Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity.

abstract：BACKGROUND:Most ovarian cancers are highly invasive in nature and the high burden of metastatic disease make them a leading cause of mortality among all gynaecological malignancies. The homeodomain transcription factor, PITX2 is associated with cancer in different tissues. Our previous studies demonstrated increased PI...

journal_title：Molecular cancer

authors： Basu M,Bhattacharya R,Ray U,Mukhopadhyay S,Chatterjee U,Roy SS

更新日期：2015-08-23 00:00:00

abstract：BACKGROUND:Metastatic renal cell carcinoma (RCC) remains the leading cause of mortality in patients with clear cell RCC arising from mutations in the von Hippel Lindau (VHL) tumor suppressor. Successful RCC tumor suppression by VHL requires the negative regulation of hypoxia inducible factor alpha (HIF alpha) protein a...

journal_title：Molecular cancer

authors： Petrella BL,Brinckerhoff CE

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:The role of TNF-alpha in affecting the fate of tumors is controversial, while some studies have reported apoptotic or necrotic effects of TNF-alpha, others provide evidence that endogenous TNF-alpha promotes growth and development of tumors. Understanding the mechanism(s) of TNF-alpha mediated growth arrest ...

journal_title：Molecular cancer

authors： Kumar PS,Shiras A,Das G,Jagtap JC,Prasad V,Shastry P

更新日期：2007-06-12 00:00:00

abstract：BACKGROUND:Perturbation of DNA methylation is frequent in cancers and has emerged as an important mechanism involved in tumorigenesis. To determine how DNA methylation is modified in the genome of primary glioma, we used Methyl-DNA immunoprecipitation (MeDIP) and Nimblegen CpG promoter microarrays to identify different...

journal_title：Molecular cancer

authors： Zhang Z,Tang H,Wang Z,Zhang B,Liu W,Lu H,Xiao L,Liu X,Wang R,Li X,Wu M,Li G

更新日期：2011-09-30 00:00:00

abstract：BACKGROUND:Amplifications at 6p22.3 are prevalent in advanced stage bladder cancer (TCC). Previous studies have identified SOX4, CDKAL, and E2F3 as targets of this amplification and therefore potential oncogenes, but the more telomeric DEK gene too has been reported as overexpressed and amplified. We have therefore inv...

journal_title：Molecular cancer

authors： Wu Q,Hoffmann MJ,Hartmann FH,Schulz WA

更新日期：2005-05-05 00:00:00

abstract：BACKGROUND:As an important means of communication, exosomes play an important role in the development of hepatocellular carcinoma (HCC). METHODS:Bioinformatics analysis, dual-luciferase reporter assays, methylation-specific quantitative PCR, and ChIP-PCR analysis were used to gain insight into the underlying mechanism...

journal_title：Molecular cancer

authors： Cao LQ,Yang XW,Chen YB,Zhang DW,Jiang XF,Xue P

更新日期：2019-10-27 00:00:00

abstract：BACKGROUND:Neuroblastoma is responsible for 15% of all childhood cancer deaths. Despite advances in treatment and disease management, the overall 5-year survival rates remain poor in high-risk disease (25-40%). MiR-497 was previously identified by our laboratory as a member of a miRNA expression signature, predictive o...

journal_title：Molecular cancer

authors： Creevey L,Ryan J,Harvey H,Bray IM,Meehan M,Khan AR,Stallings RL

更新日期：2013-03-26 00:00:00

abstract：BACKGROUND:The tumor cell lysate-pulsed, dendritic cell (DC)-based cancer vaccine approaches are being actively evaluated for application to cancer immunotherapy, hopefully at a personalized medicine base. There is apparently an emerging technical problem however, the lack of highly efficacious potency in activation of...

journal_title：Molecular cancer

authors： Lin TJ,Lin HT,Chang WT,Mitapalli S P,Hsiao PW,Yin SY,Yang NS

更新日期：2015-09-24 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the major causes of mortality. ABT-263 is a newly synthesized, orally available Bcl-2/xL inhibitor that shows promising efficacy in HCC therapy. ABT-263 inhibits the anti-apoptotic activity of Bcl-2 and Bcl-xL, but not Mcl-1. Previous reports have shown that ABT-263 u...

journal_title：Molecular cancer

authors： Wang B,Ni Z,Dai X,Qin L,Li X,Xu L,Lian J,He F

更新日期：2014-04-30 00:00:00

abstract：:Cancer research has mainly focused on alterations of genes and proteins in cancer cells themselves that result in either gain-of-function in oncogenes or loss-of-function in tumour-suppressor genes. However, stromal variables within or around tumours, including blood and lymph vessels, stromal cells and various protei...

journal_title：Molecular cancer

authors： Sun XF,Zhang H

更新日期：2006-10-06 00:00:00

abstract：BACKGROUND:Darpp-32 and t-Darpp are expressed in several forms of breast cancer. Both are transcribed from the gene PPP1R1B via alternative promoters. In humans, Darpp-32 is expressed in both normal and malignant breast tissue, whereas t-Darpp has only been found in malignant breast tissue. The exact biological functio...

journal_title：Molecular cancer

authors： Christenson JL,Kane SE

更新日期：2014-08-15 00:00:00

abstract：BACKGROUND:Incorrect segregation of whole chromosomes or parts of chromosome leads to aneuploidy commonly observed in cancer. The correct centrosome duplication, assuring assembly of a bipolar mitotic spindle, is essential for chromosome segregation fidelity and preventing aneuploidy. Alteration of p53 and pRb function...

journal_title：Molecular cancer

authors： Iovino F,Lentini L,Amato A,Di Leonardo A

更新日期：2006-09-20 00:00:00

abstract：:The early diagnosis of pancreatic cancer, as well as distinguishing between chronic pancreatitis and malignant pancreatic disease, remains still a clinical problem. Presently, there is no specific tumor marker for diagnosing pancreatic cancer. Mucin-associated marker like CA 19-9 are the most widely available pancreat...

journal_title：Molecular cancer

authors： Ringel J,Löhr M

更新日期：2003-01-07 00:00:00

abstract：BACKGROUND:In our previous studies, we have demonstrated that insulin-like growth factor binding protein-related protein1 (IGFBP-rP1) played its potential tumor suppressor role in colon cancer cells through apoptosis and senescence induction. In this study, we will further uncover the role of IGFBP-rP1 in colon cancer ...

journal_title：Molecular cancer

authors： Ruan W,Zhu S,Wang H,Xu F,Deng H,Ma Y,Lai M

更新日期：2010-10-26 00:00:00

abstract：:Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cl...

journal_title：Molecular cancer

authors： Moossavi M,Parsamanesh N,Bahrami A,Atkin SL,Sahebkar A

更新日期：2018-11-17 00:00:00

abstract：BACKGROUND:Previous reports have suggested that the VEGF receptor neuropilin-1 (NRP-1) is expressed in a singly dispersed subpopulation of cells in the normal colonic epithelium, but that expression becomes dysregulated during colorectal carcinogenesis, with higher levels in tumour suggestive of a poor prognosis. We no...

journal_title：Molecular cancer

authors： Yu DC,Bury JP,Tiernan J,Waby JS,Staton CA,Corfe BM

更新日期：2011-03-14 00:00:00

abstract：BACKGROUND:Oncolytic virotherapy is an attractive drug platform of cancer gene therapy, but efficacy and specificity are important prerequisites for success of such strategies. Previous studies determined that Apoptin is a p53 independent, bcl-2 insensitive apoptotic protein with the ability to specifically induce apop...

journal_title：Molecular cancer

authors： Li X,Liu Y,Wen Z,Li C,Lu H,Tian M,Jin K,Sun L,Gao P,Yang E,Xu X,Kan S,Wang Z,Wang Y,Jin N

更新日期：2010-01-20 00:00:00

abstract：:Gene fusions occur in up to 17% of solid tumours. Oncogenic kinases are often involved in such fusions. In lung cancer, almost 30% of patients carrying an activated oncogene show the fusion of a tyrosine kinase to an heterologous gene. Several genes are partner in the fusion with the three kinases ALK, ROS1 and RET in...

journal_title：Molecular cancer

authors： Cerrato A,Visconti R,Celetti A

更新日期：2018-02-19 00:00:00

abstract：BACKGROUND:The IκB kinase (IKK) complex, comprising the two enzymes IKKα and IKKβ, is the main activator of the inflammatory transcription factor NF-κB, which is constitutively active in many cancers. While several connections between NF-κB signaling and the oncogene c-Myc have been shown, functional links between the ...

journal_title：Molecular cancer

authors： Moser B,Hochreiter B,Basílio J,Gleitsmann V,Panhuber A,Pardo-Garcia A,Hoesel B,Salzmann M,Resch U,Noreen M,Schmid JA

更新日期：2021-01-18 00:00:00

abstract：BACKGROUND:Hodgkin lymphoma (HL) and Anaplastic Large Cell Lymphoma (ALCL), are forms of malignant lymphoma defined by unique morphologic, immunophenotypic, genotypic, and clinical characteristics, but both overexpress CD30. We used sub-megabase resolution tiling (SMRT) array-based comparative genomic hybridization to ...

journal_title：Molecular cancer

authors： Fadlelmola FM,Zhou M,de Leeuw RJ,Dosanjh NS,Harmer K,Huntsman D,Lam WL,Banerjee D

更新日期：2008-01-07 00:00:00

abstract：BACKGROUND:CD95 is a death receptor controlling not only apoptotic pathways but also activating mechanisms promoting tumor growth. During the acquisition of chemoresistance to oxaliplatin there is a progressive loss of CD95 expression in colon cancer cells and a decreased ability of this receptor to induce cell death. ...

journal_title：Molecular cancer

authors： Ametller E,García-Recio S,Costamagna D,Mayordomo C,Fernández-Nogueira P,Carbó N,Pastor-Arroyo EM,Gascón P,Almendro V

更新日期：2010-06-23 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) has one of the poorest prognoses among all cancers. Over the past several decades, investigators have made great advances in the research of PDAC pathogenesis. Importantly, identification of pancreatic cancer stem cells (PCSCs) in pancreatic cancer cases has increased our unders...

journal_title：Molecular cancer

authors： Quan M,Wang P,Cui J,Gao Y,Xie K

更新日期：2013-12-10 00:00:00

abstract：:Exosomes have emerged as a novel approach for the treatment and diagnosis of cancer after RNA content was discovered in exosomes in 2007. As important meditators of intercellular communication, exosomes have become a strong focus of investigation for researchers in the past decade, as witnessed through the exponential...

journal_title：Molecular cancer

authors： Zhou R,Chen KK,Zhang J,Xiao B,Huang Z,Ju C,Sun J,Zhang F,Lv XB,Huang G

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:Reovirus type 3 Dearing strain (ReoT3D) has an inherent propensity to preferentially infect and destroy cancer cells. The oncolytic activity of ReoT3D as a single agent has been demonstrated in vitro and in vivo against various cancers, including colon, pancreatic, ovarian and breast cancers. Its human safet...

journal_title：Molecular cancer

authors： Sei S,Mussio JK,Yang QE,Nagashima K,Parchment RE,Coffey MC,Shoemaker RH,Tomaszewski JE

更新日期：2009-07-14 00:00:00

abstract：BACKGROUND:The Sonic hedgehog (Shh) signaling pathway plays an important role in cerebellar development, and mutations leading to hyperactive Shh signaling have been associated with certain forms of medulloblastoma, a common form of pediatric brain cancer. While the fundamentals of this pathway are known, the molecular...

journal_title：Molecular cancer

authors： Lee SJ,Litan A,Li Z,Graves B,Lindsey S,Barwe SP,Langhans SA

更新日期：2015-08-19 00:00:00

abstract：:Early detection of a premalignant or cancerous oral lesion promises to improve the survival and the morbidity of patients suffering from these conditions. Cytological study of oral cells is a non-aggressive technique that is well accepted by the patient, and is therefore an attractive option for the early diagnosis of...

journal_title：Molecular cancer

authors： Mehrotra R,Gupta A,Singh M,Ibrahim R

更新日期：2006-03-23 00:00:00

abstract：BACKGROUND:Cellular senescence is a state of irreversible cell growth arrest and senescence cells permanently lose proliferation potential. Induction of cellular senescence might be a novel therapy for cancer cells. TRIB2 has been reported to participate in regulating proliferation and drug resistance of various cancer...

journal_title：Molecular cancer

authors： Hou Z,Guo K,Sun X,Hu F,Chen Q,Luo X,Wang G,Hu J,Sun L

更新日期：2018-12-12 00:00:00

abstract：BACKGROUND:Minimal residual disease is the main issue of advanced ovarian cancer treatment. According to the literature and previous results, we hypothesized that Mesenchymal Stromal Cells (MSC) could support this minimal residual disease by protecting ovarian cancer cells (OCC) from chemotherapy. In vitro study confir...

journal_title：Molecular cancer

authors： Pasquier J,Gosset M,Geyl C,Hoarau-Véchot J,Chevrot A,Pocard M,Mirshahi M,Lis R,Rafii A,Touboul C

更新日期：2018-02-19 00:00:00

abstract：BACKGROUND:Interferon regulatory factor-1 (IRF-1) is a master regulator of IFN-γ induced gene transcription. Previously we have shown that IRF-1 transcriptionally induces CEACAM1 via an ISRE (Interferon-Stimulated Response Element) in its promoter. CEACAM1 pre-mRNA undergoes extensive alternative splicing (AS) generati...

journal_title：Molecular cancer

authors： Dery KJ,Kujawski M,Grunert D,Wu X,Ngyuen T,Cheung C,Yim JH,Shively JE

更新日期：2014-03-21 00:00:00

abstract：BACKGROUND:Sorafenib, a kinase inhibitor active against various solid tumours, induces oxidative stress and ferroptosis, a new form of oxidative necrosis, in some cancer cells. Clinically-applicable biomarkers that reflect the impact of sorafenib on the redox metabolism of cancer cells are lacking. METHODS:We used gen...

journal_title：Molecular cancer

authors： Houessinon A,François C,Sauzay C,Louandre C,Mongelard G,Godin C,Bodeau S,Takahashi S,Saidak Z,Gutierrez L,Régimbeau JM,Barget N,Barbare JC,Ganne N,Chauffert B,Coriat R,Galmiche A

更新日期：2016-05-16 00:00:00