ

更新日期：2005-09-13 00:00:00

abstract：BACKGROUND:CD44 is considered as 'a' metastasis associated gene, despite the fact that it is an umbrella term for a group of molecules produced from a single gene by alternative splicing. However, little consideration is given to the above in the literature of colorectal carcinomas as well as other tumour types, leadin...

journal_title：Molecular cancer

authors： Bánky B,Rásó-Barnett L,Barbai T,Tímár J,Becságh P,Rásó E

更新日期：2012-11-14 00:00:00

abstract：BACKGROUND:Metastatic renal cell carcinoma (RCC) remains the leading cause of mortality in patients with clear cell RCC arising from mutations in the von Hippel Lindau (VHL) tumor suppressor. Successful RCC tumor suppression by VHL requires the negative regulation of hypoxia inducible factor alpha (HIF alpha) protein a...

journal_title：Molecular cancer

authors： Petrella BL,Brinckerhoff CE

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:The IκB kinase (IKK) complex, comprising the two enzymes IKKα and IKKβ, is the main activator of the inflammatory transcription factor NF-κB, which is constitutively active in many cancers. While several connections between NF-κB signaling and the oncogene c-Myc have been shown, functional links between the ...

journal_title：Molecular cancer

authors： Moser B,Hochreiter B,Basílio J,Gleitsmann V,Panhuber A,Pardo-Garcia A,Hoesel B,Salzmann M,Resch U,Noreen M,Schmid JA

更新日期：2021-01-18 00:00:00

abstract：:Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cl...

journal_title：Molecular cancer

authors： Moossavi M,Parsamanesh N,Bahrami A,Atkin SL,Sahebkar A

更新日期：2018-11-17 00:00:00

abstract：:Cancer has become a major health issue worldwide, contributing to a high mortality rate. Tumor metastasis is attributed to the death of most patients. Epithelial-to-mesenchymal transition (EMT) plays a vital role in inducing metastasis. During EMT, epithelial cells lose their characteristics, such as cell-to-cell adhe...

journal_title：Molecular cancer

authors： Shang BQ,Li ML,Quan HY,Hou PF,Li ZW,Chu SF,Zheng JN,Bai J

更新日期：2019-09-16 00:00:00

abstract：BACKGROUND:Inactivation of the Fanconi anemia (FA) pathway through defects in one of 13 FA genes occurs at low frequency in various solid cancer entities among the general population. As FA pathway inactivation confers a distinct hypersensitivity towards DNA interstrand-crosslinking (ICL)-agents, FA defects represent r...

journal_title：Molecular cancer

authors： Palagyi A,Neveling K,Plinninger U,Ziesch A,Targosz BS,Denk GU,Ochs S,Rizzani A,Meier D,Thasler WE,Hanenberg H,De Toni EN,Bassermann F,Schäfer C,Göke B,Schindler D,Gallmeier E

更新日期：2010-05-28 00:00:00

abstract：:Tumor metabolism is a thrilling discipline that focuses on mechanisms used by cancer cells to earn crucial building blocks and energy to preserve growth and overcome resistance to various treatment modalities. At the same time, therapies directed specifically against aberrant signalling pathways driven by protein tyro...

journal_title：Molecular cancer

authors： Poliaková M,Aebersold DM,Zimmer Y,Medová M

更新日期：2018-02-19 00:00:00

abstract：BACKGROUND:METTL3 is known to be involved in all stages in the life cycle of RNA. It affects the tumor formation by the regulation the m6A modification in the mRNAs of critical oncogenes or tumor suppressors. In bladder cancer, METTL3 could promote the bladder cancer progression via AFF4/NF-κB/MYC signaling network by ...

journal_title：Molecular cancer

authors： Han J,Wang JZ,Yang X,Yu H,Zhou R,Lu HC,Yuan WB,Lu JC,Zhou ZJ,Lu Q,Wei JF,Yang H

更新日期：2019-06-22 00:00:00

abstract：:Although solid tumors comprise malignant cells, they also contain many different non-malignant cell types in their micro-environment. The cellular components of the tumor stroma consist of immune and endothelial cells combined with a heterogeneous population of stromal cells which include cancer-associated fibroblasts...

journal_title：Molecular cancer

authors： Plava J,Cihova M,Burikova M,Matuskova M,Kucerova L,Miklikova S

更新日期：2019-03-30 00:00:00

abstract：BACKGROUND:The aberrant expression of microRNA-140-5p (miR-140-5p) has been described in gastric cancer (GC). However, the role of miR-140-5p in GC remains unclear. In this study, the prognostic relevance of miR-140-5p in GC was investigated and YES1 was identified as a novel target of miR-140-5p in regulating tumor pr...

journal_title：Molecular cancer

authors： Fang Z,Yin S,Sun R,Zhang S,Fu M,Wu Y,Zhang T,Khaliq J,Li Y

更新日期：2017-08-17 00:00:00

abstract：BACKGROUND:Platinum-containing chemotherapy produces specific DNA damage and is used to treat several human solid tumors. Tumors initially sensitive to platinum-based drugs frequently become resistant. Inhibition of DNA repair is a potential strategy to enhance cisplatin effectiveness. After cisplatin treatment, a bala...

journal_title：Molecular cancer

authors： Sand-Dejmek J,Adelmant G,Sobhian B,Calkins AS,Marto J,Iglehart DJ,Lazaro JB

更新日期：2011-06-16 00:00:00

abstract：BACKGROUND:Salivary Adenoid cystic carcinoma (SACC) patients with local invasion and lung metastasis are often resistant to conventional therapy such as operation, chemotherapy and radiotherapy. To explore the underling mechanisms, we studied the roles of miRNA in regulating invasiveness of SACC cells. METHODS:MicroRN...

journal_title：Molecular cancer

authors： Sun L,Liu B,Lin Z,Yao Y,Chen Y,Li Y,Chen J,Yu D,Tang Z,Wang B,Zeng S,Fan S,Wang Y,Li Y,Song E,Li J

更新日期：2015-04-29 00:00:00

abstract：:IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evid...

journal_title：Molecular cancer

authors： Christopoulos PF,Msaouel P,Koutsilieris M

更新日期：2015-02-15 00:00:00

abstract：BACKGROUND:An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, was tested side-by-side with khat in a panel of acute myeloid leukemia cell lines to elucidate me...

journal_title：Molecular cancer

authors： Bredholt T,Dimba EA,Hagland HR,Wergeland L,Skavland J,Fossan KO,Tronstad KJ,Johannessen AC,Vintermyr OK,Gjertsen BT

更新日期：2009-11-13 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumour (GIST) is the most common soft tissue sarcoma. The identification of the molecular mechanisms regulating GIST progression is vital for its treatment and prevention. Increasing reports have demonstrated that epigenetic alterations play critical roles in GIST development. Howeve...

journal_title：Molecular cancer

authors： Hu F,Li H,Liu L,Xu F,Lai S,Luo X,Hu J,Yang X

更新日期：2018-07-30 00:00:00

abstract：BACKGROUND:Human clear cell renal cell carcinoma (CRCC) remains resistant to therapies. Recent advances in Hypoxia Inducible Factors (HIF) molecular network led to targeted therapies, but unfortunately with only limited clinical significance. Elucidating the molecular processes involved in kidney tumorigenesis and resi...

journal_title：Molecular cancer

authors： Dormoy V,Danilin S,Lindner V,Thomas L,Rothhut S,Coquard C,Helwig JJ,Jacqmin D,Lang H,Massfelder T

更新日期：2009-12-16 00:00:00

abstract：BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is a highly lethal cancer that contains cellular and functional heterogeneity. Previously, we enriched a subpopulation of highly tumorigenic head and neck cancer initiating cells (HN-CICs) from HNSCC. However, the molecular mechanisms by which to govern the chara...

journal_title：Molecular cancer

authors： Wu MJ,Jan CI,Tsay YG,Yu YH,Huang CY,Lin SC,Liu CJ,Chen YS,Lo JF,Yu CC

更新日期：2010-10-27 00:00:00

abstract：BACKGROUND:High expression of P-glycoprotein is one of the well-known mechanisms of chemoresistance in chondrosarcomas. However, the role of antiapoptotic proteins, a common mechanism responsible for chemoresistance in other tumors, has not been well studied in chondrosarcomas. We examined the importance of P-glycoprot...

journal_title：Molecular cancer

authors： Kim DW,Kim KO,Shin MJ,Ha JH,Seo SW,Yang J,Lee FY

更新日期：2009-05-15 00:00:00

abstract：BACKGROUND:Granulosa cell tumors (GCTs) are relatively rare and are subtypes of the sex-cord stromal neoplasms. Methylation induced silencing in the promoters of genes such as tumor suppressor genes, DNA repair genes and pro-apoptotic genes is recognised as a critical factor in cancer development. METHODS:We examined ...

journal_title：Molecular cancer

authors： Dhillon VS,Shahid M,Husain SA

更新日期：2004-12-01 00:00:00