Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces.

abstract：BACKGROUND:The human microbial pathogen Helicobacter pylori resides in the stomach of about fifty percent of the world's population and represents a risk factor for chronic gastritis, peptic ulcers and, in rare cases, gastric cancer. Alterations of the Wnt/beta-catenin signaling pathway have been described in almost ev...

journal_title：Molecular cancer

authors： Gnad T,Feoktistova M,Leverkus M,Lendeckel U,Naumann M

更新日期：2010-02-05 00:00:00

abstract：BACKGROUND:Sigma-2 receptors are over-expressed in proliferating cancer cells, making an attractive target for the targeted treatment of pancreatic cancer. In this study, we investigated the role of the novel sigma-2 receptor ligand SW43 to induce apoptosis and augment standard chemotherapy. RESULTS:The binding affini...

journal_title：Molecular cancer

authors： Hornick JR,Xu J,Vangveravong S,Tu Z,Mitchem JB,Spitzer D,Goedegebuure P,Mach RH,Hawkins WG

更新日期：2010-11-22 00:00:00

abstract：BACKGROUND:Recently, it has been reported that long non-coding RNA (lncRNA) cancer susceptibility candidate 2 (CASC2), a novel tumor suppressor, participates in regulating the carcinogenesis and suppresses tumor progression by sponging microRNAs (miRNAs). However, the expression and function of CASC2 in hepatocellular ...

journal_title：Molecular cancer

authors： Wang Y,Liu Z,Yao B,Li Q,Wang L,Wang C,Dou C,Xu M,Liu Q,Tu K

更新日期：2017-07-17 00:00:00

abstract：INTRODUCTION:Tumor-initiating cells (TICs), aka "cancer stem cells", are believed to fuel tumors and to sustain therapy resistance and systemic metastasis. Breast cancer is the first human carcinoma in which a subpopulation of cells displaying a specific CD44+/CD24-/low/ESA+ antigenic phenotype was found to have TIC pr...

journal_title：Molecular cancer

authors： Leccia F,Del Vecchio L,Mariotti E,Di Noto R,Morel AP,Puisieux A,Salvatore F,Ansieau S

更新日期：2014-09-12 00:00:00

abstract：BACKGROUND:TGF-beta resistance often develops in breast cancer cells that in turn overproduce this cytokine to create a local immunosuppressive environment that fosters tumor growth and exacerbates the invasive and metastatic behavior of the tumor cells themselves. Smads-mediated cross-talk with the estrogen receptor h...

journal_title：Molecular cancer

authors： Ren Y,Wu L,Frost AR,Grizzle W,Cao X,Wan M

更新日期：2009-11-27 00:00:00

abstract：BACKGROUND:Breast cancer is the second leading cause of cancer related deaths among females worldwide. Berbamine (BER), a kind of bis-benzylisoquinoline alkaloid, has been used to treat clinical patients with inflammation and cancer for many years in China. The purpose of this study is to investigate the activity of BE...

journal_title：Molecular cancer

authors： Wang S,Liu Q,Zhang Y,Liu K,Yu P,Liu K,Luan J,Duan H,Lu Z,Wang F,Wu E,Yagasaki K,Zhang G

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Metastasis is the leading cause of death among breast cancer patients. Identifying key cellular factors controlling invasion and metastasis of breast cancer cells should pave the way to new therapeutic strategies efficiently interfering with the metastatic process. PAX2 (paired box 2) transcription factor is...

journal_title：Molecular cancer

authors： Beauchemin D,Lacombe C,Van Themsche C

更新日期：2011-12-14 00:00:00

abstract：BACKGROUND:Human clear cell renal cell carcinoma (CRCC) remains resistant to therapies. Recent advances in Hypoxia Inducible Factors (HIF) molecular network led to targeted therapies, but unfortunately with only limited clinical significance. Elucidating the molecular processes involved in kidney tumorigenesis and resi...

journal_title：Molecular cancer

authors： Dormoy V,Danilin S,Lindner V,Thomas L,Rothhut S,Coquard C,Helwig JJ,Jacqmin D,Lang H,Massfelder T

更新日期：2009-12-16 00:00:00

abstract：BACKGROUND:As an important means of communication, exosomes play an important role in the development of hepatocellular carcinoma (HCC). METHODS:Bioinformatics analysis, dual-luciferase reporter assays, methylation-specific quantitative PCR, and ChIP-PCR analysis were used to gain insight into the underlying mechanism...

journal_title：Molecular cancer

authors： Cao LQ,Yang XW,Chen YB,Zhang DW,Jiang XF,Xue P

更新日期：2019-10-27 00:00:00

abstract：BACKGROUND:The influence of natural regulatory T cells (nTregs) on the patients with colon cancer is unclear. Demethylated status of the Treg-specific demethylated region (TSDR) of the FOXP3 gene was reported to be a potential biomarker for the identification of nTregs. METHODS:The demethylation rate of the TSDR (TSDR...

journal_title：Molecular cancer

authors： Zhuo C,Li Z,Xu Y,Wang Y,Li Q,Peng J,Zheng H,Wu P,Li B,Cai S

更新日期：2014-06-18 00:00:00

abstract：BACKGROUND:METTL3 is known to be involved in all stages in the life cycle of RNA. It affects the tumor formation by the regulation the m6A modification in the mRNAs of critical oncogenes or tumor suppressors. In bladder cancer, METTL3 could promote the bladder cancer progression via AFF4/NF-κB/MYC signaling network by ...

journal_title：Molecular cancer

authors： Han J,Wang JZ,Yang X,Yu H,Zhou R,Lu HC,Yuan WB,Lu JC,Zhou ZJ,Lu Q,Wei JF,Yang H

更新日期：2019-06-22 00:00:00

abstract：BACKGROUND:Co-Activator Arginine Methyltransferase 1(CARM1) is an Estrogen Receptor (ER) cofactor that remodels chromatin for gene regulation via methylation of Histone3. We investigated CARM1 levels and localization across breast cancer tumors in a cohort of patients of either European or African ancestry. METHODS:We...

journal_title：Molecular cancer

authors： Davis MB,Liu X,Wang S,Reeves J,Khramtsov A,Huo D,Olopade OI

更新日期：2013-05-10 00:00:00

abstract：BACKGROUND:A maximum entropy approach is proposed to predict the cytotoxic effects of a panel of colchicine derivatives in several human cancer cell lines. Data was obtained from cytotoxicity assays performed with 21 drug molecules from the same family of colchicine compounds and correlate these results with independen...

journal_title：Molecular cancer

authors： Tseng CY,Mane JY,Winter P,Johnson L,Huzil T,Izbicka E,Luduena RF,Tuszynski JA

更新日期：2010-05-30 00:00:00

abstract：BACKGROUND:High expression of P-glycoprotein is one of the well-known mechanisms of chemoresistance in chondrosarcomas. However, the role of antiapoptotic proteins, a common mechanism responsible for chemoresistance in other tumors, has not been well studied in chondrosarcomas. We examined the importance of P-glycoprot...

journal_title：Molecular cancer

authors： Kim DW,Kim KO,Shin MJ,Ha JH,Seo SW,Yang J,Lee FY

更新日期：2009-05-15 00:00:00

abstract：BACKGROUND:Oncolytic virotherapy is an attractive drug platform of cancer gene therapy, but efficacy and specificity are important prerequisites for success of such strategies. Previous studies determined that Apoptin is a p53 independent, bcl-2 insensitive apoptotic protein with the ability to specifically induce apop...

journal_title：Molecular cancer

authors： Li X,Liu Y,Wen Z,Li C,Lu H,Tian M,Jin K,Sun L,Gao P,Yang E,Xu X,Kan S,Wang Z,Wang Y,Jin N

更新日期：2010-01-20 00:00:00

abstract：BACKGROUND:Colorectal cancer is third most common malignancy and is the second most common cause of cancer-related death. The MUC1 heterodimeric protein is aberrantly overexpressed in colorectal cancer and has been linked to poor outcomes in this disease. Here, we investigate the effects of the MUC1-C subunit inhibitor...

journal_title：Molecular cancer

authors： Ahmad R,Alam M,Hasegawa M,Uchida Y,Al-Obaid O,Kharbanda S,Kufe D

更新日期：2017-02-02 00:00:00

abstract：BACKGROUND:For long, natural killer (NK) cells have been suspected to play a critical role in suppressing the development of spontaneous metastases in cancer patients. Despite a wide range of studies it remains unclear so far to what extent primary tumor growth together with formation of distant metastases and NK cell ...

journal_title：Molecular cancer

authors： Brodbeck T,Nehmann N,Bethge A,Wedemann G,Schumacher U

更新日期：2014-11-05 00:00:00

abstract：:Since the publication of this work [1] and in response to a recent query that was brought to our attention in relation to the Western Blot in Figure 1(C) for NP2, protein lysates prepared around the same time as those presented in the manuscript in question, were run by SDS-PAGE under similar experimental conditions a...

journal_title：Molecular cancer

authors： Barr MP,Gray SG,Gately K,Hams E,Fallon PG,Davies AM,Richard DJ,Pidgeon GP,O'Byrne KJ

更新日期：2020-01-27 00:00:00

abstract：BACKGROUND:The epigenetic regulation of immune response has been demonstrated in recent studies. Nonetheless, potential roles of RNA N6-methyladenosine (m6A) modification in tumor microenvironment (TME) cell infiltration remain unknown. METHODS:We comprehensively evaluated the m6A modification patterns of 1938 gastric...

journal_title：Molecular cancer

authors： Zhang B,Wu Q,Li B,Wang D,Wang L,Zhou YL

更新日期：2020-03-12 00:00:00

abstract：:The HER4 intracellular domain (4ICD) is a potent estrogen receptor (ERalpha) coactivator with activities in breast cancer and the developing mammary gland that appear to overlap with progesterone receptor (PgR). In fact, 4ICD has recently emerged as an important regulator and predictor of tamoxifen response, a role pr...

journal_title：Molecular cancer

authors： Rokicki J,Das PM,Giltnane JM,Wansbury O,Rimm DL,Howard BA,Jones FE

更新日期：2010-06-15 00:00:00

abstract：:The mammalian target of rapamycin (mTOR), which exists in two functionally distinct complexes, mTORC1 and mTORC2 plays an important role in tumor growth. Whereas the role of mTORC1 has been well characterized in this process, little is known about the functions of mTORC2 in cancer progression. In this study, we explor...

journal_title：Molecular cancer

authors： Roulin D,Cerantola Y,Dormond-Meuwly A,Demartines N,Dormond O

更新日期：2010-03-12 00:00:00

abstract：BACKGROUND:The survival rate of head and neck squamous cell carcinoma (HNSCC) at advanced stage is poor, despite contemporary advances in treatment modalities. Recent studies have indicated that astrocyte elevated gene-1 (AEG-1), a single transmembrane protein without any known functional domains, is overexpressed in v...

journal_title：Molecular cancer

authors： Wang YP,Liu IJ,Chiang CP,Wu HC

更新日期：2013-09-24 00:00:00

abstract：:Live animal imaging is becoming an increasingly common technique for accurate and quantitative assessment of tumor burden over time. Bioluminescence imaging systems rely on a bioluminescent signal from tumor cells, typically generated from expression of the firefly luciferase gene. However, previous reports have sugge...

journal_title：Molecular cancer

authors： Tiffen JC,Bailey CG,Ng C,Rasko JE,Holst J

更新日期：2010-11-22 00:00:00

abstract：:Chimeric antigen receptor T (CAR-T) cell therapy is an emerging and effective cancer immunotherapy. Especially in hematological malignancies, CAR-T cells have achieved exciting results. Two Anti-CD19 CAR-T therapies have been approved for the treatment of CD19-positive leukemia or lymphoma. However, the application of...

journal_title：Molecular cancer

authors： Yu S,Yi M,Qin S,Wu K

更新日期：2019-08-20 00:00:00

abstract：:Gene fusions occur in up to 17% of solid tumours. Oncogenic kinases are often involved in such fusions. In lung cancer, almost 30% of patients carrying an activated oncogene show the fusion of a tyrosine kinase to an heterologous gene. Several genes are partner in the fusion with the three kinases ALK, ROS1 and RET in...

journal_title：Molecular cancer

authors： Cerrato A,Visconti R,Celetti A

更新日期：2018-02-19 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignant tumours with a poor prognosis worldwide. While early stage tumours can be treated with curative approaches such as liver transplantation or surgical resection, these are only suitable for a minority of patients. Those with advanced stage disease are on...

journal_title：Molecular cancer

authors： Huo X,Han S,Wu G,Latchoumanin O,Zhou G,Hebbard L,George J,Qiao L

更新日期：2017-10-23 00:00:00

abstract：:Monoclonal antibodies represent some of the most promising molecular targeted immunotherapies. However, understanding mechanisms by which tumors evade elimination by the immune system of the host presents a significant challenge for developing effective cancer immunotherapies. The interaction of cancer cells with the ...

journal_title：Molecular cancer

authors： Klinke DJ 2nd

更新日期：2010-09-15 00:00:00

abstract：BACKGROUND:ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin motifs) is a member of the ADAMTS family of metalloproteases. Here, we investigated mRNA and protein levels of ADAMTS-1 in normal and neoplastic tissues using qPCR, immunohistochemistry and immunoblot analyses, and we addressed the role of ADAMT...

journal_title：Molecular cancer

authors： Freitas VM,do Amaral JB,Silva TA,Santos ES,Mangone FR,Pinheiro Jde J,Jaeger RG,Nagai MA,Machado-Santelli GM

更新日期：2013-01-05 00:00:00

abstract：BACKGROUND:Although chemotherapy represents a predominant anti-cancer therapeutic modality, drug treatment efficacy is often limited due to the development of resistant tumor cells. The pregnane X receptor (PXR) affects chemotherapeutic effects by regulating targets involved in drug metabolism and transportation, but t...

journal_title：Molecular cancer

authors： Dong Y,Wang Z,Xie GF,Li C,Zuo WW,Meng G,Xu CP,Li JJ

更新日期：2017-03-29 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) is highly invasive and aggressive and lacks specific molecular targets to improve the prognosis. MiR-25-3p promotes proliferation of many tumors and its role and underlying mechanisms in TNBC remain to be well elucidated. METHODS:Differential expression of miR-25-3p in T...

journal_title：Molecular cancer

authors： Chen H,Pan H,Qian Y,Zhou W,Liu X

更新日期：2018-01-08 00:00:00