PAX2 is activated by estradiol in breast cancer cells of the luminal subgroup selectively, to confer a low invasive phenotype.

abstract：BACKGROUND:Anaplastic lymphoma kinase (ALK), which is a receptor tyrosine kinase, is essentially and transiently expressed in the developing nervous system. Recently, the deregulated expression of full-length ALK has been observed in some primary solid tumors, but little is known about its involvement in the tumorigene...

journal_title：Molecular cancer

authors： Inoue H,Hashimura M,Akiya M,Chiba R,Saegusa M

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumour (GIST) is the most common soft tissue sarcoma. The identification of the molecular mechanisms regulating GIST progression is vital for its treatment and prevention. Increasing reports have demonstrated that epigenetic alterations play critical roles in GIST development. Howeve...

journal_title：Molecular cancer

authors： Hu F,Li H,Liu L,Xu F,Lai S,Luo X,Hu J,Yang X

更新日期：2018-07-30 00:00:00

abstract：BACKGROUND:To clarify the implications of cell-free nucleic acids (cfNA) in the plasma in neoplastic disease, it is necessary to determine the kinetics of their release into the circulation. METHODS:To quantify non-tumor and tumor DNA and RNA in the plasma of tumor-bearing rats and to correlate such levels with tumor ...

journal_title：Molecular cancer

authors： García-Olmo DC,Picazo MG,Toboso I,Asensio AI,García-Olmo D

更新日期：2013-02-04 00:00:00

abstract：BACKGROUND:New therapies are urgently needed for patients with small cell lung cancer (SCLC). Chemotherapy and targeted therapies, including the Bcl-2 inhibitor ABT-737, may induce tumor cell autophagy. Autophagy can promote survival of cancer cells under stress and comprise a pathway of escape from cytotoxic therapies...

journal_title：Molecular cancer

authors： Zinn RL,Gardner EE,Dobromilskaya I,Murphy S,Marchionni L,Hann CL,Rudin CM

更新日期：2013-03-02 00:00:00

abstract：BACKGROUND:An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, was tested side-by-side with khat in a panel of acute myeloid leukemia cell lines to elucidate me...

journal_title：Molecular cancer

authors： Bredholt T,Dimba EA,Hagland HR,Wergeland L,Skavland J,Fossan KO,Tronstad KJ,Johannessen AC,Vintermyr OK,Gjertsen BT

更新日期：2009-11-13 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Molecular cancer

authors： Rong D,Lu C,Zhang B,Fu K,Zhao S,Tang W,Cao H

更新日期：2020-09-09 00:00:00

abstract：BACKGROUND:Certain types of potassium channels (known as Eag1, KCNH1, Kv10.1) are associated with the production of tumours in patients and in animals. We have now studied the expression pattern of the Eag1 channel in a large range of normal and tumour tissues from different collections utilising molecular biological a...

journal_title：Molecular cancer

authors： Hemmerlein B,Weseloh RM,Mello de Queiroz F,Knötgen H,Sánchez A,Rubio ME,Martin S,Schliephacke T,Jenke M,Heinz-Joachim-Radzun,Stühmer W,Pardo LA

更新日期：2006-10-05 00:00:00

abstract：BACKGROUND:Tumor recurrence and metastasis develop as a result of tumors' acquisition of anti-apoptotic mechanisms and therefore, it is necessary to develop novel effective therapeutics against metastatic cancers. In this study, we showed the differential TRAIL responsiveness of human prostate adenocarcinoma PC3 and hu...

journal_title：Molecular cancer

authors： Kim HB,Kim MJ,Kim DY,Lee JW,Bae JH,Kim DW,Kang CD,Kim SH

更新日期：2011-04-25 00:00:00

abstract：BACKGROUND:The Sonic hedgehog (Shh) signaling pathway plays an important role in cerebellar development, and mutations leading to hyperactive Shh signaling have been associated with certain forms of medulloblastoma, a common form of pediatric brain cancer. While the fundamentals of this pathway are known, the molecular...

journal_title：Molecular cancer

authors： Lee SJ,Litan A,Li Z,Graves B,Lindsey S,Barwe SP,Langhans SA

更新日期：2015-08-19 00:00:00

abstract：BACKGROUND:Metastasis in medulloblastoma (MB) is associated with poor survival. Recent genetic studies revealed MB to comprise distinct molecular subgroups, including the sonic hedgehog (SHH) subgroup that exhibits a relatively high rate of progression. To identify targeted therapeutics against metastasis, a better und...

journal_title：Molecular cancer

authors： Yuan L,Zhang H,Liu J,Rubin JB,Cho YJ,Shu HK,Schniederjan M,MacDonald TJ

更新日期：2013-03-05 00:00:00

abstract：BACKGROUND:There is increasing evidence that circular RNAs (circRNAs) have significant regulatory roles in cancer development and progression; however, the expression patterns and biological functions of circRNAs in renal cell carcinoma (RCC) remain largely elusive. METHOD:Bioinformatics methods were applied to screen...

journal_title：Molecular cancer

authors： Cen J,Liang Y,Huang Y,Pan Y,Shu G,Zheng Z,Liao X,Zhou M,Chen D,Fang Y,Chen W,Luo J,Zhang J

更新日期：2021-01-20 00:00:00

abstract：:This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1186/s12943-015-0389-y. ...

journal_title：Molecular cancer

authors： Bendinelli P,Maroni P,Matteucci E,Desiderio MA

更新日期：2020-08-15 00:00:00

abstract：BACKGROUND:Zebrafish have been used as a vertebrate model to study human cancers such as melanoma, rhabdomyosarcoma, liver cancer, and leukemia as well as for high-throughput screening of small molecules of therapeutic value. However, they are just emerging as a model for human brain tumors, which are among the most de...

journal_title：Molecular cancer

authors： Ju B,Chen W,Orr BA,Spitsbergen JM,Jia S,Eden CJ,Henson HE,Taylor MR

更新日期：2015-02-03 00:00:00

abstract：:Autophagy is a highly conserved catabolic process that mediates degradation of pernicious or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and organelles. It can promote or suppress tumor development, so it is a "double-edged sword" in tumors that depends on the cell and tissue typ...

journal_title：Molecular cancer

authors： Chen HT,Liu H,Mao MJ,Tan Y,Mo XQ,Meng XJ,Cao MT,Zhong CY,Liu Y,Shan H,Jiang GM

更新日期：2019-05-24 00:00:00

abstract：BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies. Neovascularization during tumorigenesis supplies oxygen and nutrients to proliferative tumor cells, and serves as a conduit for migration. Targeting oncogenes involved in angiogenesis is needed to treat organ-confined and local...

journal_title：Molecular cancer

authors： Chen Y,Wang D,Peng H,Chen X,Han X,Yu J,Wang W,Liang L,Liu Z,Zheng Y,Hu J,Yang L,Li J,Zhou H,Cui X,Li F

更新日期：2019-01-04 00:00:00

abstract：:Live animal imaging is becoming an increasingly common technique for accurate and quantitative assessment of tumor burden over time. Bioluminescence imaging systems rely on a bioluminescent signal from tumor cells, typically generated from expression of the firefly luciferase gene. However, previous reports have sugge...

journal_title：Molecular cancer

authors： Tiffen JC,Bailey CG,Ng C,Rasko JE,Holst J

更新日期：2010-11-22 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are involved in cancer development and progression, acting as tumor suppressors or oncogenes. Our previous studies have revealed that miR-148a and miR-152 are significantly down-regulated in gastrointestinal cancers. Interestingly, miR-148b has the same "seed sequences" as miR-148a and miR...

journal_title：Molecular cancer

authors： Song YX,Yue ZY,Wang ZN,Xu YY,Luo Y,Xu HM,Zhang X,Jiang L,Xing CZ,Zhang Y

更新日期：2011-01-04 00:00:00

abstract：:In recent years, thyroid malignances have become more prevalent, especially among women. The most common sporadic types of thyroid tumors of follicular origin include papillary, follicular and anaplastic thyroid carcinomas. Although modern diagnosis methods enable the identification of tumors of small diameter, tumor ...

journal_title：Molecular cancer

authors： Pstrąg N,Ziemnicka K,Bluyssen H,Wesoły J

更新日期：2018-08-08 00:00:00

abstract：BACKGROUND:Neuroblastoma is responsible for 15% of all childhood cancer deaths. Despite advances in treatment and disease management, the overall 5-year survival rates remain poor in high-risk disease (25-40%). MiR-497 was previously identified by our laboratory as a member of a miRNA expression signature, predictive o...

journal_title：Molecular cancer

authors： Creevey L,Ryan J,Harvey H,Bray IM,Meehan M,Khan AR,Stallings RL

更新日期：2013-03-26 00:00:00

abstract：BACKGROUND:Sharing the common neuroectodermal origin, melanoma and neuroblastoma are tumors widely diffused among adult and children, respectively. Clinical prognosis of aggressive neuroectodermal cancers remains dismal, therefore the search for novel therapies against such tumors is warranted. Curcumin is a phytochemi...

journal_title：Molecular cancer

authors： Pisano M,Pagnan G,Dettori MA,Cossu S,Caffa I,Sassu I,Emionite L,Fabbri D,Cilli M,Pastorino F,Palmieri G,Delogu G,Ponzoni M,Rozzo C

更新日期：2010-06-03 00:00:00

abstract：BACKGROUND:Perturbation of DNA methylation is frequent in cancers and has emerged as an important mechanism involved in tumorigenesis. To determine how DNA methylation is modified in the genome of primary glioma, we used Methyl-DNA immunoprecipitation (MeDIP) and Nimblegen CpG promoter microarrays to identify different...

journal_title：Molecular cancer

authors： Zhang Z,Tang H,Wang Z,Zhang B,Liu W,Lu H,Xiao L,Liu X,Wang R,Li X,Wu M,Li G

更新日期：2011-09-30 00:00:00

abstract：BACKGROUND:TGF-beta resistance often develops in breast cancer cells that in turn overproduce this cytokine to create a local immunosuppressive environment that fosters tumor growth and exacerbates the invasive and metastatic behavior of the tumor cells themselves. Smads-mediated cross-talk with the estrogen receptor h...

journal_title：Molecular cancer

authors： Ren Y,Wu L,Frost AR,Grizzle W,Cao X,Wan M

更新日期：2009-11-27 00:00:00

abstract：:seRNA is a noncoding RNA (ncRNA) transcribed from active super-enhancer (SE), through which SE exerts biological functions and participates in various physiological and pathological processes. seRNA recruits cofactor, RNA polymerase II and mediator to constitute and stabilize chromatin loop SE and promoter region, whi...

journal_title：Molecular cancer

authors： Tan Y,Li Y,Tang F

更新日期：2020-04-11 00:00:00

abstract：BACKGROUND:For long, natural killer (NK) cells have been suspected to play a critical role in suppressing the development of spontaneous metastases in cancer patients. Despite a wide range of studies it remains unclear so far to what extent primary tumor growth together with formation of distant metastases and NK cell ...

journal_title：Molecular cancer

authors： Brodbeck T,Nehmann N,Bethge A,Wedemann G,Schumacher U

更新日期：2014-11-05 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignant tumours with a poor prognosis worldwide. While early stage tumours can be treated with curative approaches such as liver transplantation or surgical resection, these are only suitable for a minority of patients. Those with advanced stage disease are on...

journal_title：Molecular cancer

authors： Huo X,Han S,Wu G,Latchoumanin O,Zhou G,Hebbard L,George J,Qiao L

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:Transforming Growth Factor beta (TGF-beta) plays an important role in tumor invasion and metastasis. We set out to investigate the possible clinical utility of TGF-beta antagonists in a human metastatic basal-like breast cancer model. We examined the effects of two types of the TGF-beta pathway antagonists (...

journal_title：Molecular cancer

authors： Ganapathy V,Ge R,Grazioli A,Xie W,Banach-Petrosky W,Kang Y,Lonning S,McPherson J,Yingling JM,Biswas S,Mundy GR,Reiss M

更新日期：2010-05-26 00:00:00

abstract：BACKGROUND:Circular RNAs (circRNAs) are a new type of non-coding RNAs and their functions in gastric cancer (GC) remain unclear. Recent studies have revealed that circRNAs play an important role in cancer development and certain types of pathological responses, acting as microRNA (miRNA) sponges to regulate gene expres...

journal_title：Molecular cancer

authors： Liu H,Liu Y,Bian Z,Zhang J,Zhang R,Chen X,Huang Y,Wang Y,Zhu J

更新日期：2018-10-18 00:00:00

abstract：BACKGROUND:Long non-coding RNAs (lncRNAs) have been identified as important epigenetic regulators that play critical roles in human cancers. However, the regulatory functions of lncRNAs in tumorigenesis remains to be elucidated. Here, we aimed to investigate the molecular mechanisms and potential clinical application o...

journal_title：Molecular cancer

authors： He X,Chai P,Li F,Zhang L,Zhou C,Yuan X,Li Y,Yang J,Luo Y,Ge S,Zhang H,Jia R,Fan X

更新日期：2020-07-15 00:00:00

abstract：:Oncolytic viruses (OVs) are tumor-selective, multi-mechanistic antitumor agents. They kill infected cancer and associated endothelial cells via direct oncolysis, and uninfected cells via tumor vasculature targeting and bystander effect. Multimodal immunogenic cell death (ICD) together with autophagy often induced by O...

journal_title：Molecular cancer

authors： Bartlett DL,Liu Z,Sathaiah M,Ravindranathan R,Guo Z,He Y,Guo ZS

更新日期：2013-09-11 00:00:00

abstract：BACKGROUND:Hypermethylation of promotor CpG islands is a common mechanism that inactivates tumor suppressor genes in cancer. Genes belonging to the RASSF gene family have frequently been reported as epigenetically silenced by promotor methylation in human cancers. Two members of this gene family, RASSF1A and RASSF5A ha...

journal_title：Molecular cancer

authors： Djos A,Martinsson T,Kogner P,Carén H

更新日期：2012-06-13 00:00:00