Abstract:
:MicroRNAs (miRNAs) are emerging as central players in shaping the biology of the Tumor Microenvironment (TME). They do so both by modulating their expression levels within the different cells of the TME and by being shuttled among different cell populations within exosomes and other extracellular vesicles. This review focuses on the state-of-the-art knowledge of the role of miRNAs in the complexity of the TME and highlights limitations and challenges in the field. A better understanding of the mechanisms of action of these fascinating micro molecules will lead to the development of new therapeutic weapons and most importantly, to an improvement in the clinical outcome of cancer patients.
journal_name
Mol Cancerjournal_title
Molecular cancerauthors
Frediani JN,Fabbri Mdoi
10.1186/s12943-016-0525-3subject
Has Abstractpub_date
2016-05-26 00:00:00pages
42issue
1issn
1476-4598pii
10.1186/s12943-016-0525-3journal_volume
15pub_type
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