Abstract:
:Cancer precursor/progenitor cells may initiate and sustain the growth of tumors, but evidence for their existence in human disease is indirect, relying on their in vitro properties and animal models. More directly, specific elimination of these rare cells from cancer patients should produce a delayed but progressive disappearance of differentiated malignant progeny. Here, we describe selective eradication of a putative precursor population in a patient with B-cell chronic lymphocytic leukemia, followed 6 months later by a progressive loss of mature tumor cells without further treatment. This outcome supports the presence of a rare population of precursor/progenitor cells in human malignancies, and suggests benefit from their removal.
journal_name
Mol Cancerjournal_title
Molecular cancerauthors
Foster AE,Okur FV,Biagi E,Lu A,Dotti G,Yvon E,Savoldo B,Carrum G,Andreeff M,Goodell MA,Heslop HE,Brenner MKdoi
10.1186/1476-4598-8-106subject
Has Abstractpub_date
2009-11-18 00:00:00pages
106issn
1476-4598pii
1476-4598-8-106journal_volume
8pub_type
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