Bevacizumab promotes venous thromboembolism through the induction of PAI-1 in a mouse xenograft model of human lung carcinoma.

abstract：BACKGROUND:The tumor cell lysate-pulsed, dendritic cell (DC)-based cancer vaccine approaches are being actively evaluated for application to cancer immunotherapy, hopefully at a personalized medicine base. There is apparently an emerging technical problem however, the lack of highly efficacious potency in activation of...

journal_title：Molecular cancer

authors： Lin TJ,Lin HT,Chang WT,Mitapalli S P,Hsiao PW,Yin SY,Yang NS

更新日期：2015-09-24 00:00:00

abstract：BACKGROUND:Expression of kappa gene is under the control of distinct cis-regulatory elements, including the kappa intron enhancer (iE kappa) and the kappa 3' enhancer (3'E kappa). The active enhancers and expression of immunoglobulin is generally considered to be restricted to B lymphocytes. However, accumulating evide...

journal_title：Molecular cancer

authors： Liu H,Zheng H,Duan Z,Hu D,Li M,Liu S,Li Z,Deng X,Wang Z,Tang M,Shi Y,Yi W,Cao Y

更新日期：2009-10-27 00:00:00

abstract：:The early diagnosis of pancreatic cancer, as well as distinguishing between chronic pancreatitis and malignant pancreatic disease, remains still a clinical problem. Presently, there is no specific tumor marker for diagnosing pancreatic cancer. Mucin-associated marker like CA 19-9 are the most widely available pancreat...

journal_title：Molecular cancer

authors： Ringel J,Löhr M

更新日期：2003-01-07 00:00:00

abstract：BACKGROUND:The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division. Deregulation of FOXM1 has been linked to a majority of human cancers. We previously showed that FOXM1 was upregulated in basal cell c...

journal_title：Molecular cancer

authors： Teh MT,Gemenetzidis E,Chaplin T,Young BD,Philpott MP

更新日期：2010-02-26 00:00:00

abstract：BACKGROUND:The aberrant expression of microRNA-140-5p (miR-140-5p) has been described in gastric cancer (GC). However, the role of miR-140-5p in GC remains unclear. In this study, the prognostic relevance of miR-140-5p in GC was investigated and YES1 was identified as a novel target of miR-140-5p in regulating tumor pr...

journal_title：Molecular cancer

authors： Fang Z,Yin S,Sun R,Zhang S,Fu M,Wu Y,Zhang T,Khaliq J,Li Y

更新日期：2017-08-17 00:00:00

abstract：BACKGROUND:Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic secretome delivering and trafficking for long-distance cell-to-cell communication. This stu...

journal_title：Molecular cancer

authors： Lin Q,Chen X,Meng F,Ogawa K,Li M,Song R,Zhang S,Zhang Z,Kong X,Xu Q,He F,Bai X,Sun B,Hung MC,Liu L,Wands J,Dong X

更新日期：2019-11-07 00:00:00

abstract：BACKGROUND:Previous reports have suggested that the VEGF receptor neuropilin-1 (NRP-1) is expressed in a singly dispersed subpopulation of cells in the normal colonic epithelium, but that expression becomes dysregulated during colorectal carcinogenesis, with higher levels in tumour suggestive of a poor prognosis. We no...

journal_title：Molecular cancer

authors： Yu DC,Bury JP,Tiernan J,Waby JS,Staton CA,Corfe BM

更新日期：2011-03-14 00:00:00

abstract：BACKGROUND:Alterations in lipid metabolism are inherent to the metabolic transformations that support tumorigenesis. The relationship between the synthesis, storage and use of lipids and their importance in cancer is poorly understood. The human group X secreted phospholipase A2 (hGX sPLA2) releases fatty acids (FAs) f...

journal_title：Molecular cancer

authors： Pucer A,Brglez V,Payré C,Pungerčar J,Lambeau G,Petan T

更新日期：2013-09-27 00:00:00

abstract：BACKGROUND:Lung cancer is one of the most prevalent neoplasias in developed countries. Advances in patient survival have been limited and the identification of prognostic molecules is needed. Resistance to treatment is strongly related to tumor cell adhesion to the extracellular matrix and alterations in the quantity a...

journal_title：Molecular cancer

authors： Irigoyen M,Pajares MJ,Agorreta J,Ponz-Sarvisé M,Salvo E,Lozano MD,Pío R,Gil-Bazo I,Rouzaut A

更新日期：2010-05-28 00:00:00

abstract：BACKGROUND:Insulin enhancer binding protein-1 (ISL-1), a LIM-homeodomain transcription factor, is essential for the heart, motor neuron and pancreas development. Recently, ISL-1 has been found in some types of human cancers. However, how ISL-1 exerts the role in tumor development is not clear. METHODS AND RESULTS:The ...

journal_title：Molecular cancer

authors： Zhang Q,Yang Z,Jia Z,Liu C,Guo C,Lu H,Chen P,Ma K,Wang W,Zhou C

更新日期：2014-07-29 00:00:00

abstract：BACKGROUND:Targeted therapies have improved therapeutic options of treating renal cell carcinoma (RCC). However, drug response is temporary due to resistance development. METHODS:Functional and molecular changes in RCC Caki-1 cells, after acquired resistance to the mammalian target of rapamycin (mTOR)-inhibitor everol...

journal_title：Molecular cancer

authors： Juengel E,Nowaz S,Makarevi J,Natsheh I,Werner I,Nelson K,Reiter M,Tsaur I,Mani J,Harder S,Bartsch G,Haferkamp A,Blaheta RA

更新日期：2014-06-16 00:00:00

abstract：BACKGROUND:Metastasis is the leading cause of death among breast cancer patients. Identifying key cellular factors controlling invasion and metastasis of breast cancer cells should pave the way to new therapeutic strategies efficiently interfering with the metastatic process. PAX2 (paired box 2) transcription factor is...

journal_title：Molecular cancer

authors： Beauchemin D,Lacombe C,Van Themsche C

更新日期：2011-12-14 00:00:00

abstract：BACKGROUND:Kinases downstream of growth factor receptors have been implicated in radioresistance and are, therefore, attractive targets to improve radiotherapy outcome in head and neck squamous cell carcinoma (HNSCC) patients. METHODS:An antibody-based array was used to quantify the expression levels of multiple phosp...

journal_title：Molecular cancer

authors： Stegeman H,Kaanders JH,Verheijen MM,Peeters WJ,Wheeler DL,Iida M,Grénman R,van der Kogel AJ,Span PN,Bussink J

更新日期：2013-11-05 00:00:00

abstract：BACKGROUND:Triple negative breast cancer (TNBC) remains the most challenging breast cancer subtype so far. Specific therapeutic approaches have rarely achieved clinical improvements in treatment of TNBC patients and effective molecular biomarkers are largely unknown. METHODS:We used paired TNBC samples and high throug...

journal_title：Molecular cancer

authors： Li J,Ma M,Yang X,Zhang M,Luo J,Zhou H,Huang N,Xiao F,Lai B,Lv W,Zhang N

更新日期：2020-09-11 00:00:00

abstract：BACKGROUND:ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin motifs) is a member of the ADAMTS family of metalloproteases. Here, we investigated mRNA and protein levels of ADAMTS-1 in normal and neoplastic tissues using qPCR, immunohistochemistry and immunoblot analyses, and we addressed the role of ADAMT...

journal_title：Molecular cancer

authors： Freitas VM,do Amaral JB,Silva TA,Santos ES,Mangone FR,Pinheiro Jde J,Jaeger RG,Nagai MA,Machado-Santelli GM

更新日期：2013-01-05 00:00:00

abstract：BACKGROUND:MUC16 is a cell surface mucin expressed at high levels by epithelial ovarian tumors. Following proteolytic cleavage, cell surface MUC16 (csMUC16) is shed in the extracellular milieu and is detected in the serum of cancer patients as the tumor marker CA125. csMUC16 acts as an adhesion molecule and facilitates...

journal_title：Molecular cancer

authors： Belisle JA,Horibata S,Jennifer GA,Petrie S,Kapur A,André S,Gabius HJ,Rancourt C,Connor J,Paulson JC,Patankar MS

更新日期：2010-05-24 00:00:00

abstract：BACKGROUND:The Sonic hedgehog (Shh) signaling pathway plays an important role in cerebellar development, and mutations leading to hyperactive Shh signaling have been associated with certain forms of medulloblastoma, a common form of pediatric brain cancer. While the fundamentals of this pathway are known, the molecular...

journal_title：Molecular cancer

authors： Lee SJ,Litan A,Li Z,Graves B,Lindsey S,Barwe SP,Langhans SA

更新日期：2015-08-19 00:00:00

abstract：:Since the publication of this work [1] and in response to a recent query that was brought to our attention in relation to the Western Blot in Figure 1(C) for NP2, protein lysates prepared around the same time as those presented in the manuscript in question, were run by SDS-PAGE under similar experimental conditions a...

journal_title：Molecular cancer

authors： Barr MP,Gray SG,Gately K,Hams E,Fallon PG,Davies AM,Richard DJ,Pidgeon GP,O'Byrne KJ

更新日期：2020-01-27 00:00:00

abstract：:Infection with Human papillomaviruses (HPVs) leads to the development of a wide-range of cancers, accounting for 5% of all human cancers. A prominent example is cervical cancer, one of the leading causes of cancer death in women worldwide. It has been well established that tumor development and progression induced by ...

journal_title：Molecular cancer

authors： Zhang L,Wu J,Ling MT,Zhao L,Zhao KN

更新日期：2015-04-17 00:00:00

abstract：BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is a highly lethal cancer that contains cellular and functional heterogeneity. Previously, we enriched a subpopulation of highly tumorigenic head and neck cancer initiating cells (HN-CICs) from HNSCC. However, the molecular mechanisms by which to govern the chara...

journal_title：Molecular cancer

authors： Wu MJ,Jan CI,Tsay YG,Yu YH,Huang CY,Lin SC,Liu CJ,Chen YS,Lo JF,Yu CC

更新日期：2010-10-27 00:00:00

abstract：BACKGROUND:Although gemcitabine-based chemotherapy has been established as a core multimodal therapy for non-small cell lung cancer (NSCLC) treatment, its clinical efficacy remains limited by the development of acquired resistance following tumor metastasis and relapse. In this study, we investigated how gemcitabine-re...

journal_title：Molecular cancer

authors： Wei F,Ma C,Zhou T,Dong X,Luo Q,Geng L,Ding L,Zhang Y,Zhang L,Li N,Li Y,Liu Y

更新日期：2017-07-25 00:00:00

abstract：BACKGROUND:Hypermethylation of promotor CpG islands is a common mechanism that inactivates tumor suppressor genes in cancer. Genes belonging to the RASSF gene family have frequently been reported as epigenetically silenced by promotor methylation in human cancers. Two members of this gene family, RASSF1A and RASSF5A ha...

journal_title：Molecular cancer

authors： Djos A,Martinsson T,Kogner P,Carén H

更新日期：2012-06-13 00:00:00

abstract：BACKGROUND:Cancer/testis (CT) genes have expression normally restricted to the testis, but become activated during oncogenesis, so they have excellent potential as cancer-specific biomarkers. Evidence is starting to emerge to indicate that they also provide function(s) in the oncogenic programme. Human TEX19 is a recen...

journal_title：Molecular cancer

authors： Planells-Palop V,Hazazi A,Feichtinger J,Jezkova J,Thallinger G,Alsiwiehri NO,Almutairi M,Parry L,Wakeman JA,McFarlane RJ

更新日期：2017-04-26 00:00:00

abstract：BACKGROUND:Pancreatic cancer is a highly lethal disease and has the worst prognosis of any major malignancy. G protein-coupled receptor GPR87 is reported to be overexpressed in multiple cancers. The clinical significance and biological role of GPR87 in pancreatic cancer, however, remain to be established. METHODS:GPR8...

journal_title：Molecular cancer

authors： Wang L,Zhou W,Zhong Y,Huo Y,Fan P,Zhan S,Xiao J,Jin X,Gou S,Yin T,Wu H,Liu T

更新日期：2017-03-14 00:00:00

abstract：BACKGROUND:Epigenetic regulators play a critical role in the maintenance of specific chromatin domains in an active or repressed state. Disruption of epigenetic regulatory mechanisms is widespread in cancer cells and largely contributes to the transformation process through active repression of tumor suppressor genes. ...

journal_title：Molecular cancer

authors： Yeh CH,Bai XT,Moles R,Ratner L,Waldmann TA,Watanabe T,Nicot C

更新日期：2016-02-16 00:00:00

abstract：BACKGROUND:Survivin is a dual function protein. It inhibits the apoptosis of cells by inhibiting caspases, and also promotes cell growth by stabilizing microtubules during mitosis. Over-expression of survivin has been demonstrated to induce drug-resistance to various chemo-therapeutic agents such as cisplatin (DNA dama...

journal_title：Molecular cancer

authors： Cheung CH,Chen HH,Kuo CC,Chang CY,Coumar MS,Hsieh HP,Chang JY

更新日期：2009-07-03 00:00:00

abstract：BACKGROUND:The tetraspanin CD63 is a highly N-glycosylated protein that is known to regulate cancer malignancy. However, the contribution of glycosylation of CD63 to cancer malignancy remains unclear. Previously, we reported that ribophorin II (RPN2), which is part of an N-oligosaccharyle transferase complex, is respon...

journal_title：Molecular cancer

authors： Tominaga N,Hagiwara K,Kosaka N,Honma K,Nakagama H,Ochiya T

更新日期：2014-05-31 00:00:00

abstract：:Because circulating microRNAs (miRNAs) have drawn a great deal of attention as promising novel cancer diagnostics and prognostic biomarkers, we sought to identify serum miRNAs significantly associated with outcome in glioblastoma patients. To do this, we performed global miRNA profiling in serum samples from 106 prima...

journal_title：Molecular cancer

authors： Zhao H,Shen J,Hodges TR,Song R,Fuller GN,Heimberger AB

更新日期：2017-03-11 00:00:00

abstract：BACKGROUND:The epithelial-to-mesenchymal transition (EMT) process results in a loss of cell-cell adhesion, increased cell mobility, and is crucial for enabling the metastasis of cancer cells. Recently, the enzyme SIRT1 has been implicated in a variety of physiological processes; however, its role in regulating oral can...

journal_title：Molecular cancer

authors： Chen IC,Chiang WF,Huang HH,Chen PF,Shen YY,Chiang HC

更新日期：2014-11-26 00:00:00

abstract：BACKGROUND:Sorafenib, a kinase inhibitor active against various solid tumours, induces oxidative stress and ferroptosis, a new form of oxidative necrosis, in some cancer cells. Clinically-applicable biomarkers that reflect the impact of sorafenib on the redox metabolism of cancer cells are lacking. METHODS:We used gen...

journal_title：Molecular cancer

authors： Houessinon A,François C,Sauzay C,Louandre C,Mongelard G,Godin C,Bodeau S,Takahashi S,Saidak Z,Gutierrez L,Régimbeau JM,Barget N,Barbare JC,Ganne N,Chauffert B,Coriat R,Galmiche A

更新日期：2016-05-16 00:00:00