Smad2 and Smad6 as predictors of overall survival in oral squamous cell carcinoma patients.

abstract：BACKGROUND:Interferon Regulatory Factor 5 is a transcription factor that regulates the expression of genes involved in the response to viral infection and in the stimulation of the immune system. Moreover, multiple studies have demonstrated that it negatively regulates cell growth and oncogenesis, favoring cell differe...

journal_title：Molecular cancer

authors： Massimino M,Vigneri P,Fallica M,Fidilio A,Aloisi A,Frasca F,Manzella L

更新日期：2012-04-16 00:00:00

abstract：BACKGROUND AND METHODS:Stem or progenitor cells from healthy tissues have the capacity to co-segregate their template DNA strands during mitosis. Here, we set out to test whether breast cancer cell lines also possess the ability to asymmetrically segregate their template DNA strands via non-random chromosome co-segrega...

journal_title：Molecular cancer

authors： Liu W,Jeganathan G,Amiri S,Morgan KM,Ryan BM,Pine SR

更新日期：2013-11-15 00:00:00

abstract：BACKGROUND:MUC16 is a cell surface mucin expressed at high levels by epithelial ovarian tumors. Following proteolytic cleavage, cell surface MUC16 (csMUC16) is shed in the extracellular milieu and is detected in the serum of cancer patients as the tumor marker CA125. csMUC16 acts as an adhesion molecule and facilitates...

journal_title：Molecular cancer

authors： Belisle JA,Horibata S,Jennifer GA,Petrie S,Kapur A,André S,Gabius HJ,Rancourt C,Connor J,Paulson JC,Patankar MS

更新日期：2010-05-24 00:00:00

abstract：BACKGROUND:SOX2, a high mobility group (HMG)-box containing transcription factor, is a key regulator during development of the nervous system and a persistent marker of neural stem cells. Recent studies suggested a role of SOX2 in tumor progression. In our previous work we detected SOX2 in glioma cells and glioblastoma...

journal_title：Molecular cancer

authors： Oppel F,Müller N,Schackert G,Hendruschk S,Martin D,Geiger KD,Temme A

更新日期：2011-11-09 00:00:00

abstract：:In recent years, thyroid malignances have become more prevalent, especially among women. The most common sporadic types of thyroid tumors of follicular origin include papillary, follicular and anaplastic thyroid carcinomas. Although modern diagnosis methods enable the identification of tumors of small diameter, tumor ...

journal_title：Molecular cancer

authors： Pstrąg N,Ziemnicka K,Bluyssen H,Wesoły J

更新日期：2018-08-08 00:00:00

abstract：:Several studies of tumors have revealed substantial numbers of clonally expanded somatic mutations in mitochondrial DNA (mtDNA), not observed in adjacent intact tissues. These findings were interpreted as indicating the involvement of mtDNA mutations in tumorigenesis. Such comparisons, however, ignore an important con...

journal_title：Molecular cancer

authors： Khaidakov M,Shmookler Reis RJ

更新日期：2005-09-13 00:00:00

abstract：BACKGROUND:PTEN is the second most mutated tumor suppressor gene other than p53. It suppresses tumorigenesis by dephosphorylating phosphatidylinositol (3,4,5)-triphosphate (PIP3) to phosphatidylinositol (4,5)-biphosphate (PIP2), thereby directly inhibiting phosphatidylinositol 3 kinase (PI3K)-mediated tumorigenic activ...

journal_title：Molecular cancer

authors： Fan C,He L,Kapoor A,Rybak AP,De Melo J,Cutz JC,Tang D

更新日期：2009-11-10 00:00:00

abstract：BACKGROUND:Lung cancer is the most lethal cancer and almost 90% of lung cancer is due to cigarette smoking. Even though nicotine, one of the major ingredients of cigarette smoke and the causative agent for addiction, is not a carcinogen by itself, several investigators have shown that nicotine can induce cell prolifera...

journal_title：Molecular cancer

authors： Puliyappadamba VT,Cheriyan VT,Thulasidasan AK,Bava SV,Vinod BS,Prabhu PR,Varghese R,Bevin A,Venugopal S,Anto RJ

更新日期：2010-08-20 00:00:00

abstract：BACKGROUND:Lung cancer in nonsmokers tends to be driven by a single somatic mutation or a gene fusion. KIF5B-RET fusion is an oncogene identified in non-small cell lung cancers. In this study, we verified the oncogenic activity of KIF5B-RET fusion and investigated how KIF5B-RET activates the specific signaling pathways...

journal_title：Molecular cancer

authors： Qian Y,Chai S,Liang Z,Wang Y,Zhou Y,Xu X,Zhang C,Zhang M,Si J,Huang F,Huang Z,Hong W,Wang K

更新日期：2014-07-21 00:00:00

abstract：:Cell lines are still a tool of choice for many fields of biomedical research, including oncology. Although cancer is a very complex disease, many discoveries have been made using monocultures of established cell lines. Therefore, the proper use of in vitro models is crucial to enhance our understanding of cancer. Ther...

journal_title：Molecular cancer

authors： Brodaczewska KK,Szczylik C,Fiedorowicz M,Porta C,Czarnecka AM

更新日期：2016-12-19 00:00:00

abstract：BACKGROUND:Cancer/testis (CT) genes have expression normally restricted to the testis, but become activated during oncogenesis, so they have excellent potential as cancer-specific biomarkers. Evidence is starting to emerge to indicate that they also provide function(s) in the oncogenic programme. Human TEX19 is a recen...

journal_title：Molecular cancer

authors： Planells-Palop V,Hazazi A,Feichtinger J,Jezkova J,Thallinger G,Alsiwiehri NO,Almutairi M,Parry L,Wakeman JA,McFarlane RJ

更新日期：2017-04-26 00:00:00

abstract：BACKGROUND:Phospholipid phosphatase 4 (PPAPDC1A or PLPP4) has been demonstrated to be involved in the malignant process of many cancers. The purpose of this study was to investigate the clinical significance and biological roles of PLPP4 in lung carcinoma. METHODS:PLPP4 expression was examined in 8 paired lung carcino...

journal_title：Molecular cancer

authors： Zhang X,Zhang L,Lin B,Chai X,Li R,Liao Y,Deng X,Liu Q,Yang W,Cai Y,Zhou W,Lin Z,Huang W,Zhong M,Lei F,Wu J,Yu S,Li X,Li S,Li Y,Zeng J,Long W,Ren D,Huang Y

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor (EGFR), a well-known oncogenic driver, contributes to the initiation and progression of a wide range of cancer types. Aberrant lipid metabolism including highly produced monounsaturated fatty acids (MUFA) is recognized as a hallmark of cancer. However, how EGFR regulates MUFA...

journal_title：Molecular cancer

authors： Zhang J,Song F,Zhao X,Jiang H,Wu X,Wang B,Zhou M,Tian M,Shi B,Wang H,Jia Y,Wang H,Pan X,Li Z

更新日期：2017-07-19 00:00:00

abstract：BACKGROUND:Medulloblastoma is the most common type of malignant brain tumor that afflicts children. Although recent advances in chemotherapy and radiation have improved outcomes, high-risk patients do poorly with significant morbidity. METHODS:To identify new molecular targets, we performed an integrated genomic analy...

journal_title：Molecular cancer

authors： Harris PS,Venkataraman S,Alimova I,Birks DK,Balakrishnan I,Cristiano B,Donson AM,Dubuc AM,Taylor MD,Foreman NK,Reigan P,Vibhakar R

更新日期：2014-03-24 00:00:00

abstract：:Mutations in polymerase ε (POLE) confer favorable prognosis and outcomes in various cancer types, but their role in non-small cell lung cancer (NSCLC) is unknown. Utilizing the data of 513 patients with adenocarcinoma (LUAD) and 497 patients with squamous cell carcinoma (LUSC) from The Cancer Genome Atlas (TCGA) cohor...

journal_title：Molecular cancer

authors： Liu L,Ruiz J,O'Neill SS,Grant SC,Petty WJ,Yang M,Chen K,Topaloglu U,Pasche B,Zhang W

更新日期：2018-04-12 00:00:00

abstract：BACKGROUND:In contrast to tumor-suppressive apoptosis and autophagic cell death, necrosis promotes tumor progression by releasing the pro-inflammatory and tumor-promoting cytokine high mobility group box 1 (HMGB1), and its presence in tumor patients is associated with poor prognosis. Thus, necrosis has important clinic...

journal_title：Molecular cancer

authors： Lee SY,Jeon HM,Kim CH,Ju MK,Bae HS,Park HG,Lim SC,Han SI,Kang HS

更新日期：2011-09-14 00:00:00

abstract：BACKGROUND:In the current study we investigated the role of caveolin-1 (cav-1) in pancreatic adenocarcinoma (PC) cell migration and invasion; initial steps in metastasis. Cav-1 is the major structural protein in caveolae; small Omega-shaped invaginations within the plasma membrane. Caveolae are involved in signal trans...

journal_title：Molecular cancer

authors： Lin M,DiVito MM,Merajver SD,Boyanapalli M,van Golen KL

更新日期：2005-06-21 00:00:00

abstract：:Cancer research has mainly focused on alterations of genes and proteins in cancer cells themselves that result in either gain-of-function in oncogenes or loss-of-function in tumour-suppressor genes. However, stromal variables within or around tumours, including blood and lymph vessels, stromal cells and various protei...

journal_title：Molecular cancer

authors： Sun XF,Zhang H

更新日期：2006-10-06 00:00:00

abstract：BACKGROUND:Lung cancer is one of the most prevalent neoplasias in developed countries. Advances in patient survival have been limited and the identification of prognostic molecules is needed. Resistance to treatment is strongly related to tumor cell adhesion to the extracellular matrix and alterations in the quantity a...

journal_title：Molecular cancer

authors： Irigoyen M,Pajares MJ,Agorreta J,Ponz-Sarvisé M,Salvo E,Lozano MD,Pío R,Gil-Bazo I,Rouzaut A

更新日期：2010-05-28 00:00:00

abstract：BACKGROUND:Tumor spreading is the major threat for cancer patients. The recently published anti-cancer drug salinomycin raised hope for an improved treatment by targeting therapy-refractory cancer stem cells. However, an unambiguous role of salinomycin against cancer cell migration and metastasis formation remains elus...

journal_title：Molecular cancer

authors： Kopp F,Hermawan A,Oak PS,Herrmann A,Wagner E,Roidl A

更新日期：2014-01-27 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive type of primary brain tumours. Anti-angiogenic therapies (AAT), such as bevacizumab, have been developed to target the tumour blood supply. However, GBM presents mechanisms of escape from AAT activity, including a speculated direct effect of AAT on GBM cells. Furthermore, beva...

journal_title：Molecular cancer

authors： Simon T,Pinioti S,Schellenberger P,Rajeeve V,Wendler F,Cutillas PR,King A,Stebbing J,Giamas G

更新日期：2018-08-31 00:00:00

abstract：BACKGROUND:Glioblastoma (GBM) is the most common and malignant primary intracranial human neoplasm. GBMs are characterized by the presence of extensive areas of necrosis and hypoxia. Hypoxia and its master regulator, hypoxia inducible factor 1 (HIF-1) play a key role in glioma invasion. RESULTS:To further elucidate th...

journal_title：Molecular cancer

authors： Méndez O,Zavadil J,Esencay M,Lukyanov Y,Santovasi D,Wang SC,Newcomb EW,Zagzag D

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:SKI and SnoN proteins have been shown to inhibit TGF-β signaling, acting both as transcriptional co-repressors in the cell nucleus, and as sequestrators of SMAD proteins in the cytoplasm. TGF-β, on the other hand, induces rapid, proteasome-mediated, degradation of both proteins. How elevated SKI and SnoN pro...

journal_title：Molecular cancer

authors： Javelaud D,van Kempen L,Alexaki VI,Le Scolan E,Luo K,Mauviel A

更新日期：2011-01-06 00:00:00

abstract：BACKGROUND:Sharing the common neuroectodermal origin, melanoma and neuroblastoma are tumors widely diffused among adult and children, respectively. Clinical prognosis of aggressive neuroectodermal cancers remains dismal, therefore the search for novel therapies against such tumors is warranted. Curcumin is a phytochemi...

journal_title：Molecular cancer

authors： Pisano M,Pagnan G,Dettori MA,Cossu S,Caffa I,Sassu I,Emionite L,Fabbri D,Cilli M,Pastorino F,Palmieri G,Delogu G,Ponzoni M,Rozzo C

更新日期：2010-06-03 00:00:00

abstract：BACKGROUND:Chromosomal aberrations of BCL11A at 2p16.1 have been reported in a variety of B-cell malignancies and its deficiency in mice leads to a profound block in B-cell development. RESULTS:Alternative pre-mRNA splicing of BCL11A produces multiple isoforms sharing a common N-terminus. The most abundant isoform we ...

journal_title：Molecular cancer

authors： Liu H,Ippolito GC,Wall JK,Niu T,Probst L,Lee BS,Pulford K,Banham AH,Stockwin L,Shaffer AL,Staudt LM,Das C,Dyer MJ,Tucker PW

更新日期：2006-05-16 00:00:00

abstract：BACKGROUND:Acute lymphoblastic leukemia (ALL) is the most common hematological malignancy affecting children. Despite significant progress and success in the treatment of ALL, a significant number of children continue to relapse and for them, outcome remains poor. Therefore, the search for novel therapeutic approaches ...

journal_title：Molecular cancer

authors： Sengupta TK,Leclerc GM,Hsieh-Kinser TT,Leclerc GJ,Singh I,Barredo JC

更新日期：2007-07-10 00:00:00

abstract：BACKGROUND:Tumor-associated macrophages (TAMs) are the major component of tumor-infiltrating leukocytes. TAMs are heterogeneous, with distinct phenotypes influenced by the microenvironment surrounding tumor tissues, but relatively little is known about the key molecular in these cells that contribute to malignant pheno...

journal_title：Molecular cancer

authors： Yang M,Liu J,Shao J,Qin Y,Ji Q,Zhang X,Du J

更新日期：2014-03-02 00:00:00

abstract：BACKGROUND:The implementation of gene therapy for the treatment of pituitary tumors emerges as a promising complement to surgery and may have distinct advantages over radiotherapy for this type of tumors. Up to now, suicide gene therapy has been the main experimental approach explored to treat experimental pituitary tu...

journal_title：Molecular cancer

authors： Console GM,Herenu CB,Camihort GA,Luna GC,Bracamonte MI,Morel GR,Goya RG

更新日期：2008-01-25 00:00:00

abstract：BACKGROUND:New blood vessel formation, or angiogenic switch, is an essential event in the development of solid tumors and their metastatic growth. Tumor blood vessel formation and remodeling is a complex and multi-step processes. The differentiation and recruitment of mural cells including vascular smooth muscle cells ...

journal_title：Molecular cancer

authors： Dhar K,Dhar G,Majumder M,Haque I,Mehta S,Van Veldhuizen PJ,Banerjee SK,Banerjee S

更新日期：2010-08-05 00:00:00

abstract：BACKGROUND:Osteopontin (OPN) has been shown to play many roles in the progression of cancer. We have recently demonstrated the activation of Akt by OPN. Integrin-linked kinase and PI3-kinase are integral proteins in OPN/AKT pathway in PC3 cells. To investigate the role of the extracellular receptors in OPN signaling, w...

journal_title：Molecular cancer

authors： Robertson BW,Bonsal L,Chellaiah MA

更新日期：2010-09-26 00:00:00