Recent advances in understanding tumor stroma-mediated chemoresistance in breast cancer.

abstract：BACKGROUND:Epigenetic control is essential for maintenance of tissue hierarchy and correct differentiation. In cancer, this hierarchical structure is altered and epigenetic control deregulated, but the relationship between these two phenomena is still unclear. CD133 is a marker for adult stem cells in various tissues a...

journal_title：Molecular cancer

authors： Pellacani D,Packer RJ,Frame FM,Oldridge EE,Berry PA,Labarthe MC,Stower MJ,Simms MS,Collins AT,Maitland NJ

更新日期：2011-07-29 00:00:00

abstract：BACKGROUND:Neurofibromatosis type 1 (NF1) is the most common hereditary neurocutaneous disorder and it is associated with an elevated risk for malignant tumors of tissues derived from neural crest cells. The NF1 gene is considered a tumor suppressor gene and inactivation of both copies can be found in NF1-associated be...

journal_title：Molecular cancer

authors： Rübben A,Bausch B,Nikkels A

更新日期：2006-09-10 00:00:00

abstract：BACKGROUND:Atypical adenomatous hyperplasia (AAH) and squamous cell dysplasia (SCD) are associated with the development of malignant lesions in the lung. Accurate diagnosis of AAH and SCD could facilitate earlier clinical intervention and provide useful information for assessing lung cancer risk in human populations. D...

journal_title：Molecular cancer

authors： Lowe FJ,Shen W,Zu J,Li J,Wang H,Zhang X,Zhong L

更新日期：2014-04-05 00:00:00

abstract：:Autophagy is a highly conserved catabolic process that mediates degradation of pernicious or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and organelles. It can promote or suppress tumor development, so it is a "double-edged sword" in tumors that depends on the cell and tissue typ...

journal_title：Molecular cancer

authors： Chen HT,Liu H,Mao MJ,Tan Y,Mo XQ,Meng XJ,Cao MT,Zhong CY,Liu Y,Shan H,Jiang GM

更新日期：2019-05-24 00:00:00

abstract：BACKGROUND:Human or animals lacking either JAK3 or the common gamma chain (gammac) expression display severe combined immunodeficiency disease, indicating the crucial role of JAK3 in T-cell development and the homeostasis of the immune system. JAK3 has also been suggested to contribute to the pathogenesis of tumorigene...

journal_title：Molecular cancer

authors： Kim BH,Jee JG,Yin CH,Sandoval C,Jayabose S,Kitamura D,Bach EA,Baeg GH

更新日期：2010-02-11 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumour (GIST) is the most common soft tissue sarcoma. The identification of the molecular mechanisms regulating GIST progression is vital for its treatment and prevention. Increasing reports have demonstrated that epigenetic alterations play critical roles in GIST development. Howeve...

journal_title：Molecular cancer

authors： Hu F,Li H,Liu L,Xu F,Lai S,Luo X,Hu J,Yang X

更新日期：2018-07-30 00:00:00

abstract：BACKGROUND:Neuroblastoma is responsible for 15% of all childhood cancer deaths. Despite advances in treatment and disease management, the overall 5-year survival rates remain poor in high-risk disease (25-40%). MiR-497 was previously identified by our laboratory as a member of a miRNA expression signature, predictive o...

journal_title：Molecular cancer

authors： Creevey L,Ryan J,Harvey H,Bray IM,Meehan M,Khan AR,Stallings RL

更新日期：2013-03-26 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are involved in cancer development and progression, acting as tumor suppressors or oncogenes. Our previous studies have revealed that miR-148a and miR-152 are significantly down-regulated in gastrointestinal cancers. Interestingly, miR-148b has the same "seed sequences" as miR-148a and miR...

journal_title：Molecular cancer

authors： Song YX,Yue ZY,Wang ZN,Xu YY,Luo Y,Xu HM,Zhang X,Jiang L,Xing CZ,Zhang Y

更新日期：2011-01-04 00:00:00

abstract：BACKGROUND:SLC/CCL21, normally expressed in high endothelial venules and in T cell zones of spleen and lymph nodes, strongly attracts T cells and dendritic cells (DC). We have previously shown that SLC/CCL21-mediated anti-tumor responses are accompanied by significant induction of IFNgamma and the CXC chemokines, monok...

journal_title：Molecular cancer

authors： Sharma S,Yang SC,Hillinger S,Zhu LX,Huang M,Batra RK,Lin JF,Burdick MD,Strieter RM,Dubinett SM

更新日期：2003-04-15 00:00:00

abstract：PURPOSE:Hypoxia is a major regulator of angiogenesis and always influences the release of exosomes in various types of tumors. The present review aimed to assess the role of hypoxia-induced exosomes in the tumor biology. METHODS:The relevant publications were retrieved from PubMed using keywords such as hypoxia, exoso...

journal_title：Molecular cancer

authors： Shao C,Yang F,Miao S,Liu W,Wang C,Shu Y,Shen H

更新日期：2018-08-11 00:00:00

abstract：BACKGROUND:Aurora-A is an oncogenic kinase playing well-documented roles in mitotic spindle organisation. We previously found that Aurora-A inactivation yields the formation of spindles with fragmented poles that can drive chromosome mis-segregation. Here we have addressed the mechanism through which Aurora-A activity ...

journal_title：Molecular cancer

authors： Asteriti IA,Giubettini M,Lavia P,Guarguaglini G

更新日期：2011-10-19 00:00:00

abstract：BACKGROUND:The expression of the rodent phosphoinositide-specific phospholipase C delta-4 (PLCdelta4) has been found to be elevated upon mitogenic stimulation and expression analysis have linked the upregulation of PLCdelta4 expression with rapid proliferation in certain rat transformed cell lines. The human homologue ...

journal_title：Molecular cancer

authors： Leung DW,Tompkins C,Brewer J,Ball A,Coon M,Morris V,Waggoner D,Singer JW

更新日期：2004-05-13 00:00:00

abstract：INTRODUCTION:ERBB3, one of the four members of the ErbB family of receptor tyrosine kinases, plays an important role in breast cancer etiology and progression. In the present study, we aimed to identify novel miRNAs that can potentially target ERBB3 and their biological functions. METHOD:The expression levels of miR-1...

journal_title：Molecular cancer

authors： Yan X,Chen X,Liang H,Deng T,Chen W,Zhang S,Liu M,Gao X,Liu Y,Zhao C,Wang X,Wang N,Li J,Liu R,Zen K,Zhang CY,Liu B,Ba Y

更新日期：2014-09-24 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide, and the biology of this cancer remains poorly understood. Recent evidence indicates that long non-coding RNAs (lncRNAs) are found to be dysregulated in a variety of cancers, including HCC. Taurine Up-regulated Gene...

journal_title：Molecular cancer

authors： Huang MD,Chen WM,Qi FZ,Sun M,Xu TP,Ma P,Shu YQ

更新日期：2015-09-04 00:00:00

abstract：:Exosomes are extracellular vesicles released by many cell types and have been attributed for their roles in many diseases including cancer. Exosomes secreted by tumor cells and stromal cells are critical mediators of intercellular communication in tumor microenvironments. Long noncoding RNAs (lncRNAs) are selectively ...

journal_title：Molecular cancer

authors： Sun Z,Yang S,Zhou Q,Wang G,Song J,Li Z,Zhang Z,Xu J,Xia K,Chang Y,Liu J,Yuan W

更新日期：2018-04-20 00:00:00

abstract：BACKGROUND:The poor prognosis of esophageal squamous cell carcinoma (ESCC) highlights the need for novel strategies against this disease. Our previous study suggested the involvement of CCL2 and tumor associated macrophages (TAMs) in esophageal carcinogenesis. Despite the recognition of TAMs as a promising target for c...

journal_title：Molecular cancer

authors： Yang H,Zhang Q,Xu M,Wang L,Chen X,Feng Y,Li Y,Zhang X,Cui W,Jia X

更新日期：2020-02-27 00:00:00

abstract：BACKGROUND:In recent years, circular RNAs (circRNAs), a new star of non-coding RNA, have been emerged as vital regulators and gained much attention for involvement of initiation and progression of diverse kinds of human diseases, especially cancer. However, regulatory role, clinical significance and underlying mechanis...

journal_title：Molecular cancer

authors： Yang R,Xing L,Zheng X,Sun Y,Wang X,Chen J

更新日期：2019-01-08 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) has one of the poorest prognoses among all cancers. Over the past several decades, investigators have made great advances in the research of PDAC pathogenesis. Importantly, identification of pancreatic cancer stem cells (PCSCs) in pancreatic cancer cases has increased our unders...

journal_title：Molecular cancer

authors： Quan M,Wang P,Cui J,Gao Y,Xie K

更新日期：2013-12-10 00:00:00

abstract：BACKGROUND:Expression of kappa gene is under the control of distinct cis-regulatory elements, including the kappa intron enhancer (iE kappa) and the kappa 3' enhancer (3'E kappa). The active enhancers and expression of immunoglobulin is generally considered to be restricted to B lymphocytes. However, accumulating evide...

journal_title：Molecular cancer

authors： Liu H,Zheng H,Duan Z,Hu D,Li M,Liu S,Li Z,Deng X,Wang Z,Tang M,Shi Y,Yi W,Cao Y

更新日期：2009-10-27 00:00:00

abstract：BACKGROUND:The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division. Deregulation of FOXM1 has been linked to a majority of human cancers. We previously showed that FOXM1 was upregulated in basal cell c...

journal_title：Molecular cancer

authors： Teh MT,Gemenetzidis E,Chaplin T,Young BD,Philpott MP

更新日期：2010-02-26 00:00:00

abstract：BACKGROUND:Nilotinib is a tyrosine kinase inhibitor with high target specificity. Here, we characterized the effects of nilotinib for the first time on CD4+CD25+ regulatory T cells (Tregs) which regulate anti-tumor/leukemia immune responses. DESIGN AND METHODS:Carboxyfluorescein diacetate succinimidyl ester (CFSE) and...

journal_title：Molecular cancer

authors： Fei F,Yu Y,Schmitt A,Rojewski MT,Chen B,Greiner J,Götz M,Bunjes D,Schmitt M

更新日期：2010-01-29 00:00:00

abstract：BACKGROUND:Aberrant accumulation of beta-catenin plays an important role in a variety of human neoplasms. We recently reported accumulation of beta-catenin in parathyroid adenomas from patients with primary hyperparathyroidism (pHPT). In CTNNB1 exon 3, we detected a stabilizing mutation (S37A) in 3 out of 20 analyzed a...

journal_title：Molecular cancer

authors： Björklund P,Lindberg D,Akerström G,Westin G

更新日期：2008-06-09 00:00:00

abstract：BACKGROUND:The transcription factor Runx2 has an established role in cancers that metastasize to bone. In metastatic breast cancer cells Runx2 is overexpressed and contributes to the invasive capacity of the cells by regulating the expression of several invasion genes. CBFbeta is a transcriptional co-activator that is ...

journal_title：Molecular cancer

authors： Mendoza-Villanueva D,Deng W,Lopez-Camacho C,Shore P

更新日期：2010-06-30 00:00:00

abstract：BACKGROUND:The role of TNF-alpha in affecting the fate of tumors is controversial, while some studies have reported apoptotic or necrotic effects of TNF-alpha, others provide evidence that endogenous TNF-alpha promotes growth and development of tumors. Understanding the mechanism(s) of TNF-alpha mediated growth arrest ...

journal_title：Molecular cancer

authors： Kumar PS,Shiras A,Das G,Jagtap JC,Prasad V,Shastry P

更新日期：2007-06-12 00:00:00

abstract：BACKGROUND:Colorectal cancer is third most common malignancy and is the second most common cause of cancer-related death. The MUC1 heterodimeric protein is aberrantly overexpressed in colorectal cancer and has been linked to poor outcomes in this disease. Here, we investigate the effects of the MUC1-C subunit inhibitor...

journal_title：Molecular cancer

authors： Ahmad R,Alam M,Hasegawa M,Uchida Y,Al-Obaid O,Kharbanda S,Kufe D

更新日期：2017-02-02 00:00:00

abstract：BACKGROUND:Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic secretome delivering and trafficking for long-distance cell-to-cell communication. This stu...

journal_title：Molecular cancer

authors： Lin Q,Chen X,Meng F,Ogawa K,Li M,Song R,Zhang S,Zhang Z,Kong X,Xu Q,He F,Bai X,Sun B,Hung MC,Liu L,Wands J,Dong X

更新日期：2019-11-07 00:00:00

abstract：BACKGROUND:Minimal residual disease is the main issue of advanced ovarian cancer treatment. According to the literature and previous results, we hypothesized that Mesenchymal Stromal Cells (MSC) could support this minimal residual disease by protecting ovarian cancer cells (OCC) from chemotherapy. In vitro study confir...

journal_title：Molecular cancer

authors： Pasquier J,Gosset M,Geyl C,Hoarau-Véchot J,Chevrot A,Pocard M,Mirshahi M,Lis R,Rafii A,Touboul C

更新日期：2018-02-19 00:00:00

abstract：BACKGROUND:Co-Activator Arginine Methyltransferase 1(CARM1) is an Estrogen Receptor (ER) cofactor that remodels chromatin for gene regulation via methylation of Histone3. We investigated CARM1 levels and localization across breast cancer tumors in a cohort of patients of either European or African ancestry. METHODS:We...

journal_title：Molecular cancer

authors： Davis MB,Liu X,Wang S,Reeves J,Khramtsov A,Huo D,Olopade OI

更新日期：2013-05-10 00:00:00

abstract：INTRODUCTION:Tumor-initiating cells (TICs), aka "cancer stem cells", are believed to fuel tumors and to sustain therapy resistance and systemic metastasis. Breast cancer is the first human carcinoma in which a subpopulation of cells displaying a specific CD44+/CD24-/low/ESA+ antigenic phenotype was found to have TIC pr...

journal_title：Molecular cancer

authors： Leccia F,Del Vecchio L,Mariotti E,Di Noto R,Morel AP,Puisieux A,Salvatore F,Ansieau S

更新日期：2014-09-12 00:00:00

abstract：:Cell lines are still a tool of choice for many fields of biomedical research, including oncology. Although cancer is a very complex disease, many discoveries have been made using monocultures of established cell lines. Therefore, the proper use of in vitro models is crucial to enhance our understanding of cancer. Ther...

journal_title：Molecular cancer

authors： Brodaczewska KK,Szczylik C,Fiedorowicz M,Porta C,Czarnecka AM

更新日期：2016-12-19 00:00:00