Abstract:
:A vast array of tumor-derived genetic, proteomic and cellular components are constantly released into the circulation of cancer patients. These molecules including circulating tumor DNA and RNA, proteins, tumor and immune cells are emerging as convenient and accurate liquid biomarkers of cancer. Circulating cancer biomarkers provide invaluable information on cancer detection and diagnosis, prognosticate patient outcomes, and predict treatment response. In this era of effective molecular targeted treatments and immunotherapies, there is now an urgent need to implement use of these circulating biomarkers in the clinic to facilitate personalized therapy. In this review, we present recent findings in circulating melanoma biomarkers, examine the challenges and promise of evolving technologies used for liquid biomarker discovery, and discuss future directions and perspectives in melanoma biomarker research.
journal_name
Mol Cancerjournal_title
Molecular cancerauthors
Lim SY,Lee JH,Diefenbach RJ,Kefford RF,Rizos Hdoi
10.1186/s12943-018-0757-5subject
Has Abstractpub_date
2018-01-17 00:00:00pages
8issue
1issn
1476-4598pii
10.1186/s12943-018-0757-5journal_volume
17pub_type
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