Abstract:
:Infection with Human papillomaviruses (HPVs) leads to the development of a wide-range of cancers, accounting for 5% of all human cancers. A prominent example is cervical cancer, one of the leading causes of cancer death in women worldwide. It has been well established that tumor development and progression induced by HPV infection is driven by the sustained expression of two oncogenes E6 and E7. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways that may be equally important for transformation. Among these pathways, the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signalling cascade plays a very important role in HPV-induced carcinogenesis by acting through multiple cellular and molecular events. In this review, we summarize the frequent amplification of PI3K/Akt/mTOR signals in HPV-induced cancers and discuss how HPV oncogenes E6/E7/E5 activate the PI3K/Akt/mTOR signalling pathway to modulate tumor initiation and progression and affect patient outcome. Improvement of our understanding of the mechanism by which the PI3K/Akt/mTOR signalling pathway contributes to the immortalization and carcinogenesis of HPV-transduced cells will assist in devising novel strategies for preventing and treating HPV-induced cancers.
journal_name
Mol Cancerjournal_title
Molecular cancerauthors
Zhang L,Wu J,Ling MT,Zhao L,Zhao KNdoi
10.1186/s12943-015-0361-xsubject
Has Abstractpub_date
2015-04-17 00:00:00pages
87issn
1476-4598pii
10.1186/s12943-015-0361-xjournal_volume
14pub_type
杂志文章,评审相关文献
Molecular Cancer文献大全abstract:BACKGROUND:Epidermal growth factor receptor (EGFR), a well-known oncogenic driver, contributes to the initiation and progression of a wide range of cancer types. Aberrant lipid metabolism including highly produced monounsaturated fatty acids (MUFA) is recognized as a hallmark of cancer. However, how EGFR regulates MUFA...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-017-0704-x
更新日期:2017-07-19 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with high morbidity and mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation and related mechanisms has led researchers to focus on the microenvironment where pancreatic cancers develop. The anomalous proliferation ...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-018-0927-5
更新日期:2019-01-21 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary tumor in the central nervous system. One of the most widely used chemotherapeutic drugs for GBM is temozolomide, which is a DNA-alkylating agent and its efficacy is dependent on MGMT methylation status. Little progress in improving the p...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-017-0670-3
更新日期:2017-06-07 00:00:00
abstract:BACKGROUND:Epigenetic control is essential for maintenance of tissue hierarchy and correct differentiation. In cancer, this hierarchical structure is altered and epigenetic control deregulated, but the relationship between these two phenomena is still unclear. CD133 is a marker for adult stem cells in various tissues a...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-94
更新日期:2011-07-29 00:00:00
abstract:INTRODUCTION:Tumor-initiating cells (TICs), aka "cancer stem cells", are believed to fuel tumors and to sustain therapy resistance and systemic metastasis. Breast cancer is the first human carcinoma in which a subpopulation of cells displaying a specific CD44+/CD24-/low/ESA+ antigenic phenotype was found to have TIC pr...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-213
更新日期:2014-09-12 00:00:00
abstract:BACKGROUND:Pituitary tumor transforming gene (pttg) is a novel oncogene that is expressed at higher level in most of the tumors analyzed to date compared to normal tissues. Nevertheless, its expression in prolactinomas and its relation with the pituitary dopamine receptor 2 (D2R) are not well defined. We sought to dete...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-6-4
更新日期:2007-01-12 00:00:00
abstract:BACKGROUND:High expression of the long non-coding RNA nuclear-enriched abundant transcript 1 (NEAT1) in whole blood has been reported in colorectal cancer patients; however, its' clinical significance and origin are unclear. We evaluated the diagnostic and prognostic value, and origin of whole blood NEAT1 in colorectal...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-015-0455-5
更新日期:2015-11-09 00:00:00
abstract:BACKGROUND:Previous reports have suggested that the VEGF receptor neuropilin-1 (NRP-1) is expressed in a singly dispersed subpopulation of cells in the normal colonic epithelium, but that expression becomes dysregulated during colorectal carcinogenesis, with higher levels in tumour suggestive of a poor prognosis. We no...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-27
更新日期:2011-03-14 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is one of the major causes of mortality. ABT-263 is a newly synthesized, orally available Bcl-2/xL inhibitor that shows promising efficacy in HCC therapy. ABT-263 inhibits the anti-apoptotic activity of Bcl-2 and Bcl-xL, but not Mcl-1. Previous reports have shown that ABT-263 u...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-98
更新日期:2014-04-30 00:00:00
abstract:BACKGROUND:Relapse due to chemoresistant residual disease is a major cause of death in acute myelogenous leukemia (AML). The present study was undertaken to elucidate the molecular mechanisms of chemoresistance by comparing differential gene expression in blasts from patients with resistant relapsing AML and chemosensi...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-6-31
更新日期:2007-04-23 00:00:00
abstract:BACKGROUND:Since tumor growth requires reactivation of telomerase (hTERT), this enzyme is a challenging target for drug development. Therefore, it is of great interest to identify telomerase expression and activity regulators. Retinoids are well-known inducers of granulocytic maturation associated with hTERT repression...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-018-0835-8
更新日期:2018-04-27 00:00:00
abstract:BACKGROUND:Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear hormone receptor superfamily and is highly expressed in many human tumors including breast cancer. PPARgamma has been identified as a potential target for breast cancer therapy based on the fact that its activation by syn...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-7-90
更新日期:2008-12-05 00:00:00
abstract:BACKGROUND:Perturbation of DNA methylation is frequent in cancers and has emerged as an important mechanism involved in tumorigenesis. To determine how DNA methylation is modified in the genome of primary glioma, we used Methyl-DNA immunoprecipitation (MeDIP) and Nimblegen CpG promoter microarrays to identify different...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-124
更新日期:2011-09-30 00:00:00
abstract:BACKGROUND:Deregulated circular RNAs (circRNAs) are associated with the development of cancer and therapy resistance. However, functional research of circRNAs mostly focus on potential miRNA or protein binding and more potential regulation of circRNA on host gene DNA in cancers are yet to be inspected. METHOD:We perfo...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-020-01246-x
更新日期:2020-08-24 00:00:00
abstract:BACKGROUND:Survivin is a dual function protein. It inhibits the apoptosis of cells by inhibiting caspases, and also promotes cell growth by stabilizing microtubules during mitosis. Over-expression of survivin has been demonstrated to induce drug-resistance to various chemo-therapeutic agents such as cisplatin (DNA dama...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-8-43
更新日期:2009-07-03 00:00:00
abstract::Although solid tumors comprise malignant cells, they also contain many different non-malignant cell types in their micro-environment. The cellular components of the tumor stroma consist of immune and endothelial cells combined with a heterogeneous population of stromal cells which include cancer-associated fibroblasts...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-019-0960-z
更新日期:2019-03-30 00:00:00
abstract:BACKGROUND:Hedgehog acyltransferase (Hhat) catalyzes the transfer of the fatty acid palmitate onto Sonic Hedgehog (Shh), a modification that is essential for Shh signaling activity. The Shh signaling pathway has been implicated in the progression of breast cancer. METHODS:To determine the functional significance of Hh...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-015-0345-x
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Taurine upregulated gene1 (TUG1) as a 7.1-kb lncRNA, has been shown to play an oncogenic role in various cancers. However, the biological functions of lncRNA TUG1 in small cell lung cancer (SCLC) remain unknown. The aim of this study is to explore the roles of TUG1 in cell growth and chemoresistance of SCLC ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-016-0575-6
更新日期:2017-01-09 00:00:00
abstract:BACKGROUND:Human or animals lacking either JAK3 or the common gamma chain (gammac) expression display severe combined immunodeficiency disease, indicating the crucial role of JAK3 in T-cell development and the homeostasis of the immune system. JAK3 has also been suggested to contribute to the pathogenesis of tumorigene...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-36
更新日期:2010-02-11 00:00:00
abstract::Since the publication of this work [1] and in response to a recent query that was brought to our attention in relation to the Western Blot in Figure 1(C) for NP2, protein lysates prepared around the same time as those presented in the manuscript in question, were run by SDS-PAGE under similar experimental conditions a...
journal_title:Molecular cancer
pub_type: 已发布勘误
doi:10.1186/s12943-020-1142-8
更新日期:2020-01-27 00:00:00
abstract::The concept that vegetables and fruits are relevant sources of cancer-preventive substances is strongly supported by population studies. Among others, cruciferous vegetables like broccoli, cabbage, cauliflower and Brussels sprouts are thought to affect the development of various types of cancers and especially prostat...
journal_title:Molecular cancer
pub_type: 评论,杂志文章
doi:10.1186/1476-4598-9-308
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Neuroblastoma is responsible for 15% of all childhood cancer deaths. Despite advances in treatment and disease management, the overall 5-year survival rates remain poor in high-risk disease (25-40%). MiR-497 was previously identified by our laboratory as a member of a miRNA expression signature, predictive o...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-12-23
更新日期:2013-03-26 00:00:00
abstract:BACKGROUND:Aberrant expression of microRNAs in different human cancer types has been widely reported. MiR-218 acts as a tumor suppressor in diverse human cancer types impacting regulation of multiple genes in oncogenic pathways. Here, we evaluated the expression and function of miR-218 in human lung cancer and ALDH pos...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-017-0710-z
更新日期:2017-08-22 00:00:00
abstract::Cancer research has mainly focused on alterations of genes and proteins in cancer cells themselves that result in either gain-of-function in oncogenes or loss-of-function in tumour-suppressor genes. However, stromal variables within or around tumours, including blood and lymph vessels, stromal cells and various protei...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/1476-4598-5-43
更新日期:2006-10-06 00:00:00
abstract:BACKGROUND:CD95 is a death receptor controlling not only apoptotic pathways but also activating mechanisms promoting tumor growth. During the acquisition of chemoresistance to oxaliplatin there is a progressive loss of CD95 expression in colon cancer cells and a decreased ability of this receptor to induce cell death. ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-161
更新日期:2010-06-23 00:00:00
abstract:BACKGROUND:In the current study we investigated the role of caveolin-1 (cav-1) in pancreatic adenocarcinoma (PC) cell migration and invasion; initial steps in metastasis. Cav-1 is the major structural protein in caveolae; small Omega-shaped invaginations within the plasma membrane. Caveolae are involved in signal trans...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-4-21
更新日期:2005-06-21 00:00:00
abstract:BACKGROUND:Although both circular RNAs (circRNAs) and autophagy are associated with the function of breast cancer (BC), whether circRNAs regulate BC progression via autophagy remains unknown. In this study, we aim to explore the regulatory mechanisms and the clinical significance of autophagy-associated circRNAs in BC....
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-020-01152-2
更新日期:2020-03-25 00:00:00
abstract::Gene fusions occur in up to 17% of solid tumours. Oncogenic kinases are often involved in such fusions. In lung cancer, almost 30% of patients carrying an activated oncogene show the fusion of a tyrosine kinase to an heterologous gene. Several genes are partner in the fusion with the three kinases ALK, ROS1 and RET in...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-018-0799-8
更新日期:2018-02-19 00:00:00
abstract:BACKGROUND:Anaplastic lymphoma kinase (ALK), which is a receptor tyrosine kinase, is essentially and transiently expressed in the developing nervous system. Recently, the deregulated expression of full-length ALK has been observed in some primary solid tumors, but little is known about its involvement in the tumorigene...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-017-0609-8
更新日期:2017-02-14 00:00:00
abstract:BACKGROUND:High expression of P-glycoprotein is one of the well-known mechanisms of chemoresistance in chondrosarcomas. However, the role of antiapoptotic proteins, a common mechanism responsible for chemoresistance in other tumors, has not been well studied in chondrosarcomas. We examined the importance of P-glycoprot...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-8-28
更新日期:2009-05-15 00:00:00